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Abstracts tagged "Animal models"

  • Abstract Number: 1507 • 2012 ACR/ARHP Annual Meeting

    Propylthiouracil Reduces Fibrosis in Chronic Oxidant Stress Mouse Model of Scleroderma

    Gianluca Bagnato1, Alessandra Bitto2, Natasha Irrera2, Gabriele Pizzino2, Neal Roberts3, Maurizio Cinquegrani4, Donatella Sangari1, Francesco Squadrito2, Gianfilippo Bagnato1 and Antonino Saitta4, 1Rheumatology, University of Messina, Messina, Italy, 2Pharmacology, University of Messina, Messina, Italy, 3Medical College of Virginia, Richmond, VA, 4Internal Medicine, University of Messina, Messina, Italy

    Background/Purpose: Systemic sclerosis (SSc) is characterized by fibrosis of skin and visceral organs; vascular damage and resultant ischemia; and immunological dysregulation manifested by autoantibodies. Hypothyroidism,…
  • Abstract Number: 734 • 2012 ACR/ARHP Annual Meeting

    Chemokine (C-C Motif) Receptor 2 Signaling Mediates Persistent Pain in Experimental Osteoarthritis

    Rachel E. Miller1, Phuong Tran2, Rosalina Das2, Nayereh Ghoreishi-Haack2, Richard J. Miller3 and Anne-Marie Malfait4, 1Rheumatology/Biochemistry, Rush University Medical Center, Chicago, IL, 2Rheumatology, Rush University Medical Center, Chicago, IL, 3Molecular Biochemistry and Pharmacology, Northwestern University, Chicago, IL, 4Internal Medicine/Biochemistry, Rush University Medical Center, Chicago, IL

    Background/Purpose: To investigate the role of MCP-1/CCR2 in the development of pain in osteoarthritis (OA) using a mouse model, destabilization of the medial meniscus (DMM).…
  • Abstract Number: 35 • 2012 ACR/ARHP Annual Meeting

    Changes in Tibial Bone and Cartilage Structure in a Mouse Surgical Model of Osteoarthritis

    Brett A. Tonkin1, Evange Romas2, Natalie A. Sims1 and Nicole C. Walsh1, 1St Vincent's Institute of Medical Research, Melbourne, Australia, 2Dept. of Rheumatology, St Vincent's Hospital, Melbourne, Australia

    Background/Purpose: The destabilisation of the medial meniscus (DMM) mouse osteoarthritis (OA) model is commonly used to study OA joint degeneration. In DMM-OA, the knee is…
  • Abstract Number: 2085 • 2012 ACR/ARHP Annual Meeting

    T Cell-Mediated Murine Antigen-Induced Arthritis Is Resistant to Transgenic Disruption of Glucocorticoid Signaling in Osteoblasts and Osteocytes in Vivo

    Cornelia M. Spies1, Edgar Wiebe1, Jinwen W. Tu2, Aiqing Li2, Timo Gaber1, Dörte Huscher1, Markus J. Seibel2, Hong Zhou2 and Frank Buttgereit3, 1Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, 2Bone Research Program, ANZAC Research Institute, The University of Sydney, Concord, Australia, 3Charité - Universitätsmedizin Berlin, Berlin, Germany

    Background/Purpose: The role of endogenous glucocorticoids (GC) in, and their contribution to the susceptibility and severity of rheumatoid arthritis remains inconclusive. We previously demonstrated that…
  • Abstract Number: 1513 • 2012 ACR/ARHP Annual Meeting

    TSLP Receptor Deficiency Reduces IL-13 Expression and Prevents Fibrosis in Experimental Scleroderma

    Alicia Usategui1, Vanessa Miranda1, Gabriel Criado2, Manuel J. Del Rey1, Elena Izquierdo1, Warren J. Leonard3 and Jose L. Pablos1, 1Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 2Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 3Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by progressive fibrosis of the skin and internal organs. Although SSc shares pathogenetic features with other…
  • Abstract Number: 738 • 2012 ACR/ARHP Annual Meeting

    A Novel Orally Active Phosphatidylinositol 3-Phosphate 5-Kinase (PIKfyve) Inhibitor Ameliorates Mouse Psoriasis-Like Model by Inhibition of Interleukin-12 and Interleukin-23 Production From Macrophages

    Ayatoshi Andou, Eviryanti Agung, Yukie Seki, Yoichiro Shima, Sen Takeshita, Takashi Yamamoto and Hiroyuki Eda, Exploratory Research Laboratories, Ajinomoto Pharmaceuticals Co., Ltd., Kanagawa, Japan

    Background/Purpose: Phosphatidylinositol (3,5)-bisphosphate (PI(3,5)P2) is the most recently-identified phospholipid component of cellular membrane. Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is a critical enzyme for the synthesis of…
  • Abstract Number: 37 • 2012 ACR/ARHP Annual Meeting

    Development of a Mouse Model of Natural Osteoarthritis of Knee by Induction of obesity and Bipedal Walking

    Hyun Ah Kim1, Su Jin Park2, Eun-Jeong Cheon3, Hyun A. Jung4 and Kyeong Min Son5, 1Division of Rheumatology, Department of Internal Medicine, Hallym university, Kyunggi, South Korea, 2Department of Internal Medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, 3Department of internal medicine, Hallym University Sacred Heart Hospital, Kyunggi, South Korea, 4Division of Rheumatology, Department of Internal Medicine, Hallym university sacred heart hospital, Kyunggi, South Korea, 5Division of Rheumatology, Department of Internal Medicine, Hallym university Chunchun sacred heart hospital, Chunchun, South Korea

    Background/Purpose: Animal models of osteoarthritis(OA) are used extensively in research of its pathogenesis and in search of disease modifying anti-OA drugs. However, whether current animal models…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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