Session Title: Rheumatoid Arthritis: Animal Models
Session Type: Abstract Submissions (ACR)
Background/Purpose: Annexin A1 (AnxA1) is recognized as an endogenous anti-inflammatory molecule. An AnxA1 receptor, formyl-peptide receptor 2 (FPR2), has been identified in human and mice. The contribution of FPR2 to rheumatoid arthritis (RA) is not well understood. We investigated the contribution of AnxA1 and FPR2 to the regulation of inflammatory arthritis.
Figure 1. Mice were injected with KB×N serum on day 0 and 2 and Compound 43 from day 0 to 4. *P<0.05
A. Clinical scores B. Paw thickness.
Y. H. Yang,
Z. G. Li,
E. F. Morand,
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/annexin-a1-receptor-agonist-suppresses-development-of-inflammatory-arthritis/