ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 1472

Assessing Causal Associations of Urate Levels with Type 2 Diabetes and Related Glycemic Traits Using Bidirectional Mendelian Randomization

Natalie McCormick1, Mark O'Connor1, Shelby Marozoff2, John Choi3, Aaron Leong1 and Hyon Choi4, 1Massachusetts General Hospital, Boston, MA, 2Arthritis Research Canada, Vancouver, Canada, 3Massachusetts General Hospital, Boston, 4Massachusetts General Hospital, Department of Medicine, Division of Rheumatology, Lexington, MA

Meeting: ACR Convergence 2020

Keywords: Comorbidity, Epidemiology, Genome Wide Association Studies, gout, Uric Acid, Urate

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Sunday, November 8, 2020

Session Title: Epidemiology & Public Health III: Risk Factors & Outcomes (1472–1476)

Session Type: Abstract Session

Session Time: 5:00PM-5:50PM

Background/Purpose: Type 2 diabetes (T2D) and gout/hyperuricemia frequently coexist, but the nature and direction of this relationship is unclear.  Observational studies have reported positive associations between gout/SU levels and risk of T2D but are subject to residual confounding or reverse causality bias.  We used bidirectional two-sample Mendelian randomization to obtain unconfounded evidence of these potential causal effects. 

Methods: Aggregate data from three large genome-wide association studies were used to identify genetic variants (SNPs) associated with SU levels (CKDGEN Consortium (Nat Genetics 2019; n=288,649 European-ancestry individuals; 123 SNPs)), T2D (DIAbetes Genetics Replication And Meta-analysis consortium (DIAGRAM: >34,000 T2D cases and >114,000 controls)), and related glycemic traits (Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC): >200,000 in people without diabetes).  These SNPs served as instrumental variables for the genetically determined exposures at conception, thus free of confounding by all factors after birth (e.g., lifestyle factors).

We first assessed the association between genetically-determined SU levels and T2D and levels of 3 glycemic traits, insulin resistance (HOMA-IR), fasting insulin (FI), and HbA1c, using inverse variance weighted (IVW) meta-analysis methods.  We also separately examined the effects of SNPs from genes which regulate SU levels, SLC2A9 and ABCG2, estimating Wald ratios for these individual SNPs.

We then assessed the effects of genetically-determined T2D and glycemic traits on changes in SU levels, including and excluding a pleiotropic SNP (rs1260326) mapped to the GCKR gene.

In addition to the main IVW analyses, we generated MR-Egger, weighted median and mode, and MR-PRESSO estimates to account for potential heterogeneity and horizontal pleiotropy. 

Analyses were performed with the TwoSampleMR and MR-PRESSO packages in R.

Results: Estimated effects of genetically-determined SU levels on each of the four outcomes (HOMA-IR, FI, HbA1c, and T2D) were small and non-significant (Table 1); this was consistent across MR estimates.  The SLC2A9 and ABCG2 SNPs were strongly associated with SU levels (beta=0.33 mg/dL, R2=2.4% and beta=0.25 mg/dL, R2=0.7%, respectively; both p< 0.001), but neither were associated with T2D or any glycaemic traits (Table 1). 

In the opposite direction, there was a strong association between genetically determined levels of FI and SU (beta=0.37 mg/dL, p=0.001) (Table 2), which strengthened after excluding the pleiotropic SNP in GCKR (beta=0.52 mg/dL (95% CI 0.35 to 0.66), p< 0.001).

Conclusion: Evidence from this Mendelian randomization analysis suggests that genetically raised fasting insulin, a measure of insulin resistance and precursor to T2D, is causally associated with hyperuricemia. Results are consistent with cross-sectional/observational studies and corroborate physiologic evidence for insulin’s anti-uricosuric property.  Conversely, our data do not support a causal association of SU with FI levels or T2D risk. Interventions targeting SU levels are unlikely to lower T2D risk, whereas lowering insulin resistance would lower risk of gout. 

Table 1: Causal effect estimates for genetically-determined serum urate levels (per 1 mg/dL) on type 2 diabetes risk and other glycemic trait levels

Table 2: Causal effect estimates for genetically-determined levels of fasting insulin (ascertained in non-diabetics) on levels of serum urate (mg/dL)


Disclosure: N. McCormick, None; M. O'Connor, None; S. Marozoff, None; J. Choi, None; A. Leong, None; H. Choi, AstraZeneca, 2, Takeda, 5, Selecta, 5, GlaxoSmithKline, 5, Horizon, 5.

To cite this abstract in AMA style:

McCormick N, O'Connor M, Marozoff S, Choi J, Leong A, Choi H. Assessing Causal Associations of Urate Levels with Type 2 Diabetes and Related Glycemic Traits Using Bidirectional Mendelian Randomization [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/assessing-causal-associations-of-urate-levels-with-type-2-diabetes-and-related-glycemic-traits-using-bidirectional-mendelian-randomization/. Accessed February 24, 2021.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to ACR Convergence 2020

ACR Meeting Abstracts - https://acrabstracts.org/abstract/assessing-causal-associations-of-urate-levels-with-type-2-diabetes-and-related-glycemic-traits-using-bidirectional-mendelian-randomization/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.