2017 ACR/ARHP Annual Meeting Archives - Page 2 of 201

Abstract Number: 1359

M-DAS28, M-SDAI and M-CDAI Performance in a Cohort of RA Patients with and without Concomitant Fibromyalgia
Abstract Number: 762

M10, a Caspase Cleavage Product of the Hepatocyte Growth Factor Receptor, Downregulates Bone Morphogenetic Protein-9-Induced Smad1/5/8 Phosphorylation and Collagen Production in Human Lung Fibroblasts
Abstract Number: 420

Machine Learning in Rheumatology: Development and Validation of a Predictive Model for Rheumatoid Arthritis Mortality Using Random Survival Forests
Abstract Number: 1147

Macrophage Activation Syndrome or Acquired Hemophagocytic Lymphohistiocytosis in Adults: Demographics, Clinical Characteristics, and Survivorship in an American Academic Medical Center
Abstract Number: 1999

Magnetic Resonance Imaging of Skeletal Muscles in Patients with Dermatomyositis and Polymyositis: Novel and Distinctive Characteristic Findings
Abstract Number: 54

Maintaining Angiogenesis Prevents Glucocorticoid Induced Osteonecrosis
Abstract Number: 146

Major Cardiovascular Events Among an Inception Cohort of Seniors with Rheumatoid Arthritis
Abstract Number: 1499

Major Salivary Gland Ultrasonography Bed-Side and Still Image Scoring – a Pilot Comparison in Juvenile Sjögren’s Syndrome
Abstract Number: 1879

Majority of Rheumatoid Arthritis Patients in Clinical Remission As Defined By DAS-28, CDAI, SDAI and RAPID-3 Have No Signal on Ultrasound Power Doppler
Abstract Number: 1283

Male Patients Have a More Severe Course As Female Patients with Diffuse Juvenile Systemic Scleroderma? Results from the Juvenile Scleroderma Inception Cohort Www.Juvenile-Scleroderma.Com
Abstract Number: 1116

Management of Acute Gout in Hospitalized Patients and Risk Factors for Xanthine Oxidase Inhibitor (XOI) Discontinuation or Dose Reduction
Abstract Number: 1139

Management of Gout – a Survey for Healthcare Providers in South Australia
Abstract Number: 406

Mapping Changes in Monocyte and Macrophage Populations in the Synovium: An Aging Study in Arthritic KRN Ag7 Mice
Abstract Number: 2238

Mapping Paindetect, a Neuropathic Pain Screening Tool, to Patient-Reported Outcomes Measurement Information System (PROMIS) 29 in Patients with Rheumatoid Arthritis: Developing a Neuropathic Pain Scale As a Measure of Treatment Outcome
Abstract Number: 1124

Marked Variability of Circulating Urate Concentrations in Banked Samples Based on Sample Type and Assay
Abstract Number: 789

Markers of Inflammation and Patient-Reported Measures As Predictors of Relapse in Giant Cell Arteritis
Abstract Number: 2420

Mass Cytometry Analysis of CD4+ T Cells in Patients with Rheumatoid Arthritis
Abstract Number: 179

Mass Spectrometry Imaging of Synovium: A Novel Approach to Classify the Rheumatoid and Psoriatic Arthritis Patients
Abstract Number: 2115

Mast Cell Activation Features in Ehlers-Danlos/Joint Hypermobility Patients: A Retrospective Analysis in Light of an Emerging Disease Cluster
Abstract Number: 788

Mast Cell Mediated Inhibition of Systemic IL-6 in candida Albicans Water-Soluble Fraction (CAWS) Induced Model of Large Vessel Vasculitis
Abstract Number: 552

Mast Cells Are Involved in the Pathogenesis of Sjögren Syndrome By Inducing Tissue Fibrosis
Abstract Number: 1310

Maternal and Fetal Outcomes in a Cohort of Patients Exposed to Tumor Necrosis Factor Inhibitors throughout Pregnancy
Abstract Number: 2231

MCC22, a Novel Compound That Targets Both CCR5 and Mu Opioid Receptors, Is Highly Effective in Treating Inflammatory Arthritis Pain
Abstract Number: 800

Measurement of Serum Cytokines during the Apparent Remission State of Takayasu Arteritis – What Do Cytokines Tell Us?
Abstract Number: 2318

Measurement of Serum Infliximab and Antibody Levels As an Adjunct to Clinical Decision Making Regarding Infliximab Therapy
Abstract Number: 338

Measurement Properties of Paindetect, a Neuropathic Pain Screening Tool, for Evaluating Pain Phenotype in Patients with Rheumatoid Arthritis: Developing Neuropathic Pain Scale As a Measure of Treatment Outcome By Applying Rasch Analysis
Abstract Number: 2542

Measuring Psoriasis Specific Impact on Quality of Life: Performance of Dlqi and Skindex-17 in Early Psoriatic Arthritis
Abstract Number: 763

Mechanisms of Insulin-like Growth Factor-II-Mediated Fibrosis
Abstract Number: 2469

Median Time to Lda Is Shorter in Tocilizumab Combination Therapy with Csdmards As Compared to Monotherapy in Patients with Active Rheumatoid Arthritis and Inadequate Responses to Csdmards and/or TNF Inhibitors: Sub-Analysis of the Swiss and Austrian Patients from the ACT-SURE Study
Abstract Number: 2066

Mediation Analysis to Understand Genetic Relationships between Habitual Coffee Intake and Gout
Abstract Number: 449

Medical Bugs for Pain Relief in Patients with Rheumatoid Arthritis, a Systematic Review
Abstract Number: 1044

Medical Care Costs Associated with Rheumatoid Arthritis in the US: A Meta-Analysis
Abstract Number: 97

Medical Student Interest in Rheumatology As a Career
Abstract Number: 473

Medication Utilization Patterns of Rheumatoid Arthritis Patients Receiving Anti-TNF Infusion in Community Rheumatology Practices in the United States: Will Differences in Dosing and Administration Efficiencies between Intravenous Golimumab and Infliximab Have a Cost Impact for Payers?
Abstract Number: 2783

Medications Associated with Osteoporotic Fracture Risk in Patients with Rheumatoid Arthritis
Abstract Number: 1403

Mediterranean Diet Is Inversely Associated with Risk of Rheumatoid Arthritis: A Swedish Population Based Case-Control Study
Abstract Number: 1859

Meeting the Needs of Rheumatology Health Professional Learners: the Success of the American College of Rheumatology (ACR) and Association of Rheumatology Health Professionals (ARHP) Online Educational Products
Abstract Number: 670

Membrane Attack Complex (MAC) Deposition in Lupus Nephritis Is Associated with Hypertension and Poor Clinical Response to Treatment
Abstract Number: 998

Mental Health in Patients with Axial Spondyloarthritis: Increasing Our Understanding of the Disease. Results from the Spanish Atlas
Abstract Number: 1884

Mepolizumab for the Treatment of Patients with Eosinophilic Granulomatosis with Polyangiitis: Post-Hoc Results of a Phase III Randomized, Placebo-Controlled Trial
Abstract Number: 2616

Mesenchymal Stem Cells Induce CD1c+ Tolerogenic Dendritic Cells Via up-Regulating FLT3L in Systemic Lupus Erythematosus
Abstract Number: 284

Metabolic Activity Sustains Macrophage Cytokine Production in Rheumatoid Arthritis and Coronary Artery Disease
Abstract Number: 2178

Metabolic Osteoarthritis: Relation of Cardiovascular Disease and Diabetes to Knee Osteoarthritis
Abstract Number: 1724

Metabolic Regulation of Fibrosis in Systemic Sclerosis: The CD38-NAD+ Link
Abstract Number: 2180

Metabolic Syndrome Does Not Modify the Association between Obesity and Hip Osteoarthritis
Abstract Number: 2189

Metabolic Syndrome Influences the Radiographic Progression of Knee Osteoarthritis and Condition the Risk of Erosive Hand OA
Abstract Number: 2521

Metabolic Syndrome Is Associated with Active Disease in Psoriatic Arthritis and May Contribute to Development of Syndesmophytes
Abstract Number: 2522

Metabolic Syndrome, NAFLD and LIVER Stiffness in Psoriatic Arthritis and Psoriasis Patients: A CROSS-Sectional Study
Abstract Number: 15

Methodology and Systematic Review of the Literature for the Mcmaster RARE-Best Practice Clinical Practice Guideline on Diagnosis and Management of the Catastrophic Antiphospholipid Syndrome
Abstract Number: 1406

Methods for Generating Multiple High-Dimensional Analyses of Cryopreserved Synovial Tissue Developed By the Accelerating Medicines Partnership RA/SLE Network
Abstract Number: 2295

Methotrexate As First Line Therapy in Juvenile Idiopathic Arthritis-Associated Uveitis: Myth or Reality
Abstract Number: 2453

Methotrexate Discontinuation from Combination Therapy with Adalimumab Is Not Associated with Inferior Outcomes at 6 Months
Abstract Number: 493

Methotrexate Is an Antibacterial Drug Metabolized By Human Gut Bacteria
Abstract Number: 1823

Methotrexate Requires High Serum BAFF Levels to Prevent Immunization Against TNF-α Inhibitors
Abstract Number: 443

Methotrexate Treatment Strategies in an Early Rheumatoid Arthritis Cohort
Abstract Number: 446

Methotrexate Use and Fatigue in Rheumatoid Arthritis Patients: Results from a National Patient Registry
Abstract Number: 793

Metotrexate in the Treatment of Giant Cell Arteritis: To be or Not to be
Abstract Number: 1572

MHC Associations of Ankylosing Spondylitis in East Asians Are Driven By HLA-B Amino-Acid Position 97, Confirming Findings in European Descent Subjects
Abstract Number: 2866

Microarray Pathway Analysis Comparing Baricitinib and Adalimumab in Moderate to Severe Rheumatoid Arthritis Patients, from a Phase 3 Study
Abstract Number: 1712

Microbial and Metabolic MULTI-Omic Correlations in Systemic Sclerosis Patients
Abstract Number: 1941

Microenvironmental and Systematic Evaluation of the Immunome in Osteoarthritis
Abstract Number: 1835

Microglial Defects Contribute to Neuropsychiatric Symptoms of Systemic Lupus Erythematosus
Abstract Number: 954

Microrna-21 Is a Critical Regulator of Autoimmunity through Promoting Effector and Metabolic Function of Pathogenic TH17 Cells
Abstract Number: 2669

Microvascular Flow Assessed By Dynamic Optical Coherence Tomography: First Non-Invasive Quantitative Outcome Measure of Microvascular Disease in Systemic Sclerosis
Abstract Number: 88

Mind Map Use in Rheumatology Education
Abstract Number: 2446

Minimal and Comparable Radiographic Progression By Disease Activity States in Patients with Rheumatoid Arthritis Who Continued SB5 or Reference Adalimumab and Who Switched to SB5
Abstract Number: 1351

Minimal Clinically Important Improvement (MCII) of RAPID3 (ROUTINE ASSESSMENT OF PATIENT INDEX DATA 3), an INDEX of ONLY Patient Self-Report Scores in Rheumatoid Arthritis (RA): Similar Performance to DAS28 and CDAI
Abstract Number: 2621

Minimal Renal Affection in Patients with Systemic LUPUS Erythematosus: Characteristics and Evolution
Abstract Number: 567

Minor Salivary Gland Histopathology, Major Salivary Gland Ultrasonography, and Secretory Function in Smoking Patients with Primary Sjögren’s Syndrome
Abstract Number: 643

Mir-10b-5p Is a IL-22 Regulator in CD4+T Cells from Ankylosing Spondylitis
Abstract Number: 63

MiR-146a a Key Player in Bone Metabolism
Abstract Number: 2436

MiR-146a Upregulates the TLR4/NF-κb Signaling Pathway to Promote Cytokine Expression and Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Abstract Number: 301

MiR-221-3p Overexpression Impairs Anti-Inflammatory Activity of TLR4-Stimulated M2-Macrophages
Abstract Number: 1715

Mitochondrial DNA Mutations and Respiratory Chain Dysfunction in Lung Fibrosis of Systemic Sclerosis
Abstract Number: 1011

Mitochondrial Haplogroups-Mediated Methylation Regulates Apoptosis in Osteoathritis Cartilage
Abstract Number: 1933

Mitochondrial ROS Activate the p38-MAPK/AP1 Pathway to Induce the Expression of Matrix Metalloproteases and IL-6 in Human Chondrocytes
Abstract Number: 1417

Mitophagy Defect in Fibroblast-like Synoviocytes of Rheumatoid Arthritis Is Improved By Pyruvate Treatment
Abstract Number: 14L

Miv-711, a Novel Cathepsin K Inhibitor Demonstrates Evidence of Osteoarthritis Structure Modification: Results from a 6 Month Randomized Double-Blind Placebo-Controlled Phase IIA Trial
Abstract Number: 2124

Mixed Connective Tissue Disorder Has Higher Prevalence of Arthritis and Use of Methotrexate Than Systemic Lupus Erythematosus
Abstract Number: 2326

Modeling Transcriptional Rewiring in Neutrophils through the Course of Treated Juvenile Idiopathic Arthritis
Abstract Number: 2987

Moderate and Serious Psychological Distress Among US Adults with and without Arthritis, 2002 to 2015
Abstract Number: 877

Modification of the Classification Criteria for Primary Sjögren Syndrome: An International Vignette Survey
Abstract Number: 969

Modulation of Cartilage Degradation Biomarkers Reflect the Activation and Inhibition of Pro-Inflammatory Cytokine Signaling in an Ex Vivo Model of Bovine Cartilage
Abstract Number: 48

Modulation of Subchondral Bone Turnover Is Associated with Alteration of Cartilage Tissue Quality
Abstract Number: 2875

Molecular Features Define Unique Sjögren’s Syndrome Patient Subsets
Abstract Number: 564

Molecular Identification of a Ro-Specific Salivary IgA Repertoire with Unique Clonal Signatures in Primary Sjogren’s Syndrome
Abstract Number: 1708

Molecular Imaging Biomarkers for Personalized Medicine Strategies in Systemic Sclerosis-Related Interstitial Lung Disease
Abstract Number: 772

Molecular Mechanism for the Therapeutic Effect of Extracorporeal Shock Wave Therapy on Digital Ulcers of Systemic Sclerosis
Abstract Number: 2977

Molecular Phenotypes Associated with Clinical Disease Activity in Adult Systemic Lupus Erythematosus
Abstract Number: 1019

Molecular Profiling of RA Patients Suggests a Differential Involvement of Adaptive and Innate Cell Populations in Response to Anti-TNF Treatment
Abstract Number: 1427

Monitoring of Absolute Lymphocyte Count in Patients with Rheumatoid Arthritis Treated with Tofacitinib
Abstract Number: 2314

Monoarticular Juvenile Idiopathic Arthritis: A Unique Entity?
Abstract Number: 477

Monoclonal ACPA-IgG Feature Extensive Fab Glycosylation
Abstract Number: 1579

Monocyte-Derived Dendritic Cells (MDDCs) from Spondyloarthritis (SpA) Patients Exhbit a Coordinated Downregulation of the Cholesterol (chol) Biosynthesis Pathway That Relates to Lipid Overload
Abstract Number: 1570

Monocytes from Male Patients with Ankylosing Spondylitis Display Decreased Osteoclastogenesis and Decreased RANKL/OPG Ratio
Abstract Number: 2329

Monocytes from Patients with Enthesitis Related Arthritis Produce High Levels of Pro-Inflammatory Cytokines: Role of Endogenous Ligands
Abstract Number: 968

Mononuclear Phagocytes Mediate Systemic Autoimmune Disease-Related Valvular Heart Disease Via Inflammatory Cytokine Production and Recruitment of Tissue-Reparative macrophages
Abstract Number: 1591

Monophasic Disease Course Pattern in Systemic Lupus Erythematosus
Abstract Number: 504

Monotherapy with Filgotinib, a JAK1-Selective Inhibitor, Reduces Disease-Related Biomarkers in Rheumatoid Arthritis Patients
Abstract Number: 2982

Morbidity and Mortality of Scleroderma in African Americans
Abstract Number: 1504

More Than 10 Percent Patients with Recent Onset Chronic Mechanical Back Pain Fulfill the Modified NY Criteria for Sacroiliitis
Abstract Number: 2412

Mortality and Clinical Features in Rheumatoid Arthritis and Interstitial Lung Disease
Abstract Number: 2665

Mortality in an Early Diffuse Cutaneous Systemic Sclerosis Cohort—Data from the Prospective Registry for Early Systemic Sclerosis
Abstract Number: 2679

Mortality Is Increased in Scleroderma Associated Pulmonary Arterial Hypertension Patients with Younger Age, Lower Systolic Blood Pressure, and Lower Cardiac Index, but Not in Idiopathic Pulmonary Arterial Hypertension
Abstract Number: 1333

Mortality of Tumor Necrosis Factor Transgenic Arthritic Mice with Interstitial Lung Disease Occurs with Pulmonary Arteriole Thickening and Right Ventricular Hypertrophy but Is Not Associated with Inducible Nitric Oxide Synthase Dependent Inflammatory Cell Infiltration
Abstract Number: 840

Mortality Post Hip Fracture in Rheumatoid Arthritis Compared to General Population Controls, a Population-Based Study
Abstract Number: 812

Mortality Risk and Cause-Specific Mortality in Polymyalgia Rheumatica: A Population-Based Cohort Study
Abstract Number: 2699

Mosaic, a Novel Gene, Mediating Autoimmunity in Mice
Abstract Number: 1988

Most Fibromyalgia Patients in a Rheumatology Office Practice Accept the Diagnosis of Fibromyalgia
Abstract Number: 2000

MRI Contributes to Accurate and Early Diagnosis of Non-Radiographic HLA-B27 Negative Axial Spondyloarthritis
Abstract Number: 235

MRI in Rheumatoid Arthritis: Does Quantifying the Number of Erosive Lesions Improve Detection of Subtle Erosive Progression Compared to the Omeract RA MRI Scoring System?
Abstract Number: 2962

MRI Results Following Discontinuation of Methotrexate in Patients with Rheumatoid Arthritis Treated with Subcutaneous Tocilizumab: Results from a Randomized Controlled Trial
Abstract Number: 1008

mtDNA Cybrids from OA Patients Are Less Efficient Using Glycolysis and Are More Susceptible to Apoptosis Under Stress Conditions
Abstract Number: 1746

mTOR Pathway Activation in Takayasu Arteriti
Abstract Number: 2932

mTOR Pathway Is Activated in Endothelial Cells from Patients with Takayasu Arteritis and Is Modulated By Serum IgG
Abstract Number: 2763

mTORC1 Blockade with Rapamycin and N-Acetylcysteine Reduces Anti-Phospholipid Antibody Levels in Controlled Clinical Trials of Patients with SLE
Abstract Number: 1065

Mucosal-Associated Invariant T Cell Deficiency in Systemic Lupus Erythematosus Is Realted to an Intrinsic Defect in the Ca2+/Calcineurin/NFAT1 Signaling Pathway
Abstract Number: 2711

Mucosal-Associated Invariant T Cells Are an Important Source of TNF in Rheumatoid Arthritis
Abstract Number: 759

Multi Dimensional Analysis of the Immunome in Systemic Sclerosis Reveals Functionally Related Abnormalities in MAIT and B Cell Compartments
Abstract Number: 414

Multi-Biomarker Disease Activity and Autoantibody Status Lead to Cost Effective Tapering Algorithms in Rheumatoid Arthritis Patients in Sustained Remission
Abstract Number: 361

Multi-National Observational Patient Diary Study to Assess Disease Burden of Periodic Fever Syndromes (PFS), Including Colchicine-Resistant Familial Mediterranean Fever (crFMF), TNF-Receptor Associated Periodic Syndrome (TRAPS) and Mevalonate Kinase Deficiency (MKD)
Abstract Number: 2931

Multi-Organ RNA-Sequencing of Patients with Systemic Sclerosis (SSc) Finds That Intrinsic Subsets Are Conserved across Organ Systems
Abstract Number: 1180

Multicenter Study on the Rate of Renal Function Deterioration in IgG4-Related Tubulointerstitial Nephritis
Abstract Number: 354

Multidomain Functional Assessment in a Cohort of Patients with Systemic Lupus Erythematosus: A Pilot Study
Abstract Number: 1959

Multimorbidity in Patients with Sarcoidosis: A Population-Based Cohort Study
Abstract Number: 2144

Multiple Serum Cytokine and Chemokine Profiling to Identify Combinational Biomarkers Toward Patients of Polymyositis/Dermatomyositis Complicated with Rapidly Progressive Interstitial Lung Disease
Abstract Number: 297

Multiplexed Characterization of Circulating and Joint-Derived Human Neutrophils in Inflammatory Arthritis
Abstract Number: 378

Musculoskeletal Features in Copa Syndrome
Abstract Number: 267

Musculoskeletal Ultrasound As a Diagnostic Tool for Eosinophilic Fasciitis and Correlation with MRI Findings
Abstract Number: 1072

Mutated Peptidylarginine Deiminase from Porphyromonas Gingivalis Is a Target in Rheumatoid Arthritis and Citrullinates Major RA-Autoantigens
Abstract Number: 1587

Mycobacterial Infection in Systemic Lupus Erythematosus: Clinical Significance and Associated Factors. Data from the Registry of Patients with SLE of the Spanish Society of Rheumatology (RELESSER)
Abstract Number: 1171

Mycophenolate Mofetil May Improve Interstitial Pneumonia with Autoimmune Features
Abstract Number: 2152

Mycophenolate Mofetil Treatment with or without a Calcineurin Inhibitor in Resistant Inflammatory Myopathy
Abstract Number: 1782

Mycophenolic Acid Decreases IL-10 and IL-6 Production By B Cells of Granulomatosis with Polyangiitis Patients and Healthy Controls in Vitro
Abstract Number: 872

Myocardial Abnormalities Improve in RA Patients Treated Actively – a Cardiac MRI Follow-up Study
Abstract Number: 2155

Myositis As a Complication of Checkpoint Blockade at a Comprehensive Cancer Center
Abstract Number: 2566

Myxomavirus-Derived Serpin (Serp-1) Reduces Diffuse Alveolar Hemorrhage in a Murine Model of Lupus