Abstracts tagged "Animal models"

Abstract Number: 2080 • 2012 ACR/ARHP Annual Meeting
IL-20 Is Not Involved in Mouse Collagen Induced Arthritis
Christina Andersson¹, Kyle Serikawa², Hermann Pelzer³, Peter Thygesen³, Patricia Smith², Kim Kruse², Shameek Biswas², Brian Fox², Anders Milner⁴, Peter Kvist⁵, Josephine Hebsgaard⁶, Jesper Pass⁷ and John Rømer⁸, ¹AID Models, Immunopharmacology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ²Molecular Immunology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Seattle, WA, ³Exploratory ADME, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ⁴DMPK, Cell and Antibody Analysis, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ⁵Histology, Novo Nordisk A/S, Måløv, Denmark, ⁶Histology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ⁷Antibody Thechnology, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark, ⁸Inflammation Science, Biopharmaceutical Research Unit, Novo Nordisk A/S, Måløv, Denmark
Background/Purpose: Interleukin-20 (IL-20) is a pro-inflammatory cytokine involved in the pathogenesis of rheumatoid arthritis (RA). Clinical phase 2a testing has shown that treatment with an…
Abstract Number: 1061 • 2012 ACR/ARHP Annual Meeting
Generation of Myeloid-Derived Suppressor Cells in Vitro From Murine Bone Marrow Precursors
Julia Kurko¹, Beata Tryniszewska¹, Tibor A. Rauch¹, Colt Egelston², Tibor T. Glant¹ and Katalin Mikecz¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Immunology, Rush University Medical Center, Chicago, IL
Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that expand under pathological conditions (such as cancer and autoimmune diseases) in response to local growth…
Abstract Number: 340 • 2012 ACR/ARHP Annual Meeting
Myeloid Deletion of SIRT1 Aggravates Inflammatory Arthritis Via Nuclear Factor-Kappab Activation in Animal Model of Rheumatoid Arthritis
Sang-il Lee and Yun-Hong Cheon, Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea
Background/Purpose: The nuclear factor-kappaB (NF-kB) activation plays a pivotal role and macrophages are of central importance in the pathogenesis of rheumatoid arthritis (RA). The SirT1,…
Abstract Number: 2308 • 2012 ACR/ARHP Annual Meeting
CD11c⁺ Cells Are Necessary for Myofibroblast Maintenance in Bleomycin-Induced Cutaneous Fibrosis
Jennifer J. Chia¹, Sha Tian² and Theresa T. Lu², ¹Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, New York, NY, ²Research Division, Hospital for Special Surgery, New York, NY
Background/Purpose: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease that has significant mortality and morbidity secondary to internal and cutaneous fibrosis. Though the exact…
Abstract Number: 1810 • 2012 ACR/ARHP Annual Meeting
Identification and Characterization of Synthetic Small Molecule Macrocycle Antagonists of Human IL17A
David Livingston, Sethu Alexander, Julian Bond, Timothy Briggs, Andrew Fraley, Stephen Hale, Tanya Landsman, Richard Martinelli, Kelley Shortsleeves, Nick Terrett and Nathan Walsh, Ensemble Therapeutics, Cambridge, MA
Background/Purpose: : IL17A has been demonstrated to be a key pro-inflammatory cytokine in human rheumatoid arthritis and in several rodent models of arthritis. Synthetic macrocycles…
Abstract Number: 1074 • 2012 ACR/ARHP Annual Meeting
TLR2 Deletion Promotes Arthritis and Joint Destruction Through Reduction of IL-10
Qi Quan Huang¹, Renee E. Koessler¹, Robert Birkett², Harris R. Perlman³, Lianping Xing⁴ and Richard M. Pope⁵, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁴Pathology & Lab Medicine, University of Rochester, Rochester, NY, ⁵Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: TLR2 signaling pathway has been suggested as a potential therapeutic target in RA. However, studies with mice deficient in TLR2 (TLR2-/-) and IL-1Ra suggest…
Abstract Number: 343 • 2012 ACR/ARHP Annual Meeting
Functional Impairment in an Animal Model for Rheumatoid Arthritis Assessed As Changes in Gait Is Due to Joint Destruction but Not Synovial Inflammation Per Se
Gregor Bauer¹, Constantin Aschauer¹, Birgit Niederreiter², Josef S. Smolen³, Kurt Redlich² and Silvia Hayer², ¹Dep. of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Division of Rheumatology, Department of Internal Medicine III,, Medical University of Vienna and Hietzing Hospital, Vienna, Austria
Background/Purpose: To investigate the individual impact of synovial inflammation, subchondral bone erosion or cartilage damage on functional impairment in an animal model of Rheumatoid Arthritis…
Abstract Number: 2311 • 2012 ACR/ARHP Annual Meeting
Total Glucosides of Paeony Th1 and Th17 Cell Differentiation by Blocking STAT1 and STAT3 Activation in Vivo
Ningli Li¹ and JP Lin², ¹Shanghai Institute of Immunology, Institute of medical sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Shanghai Institute of Immunology, Institute of medical sciences,Shanghai Jiao Tong University School of Medicine, Shanghai, China
Background/Purpose: Th1 and Th17 cells play very importent role in the lesions of human rheumatoid arthritis (RA). Total glucoside of paeony (TGP), an active compound extracted from…
Abstract Number: 1637 • 2012 ACR/ARHP Annual Meeting
A Novel Peptide Inhibiting the Binding Between C1q and Immunoglobulin Ameliorates Joint Destruction in Rats with Collagen-Induced Arthritis
Yu Moriguichi and Tetsuya Tomita, Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Japan
Background/Purpose: C1q is the major subcomponent of the first component of complement protein. The activation of the complement is triggered by binding of C1q to…
Abstract Number: 1022 • 2012 ACR/ARHP Annual Meeting
Imaging of Ankle Joints by MRI in Murine Models of Inflammatory Arthritis
Shawn M. Rose¹, Harris R. Perlman², Emily Alex Waters³ and Thomas Meade³, ¹Department of Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Chemistry of Life Processes Institute, Northwestern University, Evanston, IL
Background/Purpose: One of the fundamental shortcomings in the field of experimental rheumatology is the inability to non-invasively monitor the development of inflammatory arthritis longitudinally. Magnetic…
Abstract Number: 347 • 2012 ACR/ARHP Annual Meeting
The Loss of S100A4 Prevents Induction of Experimental Arthritis in Human Tumour Necrosis Factor Transgenic Mouse Model
Michal Tomcik¹, Christine Boehm², Carina Scholtysek³, Lucie Andres Cerezo⁴, Wolfgang Baum³, Clara Dees³, Christian Beyer³, Jerome Avouac⁵, Pawel Zerr³, Katrin Palumbo-Zerr³, Alfiya Akhmetshina³, Radim Becvar¹, Oliver Distler⁶, Mariam Grigorian⁷, Gerhard Kroenke³, Georg A. Schett⁸, Joerg HW Distler³ and Ladislav Senolt¹, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ²Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Institute of Rheumatology, Department of Clinical and Experimental Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁵Paris Descartes University and INSERM U1016, Rheumatology A department, Cochin Hospital, Paris, France, ⁶Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁷Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark, ⁸Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Our previous study demonstrated increased levels of S100A4 protein in sera, synovial fluid and synovial membrane of patients with rheumatoid arthritis (RA) compared to…
Abstract Number: 2313 • 2012 ACR/ARHP Annual Meeting
The Autoantibody-Inducing CD4 T Cell (aiCD4 T cell) Belongs to CCR4⁺CD45RB^lo122^lo CD4 Subpopulation: A Novel ‘Self-Organized Criticality Theory’ Explains the Cause of Systemic Lupus Erythematosus (SLE)
Yumi Miyazaki¹, Ken Tsumiyama² and Shunichi Shiozawa², ¹Kyushu University Beppu Hospital/ Kobe University Graduate School of Health Sciences, Beppu/ Kobe, Japan, ²Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…
Abstract Number: 1638 • 2012 ACR/ARHP Annual Meeting
Synovial Fibroblast Migration Is Modulated by the Focal Contact Protein Lasp-1
Adelheid Korb-Pap¹, Jan Hillen¹, Marianne Heitzmann¹, Catherine S. Chew², Stefan Butz³, Dietmar Vestweber⁴, Hermann Pavenstädt⁵ and Thomas Pap¹, ¹Institute of Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, ²Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, ³Max Planck Institute of Molecular Biomedicine, Max Planck Institute of Molecular Biomedicine, Muenster, Germany, ⁴Max Planck Institute of Molecular Biomedicine, Muenster, Germany, ⁵Internal Medicine D, Department of Nephrology and Rheumatology, University Hospital Muenster, Muenster, Germany
Background/Purpose: RA synovial fibroblasts (SF) have been suggested to contribute to the spreading of disease through their ability to leave cartilage destruction sites, migrate via…
Abstract Number: 856 • 2012 ACR/ARHP Annual Meeting
Am80, a Retinoic Acid Receptor Agonist, Ameliorates Murine Vasculitisthrough the Suppression of Neutrophil Migration and Activation
Chie Miyabe¹, Yoshishige Miyabe¹, Noriko Miura², Kei Takahashi³, Yuya Terashima⁴, Etsuko Toda⁴, Fumiko Honda⁵, Tomohiro Morio⁵, Naohito Ohno², Jun-ichi Suzuki⁶, Mitsuaki Isobe⁷, Kouji Matsushima⁴, Ryoji Tsuboi⁸, Nobuyuki Miyasaka¹ and Toshihiro Nanki⁹, ¹Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, ²Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan, ³Department of Pathology, Toho University Ohashi Medical Center, Tokyo, Japan, ⁴Department of Molecular Preventive Medicine, The University of Tokyo, Tokyo, Japan, ⁵Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan, ⁶Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Tokyo, Japan, ⁷Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan, ⁸Department of Dermatology, Tokyo Medical University, Tokyo, Japan, ⁹Department of Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan
Background/Purpose: Vasculitis is characterized by leukocyte infiltration in the vessel walls with destructive damage to mural structures. Retinoids are compounds that bind to retinoic acid…
Abstract Number: 311 • 2012 ACR/ARHP Annual Meeting
The DEK Autoantigen Regulates Formation of Neutrophil Extracellular Traps and Zymosan Induced Arthritis in Mice
Nirit Mor-Vaknin¹, Anjan K. Saha², Maureen Legendre¹, Marta J. Gonzalez-Hernandez³, M. Asif Amin⁴, Bradley J. Rabquer⁵, Julie M. Jorns⁶, Mariana J. Kaplan⁷, Barbara S. Adams⁸, David A. Fox⁹, Alisa E. Koch¹⁰ and David Markovitz¹, ¹Internal Medicine, University of Michigan, Ann Arbor, MI, ²Medical School, University of Michigan, Ann Arbor, MI, ³Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, ⁴Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁵University of Michigan Medical School, Ann Arbor, MI, ⁶Pathology, Ann Arbor, MI, ⁷Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD, ⁸University of Michigan, Ann Arbor, MI, ⁹Rheumatology/Int Medicine, Univ of Michigan Med Ctr, Ann Arbor, MI, ¹⁰Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: The nuclear oncoprotein DEK is a known autoantigen associated with juvenile idiopathic arthritis (JIA) and other autoimmune diseases. DEK is actively secreted by human…

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