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Abstracts tagged "gout"

  • Abstract Number: 1581 • ACR Convergence 2022

    Presence of Sonographic Crystal Deposits and Power-Doppler Signal in Patients with Gout Fulfilling Remission Criteria: A Multicenter Study

    Nalia Domínguez-Lirón1, Eugenio De Miguel2, Agustín Martínez-Sanchis3, Diana Peiteado2, Blanca Garcia-Magallon4, Esther Vicente-Rabaneda5, Enrique Calvo6, Basilio Rodríguez7, Alejandro Prada8, Boris Anthony Blanco Cáceres9, José Antonio Bernal10, Francisca Sivera11, Santos Castañeda5, Sonia Mínguez7, Laura Barrio8, Mónica Vázquez-Díaz9, José Miguel Senabre12, Cristina Bohorquez13 and Mariano Andrès3, 1Miguel Hernández University, Alicante, Spain, 2Hospital Universitario La Paz, Madrid, Spain, 3Dr Balmis Alicante General University Hospital-ISABIAL, Alicante, Spain, 4Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain, 5Division of Rheumatology, Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain, 6Hospital Universitario Infanta Leonor, Madrid, Spain, 7Althaia Xarxa Assistencial Universitaria De Manresa, Manresa, Spain, 8Hospital Universitario de Torrejon, Madrid, Spain, 9Hospital Universitario Ramón y Cajal, Madrid, Spain, 10Hospital Marina Baixa (Villajoyosa), Alicante, Spain, 11Hospital Universitario de Elda, San Vicente del Raspeig, Spain, 12Hospital Marina Baixa, Villajoyosa, Spain, 13University Hospital Príncipe de Asturias, Immune System Diseases-Rheumatology Service, Alcalá de Henares, Madrid, Spain

    Background/Purpose: The applicability of the preliminary remission criteria for gout [PMID 26414176] in clinical practice is unknown. This study evaluates the sonographic prevalence of monosodium…
  • Abstract Number: 1798 • ACR Convergence 2022

    Health-Related Quality of Life Improvements Resulting from a Treat-to-Target Strategy in the Management of Gout: Post- Hoc Analysis of a Multicenter, Randomized, Double-Blind, Non-Inferiority Trial

    Lindsay Helget1, James O'Dell1, Jeff Newcomb1, Maria Androsenko2, Mary Brophy2, Anne Davis-Karim3, Bryant England1, Ryan Ferguson2, Michael Pillinger4, Tuhina Neogi5, Paul Palevsky6, Hongsheng Wu2 and Ted Mikuls7, 1University of Nebraska Medical Center, Omaha, NE, 2VA Boston Cooperative Studies Program Coordinating Center, Boston, MA, 3VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM, 4NYU Grossman School of Medicine, New York, NY, 5Boston University School of Medicine, Boston, MA, 6University of Pittsburgh School of Medicine, Pittsburgh, Pittsburgh, 7Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The ACR recommends a treat-to-target strategy in gout management, centered on the titration of urate lowering therapy (ULT) to a goal serum urate (SU)…
  • Abstract Number: 1816 • ACR Convergence 2022

    Assessing Urate Deposition and Inflammation in the Vasculature of Gout Patients Using Dual Energy Computed Tomography and Positron Emission Tomography Pre and Post Pegloticase- a Pilot Study

    Ira Khanna, Venkatesh Mani, Renata Pyzik, Audrey Kaufman, Wei Wei Chi, Emilia Bagiella, Philip Robson and Yousaf Ali, Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Gout is the most common inflammatory arthritis, caused by hyperuricemia and subsequent deposition of aggregated monosodium urate (MSU) crystals in both articular and extra-articular…
  • Abstract Number: 1582 • ACR Convergence 2022

    Allopurinol Use and Risk of Acute Coronary Syndrome in Patients with Incident Gout: A Population-based Study in Sweden

    Panagiota Drivelegka1, Lennart Jacobsson2, Karin Bengtsson3 and Mats Dehlin4, 1Department of Rheumatology, Sahlgrenska University Hospital, Gothenburg, Sweden, 2Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden, 3Department of Rheumatology and Inflammation research, University of Gothenburg, Salhgrenska Academy, Gothenburg, Sweden, 4Dept of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Gout is associated with an increased risk of cardiovascular disease, with accumulated evidence that gout is an independent risk factor. Whether allopurinol use alters…
  • Abstract Number: 1799 • ACR Convergence 2022

    Evaluation of Adherence to and Agreement with the 2020 American College of Rheumatology Guideline for the Management of Gout by US Rheumatologists

    Naomi Schlesinger1, Michael Pillinger2 and Peter Lipsky3, 1Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 2NYU Grossman School of Medicine, New York, NY, 3AMPEL BioSolutions, Charlottesville, VA

    Background/Purpose: The American College of Rheumatology (ACR) developed an updated guideline in 2020 for the management of gout.1 This study evaluates US rheumatologists' stated adherence…
  • Abstract Number: 1818 • ACR Convergence 2022

    Hepatic Steatosis and Fibrosis in Patients with Gout Detected by Elastography

    Naomi Schlesinger1, ankoor patel1, Vinod Rustgi1, Anthony Yeo2 and Peter Lipsky3, 1Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 2Horizontherapeutics, New York, NY, 3AMPEL BioSolutions, Charlottesville, VA

    Background/Purpose: Gout is associated with non-alcoholic fatty liver disease (NAFLD), but neither the frequency nor severity of NAFLD in gout is well described. Elastography is…
  • Abstract Number: 0001 • ACR Convergence 2022

    12-month Findings of the Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy and Safety Study of Methotrexate to Increase Response Rates in Patients with Uncontrolled GOut Receiving Pegloticase (MIRROR RCT)

    John Botson1, kenneth saag2, Jeff Peterson3, Katie Obermeyer4, Brian LaMoreaux4, Suneet Grewal5, Amar Majjhoo6, John Tesser7 and Michael Weinblatt8, 1Orthopedic Physicians Alaska, Anchorage, AK, 2University of Alabama at Birmingham, Birmingham, AL, 3Western Washington Arthritis Clinic, Seattle, WA, 4Horizon Therapeutics plc, Deerfield, IL, 5East Bay Rheumatology Medical Group, Inc., San Leandro, CA, 6Shores Rheumatology, PC, Troy, MI, 7Arizona Arthritis & Rheumatology Associates, Phoenix, AZ, 8Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: The MIRROR RCT trial examined pegloticase (PEGylated uricase) safety and efficacy with methotrexate (MTX) vs placebo (PBO) as co-therapy. Sustained urate-lowering rate during Month…
  • Abstract Number: 1583 • ACR Convergence 2022

    Race and Disease Severity Predict Reduced Response to Treat-to-Target Urate Lowering Therapy in Gout: Post-hoc Analysis of a Multicenter, Randomized, Double-Blind, Non-Inferiority Trial

    Lindsay Helget1, James O'Dell1, Jeff Newcomb1, Maria Androsenko2, Mary Brophy2, Anne Davis-Karim3, Bryant England1, Ryan Ferguson2, Michael Pillinger4, Tuhina Neogi5, Paul Palevsky6, Hongsheng Wu2 and Ted Mikuls7, 1University of Nebraska Medical Center, Omaha, NE, 2VA Boston Cooperative Studies Program Coordinating Center, Boston, MA, 3VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM, 4NYU Grossman School of Medicine, New York, NY, 5Boston University School of Medicine, Boston, MA, 6University of Pittsburgh School of Medicine, Pittsburgh, Pittsburgh, 7Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The ACR recommends a treat-to-target strategy in the management of gout, involving titration of urate lowering therapy (ULT) to a serum urate (SU) goal…
  • Abstract Number: 1800 • ACR Convergence 2022

    Successful Establishment of Chronic Gouty Arthritis Model in C57BL/6 Mice

    Yue Yin1, Yun Zhang1, Hong Di1, Xinxin Han1 and Xuejun Zeng2, 1Peking Union Medical College Hospital, Beijing, China, 2Department of General Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China

    Background/Purpose: Gout is an inflammatory disease caused by the deposition of MSU crystals in joints and other parts. At present, little progress in the research…
  • Abstract Number: 1820 • ACR Convergence 2022

    Targeted Plasma Lipidomics Distinguishes Patients with Gout and Hyperuricemia from Controls

    Blanka Stiburkova1, Kateřina Pavelcová1, Jana Bohatá1, Karel Pavelka2, Lenka Hasíková1, Jakub Závada1, Aleš Kvasnička3, Dana Dobešová3 and David Friedecký3, 1Institute of Rheumatology, Prague, Czech Republic, 2Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Praha, Czech Republic, 3Palacky University Olomouc, Olomouc, Czech Republic

    Background/Purpose: Gout is the most common type of inflammatory arthritis, characterised by chronic deposition of uric acid crystals in the joints, affecting approx. 1-2% of…
  • Abstract Number: 0112 • ACR Convergence 2022

    What Drives Racial Disparities in Gout in the USA? – Population-Based, Sex-Specific, Casual Mediation Analysis

    Natalie McCormick1, Leo Lu2, Chio Yokose3, amit johi4, Tony Merriman5, kenneth saag6, Yuqing Zhang7 and Hyon Choi8, 1Massachusetts General Hospital, Boston, MA, 2Arthritis Research Canada, Vancouver, BC, Canada, 3Massachusetts General Hospital, Waltham, MA, 4Regeneron, Boston, MA, 5University of Otago, Dunedin, New Zealand, 6University of Alabama at Birmingham, Birmingham, AL, 7Massachusetts General Hospital, Quincy, MA, 8MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA

    Background/Purpose: Emerging US cohort data suggest gout and hyperuricemia impart larger burdens on adults self-reporting Black race, especially Black women, than those self-reporting White race.[1,2]…
  • Abstract Number: 1633 • ACR Convergence 2022

    Genetic Risk, Adherence to a Healthy Lifestyle, and Incident Gout in US Women and Men

    Kehuan Lin1, Natalie McCormick1, Leo Lu2, amit johi3, Chio Yokose4 and Hyon Choi5, 1Massachusetts General Hospital, Boston, MA, 2Arthritis Research Canada, Vancouver, BC, Canada, 3Regeneron, Boston, MA, 4Massachusetts General Hospital, Waltham, MA, 5MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA

    Background/Purpose: Lifestyle and genetic factors have been independently related to incident gout risk. However, it remains unknown whether the genetic risk of gout is affected…
  • Abstract Number: 1802 • ACR Convergence 2022

    The Utility of Dual-energy Computed Tomography in Gout Patients During Urate Lowering Therapy

    Min Jung Kim1, Mi Hyeon Kim2, SE RIM CHOI2, Youjin Jung2, Ji In Jung2, Ju Yeon Kim2, Jee Won Chai3 and Kichul Shin4, 1Seoul Metropolitan Government Boramae Medical center, Dongjak-gu, Seoul, Republic of Korea, 2Seoul National University Hospital, Seoul, Republic of Korea, 3Seoul Metropolitan Government–Seoul National University Boramae Medical Center, Seoul, Republic of Korea, 4Seoul Metropolitan Government- Seoul National University Boramae Medical Center, Seoul, Republic of Korea

    Background/Purpose: To investigate whether monosodium urate (MSU) deposition measured by dual-energy computed tomography (DECT) could help predict acute flares after discontinuing colchicine prophylaxis in patients…
  • Abstract Number: 1821 • ACR Convergence 2022

    Colchicine and Other Gout Medications and the Risk of COVID-19 Infection, Hospitalization, and Subsequent Outcomes in People with Gout

    Jasvinder singh1, Timothy Bergquist2, Vithal Madhira3 and Alfred Anzalone4, 1University of Alabama at Birmingham, Birmingham, AL, 2Sage Bionetworks, Seattle, WA, 3Palila Software, L.L.C., Reno, NV, 4University of Nebraska Medical Center, Ohama, NE

    Background/Purpose: To examine whether the use of colchicine and other gout medications is associated with the risk of COVID-19 infection, hospitalization, and subsequent outcomes in…
  • Abstract Number: 0118 • ACR Convergence 2022

    Sex-Based Variations in Emergency Department Utilization by Persons with Inflammatory Arthritis Conditions

    Cheryl Barnabe1, Patrick McLane2, Nadia Luca1, Katie Lin1, Kelsey Chomistek1, Meghan Elliott1, Shanon McQuitty3, Eileen Davidson3, Clare Hildebrandt4, Steven Katz2, Brian Holroyd2 and Claire Barber1, 1University of Calgary, Calgary, AB, Canada, 2University of Alberta, Edmonton, AB, Canada, 3Arthritis Research Canada, Vancouver, BC, Canada, 4Patient and Family Advisors, Alberta Health Services, Calgary, AB, Canada

    Background/Purpose: High quality ambulatory care provision should mitigate avoidable emergency department (ED) visits by persons with inflammatory arthritis (IA) conditions and address the unique realities…
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