Abstract Number: 101 • ACR/ARP Annual Meeting 2019
CD126 Negative CD4+Foxp3+ Cell Represents a Superior Treg Subset in Treating Autoimmune Diseases
Background/Purpose: Regulatory T (Treg) cells play an important role in maintaining immunologic homeostasis. Abnormal Treg cells were found in some autoimmune diseases. Transferred natural Treg…Abstract Number: 1001 • ACR/ARP Annual Meeting 2019
Oral Collagen Type V Supplementation Inhibits Cartilage Degeneration in Experimental Arthritis
Background/Purpose: It is known that collagen V (col V) can generate autoimmunity when exposed. In contrast, induction of tolerance with col V supplementation is able…Abstract Number: 109 • ACR/ARP Annual Meeting 2019
Targeting CD6 Expression Attenuates T Cell Activity in Murine Collagen Induced Arthritis
Background/Purpose: CD6, an important regulator of T cell function, interacts with the ligands CD166 and CD318. We previously examined CD318 expression on synovial tissues (STs)…Abstract Number: 1040 • ACR/ARP Annual Meeting 2019
Proposition of a Novel Animal Model of Systemic Sclerosis Induced by Type V Collagen in C57BL/6 Mice Reproducing Fibrosis, Vasculopathy and Autoimmunity
Background/Purpose: A better knowledge of the mechanisms and biomarkers of skin and lung damage in systemic sclerosis (SSc) related fibrosis remain a challenge. Our aim was…Abstract Number: 978 • ACR/ARP Annual Meeting 2019
Light Mediated Therapeutics in Arthritis
Background/Purpose: Rheumatoid arthritis (RA) therapies are constrained by the failure to deliver sufficient quantities of drug to the inflamed site, systemic side effects, and the…Abstract Number: 1052 • ACR/ARP Annual Meeting 2019
The PPAR Agonist Lanifibranor Protects Against Right Ventricular Hypertrophy in a Mouse Model of Systemic Sclerosis Associated Pulmonary Hypertension
Background/Purpose: The TβRIIΔk-fib transgenic mouse model of systemic sclerosis (SSc) develops constitutive structural vasculopathy with vessel wall fibrosis and is susceptible to pulmonary hypertension (PH)…Abstract Number: 980 • ACR/ARP Annual Meeting 2019
Sema3B Expression Is Reduced in Rheumatoid Arthritis Patients and Has a Protective Role in a Murine Model of Arthritis
Background/Purpose: The semaphorin family is a large group of proteins initially described in axon guidance. However, semaphorins also play a role in other processes involved…Abstract Number: 1774 • ACR/ARP Annual Meeting 2019
Potential Involvement of OX40 Expressing Tfh Cells on Regulation of Autoantibody Sialylation in Experimental and Rheumatoid Arthritis
Background/Purpose: Recently, IL-23-Th17 cells axis and hyposialylation of antibodies were proved to be linked to experimental and rheumatoid arthritis. However it remains uncertain how Tfh,…Abstract Number: 981 • ACR/ARP Annual Meeting 2019
Adipocytokines and Obesity in the Context of Rheumatoid and Osteoarthritis Mouse Models
Background/Purpose: Adipocytokines are bioactive factors mainly produced by adipose tissue and exert many important effects on energy homeostasis as well as immune responses. Osteoarthritis (OA)…Abstract Number: 1775 • ACR/ARP Annual Meeting 2019
Cholesterol Sequestering in Macrophages Contributes to the Lipid Paradox in Chronic Arthritis
Background/Purpose: Patients with active rheumatoid arthritis (RA) have increased cardiovascular mortality, paradoxically associated with reduced circulating lipid levels. Several disease-modifying antirheumatic drugs (DMARDs), such as…Abstract Number: 982 • ACR/ARP Annual Meeting 2019
A Novel Role for Nod2 in Controlling Autoantibody Production and Arthritis in SKG Mice
Background/Purpose: Rheumatoid arthritis (RA) is a systemic inflammatory disease that manifests in a chronic and debilitating polyarthritis. Although the etiology of RA is unknown pathogenic…Abstract Number: 1974 • ACR/ARP Annual Meeting 2019
The Rat Homolog to FX201, a Gene Therapy in Development for the Treatment of Osteoarthritis, Demonstrates Dose-Dependent Decreases in the Severity of Cartilage and Bone Lesions Following Anterior Cruciate Ligament Transection
Background/Purpose: Acute injury to the anterior cruciate ligament (ACL) is a common cause of posttraumatic OA in humans, and ACL transection (ACLT) in rats is…Abstract Number: 988 • ACR/ARP Annual Meeting 2019
Translational Imaging of Treatment Effects for a Novel Anti-TNF-Steroid Antibody Drug Conjugate in a Rat Model of Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory joint disease of autoimmune etiology. If insufficiently treated, RA leads to joint damage and irreversible disability. Although there…Abstract Number: 2737 • ACR/ARP Annual Meeting 2019
HIF-1α and miR-210 Differential and Lineage-specific Expression in Systemic Lupus Erythematosus
Background/Purpose: Hypoxia inducible factor 1 is a key transcription factor that regulates the cellular response to oxygen stress. In the adaptive immune system, HIF-1α is…Abstract Number: 989 • ACR/ARP Annual Meeting 2019
Lineage Tracing of Murine Lymphatic Smooth Muscle Cells to Determine the Role of the Lymphatic System in Inflammatory Arthritis
Background/Purpose: Dysfunction of lymphatic vessel contraction has been implicated in inflammatory arthritis progression and arthritic flare in murine models. Previous studies have demonstrated that tumor…
ACR Meeting Abstracts