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  • Abstract Number: 1074 • ACR Convergence 2020

    A Novel Autoantibody Recognizing a 65-kDa Protein Is Associated with Scleromyositis with Head Drop and/or Bent Spine

    Karel Venne1, Valérie Leclair2, Julie D'Aoust1, Océane Landon-Cardinal3, Alexandra Albert4, Julie Beauchemin5, Denis Brunet6, Lucie Roy7, Benjamin Ellezam8, Jason Karamchandani9, Rami Massie10, Erin O'Ferrall10, Alain Meyer11, Yves Troyanov12, Minoru Satoh13, Marvin Fritzler14 and Marie Hudson2, 1Division of Rheumatology, Rheumatology Fellow, McGill University,, Montreal, QC, Canada, 2Division of Rheumatology, Jewish General Hospital, Montréal, QC, Canada, 3Division of Rheumatology, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, 4Division of Rheumatology, Centre Hospitalier de l’Université Laval, Québec, QC, Canada, 5Division of Rheumatology, Hôpital Charles-Lemoyne, Longueuil, QC, Canada, 6Division of Neurology, Centre Hospitalier de l’Université Laval, Quebec, QC, Canada, 7Division of Rheumatology, CIUSSS du Saguenay Lac-Saint-Jean, Saguenay, Canada, 8Division of Pathology, CHU Sainte-Justine, Montreal, QC, Canada, 9Department of Pathology, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, 10Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, 11Service de rhumatologie et Centre de références des maladies autoimmunes rares, Hôpitaux universitaires de Strasbourg, Strasbourg, France, 12Division of Rheumatology, Hôpital du Sacré-Coeur, Montréal, QC, Canada, 13Department of Clinical Nursing, University of Occupational and Environmental Health, Kitakyushu, Japan, 14Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

    Background/Purpose: Scleromyositis (SM) is an emerging subgroup of autoimmune myositis associated with features of systemic sclerosis (SSc). There is a paucity of data on scleromyositis…
  • Abstract Number: 1075 • ACR Convergence 2020

    Diagnostic Utility of Myositis Antibodies in HyperCKemia: A University Affiliated Single Center Retrospective Study

    Sandeepkumar Gupta1, Debendra Pattanaik2, Tulio Bertorini2 and Amado Afreire3, 1Medical College Of Georgia at Augusta University Medical Center, Augusta, GA, 2University of Tennessee Health Science Center, Memphis, TN, 3University of Tennessee Health Science Cente, Memphis, TN

    Background/Purpose: Myositis specific and associated autoantibodies are now being used more frequently in the diagnosis of idiopathic inflammatory myositis. However there is a no study…
  • Abstract Number: 1076 • ACR Convergence 2020

    Anti-Jo1 Antibody Quantification Serve as a Prognostic Factor in Anti-synthetase Syndrom

    Lois Bolko1, Kevin Didier2, Jean-Hugues Salmon1, Makoto Miyara3, Segolene Toquet2, Amelie Servettaz2, Yves Allenbach3, Olivier Benveniste4 and Baptiste Hervier5, 1Maison Blanche Hospital, Reims, Champagne-Ardenne, France, 2Robert Debre Hospital, Reims, Champagne-Ardenne, France, 3Sorbonne Université, Paris, Ile-de-France, France, 4Sorbonne Université, paris, France, 5Saint-Louis Hospital, Paris, Ile-de-France, France

    Background/Purpose: Anti-Synthetase Syndrome (ASyS) is a rare systemic autoimmune disease defined by a combination of pulmonary, muscle, joint, and skin manifestations and the presence of…
  • Abstract Number: 1077 • ACR Convergence 2020

    Glucagon-like Peptide-1 Receptor Agonist Suppresses Muscle Inflammation and Muscle Fiber Death, and Ameliorates Muscle Weakness in Experimental Polymyositis

    Mari Kamiya1, Seon Uk Kim2, Jeong Yeon Kim3, Shinsuke Yasuda4, Eun Young Lee5 and Fumitaka Mizoguchi1, 1Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 2Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Jongno-gu, Seoul, Republic of Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, 4Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Tokyo, Japan, 5Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

    Background/Purpose: Glucocorticoids (GC) are the cornerstone of the treatment for polymyositis (PM). However, the treatment with GC causes GC-induced myopathy, which further deteriorates the muscle…
  • Abstract Number: 1078 • ACR Convergence 2020

    Highly Reactive anti-Jo1 Autoantibodies to Distinct HisRS Variants and Domains Associate with Lung and Joint Involvement in Patients with Myositis

    Antonella Notarnicola1, Charlotta Preger2, Susanna L. Lundström2, Nuria Renard2, Edvard Wigren2, Eveline Van Gompel2, Angeles S. Galindo-Feria2, Helena Persson3, Maryam Fathi4, Johan Grunewald2, Per-Johan Jakobsson2, Susanne Gräslund2, Ingrid Lundberg5 and Cátia Fernandes-Cerqueira2, 1Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, 2Karolinska Institutet, stockholm, Sweden, 3Science for Life Laboratories, KTH, Stockholm, Sweden, 4Karolinska University Hospital, stockholm, Sweden, 5Division of Rheumatology, Department of Medicine, Karolinska Institutet,, Stockholm, Sweden

    Background/Purpose: To address the reactivity and affinity against histidyl-transfer RNA synthetase (HisRS) autoantigen of anti-Jo1 autoantibodies from serum and bronchoalveolar lavage fluid (BALF) and associations…
  • Abstract Number: 1079 • ACR Convergence 2020

    Sex Differences in Antibody Profile, Phenotype, and Treatment Response in a Racially Diverse Population with Idiopathic Inflammatory Myopathies

    Ana Valle1, Jammie Law2, Katherine Mullins3 and Shereen Mahmood4, 1Albert Einstein College of Medicine, New York, NY, 2Montefiore Medical Center, Bronx, NY, 3Montefiore Medical Center, BROOKLYN, NY, 4Albert Einstein College of Medicine / Montefiore Medical Center, Wantagh, NY

    Background/Purpose: It is established that autoimmune diseases are more common in females than males. Large scale idiopathic inflammatory myopathy (IIM) registries have shown a similar…
  • Abstract Number: 1080 • ACR Convergence 2020

    Sensitivity and Specificity of the 2017 EULAR/ACR Criteria for Idiopathic Inflammatory Myopathies in a Cohort of Patients from Latin America

    Antonia Maria Valenzuela Vergara1, Magdalena Torres1 and Alejandro Deves1, 1Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of diseases characterized by muscle inflammation and internal organ involvement. The Bohan & Peter (B&P) criteria…
  • Abstract Number: 1081 • ACR Convergence 2020

    Patient-reported Outcomes in Early Autoimmune Inflammatory Myopathies

    Valérie Leclair1, Brett Thombs2, Mianbo Wang3, Evelyne Vinet4, Alexandra Albert5 and Marie Hudson6, 1Division of Rheumatology, Jewish General Hospital, Montreal, QC, Canada, 2Department of Psychology, McGill University, Montreal, QC, Canada, 3Lady Davis institute for Medical Research, Montreal, QC, Canada, 4McGill University Health Center, Montreal, QC, Canada, 5Division of Rheumatology, Centre Hospitalier de l’Université Laval, Québec, QC, Canada; Department of Medicine, Université Laval, Québec, QC, Canada., Neuville, Canada, 6Division of Rheumatology, Jewish General Hospital, Montréal, QC, Canada

    Background/Purpose: Patient-reported outcomes (PROs) are increasingly used in rheumatology. Such outcomes are under-reported in autoimmune inflammatory myopathies (AIM) especially in incident cohorts. The objective of…
  • Abstract Number: 1082 • ACR Convergence 2020

    The Presence of Anti-Jo1, anti-PL7, And/or anti-MDA5 Antibodies in Idiopathic Inflammatory Myopathy Confers an Increased Risk of a Significant Restrictive Pulmonary Defect

    Dmitriy Cherny1 and Carrie Richardson1, 1Rush University Medical Center, Chicago, IL

    Background/Purpose: A subset of patients with idiopathic inflammatory myopathy develop significant restrictive lung disease, although risk factors for this are poorly defined. Autoantibodies may be…
  • Abstract Number: 1083 • ACR Convergence 2020

    Alterations of Lipid Profile in IIM Patients Are Associated with Disease Activity, Duration, and Glucocorticoid Treatment

    Sabina Oreska1, Hana Storkanova2, Maja Spiritovic3, Barbora Hermankova4, Michal Vrablik5, Karel Pavelka6, Ladislav Šenolt6, Heřman Mann2, Jiří Vencovský6 and Michal Tomcik7, 1Institute of Rheumatology, Prague, Czech Republic. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Praha 2, Czech Republic, 2Institute of Rheumatology, Prague, Czech Republic. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 3Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic, 4Faculty of Physical Education and Sport, Department of Physiotherapy, Charles University, Prague, Czech Republic,, Prague, Czech Republic, 53rd Department of Internal Medicine, General University Hospital, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 6Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 7Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are characterized by skeletal muscle and organ involvement and chronic course. Systemic inflammation, limited mobility, and glucocorticoid treatment can have…
  • Abstract Number: 1084 • ACR Convergence 2020

    Consumer-based Activity Trackers in Evaluation of Physical Function in Myositis Patients

    Didem Saygin1, Bonny Rockette-Wagner2, Chester Oddis3, Diane Koontz1, Siamak Moghadam-Kia1 and Rohit Aggarwal2, 1University of Pittsburgh Medical Center, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA, 3Department of Medicine, Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Idiopathic inflammatory myopathies are systemic inflammatory conditions characterized by muscle weakness and reduced muscle endurance that limit activities of daily living. Daily step count…
  • Abstract Number: 1085 • ACR Convergence 2020

    Pain in Myositis Is Associated with the Disease Activity

    Anjana Chandrasekhara Pillai1, Chester Oddis2, Siamak Moghadam-Kia3, Dana Ascherman4, Nicole Neiman5, Diane Koontz5, Ren Dianxu5 and Rohit Aggarwal4, 1UPMC Mckeesport, Pittsburgh, PA, 2Department of Medicine, Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, 3University of Pittsburgh Medical Center, Pittsburgh, PA, 4University of Pittsburgh, Pittsburgh, PA, 5UPMC, Pittsburgh, PA

    Background/Purpose: Pain in myositis is poorly studied and multifactorial relating to muscle weakness, arthritis, myofasciitis, fibromyalgia or other co-morbidities. We sought to prospectively evaluate patient-reported…
  • Abstract Number: 1086 • ACR Convergence 2020

    The Diagnostic Value and Clinical Significance of Myositis-Specific Antibodies in Patients Suspected to Have Autoimmune Myopathies and/or Autoimmune Rheumatic Diseases

    Sarah El Chami1, Christopher Williams1, Ghaith Noaiseh1, Amrita Bath1 and Duaa Jabari1, 1The University of Kansas Health System, Kansas city, KS

    Background/Purpose: Myositis-specific antibodies (MSA) are thought to be highly specific in patients with idiopathic inflammatory myopathies.[1] However, in clinical practice these antibodies are frequently found…
  • Abstract Number: 1087 • ACR Convergence 2020

    Plasma-derived Extracellular Vesicles Induced STING-mediated Proinflammatory Effects in Dermatomyositis

    Yubin Li1, Christina Bax2, Jay Patel3, Adarsh Ravishankar3, Krisha Desai4, Majid Zeidi4, Muhammad Bashir4 and Victoria Werth1, 1University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, PA, 2University of Pennsylvania, Department of Dermatology, Philadelphia, 3University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, 4University of Pennsylvania, Philadelphia

    Background/Purpose: Dermatomyositis (DM) is an acquired inflammatory myopathy characterized by chronic skin inflammation. The pathogenesis of DM is still unclear. Extracellular vesicles (EVs) are lipid…
  • Abstract Number: 1088 • ACR Convergence 2020

    Recruitment Rates of Virtual Remote Research (Tele-Research) in Myositis

    Siamak Moghadam-Kia1, Chester Oddis2, Swamy Venturupalli3, Shalini Mahajan4, Daphne Scaramangas Plumley5, Dana Ascherman6, Nicole Neiman7, Faith Onelangsy7, Diane Koontz1, Kim Goldby-Reffner7, Sedin Dzanco7, Lei Zhu6 and Rohit Aggarwal6, 1University of Pittsburgh Medical Center, Pittsburgh, PA, 2Department of Medicine, Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, 3Cedars Sinai Medical Center, Los Angeles, 4Attune Health, Los Angeles, 5Attune Health, Los Angeles, CA, 6University of Pittsburgh, Pittsburgh, PA, 7UPMC, Pittsburgh

    Background/Purpose: There is a paucity of randomized, controlled clinical trials in myositis. Subject enrollment and retention in clinical trials for this rare, heterogeneous disease has…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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