Abstracts tagged "Animal models"

Abstract Number: 1442 • 2012 ACR/ARHP Annual Meeting
IRF-1 Deficient Lupus-Prone MRL/Lpr Mice Show Reduced Glomerulonephritis but Develop Severe Interstitial Nephritis, Renal Vasculitis and Pulmonary Granulomas with Propensity for Th2 Polarity
Hidemaru Sekine¹, Takeshi Machida¹, Natsumi Sakamoto¹, Eiji Suzuki², Xian Zhang³, Christopher Reilly⁴ and Gary S. Gilkeson⁵, ¹Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan, ²Medicine, Medical University of South Carolina, Charleston, SC, ³Medicine, Medical University of South Carolina and Ralph H. Johnson VA Medical Center, Charleston, SC, ⁴Virginia Tech, Blacksburg, VA, ⁵Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: The transcription factor interferon regulatory factor-4 (IRF-4) and -1 (IRF-1) are members of the IRF family of transcription regulators and involved in the development…
Abstract Number: 2091 • 2012 ACR/ARHP Annual Meeting
The Effect of Pretreatment with Capsaicin On Measurement of Arthritis Pain by Dynamic Weight Bearing and Evoked Pain Responses in an Acute Murine Arthritis Model
Hollis E. Krug¹, Christopher W. Dorman², Sandra Frizelle² and Maren L. Mahowald³, ¹Medicine, VA Health Care System, Minneapolis, MN, ²Research, Minneapolis VA Health Care System, Minneapolis, MN, ³Medicine, University of Minnesota Medical School and Minneapolis VA Health Care System, Minneapolis, MN

Background/Purpose: Murine models are important to study arthritis pain and new analgesics, however measuring pain in mice is challenging. The Dynamic Weight Bearing (DWB) device…
Abstract Number: 2680 • 2012 ACR/ARHP Annual Meeting
Soluble Receptor for Advanced Glycation End Products Alleviates Nephritis in NZB/WF1 Mice
Sang-Won Lee¹, Kyu-Hyoung Park¹, Sungha Park², Ji-Hye Kim¹, Sung-You Hong², Soo Kon Lee³, Donghoon Choi² and Yong-Beom Park⁴, ¹Internal Medicine, Yonse University College of Medicine, Seoul, South Korea, ²Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ³Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ⁴Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
Background/Purpose: The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor that interacts with multiple ligands such as high mobility group box 1…
Abstract Number: 585 • 2012 ACR/ARHP Annual Meeting
Relative Overexpression of Membrane-Bound Versus Soluble TNF in Human and Experimental Spondyloarthritis
Carmen Ambarus¹, Leonie M. van Duivenvoorde¹, Huriatul Masdar¹, Melissa N. van Tok², Paul P. Tak¹, Nataliya Yeremenko³ and Dominique L. Baeten³, ¹Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ³Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Macrophages and their pro-inflammatory cytokines, including TNF, are pivotal mediators of chronic synovitis in rheumatoid arthritis (RA) as well as spondyloarthritis (SpA). Despite similar…
Abstract Number: 1441 • 2012 ACR/ARHP Annual Meeting
Epstein Barr Virus CD40 Functional Mimic Latent Membrane Protein-1 Drives Cellular Molecular Mimicry in the Presence of Epstein Barr Virus Nuclear Antigen-1 in a Novel Murine Model of Lupus-Like Disease
Melissa E. Munroe¹, Jourdan R. Anderson², Timothy F. Gross³, Laura L. Stunz⁴, Gail A. Bishop⁴ and Judith A. James⁵, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴The University of Iowa, Iowa City, IA, ⁵Oklahoma Medical Research Foundation; University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Immune dysregulation underlies the complex pathogenesis of SLE. Infection with Epstein Barr Virus (EBV) and expression of latent protein Epstein Barr Virus Nuclear Antigen-1…
Abstract Number: 2088 • 2012 ACR/ARHP Annual Meeting
Annexin A1 Receptor Agonist Suppresses Development of Inflammatory Arthritis
Yuan Hang Yang¹, Yuan Jia², Wenping Kao¹, Wuqi Song³, Zhan-guo Li⁴ and Eric F. Morand¹, ¹Centre for Inflammatory Diseases, Monash University, Melbourne, Australia, ²Department of Rheumatology and Immunology,Clinical Immunology Center, Peking University People's Hospital, Beijing, China, ³Harbin Medical University, Harbin, China, ⁴Rheumatology, Peking University People's Hospital, Beijing, China
Background/Purpose: Annexin A1 (AnxA1) is recognized as an endogenous anti-inflammatory molecule. An AnxA1 receptor, formyl-peptide receptor 2 (FPR2), has been identified in human and mice.…
Abstract Number: 2681 • 2012 ACR/ARHP Annual Meeting
Blocking the Serum Protease Inhibitor Activity of Plasminogen Activator Inhibitor-1 Protects Mice From Development of Glomerulonephritis in a Model of Lupus Nephritis
Brian Naiman¹, Tracy Delaney¹, Lily Cheng², Philip Brohawn², Chris Morehouse², Christopher Groves¹, Isabelle de-Mendez³, Dominic Corkill⁴, Anthony Coyle⁵, Ronald Herbst¹ and Jane Connor¹, ¹Respiration, Inflammation and Autoimmunity, MedImmune, LLC, Gaithersburg, MD, ²Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ³Research, MedImmune, LLC, Cambridge, United Kingdom, ⁴Respiration, Inflammation and Autoimmunity, MedImmune, LLC, Cambridge, United Kingdom, ⁵Centers for Therapeutic Innovation, Pfizer, Inc. (formerly MedImmune LLC, Gaithersburg, MD, USA), Cambridge, MA
Background/Purpose: Lupus nephritis is an autoimmune disorder which is characterized by extracellular matrix accumulation driven by immune complex deposition and in which thrombosis and sclerosis…