Abstracts tagged "Animal models"

Abstract Number: 25 • 2012 ACR/ARHP Annual Meeting
Activation of the Canonical Wnt Signaling Pathway Is Tissue Dependent in Osteoarthritic Joints: Distinct Mechanisms of Regulation by Wnt Antagonists
Thomas Funck-Brentano¹, Wafa Bouaziz¹, Hilene Lin¹, Valerie Geoffroy¹, Eric Hay¹ and Martine Cohen-Solal², ¹INSERM U606 Paris 7 university, Paris, France, ²Rhumatologie A, INSERM U606 Hôpital Lariboisière, Centre Viggo Petersen, Paris, France
Background/Purpose: Wnt signaling pathway is a major regulator of bone and cartilage remodeling. Modulation of this pathway has lead to controversial results on joint cartilage…
Abstract Number: 757 • 2012 ACR/ARHP Annual Meeting
Beneficial Role of Rapamycin in Experimental Autoimmune Myositis
Nicolas Prevel¹, Yves Allenbach², David Klatzman¹, Benoit Salomon¹ and Olivier Benveniste³, ¹UPMC Université Paris 06, UMR 7211, Paris, France, ²Internal Medicine Dpt 1, Pitié-Salpêtrière Hospital, APHP, Paris, France, ³Internal Medecine Dpt 1, Pitié-Salpêtrière Hospital, APHP, Paris, France
Background/Purpose: Idiopathic inflammatory myopathies are a heterogeneous group of different diseases, classified into four main categories: dermatomyositis, polymyositis, immune-mediated necrotizing myopathy, and sporadic inclusion body…
Abstract Number: 1518 • 2012 ACR/ARHP Annual Meeting
Damage-Associated Endogenous TLR4 Ligand Fibronectin-EDA Is Overexpressed in Scleroderma and Drives Persistent Fibrosis Via TLR4 and Inhibition of TLR4 Prevents and Reverses Experimental Dermal Fibrosis: Novel Target for Scleroderma Therapy
Swati Bhattacharyya¹, Zenshiro Tamaki², Wenxia Wang³, Paul Hoover⁴, Adam Booth⁵, Alyssa Dreffs⁶, Monique E. Hinchcliff⁷, Feng Fang⁸, Spiro Getsios⁴, Hang Yin⁹, Eric S. White⁶ and John Varga¹⁰, ¹Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Medicine, Rheumatology, Northwestern Univ Med School, Chicago, IL, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁴Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁵Ann Arbor, MI, ⁶Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁷Division of Rheumatology, Northwestern Univ Med School, Chicago, IL, ⁸Rheumatology Division, Northwestern University, Chicago, IL, ⁹University of Colorado at Boulder, Boulder, CO, ¹⁰Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Recent studies implicate innate immune signaling and Toll like receptor-4 (TLR4) in fibrogenesis. We hypothesized that injury in scleroderma leads to tissue accumulation of…
Abstract Number: 2082 • 2012 ACR/ARHP Annual Meeting
Peripheral and Local Effects of Anti-C5aR Treatment in the Collagen Induced Arthritis Model
Christina Andersson¹, Carola Wenander¹, Pernille Usher², Josephine Hebsgaard² and Lars Hornum³, ¹AID Models, Immunopharmacology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ²Histology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ³Immunopharmacology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark
Background/Purpose: The activated C5a-fragment of complement factor C5 is a potent pro-inflammatory effector molecule that chemo-attracts and activates myeloid cells such as neutrophils, monocytes, and…
Abstract Number: 329 • 2012 ACR/ARHP Annual Meeting
The SYK Inhibitor, Fostamatinib, Administered Alone or in Combination with Methotrexate in Rat Collagen-Induced Arthritis, Reduces Bone Erosions, Biomarkers of Cartilage/Bone Destruction, and Synovial Osteoclastogenic Cytokines
Polly Pine¹, Ayodele Apatira¹, Betty Y. Chang¹, Nathan Schoettler², Elliott B. Grossbard³ and Ernest Brahn², ¹Pharmacology, Rigel Pharmaceuticals, So San Francisco, CA, ²Rheumatology, UCLA School of Medicine, Los Angeles, CA, ³Rigel Pharmaceuticals, So San Francisco, CA
Background/Purpose: Spleen tyrosine kinase (SYK) is expressed in hematopoietic cells and is a major downstream regulator of signaling through Fcγ and immunoglobulin receptors as well…
Abstract Number: 787 • 2012 ACR/ARHP Annual Meeting
Aberrant Adipogenesis in the Pathogenesis of Scleroderma
Roberta Goncalves Marangoni¹, Jun Wei², Monique E. Hinchcliff¹, Feng Fang³, Warren Tourtellotte⁴ and John Varga⁵, ¹Division of Rheumatology, Northwestern University Medical School, Chicago, IL, ²Rheumatology Division, Northwestern University, Chicago, IL, ³Rheumatology Division, Northwestern University Medical School, Chicago, IL, ⁴Pathology, Northwestern University Medical School, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Skin fibrosis in systemic sclerosis (SSc) is associated with loss of subcutaneous adipose tissue (SCAT) and reduction in adiponectin. The mechanism underlying SCAT atrophy…
Abstract Number: 1603 • 2012 ACR/ARHP Annual Meeting
Inhibitor of DNA Binding 1 As a Secreted Angiogenic Transcription Factor in Rheumatoid Arthritis
Takeo Isozaki¹, M. Asif Amin², Alisa E. Koch³, Ali Arbab⁴, Stephanie A. Shuman¹, Christine M. Ha¹, G. Kenneth Haines III⁵ and Jeffrey H. Ruth⁶, ¹Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ²Department of Medicine, University of Michigan, Ann Arbor, MI, ³Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI, ⁴Diagnostic Radiology, Henry Ford Hospital and Medical Centers, Detroit, MI, ⁵Department of Pathology, Yale University, New Haven, CT, ⁶Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is characterized by enhanced blood vessel development in joint synovium. This involves the recruitment of endothelial progenitor cells (EPCs), allowing for…
Abstract Number: 2300 • 2012 ACR/ARHP Annual Meeting
The Effects of Salvianolic Acid B in Fibrotic Models in Vivo and in Vitro
Qingmei Liu¹, Wenyu Wu², Wenzheng Tu³, Haiyan Chu¹, Yanyun Ma¹, Hejian Zou⁴, Xiaodong Zhou⁵ and Jiu-Cun Wang¹, ¹Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, ²Huashan Hospital, Shanghai, China, ³Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai, China, ⁴Rheumatology, Huashan Hospital, Shanghai, China, ⁵Rheumatology, University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: , Methods: , Results: and Conclusion: Background: Scleroderma or systemic sclerosis (SSc) is characterized by the fibrosis of skin and visceral organs. Salvianolic acid…
Abstract Number: 326 • 2012 ACR/ARHP Annual Meeting
Silencing Intraarticular Snail Expression Ameliorates Rat Collagen-Induced Arthritis Through Induction of Mesenchymal-Epithelial Transition in Synovial Fibroblasts
Chrong-Reen Wang¹, Shih-Yao Chen², Ai-Li Shiau³, Yuan-Tsung Li⁴, Ming-Fei Liu⁵ and Chao-Liang Wu², ¹Section of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ²Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, ³Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁴Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ⁵Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan
Background/Purpose: Morphological characteristics of rheumatoid arthritis (RA) synovial fibroblasts (SF) are similar to transformed cells. We hypothesized that epithelial-mesenchymal transition (EMT) of SF regulated by…
Abstract Number: 785 • 2012 ACR/ARHP Annual Meeting
Resident Lung Fibroblast Gene Expression Signatures Predict Susceptibility or Resistance to Experimental Lung Fibrosis
Emma Derrett-Smith¹, Rachel Hoyles¹, Korsa Khan², David J. Abraham³ and Christopher P. Denton², ¹Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ³UCL Medical School, London, United Kingdom
Background/Purpose: In scleroderma (SSc), lung fibrosis is linked to epithelial damage and dysregulated repair mechanisms. Resident lung fibroblasts may affect multiple cell types including…
Abstract Number: 1634 • 2012 ACR/ARHP Annual Meeting
Delivering Mesenchymal Stem Cells to Arthritic Joints with Nano-Fiber Scaffold Resulted in Inhibition of Arthritis and Joint Damage in Arthritis Models
Xiangmei Zhang¹, Kunihiro Yamaoka¹, Koshiro Sonomoto¹, Masahiro Kondo¹, Shunsuke Fukuyo¹, Makoto Satake², Hiroaki Kaneko², Kazuhisa Nakano¹, Shingo Nakayamada³, Yosuke Okada¹ and Yoshiya Tanaka¹, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²The Third Laboratory, Integrative Technology Research Institute, Teijin Limited, Tokyo, Japan, ³First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose: Even though treatment of rheumatoid arthritis (RA) has emerged, aiming bone repair is still a challenge. Mesenchymal stem cells (MSCs) possess immunoregulatory function with…
Abstract Number: 2290 • 2012 ACR/ARHP Annual Meeting
Type I Interferon Associated Gene IRF7 in the Pathogenesis of Fibrosis in Systemic Sclerosis (SSc)
Minghua Wu¹, Michael R. Blackburn², Shervin Assassi¹, Xiaochun Liu¹, John D. Reveille¹, Filemon K. Tan¹, Sandeep K. Agarwal³ and Maureen D. Mayes¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, TX, ³Medicine, Section of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX
Background/Purpose: Fibrosis in Systemic Sclerosis is characterized by excessive collagen production and accumulation in the skin and lungs. It has been increasingly appreciated that a…
Abstract Number: 311 • 2012 ACR/ARHP Annual Meeting
The DEK Autoantigen Regulates Formation of Neutrophil Extracellular Traps and Zymosan Induced Arthritis in Mice
Nirit Mor-Vaknin¹, Anjan K. Saha², Maureen Legendre¹, Marta J. Gonzalez-Hernandez³, M. Asif Amin⁴, Bradley J. Rabquer⁵, Julie M. Jorns⁶, Mariana J. Kaplan⁷, Barbara S. Adams⁸, David A. Fox⁹, Alisa E. Koch¹⁰ and David Markovitz¹, ¹Internal Medicine, University of Michigan, Ann Arbor, MI, ²Medical School, University of Michigan, Ann Arbor, MI, ³Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, ⁴Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁵University of Michigan Medical School, Ann Arbor, MI, ⁶Pathology, Ann Arbor, MI, ⁷Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD, ⁸University of Michigan, Ann Arbor, MI, ⁹Rheumatology/Int Medicine, Univ of Michigan Med Ctr, Ann Arbor, MI, ¹⁰Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: The nuclear oncoprotein DEK is a known autoantigen associated with juvenile idiopathic arthritis (JIA) and other autoimmune diseases. DEK is actively secreted by human…
Abstract Number: 856 • 2012 ACR/ARHP Annual Meeting
Am80, a Retinoic Acid Receptor Agonist, Ameliorates Murine Vasculitisthrough the Suppression of Neutrophil Migration and Activation
Chie Miyabe¹, Yoshishige Miyabe¹, Noriko Miura², Kei Takahashi³, Yuya Terashima⁴, Etsuko Toda⁴, Fumiko Honda⁵, Tomohiro Morio⁵, Naohito Ohno², Jun-ichi Suzuki⁶, Mitsuaki Isobe⁷, Kouji Matsushima⁴, Ryoji Tsuboi⁸, Nobuyuki Miyasaka¹ and Toshihiro Nanki⁹, ¹Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, ²Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan, ³Department of Pathology, Toho University Ohashi Medical Center, Tokyo, Japan, ⁴Department of Molecular Preventive Medicine, The University of Tokyo, Tokyo, Japan, ⁵Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan, ⁶Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Tokyo, Japan, ⁷Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan, ⁸Department of Dermatology, Tokyo Medical University, Tokyo, Japan, ⁹Department of Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan
Background/Purpose: Vasculitis is characterized by leukocyte infiltration in the vessel walls with destructive damage to mural structures. Retinoids are compounds that bind to retinoic acid…
Abstract Number: 1639 • 2012 ACR/ARHP Annual Meeting
FLIP in Macrophages Promotes the Progression of Serum Transfer-Induced Arthritis
Qi Quan Huang¹, Robert Birkett², Renee E. Koessler¹, G. Kenneth Haines III³, Harris R. Perlman⁴ and Richard M. Pope⁵, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Pathology, Yale University, New Haven, CT, ⁴Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: Flip is well known as an anti-apoptotic protein induced by chronic inflammation that protects against death receptor-mediated apoptosis. Employing a FLIP myeloid lineage knock-out…