Abstracts tagged "Animal models"

Abstract Number: 2080 • 2012 ACR/ARHP Annual Meeting
IL-20 Is Not Involved in Mouse Collagen Induced Arthritis
Christina Andersson¹, Kyle Serikawa², Hermann Pelzer³, Peter Thygesen³, Patricia Smith², Kim Kruse², Shameek Biswas², Brian Fox², Anders Milner⁴, Peter Kvist⁵, Josephine Hebsgaard⁶, Jesper Pass⁷ and John Rømer⁸, ¹AID Models, Immunopharmacology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ²Molecular Immunology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Seattle, WA, ³Exploratory ADME, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ⁴DMPK, Cell and Antibody Analysis, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ⁵Histology, Novo Nordisk A/S, Måløv, Denmark, ⁶Histology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ⁷Antibody Thechnology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ⁸Inflammation Science, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark
Background/Purpose: Interleukin-20 (IL-20) is a pro-inflammatory cytokine involved in the pathogenesis of rheumatoid arthritis (RA). Clinical phase 2a testing has shown that treatment with an…
Abstract Number: 2306 • 2012 ACR/ARHP Annual Meeting
Intratracheal Instillation of Omniscan in an Adenine-Induced Model of Chronic Renal Failure: A New Model of Nephrogenic Systemic Fibrosis
Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Nephrogenic Systemic Fibrosis (NSF), a generalized progressive fibrotic disorder, occurs in some patients with renal insufficiency exposed to various gadolinium based contrast agents (GdBCA). …
Abstract Number: 332 • 2012 ACR/ARHP Annual Meeting
Blockade of CTGF Restores Aberrant Ostoclastgenesis in Collagen Induced Arthritis (CIA) Mice Through Inhibition of Th-17 Differentiation
Kazuhisa Nozawa¹, Maki Fujishiro², Ayako Yamaguchi¹, Mikiko Kawasaki², Shouzou Ichinose², Mitsuaki Yanagida², Kazuhisa Iwabuchi², Keigo Ikeda³, Shinji Morimoto⁴, Megumi Morioka⁵, Yoshinari Takasaki⁶ and Iwao Sekigawa³, ¹Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Institute for Environment and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan, ³Internal Medicine 2, Juntendo University Urayasu Hospital, Tomioka, Urayasu, Chiba, Japan, ⁴Juntendo University Urayasu Hospital, Tokyo, Japan, ⁵Nihon Nosan Corporation, Nihon Nosan Corporation, Kanagawa, Japan, ⁶Internal Medicine and Rheumatology,, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Our previous study demonstrated changes in the profiles of serum protein biomarkers in infliximab-treated rheumatoid arthritis (RA) patients using a novel approach to proteomic…
Abstract Number: 1056 • 2012 ACR/ARHP Annual Meeting
Fc Receptor Gamma-Dependent Autoimmune Endocarditis in K/BxN Mice
Patricia M. Hobday¹, Jennifer L. Auger², J. Sjef Verbeek³, Jeffrey V. Ravetch⁴ and Bryce A. Binstadt², ¹Department of Pediatrics, Division of Pediatric Rheumatology, University of Minnesota, Minneapolis, MN, ²Center for Immunology and Department of Pediatrics, University of Minnesota, Minneapolis, MN, ³Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands, ⁴The Rockefeller University, New York, NY
Background/Purpose: Arthritis and endocarditis co-exist in several human rheumatic diseases, including systemic lupus erythematosus, rheumatic fever, and rheumatoid arthritis. K/BxN TCR transgenic mice, well known…
Abstract Number: 2078 • 2012 ACR/ARHP Annual Meeting
Low-Density Lipoprotein Receptor Deficiency Ameliorates the Development of Inflammatory Arthritis
Shawn Rose¹ and Harris R. Perlman², ¹Department of Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL
Background/Purpose: Patients with rheumatoid arthritis (RA) carry a higher risk of cardiovascular disease compared to the general population. The low-density lipoprotein receptor (LDLR) and Apolipoprotein…
Abstract Number: 2327 • 2012 ACR/ARHP Annual Meeting
CGEN-15001, a Novel Negative Costimulatory Fusion Protein Is Effective in the Collagen-Induced Arthritis Mouse Model of Rheumatoid Arthritis
Iris Hecht¹, Kay McNamee², Ilan Vaknin³, Anat Oren³, Joseph R. Podojil⁴, Galit Rotman³, Eyal Neria³, Stephen D. Miller⁴ and Richard O. Williams², ¹R&D, Compugen Ltd., Tel Aviv, Israel, ²Kennedy Institute of Rheumatology, Oxford University, Oxford, United Kingdom, ³Compugen Ltd., Tel Aviv, Israel, ⁴Microbiology-Immunology, Northwestern University, Chicago, IL
Background/Purpose: CGEN-15001 is a recombinant Fc fusion protein consisting of the extracellular domain of CGEN-15001T, a protein predicted to be a member of the B7/CD28…
Abstract Number: 331 • 2012 ACR/ARHP Annual Meeting
PDL241, a Novel Humanized Monoclonal Antibody, Reveals CD319 As a Therapeutic Target for Rheumatoid Arthritis
Michel P.M. Vierboom¹, Jacky Woo², Hakju Kwon², Debra Chao², Shiming Ye², Jianmin Li², Karen Lin², Irene Tang², Nicole Belmar², Taymar Hartman², Elia Breedveld¹, Bert A. ‘t Hart¹ and Gary C. Starling², ¹Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, Netherlands, ²Abbott Biotherapeutics, Redwood City, CA
Background/Purpose: Current therapies have shown tremendous progress in the treatment of rheumatoïd arthritis (RA). However, a substantial group of RA patients are still refractory to…
Abstract Number: 1076 • 2012 ACR/ARHP Annual Meeting
FLIP in Dendritic Cells May Regulate Hematopoietic Homeostasis and Modulating Inflammation and Immunity
Qi Quan Huang¹, Robert Birkett², Harris R. Perlman³ and Richard M. Pope⁴, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁴Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: We previously demonstrated that FLIP in myeloid linage cells is necessary for neutrophil homeostasis and macrophage differentiation. Therefore studies were performed to determine the…
Abstract Number: 2072 • 2012 ACR/ARHP Annual Meeting
Bone Formation and Resorption Are Both Increased in Autoimmune Arthritis
Kresten K. Keller¹, Jesper Skovhus Thomsen², Kristian Stengaard-Pedersen¹, Frederik Dagnæs-Hansen³, Jens R. Nyengaard⁴ and Ellen-Margrethe Hauge¹, ¹Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ²Institute of Anatomy, Aarhus University, ³Institute of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark, ⁴Stereology and Electron Microscopy Laboratory, Centre for Stochastic Geometry and Advanced Bioimaging. Aarhus University hospital, Aarhus, Denmark
Background/Purpose: Bone destruction in the joints of patients with rheumatoid arthritis (RA) is the result of a combination of osteoclastic bone resorption and osteoblastic bone…
Abstract Number: 2523 • 2012 ACR/ARHP Annual Meeting
Periodontal Pathogens Directly Promote Autoimmune Experimental Arthritis by Inducing a Toll-Like Receptor 2 and Interleukin-1 Driven Th17 Response
Shahla Abdollahi-Roodsaz¹, Sabrina Garcia de Aquino², Marije I. Koenders³, Fons A. van de Loo⁴, Ger J. Pruijn⁵, Mario J. Avila Campos⁶, Fernando Q. Cunha⁷, Joni A. Cirelli² and Wim B. van den Berg¹, ¹Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Department of Diagnosis and Oral Surgery, Periodontic Division, Araraquara Dental School, Sao Paolo, Brazil, ³Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ⁴Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁵Department of Biomolecular Chemistry, Radboud University, Nijmegen, Netherlands, ⁶Department of Microbiology, Institute of Biomedical Sciences—ICB/USP, Sao Paulo, Brazil, ⁷Department of Pharmacology, School of Medicine of Ribeirao Preto, Sao Paolo, Brazil
Background/Purpose: The periodontal pathogen Porphyromonas gingivalishas been associated with the pathogenesis of rheumatoid arthritis (RA) because of its ability to citrullinate mammalian proteins and to…
Abstract Number: 438 • 2012 ACR/ARHP Annual Meeting
Methyl Supplementation of Rheumatoid Arthritis Synovial Fibroblasts Regulates the Expression of Transcription Factors and Matrix Metalloproteinases
Edvardas Bagdonas¹, Emmanuel Karouzakis², Astrid Jungel², Caroline Ospelt¹, Renate E. Gay¹, Steffen Gay¹, Beat A. Michel¹ and Michel Neidhart¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland
Background/Purpose: Previously we reported that methyl supplementation can reverse the global hypomethylation of rheumatoid arthritis synovial fibroblasts (RASF) and attenuate their aggressive behaviour. Now we…
Abstract Number: 1450 • 2012 ACR/ARHP Annual Meeting
MEDI-551 Depletes a Majority of Murine B Cells and Reduces Serum Titers of Autoantibodies in the SLE1-huCD19 TG Mice
Sandra Gallagher¹, Yue Wang¹, Isharat Yusuf¹, Thomas McCaughtry¹, Ronald Herbst² and Laura Carter¹, ¹Respiratory, Inflammation and Autoimmune, MedImmune, Gaithersburg, MD, ²Respiration, Inflammation and Autoimmunity, MedImmune, Gaithersburg, MD
Background/Purpose: Systemic Lupus Erythematosus (SLE) is characterized by chronic inflammation that can affect various organs. Hyperactive B cells appear to be key drivers in SLE…
Abstract Number: 2069 • 2012 ACR/ARHP Annual Meeting
Proteinase Activated Receptor-4 Stimulation Promotes Leukocyte Adhesion in the Rat Knee Joint
Jason J. McDougall, Departments of Pharmacology and Anaesthesia, Dalhousie University, Halifax, NS, Canada
Background/Purpose: Proteinase activated receptors (PARs) are a family of G protein-coupled receptors that signal by enzymatic cleavage of the receptor in a specific extracellular domain.…
Abstract Number: 2682 • 2012 ACR/ARHP Annual Meeting
Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses IL-2 Production and Regulatory T Cell Activity in Systemic Lupus Erythematosus
Tomohiro Koga¹, Kunihiro Ichinose², Masayuki Mizui³, José C. Crispín⁴ and George C. Tsokos⁴, ¹Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ²Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Division of Rheumatology, Department of Medicine,, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA
Background/Purpose: T cells from patients with SLE exhibit abnormal signaling upon TCR engagement and have an altered gene expression profile. Accordingly, the regulation of several transcription factors…
Abstract Number: 519 • 2012 ACR/ARHP Annual Meeting
Sex-Specific Regulatory T Cell Dysfunction in a Mouse Model of Sjögren Syndrome
Scott M. Lieberman¹, Portia A. Kreiger² and Gary A. Koretzky³, ¹Pediatrics, Div Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Pathology, Nemours/A.I. DuPont Hospital for Children, Wilmington, DE, ³Medicine, University Pennsylvania, Philadelphia, PA
Background/Purpose: CD4+Foxp3+ regulatory T cells (Tregs) are a specialized population of lymphocytes which prevent autoimmunity in normal hosts. Treg dysfunction has been implicated in autoimmunity; however results…