Abstracts tagged "Animal models"

Abstract Number: 2892 • 2013 ACR/ARHP Annual Meeting
Masp-1/3 Deficient MRL/Lpr Mice Lack The Alternative Complement Pathway Activation and Are Protected From Development Of Lupus-Like Glomerulonephritis
Takeshi Machida¹, Natsumi Sakamoto¹, Teizo Fujita¹, Minoru Takahashi² and Hideharu Sekine¹, ¹Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan, ²Department of Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan
Background/Purpose: Complement has both protective and pathogenic functions in lupus due to a balance between its role in the clearance of immune complexes (ICs) and…
Abstract Number: 1848 • 2013 ACR/ARHP Annual Meeting
Human Gingiva-Derived Mesenchymal Stromal Cells Inhibit Graft-Versus-Host Disease Through CD39 and IDO
Song Guo Zheng¹, Maogeng Chen¹, Dong Dong Chen², Jian Gu³ and Yi Shen⁴, ¹Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Medicine, Zhoushan Hospital at Zhejiang Province, Zhoushan, China, ³Medcine, University of Southern California Keck School of Medicine, Los Angeles, CA, ⁴Medicine, Shanghai East Hospital at Tongji University, Shanghai, China
Background/Purpose: We recently have reported that human-derived gingival mesenchymal stem cells (GMSC) have strong capacity to suppress immune responses and T cell-mediated collagen-induced arthritis, however,…
Abstract Number: 1156 • 2013 ACR/ARHP Annual Meeting
Suppression Of Immune Responses and Joint Inflammation By Myeloid-Derived Suppressor Cells In a T Cell-Dependent Mouse Model Of Rheumatoid Arthritis
Katalin Mikecz¹, Julia Kurko¹, Timea Ocsko¹, Andras Vida¹, Beata Tryniszewska¹, Tibor A. Rauch¹, Joel A. Block², Robert S. Katz³, Anjali Nair², Carla R. Scanzello⁴ and Tibor T. Glant¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Section of Rheumatology, Rush University Medical Center, Chicago, IL, ³Rush Medical College, Chicago, IL, ⁴Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of innate immune cells with immunosuppressive properties. We previously identified MDSCs in the synovial fluid (SF)…
Abstract Number: 2311 • 2012 ACR/ARHP Annual Meeting
Total Glucosides of Paeony Th1 and Th17 Cell Differentiation by Blocking STAT1 and STAT3 Activation in Vivo
Ningli Li¹ and JP Lin², ¹Shanghai Institute of Immunology, Institute of medical sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Shanghai Institute of Immunology, Institute of medical sciences,Shanghai Jiao Tong University School of Medicine, Shanghai, China
Background/Purpose: Th1 and Th17 cells play very importent role in the lesions of human rheumatoid arthritis (RA). Total glucoside of paeony (TGP), an active compound extracted from…
Abstract Number: 1637 • 2012 ACR/ARHP Annual Meeting
A Novel Peptide Inhibiting the Binding Between C1q and Immunoglobulin Ameliorates Joint Destruction in Rats with Collagen-Induced Arthritis
Yu Moriguichi and Tetsuya Tomita, Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Japan
Background/Purpose: C1q is the major subcomponent of the first component of complement protein. The activation of the complement is triggered by binding of C1q to…
Abstract Number: 1074 • 2012 ACR/ARHP Annual Meeting
TLR2 Deletion Promotes Arthritis and Joint Destruction Through Reduction of IL-10
Qi Quan Huang¹, Renee E. Koessler¹, Robert Birkett², Harris R. Perlman³, Lianping Xing⁴ and Richard M. Pope⁵, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁴Pathology & Lab Medicine, University of Rochester, Rochester, NY, ⁵Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: TLR2 signaling pathway has been suggested as a potential therapeutic target in RA. However, studies with mice deficient in TLR2 (TLR2-/-) and IL-1Ra suggest…
Abstract Number: 343 • 2012 ACR/ARHP Annual Meeting
Functional Impairment in an Animal Model for Rheumatoid Arthritis Assessed As Changes in Gait Is Due to Joint Destruction but Not Synovial Inflammation Per Se
Gregor Bauer¹, Constantin Aschauer¹, Birgit Niederreiter², Josef S. Smolen³, Kurt Redlich² and Silvia Hayer², ¹Dep. of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Division of Rheumatology, Department of Internal Medicine III,, Medical University of Vienna and Hietzing Hospital, Vienna, Austria
Background/Purpose: To investigate the individual impact of synovial inflammation, subchondral bone erosion or cartilage damage on functional impairment in an animal model of Rheumatoid Arthritis…
Abstract Number: 2313 • 2012 ACR/ARHP Annual Meeting
The Autoantibody-Inducing CD4 T Cell (aiCD4 T cell) Belongs to CCR4⁺CD45RB^lo122^lo CD4 Subpopulation: A Novel ‘Self-Organized Criticality Theory’ Explains the Cause of Systemic Lupus Erythematosus (SLE)
Yumi Miyazaki¹, Ken Tsumiyama² and Shunichi Shiozawa², ¹Kyushu University Beppu Hospital/ Kobe University Graduate School of Health Sciences, Beppu/ Kobe, Japan, ²Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…
Abstract Number: 1638 • 2012 ACR/ARHP Annual Meeting
Synovial Fibroblast Migration Is Modulated by the Focal Contact Protein Lasp-1
Adelheid Korb-Pap¹, Jan Hillen¹, Marianne Heitzmann¹, Catherine S. Chew², Stefan Butz³, Dietmar Vestweber⁴, Hermann Pavenstädt⁵ and Thomas Pap¹, ¹Institute of Experimental Muskuloskeletal Medicine, University Hospital Muenster, Muenster, Germany, ²Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA, ³Max Planck Institute of Molecular Biomedicine, Max Planck Institute of Molecular Biomedicine, Muenster, Germany, ⁴Max Planck Institute of Molecular Biomedicine, Muenster, Germany, ⁵Internal Medicine D, Department of Nephrology and Rheumatology, University Hospital Muenster, Muenster, Germany
Background/Purpose: RA synovial fibroblasts (SF) have been suggested to contribute to the spreading of disease through their ability to leave cartilage destruction sites, migrate via…
Abstract Number: 1022 • 2012 ACR/ARHP Annual Meeting
Imaging of Ankle Joints by MRI in Murine Models of Inflammatory Arthritis
Shawn M. Rose¹, Harris R. Perlman², Emily Alex Waters³ and Thomas Meade³, ¹Department of Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Chemistry of Life Processes Institute, Northwestern University, Evanston, IL
Background/Purpose: One of the fundamental shortcomings in the field of experimental rheumatology is the inability to non-invasively monitor the development of inflammatory arthritis longitudinally. Magnetic…
Abstract Number: 347 • 2012 ACR/ARHP Annual Meeting
The Loss of S100A4 Prevents Induction of Experimental Arthritis in Human Tumour Necrosis Factor Transgenic Mouse Model
Michal Tomcik¹, Christine Boehm², Carina Scholtysek³, Lucie Andres Cerezo⁴, Wolfgang Baum³, Clara Dees³, Christian Beyer³, Jerome Avouac⁵, Pawel Zerr³, Katrin Palumbo-Zerr³, Alfiya Akhmetshina³, Radim Becvar¹, Oliver Distler⁶, Mariam Grigorian⁷, Gerhard Kroenke³, Georg A. Schett⁸, Joerg HW Distler³ and Ladislav Senolt¹, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ²Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Institute of Rheumatology, Department of Clinical and Experimental Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ⁵Paris Descartes University and INSERM U1016, Rheumatology A department, Cochin Hospital, Paris, France, ⁶Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁷Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark, ⁸Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Our previous study demonstrated increased levels of S100A4 protein in sera, synovial fluid and synovial membrane of patients with rheumatoid arthritis (RA) compared to…
Abstract Number: 2323 • 2012 ACR/ARHP Annual Meeting
A Genetic Polymorphism on New Zealand Black Chromosome 1 Is Associated with Abnormal Dendritic Cell Function Leading to Expansion of T_H1, T_H17 and T Follicular Helper (T_FH) Cells
Nafiseh Talaei¹, Carolina Landolt-Marticorena², Babak Noamani¹, Evelyn Pau³, Nan-Hua Chang⁴ and Joan E. Wither⁵, ¹Genetics and developmental biology, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ²Rheumatology, University Health Network, Toronto, ON, Canada, ³Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ⁴Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ⁵1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: We have previously shown that B6 mice with an introgressed homozygous New Zealand Black chromosome (c) 1 interval (70 to 100 cM) develop high titres…
Abstract Number: 1639 • 2012 ACR/ARHP Annual Meeting
FLIP in Macrophages Promotes the Progression of Serum Transfer-Induced Arthritis
Qi Quan Huang¹, Robert Birkett², Renee E. Koessler¹, G. Kenneth Haines III³, Harris R. Perlman⁴ and Richard M. Pope⁵, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Pathology, Yale University, New Haven, CT, ⁴Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: Flip is well known as an anti-apoptotic protein induced by chronic inflammation that protects against death receptor-mediated apoptosis. Employing a FLIP myeloid lineage knock-out…
Abstract Number: 856 • 2012 ACR/ARHP Annual Meeting
Am80, a Retinoic Acid Receptor Agonist, Ameliorates Murine Vasculitisthrough the Suppression of Neutrophil Migration and Activation
Chie Miyabe¹, Yoshishige Miyabe¹, Noriko Miura², Kei Takahashi³, Yuya Terashima⁴, Etsuko Toda⁴, Fumiko Honda⁵, Tomohiro Morio⁵, Naohito Ohno², Jun-ichi Suzuki⁶, Mitsuaki Isobe⁷, Kouji Matsushima⁴, Ryoji Tsuboi⁸, Nobuyuki Miyasaka¹ and Toshihiro Nanki⁹, ¹Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, ²Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan, ³Department of Pathology, Toho University Ohashi Medical Center, Tokyo, Japan, ⁴Department of Molecular Preventive Medicine, The University of Tokyo, Tokyo, Japan, ⁵Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan, ⁶Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Tokyo, Japan, ⁷Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan, ⁸Department of Dermatology, Tokyo Medical University, Tokyo, Japan, ⁹Department of Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan
Background/Purpose: Vasculitis is characterized by leukocyte infiltration in the vessel walls with destructive damage to mural structures. Retinoids are compounds that bind to retinoic acid…
Abstract Number: 311 • 2012 ACR/ARHP Annual Meeting
The DEK Autoantigen Regulates Formation of Neutrophil Extracellular Traps and Zymosan Induced Arthritis in Mice
Nirit Mor-Vaknin¹, Anjan K. Saha², Maureen Legendre¹, Marta J. Gonzalez-Hernandez³, M. Asif Amin⁴, Bradley J. Rabquer⁵, Julie M. Jorns⁶, Mariana J. Kaplan⁷, Barbara S. Adams⁸, David A. Fox⁹, Alisa E. Koch¹⁰ and David Markovitz¹, ¹Internal Medicine, University of Michigan, Ann Arbor, MI, ²Medical School, University of Michigan, Ann Arbor, MI, ³Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, ⁴Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁵University of Michigan Medical School, Ann Arbor, MI, ⁶Pathology, Ann Arbor, MI, ⁷Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD, ⁸University of Michigan, Ann Arbor, MI, ⁹Rheumatology/Int Medicine, Univ of Michigan Med Ctr, Ann Arbor, MI, ¹⁰Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: The nuclear oncoprotein DEK is a known autoantigen associated with juvenile idiopathic arthritis (JIA) and other autoimmune diseases. DEK is actively secreted by human…

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