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Abstracts tagged "Apoptosis"

  • Abstract Number: 1835 • 2017 ACR/ARHP Annual Meeting

    Microglial Defects Contribute to Neuropsychiatric Symptoms of Systemic Lupus Erythematosus

    Hadijat Makinde1, Philip J. Homan2, Harris Perlman2 and Carla Cuda2, 1Northwestern University, Chicago, IL, 2Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE), including headaches, cognitive dysfunction and psychiatric disorders, appear in up to 75% of SLE patients and may…
  • Abstract Number: 2576 • 2017 ACR/ARHP Annual Meeting

    Caspase 8 in Dendritic Cells Suppresses IRF5 Activation through Endosomal TLR Signaling to Prevent SLE-like Disease

    FuNien Tsai1, Harris Perlman2 and Carla Cuda2, 1Medicine-Rheumatology, Northwestern University-Feinberg School of Medicine, Chicago, IL, 2Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Previous studies implicate dendritic cells (DCs) in the pathogenesis of systemic lupus erythematosus (SLE), yet the mechanisms underlying this involvement are not yet clear.…
  • Abstract Number: 810 • 2016 ACR/ARHP Annual Meeting

    Microrna-125b As a Potential Anti-Fibrotic and Anti-Apoptotic Regulator in Systemic Sclerosis

    Anastasiia Kozlova1, Elena Pachera1, Florian Renoux2, Michal Rudnik1, Britta Maurer1, Astrid Jüngel3, Joerg H.W Distler4, Gabriela Kania1 and Oliver Distler1, 1Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Depertment of Rheumatology, University Hospital Zurich, Schlieren, Switzerland, 3Ctr Exp Rheum, Univ Hosp Zurich / Zurich Ctr Integr Hum Physiol (ZIHP), Zurich, Switzerland, 4Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: MicroRNAs (miRs) are a class of small, noncoding RNAs that regulate many biological processes. Some microRNAs are involved in skin fibrosis. Here, we aimed…
  • Abstract Number: 1747 • 2016 ACR/ARHP Annual Meeting

    Dissecting the Role of Single Complement Deficiencies in a Novel Model for Apoptotic Cell-Induced Lupus

    Lucrezia Colonna1, Clayton J. Sontheimer2, Lena M. Tanaka3, Kelly L. Hudkins4, Charles E. Alpers4, Keith B. Elkon1 and YuFeng Peng3, 1Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2Pediatric Rheumatology, University of Washington, Seattle, WA, 3Division of Rheumatology, University of Washington, Seattle, WA, 4Pathology, University of Washington, Seattle, WA

    Background/Purpose: The role of complement in Systemic Lupus Erythematosus (SLE) is complex as complement deficiencies in early components of the classical pathway cause lupus with…
  • Abstract Number: 1916 • 2016 ACR/ARHP Annual Meeting

    Heightened MAIT Cell Sensitivity to MR1 Ligands Could Impact Control of Dysbiosis in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis

    Diahann Jansen1, Elizabeth Klinken1, Hendrik Nel2, Soi Cheng Law2, Helen Benham3,4,5, Lisa Cummins6, Matthew Brown7, Tony Kenna2, Ligong Liu8, David Fairlie8, Jamie Rossjohn9,10,11, Mark Morrison3, Ranjeny Thomas3, Paraic O Cuiv1, James McCluskey12 and Alexandra Corbett12, 1The University of Queensland Diamantina Institute, Translational Research Institute, Woolloongabba, Australia, 2The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, 3Translational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia, 4University of Queensland School of Medicine, Brisbane, Australia, 5Rheumatology, Princess Alexandra Hospital, Woolloongabba, Australia, 6Princess Alexandra Hospital, Woolloongabba, Australia, 7Queensland University of Technology, Brisbane, Australia, 8Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia, 9Infection and Immunity Program, Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia, 10Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom, 11Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Australia, 12Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Australia

    Background/Purpose: Mucosal associated invariant T (MAIT) cells are an innate-like lymphocyte population predominant at mucosal sites, which express a semi-invariant T cell receptor restricted to…
  • Abstract Number: 2060 • 2016 ACR/ARHP Annual Meeting

    Bim Suppresses the Development of SLE By Limiting Macrophage Inflammatory Responses

    FuNien Tsai1, Carla Cuda2, Harris R. Perlman3, Philip J. Homan4, Salina Dominguez2, Alexander Shaffer3, George Kenneth Haines III5 and Jack Hutcheson6, 1Medicine-Rheumatology, Northwestern University-Feinberg School of Medicine, Chicago, IL, 2Northwestern University, Chicago, IL, 3Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, 4Medicine-Rheumatology, Northwestern University, Chicago, IL, 5Mount Sinai, New York, NY, 6UT Southwestern, Dallas, TX

    Background/Purpose: The Bcl-2 family guards the mitochondrial apoptotic pathway. Among numerous Bcl-2 antagonists, only the loss of Bim in mice leads to the development of…
  • Abstract Number: 2557 • 2016 ACR/ARHP Annual Meeting

    Tumor Necrosis Factor (TNF) Sensitizes Rheumatoid Synovial Fibroblasts to TRPA1-Mediated Calcium Flux, Anti-Proliferation and Cell Death

    Torsten Lowin1, Rainer Straub2 and Georg Pongratz3, 1Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany, 2Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine, University Hospital Regensburg, Regensburg, Germany, 3Rheumatology - Hiller Research Center Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany

    Background/Purpose:  In rheumatoid arthritis (RA), synovial fibroblasts (SF) are one main contributor of joint destruction since they resist apoptosis and secrete pro-inflammatory cytokines and matrix…
  • Abstract Number: 2558 • 2016 ACR/ARHP Annual Meeting

    Dissociation of the Inhibitory Apoptosis Stimulating Protein of p53 (iASPP) Binding with Transcription Factor p73 Induces Synovial Fibroblast Apoptosis in the Rheumatoid Joint

    Chrong-Reen Wang1, Shih-Yao Chen1, Ai-Li Shiau2, Ming-Fei Liu1 and Chao-Liang Wu3, 1Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan, 2Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, 3Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan

    Background/Purpose:   Apoptosis-resistant synovial fibroblasts (SFs) constitute the major cell component of pannus tissues in rheumatoid arthritis (RA). In tumor cells, the binding of inhibitory…
  • Abstract Number: 2561 • 2016 ACR/ARHP Annual Meeting

    A Novel Pharmacological Action of MTX on RA Fibroblast-like Synoviocytes Via Circadian Clock Genes

    Kohjin Suzuki1, Kohsuke Yoshida1, Teppei Hashimoto2, Kenta Kaneshiro1, Ayako Nakai1, Naonori Hashimoto1, Yoshiko Kawasaki2, Nao Shibanuma3, Natsuko Nakagawa4, Yoshitada Sakai5 and Akira Hashiramoto6, 1Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan, 2Department of Rheumatology, Kobe Kaisei Hospital, Kobe, Japan, 3Departmant of Orthopaedic Surgery, Kobe Kaisei Hospital, Kobe, Japan, 4Department of Orthopaedic Surgery, Konan-Kakogawa Hospital, Kakogawa, Japan, 5Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, 6Department of Biophysics, Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan

    Background/Purpose: The circadian rhythm is disrupted in patients with rheumatoid arthritis (RA), and we have shown that tumor necrosis factor(TNF)-ƒ¿ inhibits the expression of circadian…
  • Abstract Number: 3143 • 2016 ACR/ARHP Annual Meeting

    The Caspase 8/RIPK3 Signaling Axis in Dendritic Cells Controls Joint Homeostasis Under Steady-State and Arthritic Conditions

    Salina Dominguez1, Harris R. Perlman2 and Carla Cuda1, 1Northwestern University, Chicago, IL, 2Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL

    Background/Purpose: Rheumatoid arthritis (RA) manifests in persistent synovial inflammation, cellular infiltration and pro-inflammatory cytokine production, and results in progressive joint destruction. Dendritic cells (DCs) have…
  • Abstract Number: 3215 • 2015 ACR/ARHP Annual Meeting

    Bim Suppresses the Development of SLE By Limiting Macrophage Inflammatory Responses

    Fu-Nien Tsai1 and Harris R. Perlman2, 1Medicine, Rhuematology, Northwestern University, Chicago, IL, 2Feinberg School of Medicine, Northwestern University, Chicago, IL

    Background/Purpose: The Bcl-2 family guards the mitochondrial apoptotic pathway. Among numerous Bcl-2 antagonists, only the loss of Bim in mice leads to the development of…
  • Abstract Number: 8 • 2015 ACR/ARHP Annual Meeting

    Bay 11-7085 Induces Glucocorticoid Receptor Activation and Autophagy to Initiate Human Synovial Fibroblast Cell Death

    Biserka Relic1, Edith Charlier2, Céline Deroyer1, Olivier Malaise1, Sophie Neuville1, Aline Desoroux1, Philippe Gillet3, Michel G. Malaise1 and Dominique de Seny1, 1Department of Rheumatology- GIGA Research - Arthropôle - University of Liège - CHU Liège, Liège, Belgium, 2Department of Rheumatology, Department of Rheumatology- GIGA Research - Arthropôle - University of Liège - CHU Liège, Liège, Belgium, 3Orthopaedic Surgery Department-University of Liège-CHU de Liège, Liège, Belgium

    Background/Purpose: BAY 11-7085 is an inhibitor of IκBα phosphorylation that leads to NF-κB inactivation and downregulation of inflammation in mouse model of asthma, in articular…
  • Abstract Number: 810 • 2015 ACR/ARHP Annual Meeting

    Human Parvovirus B19 Nonstructural Protein 1 (NS1) Helicase Breaks Tolerance to Self dsDNA: A Model for Viral Induction of Autoimmunity

    Heidi Pirttinen1, Kanoktip Puttaraksa1, Robert J. Lagier2, Stanley J. Naides3 and Leona Gilbert1, 1Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland, 2Research Support, Alameda, Quest Diagnostics Alameda, Alameda, CA, 3Immunology, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA

    Background/Purpose:  B19 virus (B19V) is common, infects all ages, and is associated with various clinical syndromes including SLE-like autoimmunity. We previously demonstrated that B19 NS1,…
  • Abstract Number: 1037 • 2015 ACR/ARHP Annual Meeting

    Impaired Regulatory T Cell Survival in the Pathogenesis of Autoreactive Arthritis Mediated By CD11c-Deletion of Flip

    Qi Quan Huang1, Renee E. Doyle1, Robert Birkett2, Deyu Fang3, Syamal K. Datta1 and Richard M. Pope1, 1Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose:  We have generated a mouse line with Flip conditionally deleted in CD11c-cre expressing cells (CD11c-Flip-KO, named HUPO), which spontaneously develops erosive arthritis resembling rheumatoid…
  • Abstract Number: 1616 • 2015 ACR/ARHP Annual Meeting

    Identification of Genes Regulating TRAIL-Induced Apoptosis in Rheumatoid Arthritis Fibroblasts-like Synoviocytes (RA FLS)

    Rachel Audo1,2, Bernard Combe3,4, Michael Hahne5 and Jacques Morel6, 1Rheumatology, Teaching Hospital of Lapeyronie, Montpellier, France, 2IGMM, CNRS UMR5535, Montpellier, Montpellier, France, 3Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, 4Montpellier University, Montpellier, France, 5IGMM-CNRS UMR5535, Montpellier, France, 6Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France

    Background/Purpose: We previously described that sensitivity to TRAIL-induced apoptosis varied in rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) from one patient to another, and was inversly correlated…
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