ACR Meeting Abstracts

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Abstracts tagged "Animal models"

  • Abstract Number: 1059 • 2012 ACR/ARHP Annual Meeting

    Endogenous Complement Factor H Plays an Important Role in Controlling Immune Complex-Induced Inflammatory Arthritis

    Nirmal K. Banda1, Gaurav Mehta2, Viviana P. Ferreira3, Claudio Cortes3, Michael K. Pangburn4, William P. Arend2 and V. Michael Holers2, 1University of Colorado School of Medicine, Aurora, CO, 2Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 3Department of Medical Microbiology and Immunology, University of Toledo Health Science Campus, Toledo, OH, 4Department of Biochemistry, University of Texas Health Sciences Center, Tyler, TX

    Background/Purpose: The complement system, a major component of innate immunity, likely plays an important role in the pathogenesis of rheumatoid arthritis (RA).  Factor H (fH)…
  • Abstract Number: 335 • 2012 ACR/ARHP Annual Meeting

    Treatment with Bgp-15, a Novel Insulin Sensitizer Attenuates Collagen-Induced Arthritis in DBA/1 Mice

    Peter Mandl1, Silvia Hayer2, Stephan Blüml3, Victoria Saferding1, Despoina Sykoutri1, Kurt Redlich2 and Josef S. Smolen4, 1Rheumatology, Medical University of Vienna, Vienna, Austria, 2Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 3Department of Rheumatology, Medical University of Vienna, Vienna, Austria, 4Department of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria

    Background/Purpose: BGP-15, a small synthetic hydroxylamine derivative is a member of a new class of insulin-sensitizing medications also known as chaperone-inducers. Beside its beneficial effects…
  • Abstract Number: 2308 • 2012 ACR/ARHP Annual Meeting

    CD11c+ Cells Are Necessary for Myofibroblast Maintenance in Bleomycin-Induced Cutaneous Fibrosis

    Jennifer J. Chia1, Sha Tian2 and Theresa T. Lu2, 1Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, New York, NY, 2Research Division, Hospital for Special Surgery, New York, NY

    Background/Purpose: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease that has significant mortality and morbidity secondary to internal and cutaneous fibrosis. Though the exact…
  • Abstract Number: 1810 • 2012 ACR/ARHP Annual Meeting

    Identification and Characterization of Synthetic Small Molecule Macrocycle Antagonists of Human IL17A

    David Livingston, Sethu Alexander, Julian Bond, Timothy Briggs, Andrew Fraley, Stephen Hale, Tanya Landsman, Richard Martinelli, Kelley Shortsleeves, Nick Terrett and Nathan Walsh, Ensemble Therapeutics, Cambridge, MA

    Background/Purpose: :  IL17A has been demonstrated to be a key pro-inflammatory cytokine in human rheumatoid arthritis and in several rodent models of arthritis.  Synthetic macrocycles…
  • Abstract Number: 1061 • 2012 ACR/ARHP Annual Meeting

    Generation of Myeloid-Derived Suppressor Cells in Vitro From Murine Bone Marrow Precursors

    Julia Kurko1, Beata Tryniszewska1, Tibor A. Rauch1, Colt Egelston2, Tibor T. Glant1 and Katalin Mikecz1, 1Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 2Immunology, Rush University Medical Center, Chicago, IL

    Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that expand under pathological conditions (such as cancer and autoimmune diseases) in response to local growth…
  • Abstract Number: 340 • 2012 ACR/ARHP Annual Meeting

    Myeloid Deletion of SIRT1 Aggravates Inflammatory Arthritis Via Nuclear Factor-Kappab Activation in Animal Model of Rheumatoid Arthritis

    Sang-il Lee and Yun-Hong Cheon, Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea

    Background/Purpose: The nuclear factor-kappaB (NF-kB) activation plays a pivotal role and macrophages are of central importance in the pathogenesis of rheumatoid arthritis (RA). The SirT1,…
  • Abstract Number: 2311 • 2012 ACR/ARHP Annual Meeting

    Total Glucosides of Paeony Th1 and Th17 Cell Differentiation by Blocking STAT1 and STAT3 Activation in Vivo

    Ningli Li1 and JP Lin2, 1Shanghai Institute of Immunology, Institute of medical sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2Shanghai Institute of Immunology, Institute of medical sciences,Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Background/Purpose: Th1 and Th17 cells play very importent role in the lesions of human rheumatoid arthritis (RA). Total glucoside of paeony (TGP), an active compound extracted from…
  • Abstract Number: 1637 • 2012 ACR/ARHP Annual Meeting

    A Novel Peptide Inhibiting the Binding Between C1q and Immunoglobulin Ameliorates Joint Destruction in Rats with Collagen-Induced Arthritis

    Yu Moriguichi and Tetsuya Tomita, Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Japan

    Background/Purpose: C1q is the major subcomponent of the first component of complement protein. The activation of the complement is triggered by binding of C1q to…
  • Abstract Number: 1074 • 2012 ACR/ARHP Annual Meeting

    TLR2 Deletion Promotes Arthritis and Joint Destruction Through Reduction of IL-10

    Qi Quan Huang1, Renee E. Koessler1, Robert Birkett2, Harris R. Perlman3, Lianping Xing4 and Richard M. Pope5, 1Medicine/Rheumatology, Northwestern University, Chicago, IL, 2Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Feinberg School of Medicine, Northwestern University, Chicago, IL, 4Pathology & Lab Medicine, University of Rochester, Rochester, NY, 5Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL

    Background/Purpose: TLR2 signaling pathway has been suggested as a potential therapeutic target in RA.  However, studies with mice deficient in TLR2 (TLR2-/-) and IL-1Ra suggest…
  • Abstract Number: 343 • 2012 ACR/ARHP Annual Meeting

    Functional Impairment in an Animal Model for Rheumatoid Arthritis Assessed As Changes in Gait Is Due to Joint Destruction but Not Synovial Inflammation Per Se

    Gregor Bauer1, Constantin Aschauer1, Birgit Niederreiter2, Josef S. Smolen3, Kurt Redlich2 and Silvia Hayer2, 1Dep. of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 2Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 3Division of Rheumatology, Department of Internal Medicine III,, Medical University of Vienna and Hietzing Hospital, Vienna, Austria

    Background/Purpose: To investigate the individual impact of synovial inflammation, subchondral bone erosion or cartilage damage on functional impairment in an animal model of Rheumatoid Arthritis…
  • Abstract Number: 2313 • 2012 ACR/ARHP Annual Meeting

    The Autoantibody-Inducing CD4 T Cell (aiCD4 T cell) Belongs to CCR4+CD45RBlo122lo CD4 Subpopulation: A Novel ‘Self-Organized Criticality Theory’ Explains the Cause of Systemic Lupus Erythematosus (SLE)

    Yumi Miyazaki1, Ken Tsumiyama2 and Shunichi Shiozawa2, 1Kyushu University Beppu Hospital/ Kobe University Graduate School of Health Sciences, Beppu/ Kobe, Japan, 2Kyushu University Beppu Hospital, Beppu, Japan

    Background/Purpose:  We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…
  • Abstract Number: 1638 • 2012 ACR/ARHP Annual Meeting

    Synovial Fibroblast Migration Is Modulated by the Focal Contact Protein Lasp-1

    Adelheid Korb-Pap1, Jan Hillen1, Marianne Heitzmann1, Catherine S. Chew2, Stefan Butz3, Dietmar Vestweber4, Hermann Pavenstädt5 and Thomas Pap1, 1Institute of Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, 2Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, 3Max Planck Institute of Molecular Biomedicine, Max Planck Institute of Molecular Biomedicine, Muenster, Germany, 4Max Planck Institute of Molecular Biomedicine, Muenster, Germany, 5Internal Medicine D, Department of Nephrology and Rheumatology, University Hospital Muenster, Muenster, Germany

    Background/Purpose: RA synovial fibroblasts (SF) have been suggested to contribute to the spreading of disease through their ability to leave cartilage destruction sites, migrate via…
  • Abstract Number: 1022 • 2012 ACR/ARHP Annual Meeting

    Imaging of Ankle Joints by MRI in Murine Models of Inflammatory Arthritis

    Shawn M. Rose1, Harris R. Perlman2, Emily Alex Waters3 and Thomas Meade3, 1Department of Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, 2Feinberg School of Medicine, Northwestern University, Chicago, IL, 3Chemistry of Life Processes Institute, Northwestern University, Evanston, IL

    Background/Purpose: One of the fundamental shortcomings in the field of experimental rheumatology is the inability to non-invasively monitor the development of inflammatory arthritis longitudinally.  Magnetic…
  • Abstract Number: 347 • 2012 ACR/ARHP Annual Meeting

    The Loss of S100A4 Prevents Induction of Experimental Arthritis in Human Tumour Necrosis Factor Transgenic Mouse Model

    Michal Tomcik1, Christine Boehm2, Carina Scholtysek3, Lucie Andres Cerezo4, Wolfgang Baum3, Clara Dees3, Christian Beyer3, Jerome Avouac5, Pawel Zerr3, Katrin Palumbo-Zerr3, Alfiya Akhmetshina3, Radim Becvar1, Oliver Distler6, Mariam Grigorian7, Gerhard Kroenke3, Georg A. Schett8, Joerg HW Distler3 and Ladislav Senolt1, 1Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 2Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 3Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 4Institute of Rheumatology, Department of Clinical and Experimental Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 5Paris Descartes University and INSERM U1016, Rheumatology A department, Cochin Hospital, Paris, France, 6Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 7Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark, 8Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Our previous study demonstrated increased levels of S100A4 protein in sera, synovial fluid and synovial membrane of patients with rheumatoid arthritis (RA) compared to…
  • Abstract Number: 2323 • 2012 ACR/ARHP Annual Meeting

    A Genetic Polymorphism on New Zealand Black Chromosome 1 Is Associated with Abnormal Dendritic Cell Function Leading to Expansion of TH1, TH17 and T Follicular Helper (TFH) Cells

    Nafiseh Talaei1, Carolina Landolt-Marticorena2, Babak Noamani1, Evelyn Pau3, Nan-Hua Chang4 and Joan E. Wither5, 1Genetics and developmental biology, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, 2Rheumatology, University Health Network, Toronto, ON, Canada, 3Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, 4Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 51E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: We have previously shown that B6 mice with an introgressed homozygous New Zealand Black chromosome (c) 1 interval (70 to 100 cM) develop high titres…
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