ACR Meeting Abstracts

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Abstracts tagged "gout"

  • Abstract Number: L05 • ACR Convergence 2024

    Prolonged Plasma Urate-Lowering After a Single Intravenous Administration of PRX-115, a Novel PEGylated Uricase, in Participants with Elevated Urate Levels

    Christian Schwabe1, Orit Cohen Barak2, Alexandra Cole3, Hadar Reuveni2, Liron Shelev2, Liora Blinder-Haddad2 and Nicola Dalbeth4, 1NZCR, Auckland, New Zealand, 2Protalix Ltd, Karmiel, Israel, 3NZCR, Christchurch, New Zealand, 4University of Auckland, Auckland, New Zealand

    Background/Purpose: PEGylated uricases have already demonstrated therapeutic modality in the treatment of refractory gout patients. PRX-115 is a recombinant homotetrameric uricase enzyme, produced from Candida…
  • Abstract Number: 0279 • ACR Convergence 2024

    Macrophage Intracellular Fates of Monosodium Urate and Calcium Pyrophosphate Crystals: Phagocytosis, Exchanged/expulsion and Dissolution of Crystals

    Charles Leroy1, Nghia Pham2, François Brial3, Brenda Kischkel4, gwénaêlle Jayat5, Elena Ishow6, Christèle Combes7, Leo Joosten4, Augustin Latourte8, Pascal Richette9 and Hang-Korng Ea10, 1Inserm 1132 / Université Paris Cité, levallois-perret, France, 2INSERM 1132, BIOSCAR, Lariboisière hospital, Paris, France, 3Inserm 1132/ Université Paris Cité, Paris, France, 4Radboudumc, Nijmegen, Netherlands, 5Université Paris cité / Inserm 1132, paris, France, 6Université de Nantes / Ceisam, Nantes, France, 7INP-ENSIACET, Toulouse, France, 8AP-HP, Paris, France, 9Lariboisière Hospital, Paris, France, 10Université Paris Cité, INSERM UMR 1132 BIOSCAR, Paris, France

    Background/Purpose: Gout, due to the presence of monosodium urate crystals (MSU) and calcium pyrophosphate (CPP) crystal deposition disease are both responsible for recurrent inflammation flares.…
  • Abstract Number: 1085 • ACR Convergence 2024

    Pharmacokinetics and Pharmacodynamics of Tigulixostat in Participants with Mild, Moderate, and Severe Renal Impairment

    Ashish Kumar1, Ali Hariri1, Yunjung Lee2 and Minhyung Lee2, 1LG Chem Life Sciences USA, Boston, MA, 2LG Chem, Seoul, Republic of Korea

    Background/Purpose: Tigulixostat is a potent and highly selective non-purine based xanthine oxidase inhibitor (XOi) being investigated for the management of hyperuricemia in patients with gout.…
  • Abstract Number: 1103 • ACR Convergence 2024

    The Role of Renal Dual-Energy CT in Exploring the Gouty Kidney: The RENODECT Study

    Tristan Pascart1, Elie Dauphin1, Chio Yokose2, Charlotte Jauffret3, Hyon K. Choi4 and Jean-François Budzik5, 1Université Catholique de Lille, Lille, Nord-Pas-de-Calais, France, 2Massachusetts General Hospital, Boston, MA, 3Lille Catholic University, Lille, Nord-Pas-de-Calais, France, 4Massachusetts General Hospital, Lexington, MA, 5Lille Catholic University, Lille, France

    Background/Purpose: Chronic kidney disease (CKD) is a common feature in gout, and can have multiple causes, some of which are gout specific, such as gout…
  • Abstract Number: 2010 • ACR Convergence 2024

    The Influence of Treat-to-target Urate Lowering Therapy and Anti-inflammatory Prophylaxis on Circulating Measures of Inflammation in Gout

    Austin Wheeler1, Tanner Ourada2, Michael Duryee1, Bryant England1, Richard Reynolds3, James O'Dell1, Jeff Newcomb1, Michael Pillinger4, Robert Terkeltaub5, Ryan Ferguson6, Mary Brophy6, Tony Merriman7 and Ted Mikuls1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Nebraska-Medical Center: College of Medicine, Omaha, NE, 3University of Alabama at Birmingham, Birmingham, AL, 4New York University Grossman School of Medicine, New York,, NY, 5Retired, San Diego, CA, 6Veterans Affairs, Boston, MA, 7University of Alabama at Birmingham, Homewood, AL

    Background/Purpose: Gout is the most common inflammatory arthritis worldwide and is associated with substantial cardiometabolic morbidity and mortality. In the STOP Gout trial (O’Dell JR…
  • Abstract Number: 2557 • ACR Convergence 2024

    The Relation of Colchicine to Knee/hip Replacement Among People with Gout in a Population-based Cohort Study

    Zhiqiang Wang1, Sarah Tilley2, Christine Peloquin2, Eva Petrow3, Margaret Clancy2 and Tuhina Neogi2, 1Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China, Guangzhou, Guangdong, China (People's Republic), 2Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 3Boston Medical Center, Boston, MA

    Background/Purpose: Colchicine, an anti-inflammatory drug commonly used in gout, has been associated with a lower incidence of total knee/hip replacement compared to placebo among participants…
  • Abstract Number: 0280 • ACR Convergence 2024

    Trends in Management and Consultations for Gout: A Study of 18 Million Adults Using the OpenSAFELY Platform

    Mark Russell1, Jon Massey2, Edward Roddy3, Brian MacKenna4, Seb Bacon4, Ben Goldacre4, Colm Andrews4, George Hickman4, Amir Mehrkar2, Arti Mahto5, Andrew Rutherford6, Samir Patel1, Maryam Adas7, Edward Alveyn7, deepak Nagra1, Katie Bechman7, Joanna Ledingham8, Joanna Hudson9, Sam Norton1, Andrew Cope7 and James Galloway10, 1King's College London, London, England, United Kingdom, 2University of Oxford, Oxford, England, United Kingdom, 3Keele University, Keele, England, United Kingdom, 4University of Oxford, Oxford, United Kingdom, 5King's College Hospital NHS Foundation Trust, London, United Kingdom, 6King's College Hospital NHS Foundation Trust, London, England, United Kingdom, 7King's College London, London, United Kingdom, 8Portsmouth Hospitals University NHS Trust, Portsmouth, United Kingdom, 9King's College London, King's College London, United Kingdom, 10Centre for Rheumatic Diseases, King's College London, London, United Kingdom

    Background/Purpose: Data from before the COVID-19 pandemic had shown persistently poor care for people with gout in many countries worldwide. Whether this was further exacerbated…
  • Abstract Number: 1086 • ACR Convergence 2024

    Risk Factors Associated with Loss to Follow-up in a Prospective Gout Cohort

    HYUNSUE DO1, Min Jung Kim2, Kichul Shin3 and Ki Won Moon4, 1Kangwon national university hospital, Seoul, South Korea, 2Seoul Metropolitan Government Boramae Medical center, Dongjak-gu, Seoul, South Korea, 3Seoul Metropolitan Government- Seoul National University Boramae Medical Center, Seoul, South Korea, 4Kangwon National University hospital, Chuncheon-si, Republic of Korea

    Background/Purpose: Gout, a prevalent form of inflammatory arthritis, is generally considered to be easy to manage with urate lowering agent. However, many patients with gout…
  • Abstract Number: 1109 • ACR Convergence 2024

    Differences Between Correlation and Causal Inference in Detecting Predictors of Undefined Crystal Arthropathy in Women

    Laura Scagnellato1, Antonio Collesei2, Sonia farah3, Carlomaurizio Montecucco4, Francesca Oliviero5, Bernd raffeiner6, Marta favero5, Amelia Damasco5, doria Andrea5, Fausto Salaffi3 and Roberta Ramonda7, and SIR Study Group on Crystal Arthropaties, 1Rheumatology Unit, University of Padova, Padova, Italy, 2IRCCS Istituto Oncologico Veneto IOV, Padova, Italy, 3Polytechnic University of Marche, Jesi (AN), Italy, 4IRCCS policlinico S. Matteo foundation, University of Pavia, Pavia, Italy, 5University of Padova, Padova, Italy, 6General Hospital of Bolzano, Bolzano, Italy, 7Rheumatology Unit, University of Padova, Italy, Padova, Italy

    Background/Purpose: Crystal arthropaties, including gout and calcium pyrophosphate deposition disease (CPPD), are prevalent and burdensome conditions. The ALLSTAR model allows the identification of reliable causal,…
  • Abstract Number: 2011 • ACR Convergence 2024

    The Relationship Between Anti-drug Antibodies, Infusion Reactions, and Loss of Urate-lowering Response in Patients with Uncontrolled Gout Treated with Pegloticase

    Sanjay Chabra1, Afroz Mohammad2, Katie Obermeyer2, Yang Song2, Lissa Padnick-Silver2, Brian LaMoreaux3 and Peter Lipsky4, 1Texas Arthritis Center, El Paso, TX, 2Amgen, Inc., Thousand Oaks, CA, 3Amgen, Inc., Deerfield, IL, 4AMPEL BioSolutions, Charlottesville, VA

    Background/Purpose: Immunogenicity of pegloticase, a PEGylated uricase, can limit a sustained urate-lowering response and increase risk for infusion reactions (IRs).1 The MIRROR RCT trial demonstrated…
  • Abstract Number: 2558 • ACR Convergence 2024

    Development of Non-genetic Risk Stratification Model of Severe Allopurinol Hypersensitivity Syndrome, a Multicenter Study in Thailand

    Patapong Towiwat1, Wichittra Tassaneeyakul2, Suppachai Lawanaskol3, Chonlaphat Sukasem4, Nontaya Nakkam2, Ticha Rerkpattanapipat4, Jettanong Klaewsongkram5, Pawinee Rerknimitr5, Duangkamon Poolpun6, Worawit Louthrenoo7 and Niwat Saksit8, 1Naresuan university, Phitsanulok, Thailand, 2Khon Kaen university, Khon Kaen, Thailand, 3Chaiprakan hospital, Chiang Mai, Thailand, 4Mahidol university, Bangkok, Thailand, 5Chulalongkorn university, Bangkok, Thailand, 6Buddhachinaraj hospital, Phitsanulok, Thailand, 7Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, Chiang Mai, Thailand, 8Phayao university, Phayao, Thailand

    Background/Purpose: Severe allopurinol hypersensitivity (SAH), although uncommon, is a serious adverse event of allopurinol.  Both genetic (HLA-B*58:01) and non-genetic factors (female gender, age ≥60-65 years,…
  • Abstract Number: 0133 • ACR Convergence 2024

    The Association Between Gout and Gallstone Disease: US General Population Analysis

    Chio Yokose1, Bohang Jiang2, Natalie McCormick2, Sharan Rai2 and Hyon K. Choi3, 1Massachusetts General Hospital, Waltham, MA, 2Massachusetts General Hospital, Boston, MA, 3Massachusetts General Hospital, Lexington, MA

    Background/Purpose: Gout is associated with kidney stones, but its association with gallstone disease is not known. Gout and gallstone disease have several shared risk factors…
  • Abstract Number: 0281 • ACR Convergence 2024

    Intra-articular Treatment Combining Sustained Release Colchicine Encapsulated in Microspheres, and Ropivacaine, Is Effective in Inflammatory Arthritis in Rats

    Julien GRASSOT1, Farah MARZOUKI2, Roxane HERVE3, Magali BECKLER4, Luca SEMERANO5, Natacha BESSIS6, Elodie RIVIERE7, Charles SANSON2, Gauthier POULIQUEN2, Philippe POULETTY8 and Marie-Christophe BOISSIER9, 1PK MED, LYON, Rhone-Alpes, France, 2PK MED, LYON, France, 3INSERM U1125, Bobigny, France, 4INSERM 1125, Bobigny, France, 5Avicenne Teaching Hospital APHP, Bobigny, France, 6INSERM, Université Sorbonne Paris Nord, PARIS, France, 7INSERM, Université Sorbonne Paris Nord, APHP, PARIS, France, 8PK MED, PARIS, France, 9University Sorbonne Paris Nord, Bobigny, France

    Background/Purpose: Gout is a common disease with a prevalence and incidence on the rise worldwide. However, approved treatments to treat acute gout flares have slow…
  • Abstract Number: 1087 • ACR Convergence 2024

    Sex Differences in Clinical Features and Mortality in Gout: A Nationwide Retrospective Cohort Study

    HYUNSUE DO1, Kwanyoung Choe2, Min Jung Kim3, Kichul Shin4 and Ki Won Moon5, 1Kangwon national university hospital, Seoul, South Korea, 2Yeongjusi Health Center, Yeongjusi, Republic of Korea, 3Seoul Metropolitan Government Boramae Medical center, Dongjak-gu, Seoul, South Korea, 4Seoul Metropolitan Government- Seoul National University Boramae Medical Center, Seoul, South Korea, 5Kangwon National University hospital, Chuncheon-si, Republic of Korea

    Background/Purpose: Patients with gout have several coexisting conditions that impact mortality. Studies on clinical features and mortality of female patients with gout are limited, as…
  • Abstract Number: 1245 • ACR Convergence 2024

    Inpatient Discontinuation of Allopurinol – A Quality Improvement (QI) Initiative

    Stephanie Tancer1, Basmah Al Dulaijan2 and Puja Khanna3, 1University of Michigan Department of Internal Medicine, Division of Rheumatology, Ann Arbor, MI, 2Michigan Medicine, Ann Arbor, MI, 3University of Michigan, Ann Arbor, MI

    Background/Purpose: Gout is a chronic inflammatory arthritis induced by hyperuricemia and manifested by recurrent acute flares of debilitating joint pain when left untreated. Allopurinol is…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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