ACR Meeting Abstracts

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Abstracts tagged "Animal models"

  • Abstract Number: 2084 • 2012 ACR/ARHP Annual Meeting

    ASP015K: A Novel JAK Inhibitor Demonstrated Potent Efficacy in Adjuvant-Induced Arthritis Model in Rats

    Shunji Yamazaki1, Masamichi Inami1, Misato Ito1, Yasutomo Fujii1, Kaori Hanaoka1, Kaoru Yamagami1, Kenji Okuma1, Yoshiaki Morita1, Shohei Shirakami2, Takayuki Inoue2, Susumu Miyata3 and Yasuyuki Higashi1, 1Pharmacology Research Labs, Astellas Pharma Inc., Tsukuba, Japan, 2Chemistry Research Labs, Astellas Pharma Inc., Tsukuba, Japan, 3Research Planning & Administration, Astellas Pharma Inc., Tsukuba, Japan

    Background/Purpose: The Janus kinase (JAK) family of enzymes plays a key role in cytokine signaling, which is involved in the pathogenic events of immune-mediated disorders…
  • Abstract Number: 1507 • 2012 ACR/ARHP Annual Meeting

    Propylthiouracil Reduces Fibrosis in Chronic Oxidant Stress Mouse Model of Scleroderma

    Gianluca Bagnato1, Alessandra Bitto2, Natasha Irrera2, Gabriele Pizzino2, Neal Roberts3, Maurizio Cinquegrani4, Donatella Sangari1, Francesco Squadrito2, Gianfilippo Bagnato1 and Antonino Saitta4, 1Rheumatology, University of Messina, Messina, Italy, 2Pharmacology, University of Messina, Messina, Italy, 3Medical College of Virginia, Richmond, VA, 4Internal Medicine, University of Messina, Messina, Italy

    Background/Purpose: Systemic sclerosis (SSc) is characterized by fibrosis of skin and visceral organs; vascular damage and resultant ischemia; and immunological dysregulation manifested by autoantibodies. Hypothyroidism,…
  • Abstract Number: 734 • 2012 ACR/ARHP Annual Meeting

    Chemokine (C-C Motif) Receptor 2 Signaling Mediates Persistent Pain in Experimental Osteoarthritis

    Rachel E. Miller1, Phuong Tran2, Rosalina Das2, Nayereh Ghoreishi-Haack2, Richard J. Miller3 and Anne-Marie Malfait4, 1Rheumatology/Biochemistry, Rush University Medical Center, Chicago, IL, 2Rheumatology, Rush University Medical Center, Chicago, IL, 3Molecular Biochemistry and Pharmacology, Northwestern University, Chicago, IL, 4Internal Medicine/Biochemistry, Rush University Medical Center, Chicago, IL

    Background/Purpose: To investigate the role of MCP-1/CCR2 in the development of pain in osteoarthritis (OA) using a mouse model, destabilization of the medial meniscus (DMM).…
  • Abstract Number: 35 • 2012 ACR/ARHP Annual Meeting

    Changes in Tibial Bone and Cartilage Structure in a Mouse Surgical Model of Osteoarthritis

    Brett A. Tonkin1, Evange Romas2, Natalie A. Sims1 and Nicole C. Walsh1, 1St Vincent's Institute of Medical Research, Melbourne, Australia, 2Dept. of Rheumatology, St Vincent's Hospital, Melbourne, Australia

    Background/Purpose: The destabilisation of the medial meniscus (DMM) mouse osteoarthritis (OA) model is commonly used to study OA joint degeneration. In DMM-OA, the knee is…
  • Abstract Number: 2085 • 2012 ACR/ARHP Annual Meeting

    T Cell-Mediated Murine Antigen-Induced Arthritis Is Resistant to Transgenic Disruption of Glucocorticoid Signaling in Osteoblasts and Osteocytes in Vivo

    Cornelia M. Spies1, Edgar Wiebe1, Jinwen W. Tu2, Aiqing Li2, Timo Gaber1, Dörte Huscher1, Markus J. Seibel2, Hong Zhou2 and Frank Buttgereit3, 1Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, 2Bone Research Program, ANZAC Research Institute, The University of Sydney, Concord, Australia, 3Charité - Universitätsmedizin Berlin, Berlin, Germany

    Background/Purpose: The role of endogenous glucocorticoids (GC) in, and their contribution to the susceptibility and severity of rheumatoid arthritis remains inconclusive. We previously demonstrated that…
  • Abstract Number: 1513 • 2012 ACR/ARHP Annual Meeting

    TSLP Receptor Deficiency Reduces IL-13 Expression and Prevents Fibrosis in Experimental Scleroderma

    Alicia Usategui1, Vanessa Miranda1, Gabriel Criado2, Manuel J. Del Rey1, Elena Izquierdo1, Warren J. Leonard3 and Jose L. Pablos1, 1Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 2Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 3Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and internal organs. Although SSc shares pathogenetic features with other…
  • Abstract Number: 738 • 2012 ACR/ARHP Annual Meeting

    A Novel Orally Active Phosphatidylinositol 3-Phosphate 5-Kinase (PIKfyve) Inhibitor Ameliorates Mouse Psoriasis-Like Model by Inhibition of Interleukin-12 and Interleukin-23 Production From Macrophages

    Ayatoshi Andou, Eviryanti Agung, Yukie Seki, Yoichiro Shima, Sen Takeshita, Takashi Yamamoto and Hiroyuki Eda, Exploratory Research Laboratories, Ajinomoto Pharmaceuticals Co., Ltd., Kanagawa, Japan

    Background/Purpose: Phosphatidylinositol (3,5)-bisphosphate (PI(3,5)P2) is the most recently-identified phospholipid component of cellular membrane. Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is a critical enzyme for the synthesis of…
  • Abstract Number: 37 • 2012 ACR/ARHP Annual Meeting

    Development of a Mouse Model of Natural Osteoarthritis of Knee by Induction of obesity and Bipedal Walking

    Hyun Ah Kim1, Su Jin Park2, Eun-Jeong Cheon3, Hyun A. Jung4 and Kyeong Min Son5, 1Division of Rheumatology, Department of Internal Medicine, Hallym university, Kyunggi, South Korea, 2Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, 3Department of internal medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, 4Division of Rheumatology, Department of Internal Medicine, Hallym university sacred heart hospital, Kyunggi, South Korea, 5Division of Rheumatology, Department of Internal Medicine, Hallym university Chunchun sacred heart hospital, Chunchun, South Korea

    Background/Purpose: Animal models of osteoarthritis(OA) are used extensively in research of its pathogenesis and in search of disease modifying anti-OA drugs. However, whether current animal models…
  • Abstract Number: 2086 • 2012 ACR/ARHP Annual Meeting

    PI3-Kinase Controls Inflammatory Bone Destruction by Regulating the Osteoclastogenic Potential of Myeloid Cells

    Stephan Blueml1, Gernot Schabbauer2, Antonia Puchner3, Emine Sahin2, Victoria Saferding4, Birgit Niederreiter5, Josef S. Smolen6 and Kurt Redlich5, 1Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 2Vascular Biology and Thrombosis research, Medical University Vienna, Vienna, Austria, 3Dpt of Rheumatology, Medical University Vienna, Vienna, Austria, 4Rheumatology, Medical University of Vienna, Vienna, Austria, 5Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 6Division of Rheumatology, Department of Internal Medicine III,, Medical University of Vienna and Hietzing Hospital, Vienna, Austria

    Background/Purpose: Local bone destruction in rheumatoid arthritis, psoriasisarthritis or ankylosing spondylitis is a serious health burden and the major cause of disability and severely reduced…
  • Abstract Number: 1440 • 2012 ACR/ARHP Annual Meeting

    Lupus-Prone Mice Demonstrate Enhanced Neutrophil Extracellular Trap Formation: Implications for Autoantibody Formation and Organ Damage

    Jason S. Knight1, Alexander A. O'Dell1, Wenpu Zhao2, Ritika Khandpur2, Srilakshmi Yalavarthi2 and Mariana J. Kaplan3, 1Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2University of Michigan Rheumatology, Ann Arbor, MI, 3Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD

    Background/Purpose: Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation—the programmed release of chromatin fibers decorated with granular antimicrobial peptides—is as an important activator…
  • Abstract Number: 731 • 2012 ACR/ARHP Annual Meeting

    A Systems Biology Approach to Elucidating Pathways Active During the Development of Osteoarthritis

    Richard F. Loeser1, Amy L. Olex2, Brian Westwood2, Margaret A. McNulty3, Cathy S. Carlson3, Michael Callahan4, Cristin Ferguson4 and Jacquelyn S. Fetrow2, 1Section Of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 2Computer Science, Wake Forest University, Winston-Salem, NC, 3Veterinary and Diagnostic Medicine, University of Minnesota, St. Paul, MN, 4Orthopedic Surgery, Wake Forest School of Medicine, Winston-Salem, NC

    Background/Purpose: OA affects the entire joint but most studies have focused on the disease process in a single tissue. In this study, we identified genes…
  • Abstract Number: 25 • 2012 ACR/ARHP Annual Meeting

    Activation of the Canonical Wnt Signaling Pathway Is Tissue Dependent in Osteoarthritic Joints: Distinct Mechanisms of Regulation by Wnt Antagonists

    Thomas Funck-Brentano1, Wafa Bouaziz1, Hilene Lin1, Valerie Geoffroy1, Eric Hay1 and Martine Cohen-Solal2, 1INSERM U606 Paris 7 university, Paris, France, 2Rhumatologie A, INSERM U606 Hôpital Lariboisière, Centre Viggo Petersen, Paris, France

    Background/Purpose: Wnt signaling pathway is a major regulator of bone and cartilage remodeling. Modulation of this pathway has lead to controversial results on joint cartilage…
  • Abstract Number: 2088 • 2012 ACR/ARHP Annual Meeting

    Annexin A1 Receptor Agonist Suppresses Development of Inflammatory Arthritis

    Yuan Hang Yang1, Yuan Jia2, Wenping Kao1, Wuqi Song3, Zhan-guo Li4 and Eric F. Morand1, 1Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, 2Department of Rheumatology and Immunology,Clinical Immunology Center, Peking University People's Hospital, Beijing, China, 3Harbin Medical University, Harbin, China, 4Rheumatology, Peking University People's Hospital, Beijing, China

    Background/Purpose: Annexin A1 (AnxA1) is recognized as an endogenous anti-inflammatory molecule. An AnxA1 receptor, formyl-peptide receptor 2 (FPR2), has been identified in human and mice.…
  • Abstract Number: 1441 • 2012 ACR/ARHP Annual Meeting

    Epstein Barr Virus CD40 Functional Mimic Latent Membrane Protein-1 Drives Cellular Molecular Mimicry in the Presence of Epstein Barr Virus Nuclear Antigen-1 in a Novel Murine Model of Lupus-Like Disease

    Melissa E. Munroe1, Jourdan R. Anderson2, Timothy F. Gross3, Laura L. Stunz4, Gail A. Bishop4 and Judith A. James5, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4The University of Iowa, Iowa City, IA, 5Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Immune dysregulation underlies the complex pathogenesis of SLE. Infection with Epstein Barr Virus (EBV) and expression of latent protein Epstein Barr Virus Nuclear Antigen-1…
  • Abstract Number: 585 • 2012 ACR/ARHP Annual Meeting

    Relative Overexpression of Membrane-Bound Versus Soluble TNF in Human and Experimental Spondyloarthritis

    Carmen Ambarus1, Leonie M. van Duivenvoorde1, Huriatul Masdar1, Melissa N. van Tok2, Paul P. Tak1, Nataliya Yeremenko3 and Dominique L. Baeten3, 1Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 2Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 3Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: Macrophages and their pro-inflammatory cytokines, including TNF, are pivotal mediators of chronic synovitis in rheumatoid arthritis (RA) as well as spondyloarthritis (SpA). Despite similar…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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