Abstracts tagged "autoantibodies"

Abstract Number: 020 • 2020 Pediatric Rheumatology Symposium
Murine Roseolovirus Induces Autoimmune Disease and Development of Autoantibodies
Tarin Bigley¹ and Wayne Yokoyama ², ¹Washington University in St. Louis, Saint Louis, Missouri, ²Washington University in St. Louis, St Louis, Missouri
Background/Purpose: Murine roseolovirus (MRV) is a recently sequenced beta-herpesvirus that is a natural murine pathogen and is genetically highly related to HHV6 and HHV7. The…
Abstract Number: 054 • 2020 Pediatric Rheumatology Symposium
Clinical and Laboratory Characteristics in Juvenile-onset Systemic Lupus Erythematosus Across Age Groups
Joseph Massias ¹, Eve Smith ¹, Michael Beresford ¹ and Christian Hedrich¹, ¹University of Liverpool, Liverpool, United Kingdom
Background/Purpose: Systemic lupus erythematous (SLE) is a systemic autoimmune/inflammatory condition. Up to 20% of patients develop symptoms before their 18th birthday and are diagnosed with…
Abstract Number: 163 • 2020 Pediatric Rheumatology Symposium
Anti-Dense Fine Speckled (DFS) Autoantibodies in Autoinflammatory Vasculopathies
Asa Laestadius¹, May Choi ¹, Marvin Fritzler ¹, Aurore Fifi-Mah ², Susanne Benseler ³ and Joao Dantas ¹, ¹University of Calgary, Calgary, Canada, ²Calgary, Canada, ³Univeristy of Calgary, Calagry, Canada
Background/Purpose: Autoantibodies to dense fine speckles 70 (DFS70) is now recognized to be more common among apparently healthy individuals compared to patients with ANA-related rheumatic…
Abstract Number: 1028 • 2019 ACR/ARP Annual Meeting
Lupus Auto-antibodies Act as Positive Allosteric Modulators at GluN2A-containing NMDA Receptors to Induce Excitotoxicity and Spatial Memory Deficits
Kelvin Chan¹, Jacquelyn Nestor ², Tomas Huerta ², Czeslawa Kowal ², Patricio Huerta ², Bruce Volpe ², Betty Diamond ³ and Lonnie Wollmuth ¹, ¹Stony Brook University School of Medicine, Stony Brook, NY, ²Feinstein Institutes for Medical Research, Manhasset, NY, ³Feinstein Institutes for Medical Research, Manhasset
Background/Purpose: Patients with Systemic lupus erythematosus (SLE) experience various peripheral and central nervous system manifestations including spatial memory impairment. A subset of auto-antibodies (DNRAbs) cross-react…
Abstract Number: 2739 • 2019 ACR/ARP Annual Meeting
Skin Disease Activity and Autoantibody Phenotype Are Major Determinants of Blood Interferon Signatures in Dermatomyositis
Mika Tabata¹, Kavita Sarin ², Karen Page ³, Christine Huard ³, Shanrong Zhao ³, Donald Bennett ³, Jillian Johnson ³, Kristen Johnson ³ and David Fiorentino ², ¹Stanford University School of Medicine, Stanford, CA, ²Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, ³Pfizer, Boston
Background/Purpose: Interferon (IFN) signaling is upregulated in dermatomyositis (DM) and thought to play a role in pathogenesis. An IFN gene signature in peripheral blood of…
Abstract Number: 1464 • 2019 ACR/ARP Annual Meeting
The Oral Microbiome as a Risk Factor for Benign or Pathologic Autoimmunity Associated with Anti-SSA/Ro Positivity and Mimicry for Von Willebrand Factor Type a Domain Protein (vWFA) of L. Mirabilis
Robert Clancy¹, Miranda Marion ², Peter Izmirly ¹, Hannah Ainsworth ³, Timothy Howard ³, Mala Masson ¹, Jill Buyon ¹ and Carl Langefeld ³, ¹NYU School of Medicine, New York, ²Wake Forest School of Medicine, Winston-Salem, NC, ³Wake Forest School of Medicine, Winston-Salem
Background/Purpose: Autoantibody production precedes SLE or SS by years, including anti-Ro. Anti-Ro+ mothers of children with congenital heart block (CHB) are a unique population at…
Abstract Number: 2815 • 2019 ACR/ARP Annual Meeting
Lower IL-4R in IgD+ Naïve B Cells Is a Pre-disposing Factor for Development of T-bet+ DN2 B Cells in Systemic Lupus Erythematosus
John Mountz¹, Min Gao ², Qi Wu ³, PingAr Yang ², Alex Essman ⁴, Oluwagbemiga Ojo ⁴, Shanrun Liu ², Jake Chen ², Iñaki Sanz ⁵, W. Winn Chatham ² and Hui-Chen Hsu ², ¹University of Alabama at Birmingham and Birmingham VAMC, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, ⁵Emory University, ATLANTA, GA
Background/Purpose: Studies to date have primarily focused on stimulators that are overexpressed and activate B cells in SLE subjects. Factors that can maintain B cells…
Abstract Number: 1615 • 2019 ACR/ARP Annual Meeting
The Effects of Anti-glutamate Receptor Subunit Antiantibodies on Systemic Lupus Erythematosus Without Neuropsychiatric Involvement
Yoshiyuki Arinuma ¹, Yasuhiro Hasegawa ¹, Takumi Muramatsu¹, Yu Matsueda ¹ and Kunihiro Yamaoka ¹, ¹Department of Rheumatology and Infectious Diseaes, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
Background/Purpose: Autoantibodies against N-methyl-D-aspartate receptor subunit GluN2 (anti-GluN2) in the cerebrospinal fluid are known to be related with the development of diffuse psychiatric/neuropsychological manifestations in…
Abstract Number: 1648 • 2019 ACR/ARP Annual Meeting
Systemic Sclerosis Auto-antibody Profiles Predict Interstitial Lung Disease Onset but Not Progression
Boyang Zheng¹, Mianbo Wang ², Marvin Fritzler ³, May Choi ³, Murray Baron ⁴ and Marie Hudson ⁵, ¹Jewish General Hospital, McGill University, Montreal, QC, Canada, ²Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada, ³Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁴Jewish General Hospital, McGill University, Montreal, Canada, ⁵Jewish General Hospital, Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, QC, Canada
Background/Purpose: Interstitial lung disease (ILD) is frequent manifestation and a leading cause of mortality in systemic sclerosis (SSc). Some SSc-related autoantibodies (aAbs), especially anti-topoisomerase I…
Abstract Number: 1774 • 2019 ACR/ARP Annual Meeting
Potential Involvement of OX40 Expressing Tfh Cells on Regulation of Autoantibody Sialylation in Experimental and Rheumatoid Arthritis
Izumi Kurata¹, Isao Matsumoto ¹, Natsuko Mikami ¹, Ayako Ohyama ¹, Atsumu Osada ¹, Yuya Kondo ¹, Hiroto Tsuboi ¹ and Takayuki Sumida ¹, ¹Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Recently, IL-23-Th17 cells axis and hyposialylation of antibodies were proved to be linked to experimental and rheumatoid arthritis. However it remains uncertain how Tfh,…
Abstract Number: 47 • 2019 ACR/ARP Annual Meeting
Autoreactivity to Acetylated Histones Defines a Subset of RA Patients and Is Associated with Acetyl – Citrulline Anti-Modified Protein Autoantibody (AMPA) Cross-Reactivity
Peter Sahlström ¹, Lisa Liljefors ¹, Vijay Joshua ², Natalia Sherina ¹, Radha Thyagarajan ¹, Lena Israelsson ², Ragnhild Stålesen ², Monika Hansson ³, Khaled Amara ², Ulf Reimer ⁴, Leonid Padyukov ¹, Elisabet Svenungsson ⁵, Karin Lundberg ¹, Anca Catrina ³, Lars Klareskog ³, Vivianne Malmström ² and Caroline Grönwall², ¹Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden., Stockholm, Sweden, ³Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, ⁴JPT Peptide Technologies, Berlin, Germany, ⁵Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Serum anti-citrullinated protein autoantibodies (ACPA) in rheumatoid arthritis (RA) display reactivity to a variety of cit-autoantigens. Studies of human ACPA mAbs have revealed that…
Abstract Number: 1868 • 2019 ACR/ARP Annual Meeting
Clinical Correlations of Autoantibodies Against Heat Shock Cognate 71 kDa Protein in Patients with Juvenile Dermatomyositis
Rie Karasawa¹, James N. Jarvis ², Toshiko Sato ¹, Megumi Tanaka ¹, Mark Hicar ², Kazuo Yudoh ¹, Terrance O’Hanlon ³, Payam Noroozi-Farhadi ³ and Lisa G. Rider ⁴, ¹Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, ²University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, ³NIEHS, NIH, Bethesda, MD, ⁴Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Bethesda, MD
Background/Purpose: Juvenile dermatomyositis (JDM) is an inflammatory myopathy characterized by prominent vascular and perivascular inflammation in affected skeletal muscles. The mechanisms of vessel injury in…
Abstract Number: 80 • 2019 ACR/ARP Annual Meeting
The Role of Adopter Protein SH3BP2 in a Murine Systemic Lupus Erythematosus Model
Kyoko Kawahara¹, Tomoyuki Mukai ², Akiko Nagasu ¹, Masanori Iseki ³, Hajime Nagasu ⁴, Shoko Tshuji ¹, Takahiko Akagi ¹, Yasuyoshi Ueki ⁵ and Yoshitaka Morita ¹, ¹Department of Rheumatology, Kawasaki medical School, Kurashiki, Okayama, Japan, ²Department of Rheumatology, Kawasaki medical School, Kurashiki, Okayama, Okayama, Japan, ³Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama, Japan, ⁴Department of Nephrology and Hypertension, Kawasaki medical School, Kurashiki, Okayama, Japan, ⁵Department of Biomedical Sciences and Comprehensive Care Indiana University School of Dentistry, Indianapolis, IN
Background/Purpose: An adaptor protein SH3BP2 (Src homology 3 domain-binding protein 2) is widely expressed in immune cells and controls intracellular signaling pathways, such as Syk,…
Abstract Number: 1900 • 2019 ACR/ARP Annual Meeting
Assessing Commercial Titers of anti-Ro60 and Ro52 Antibodies to Risk Stratify Surveillance of Anti-Ro/SSA Antibody Positive Pregnancies
Kimberly Robins ¹, Rohit Bhan¹, Catherine Trad ¹, Rebecca Cohen ¹, Miao Chang ¹, Benjamin Wainwright ¹, Mala Masson ¹, Shilpi Mehta-Lee ¹, Peter Izmirly ¹, Robert Clancy ¹, Bettina Cuneo ² and Jill Buyon ¹, ¹NYU School of Medicine, New York, ²Children's Hospital Colorado, Aurora
Background/Purpose: Pregnancy counseling of all anti-Ro positive women includes advice regarding the development of congenital heart block (CHB), albeit the risk is only 2% for…
Abstract Number: 126 • 2019 ACR/ARP Annual Meeting
Antibodies Targeting Mitochondrial Antigens Are Associated with Reduced Thrombotic Events in APS
Yann Becker¹, Anne-Sophie Julien ², Alexandra Godbout ³, Éric Boilard ³ and Paul Fortin ⁴, ¹Département de microbiologie et immunologie, Centre de recherche du CHU de Québec - Université Laval, Canada, Quebec, QC, Canada, ²Service de consultation statistique (SCS). Département de mathématiques et de statistique, Québec, QC, Canada, ³Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Québec – Université Laval, Québec, Qc, Canada, Québec, QC, Canada, ⁴Division de Rhumatologie, Département de Médecine, CHU de Québec – Université Laval, Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Québec – Université Laval, Canada, Quebec, QC, Canada
Background/Purpose: Mitochondria are intracellular organelles involved in many biological pathways such as energy supply by oxidative phosphorylation and apoptosis. Mitochondria are considered as derived from…

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