ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Uric Acid, Urate"

  • Abstract Number: 1796 • ACR Convergence 2022

    Peripheral Vascular Disease and Sequelae in Individuals with Gout, Diabetes, or Both Among US Veterans

    Nicole Leung1, Michael Toprover1, Charles Fang2, Michael Pillinger3 and Jay Pendse4, 1Division of Rheumatology, New York University Grossman School of Medicine and Rheumatology Section, New York Harbor Health Care System, New York Campus of the U.S. Department of Veterans Affairs, New York, NY, 2Department of Surgery Division of Vascular and Endovascular Surgery, University of Massachusetts Medical School, Worcester, MA, 3NYU Grossman School of Medicine, New York, NY, 4Division of Endocrinology, New York University Grossman School of Medicine and Endocrinology Section, New York Harbor Health Care System, New York Campus of the U.S. Department of Veterans Affairs, New York, NY

    Background/Purpose: Peripheral vascular disease (PVD) causes substantial morbidity and mortality. Patients with gout are known to have increased coronary artery disease risk but less is…
  • Abstract Number: 1797 • ACR Convergence 2022

    Factors Driving Opioid Use in United States Veterans with Gout

    Lindsay Helget1, Bryant England1, Punyasha Roul2, Harlan Sayles1, Alison Petro1, Tuhina Neogi3, James O'Dell1 and Ted Mikuls4, 1University of Nebraska Medical Center, Omaha, NE, 2UNMC, Omaha, NE, 3Boston University School of Medicine, Boston, MA, 4Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Patients with gout often seek care for painful flares and nearly one-third are prescribed opioids during acute ambulatory visits. Unfortunately, opioids do not address…
  • Abstract Number: 1798 • ACR Convergence 2022

    Health-Related Quality of Life Improvements Resulting from a Treat-to-Target Strategy in the Management of Gout: Post- Hoc Analysis of a Multicenter, Randomized, Double-Blind, Non-Inferiority Trial

    Lindsay Helget1, James O'Dell1, Jeff Newcomb1, Maria Androsenko2, Mary Brophy2, Anne Davis-Karim3, Bryant England1, Ryan Ferguson2, Michael Pillinger4, Tuhina Neogi5, Paul Palevsky6, Hongsheng Wu2 and Ted Mikuls7, 1University of Nebraska Medical Center, Omaha, NE, 2VA Boston Cooperative Studies Program Coordinating Center, Boston, MA, 3VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM, 4NYU Grossman School of Medicine, New York, NY, 5Boston University School of Medicine, Boston, MA, 6University of Pittsburgh School of Medicine, Pittsburgh, Pittsburgh, 7Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The ACR recommends a treat-to-target strategy in gout management, centered on the titration of urate lowering therapy (ULT) to a goal serum urate (SU)…
  • Abstract Number: 1799 • ACR Convergence 2022

    Evaluation of Adherence to and Agreement with the 2020 American College of Rheumatology Guideline for the Management of Gout by US Rheumatologists

    Naomi Schlesinger1, Michael Pillinger2 and Peter Lipsky3, 1Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 2NYU Grossman School of Medicine, New York, NY, 3AMPEL BioSolutions, Charlottesville, VA

    Background/Purpose: The American College of Rheumatology (ACR) developed an updated guideline in 2020 for the management of gout.1 This study evaluates US rheumatologists' stated adherence…
  • Abstract Number: 0001 • ACR Convergence 2022

    12-month Findings of the Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy and Safety Study of Methotrexate to Increase Response Rates in Patients with Uncontrolled GOut Receiving Pegloticase (MIRROR RCT)

    John Botson1, kenneth saag2, Jeff Peterson3, Katie Obermeyer4, Brian LaMoreaux4, Suneet Grewal5, Amar Majjhoo6, John Tesser7 and Michael Weinblatt8, 1Orthopedic Physicians Alaska, Anchorage, AK, 2University of Alabama at Birmingham, Birmingham, AL, 3Western Washington Arthritis Clinic, Seattle, WA, 4Horizon Therapeutics plc, Deerfield, IL, 5East Bay Rheumatology Medical Group, Inc., San Leandro, CA, 6Shores Rheumatology, PC, Troy, MI, 7Arizona Arthritis & Rheumatology Associates, Phoenix, AZ, 8Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: The MIRROR RCT trial examined pegloticase (PEGylated uricase) safety and efficacy with methotrexate (MTX) vs placebo (PBO) as co-therapy. Sustained urate-lowering rate during Month…
  • Abstract Number: 1802 • ACR Convergence 2022

    The Utility of Dual-energy Computed Tomography in Gout Patients During Urate Lowering Therapy

    Min Jung Kim1, Mi Hyeon Kim2, SE RIM CHOI2, Youjin Jung2, Ji In Jung2, Ju Yeon Kim2, Jee Won Chai3 and Kichul Shin4, 1Seoul Metropolitan Government Boramae Medical center, Dongjak-gu, Seoul, Republic of Korea, 2Seoul National University Hospital, Seoul, Republic of Korea, 3Seoul Metropolitan Government–Seoul National University Boramae Medical Center, Seoul, Republic of Korea, 4Seoul Metropolitan Government- Seoul National University Boramae Medical Center, Seoul, Republic of Korea

    Background/Purpose: To investigate whether monosodium urate (MSU) deposition measured by dual-energy computed tomography (DECT) could help predict acute flares after discontinuing colchicine prophylaxis in patients…
  • Abstract Number: 0550 • ACR Convergence 2022

    Improving the Accuracy of Automated Gout Flare Ascertainment Using Natural Language Processing of Medical Records and Linked Medicare Claims Data for Real-world Comparative Effectiveness Research

    Kazuki Yoshida, Tianrun Cai, Lily G Bessette, Erin Kim, Su Been Lee, Luke E Zabotka, Alec Sun, Julianna M. Mastrorilli, Theresa A. Oduol, Jun Liu, Daniel Solomon, Katherine Liao and Seoyoung Kim, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Gout flares are challenging to study using large real-world data because flares are episodic with varying severity and clinical manifestations. Furthermore, there is no…
  • Abstract Number: 1814 • ACR Convergence 2022

    Pegloticase for Uncontrolled Gout in Patients with History of Kidney Transplant: Pharmacokinetics and Immunogenicity in the PROTECT Clinical Trial

    Abdul Abdellatif1, Yan Xin2, Jason Chamberlain3, Lin Zhao2, Katya Cherny3, Brad Marder4, John D Scandling5 and kenneth saag6, 1Kidney Hypertension Transplant Clinic Clear Lake Specialties, Webster, TX, 2Horizon Therapeutics, Deerfield, IL, 3Horizon Therapeutics plc, Deerfield, IL, 4Horizon Therapeutics, Denver, CO, 5Stanford University School of Medicine, Division of Nephrology, Palo Alto, CA, 6University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Immunomodulator co-therapy with pegloticase has been shown to reduce immunogenicity (anti-drug antibody [ADA] development), which markedly improves response rates with pegloticase while reducing risk…
  • Abstract Number: 1006 • ACR Convergence 2022

    Impact of Uric Acid Levels on Clinical and Radiographic Characteristics in Psoriatic Arthritis and Response to Secukinumab: A Pooled “Post Hoc” Analysis from Five Phase 3 Studies

    Renaud FELTEN1, Laura Widawski2, Lionel Spielmann2, Corine Gaillez3, Weibin Bao4, Hugh O’Neill5, jacques-eric gottenberg6, Pierre-Marie Duret2 and Laurent Messer7, 1Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 2Colmar Civilian Hospitals, Colmar, France, 3Novartis Pharma AG, Basel, Switzerland, 4Novartis Pharmaceuticals Corporation, East Hanover, NJ, 5Novartis Ireland Limited, Dublin, Ireland, 6Strasbourg University Hospital, Strasbourg, France, 7Colmar Civil Hospitals, Colmar, France

    Background/Purpose: Hyperuricemia (HU), a common metabolic abnormality, may result in development of gout, which is an inflammatory arthritic condition1,2. Patients (pts) with psoriasis (PsO)/psoriatic arthritis…
  • Abstract Number: 1826 • ACR Convergence 2022

    Association of High Uric Acid Levels with Low Bone Mineral Density in Pre- but Not Post-menopausal Women with Rheumatoid Arthritis

    Sandra Hermann1, Andriko Palmowski1, Bukrhard Muche2, Kay-Geert Hermann3, Edgar Wiebe1 and Frank Buttgereit4, 1Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 2Charité University Hospital, CCM, Berlin, Germany, 3Charité - Universitätsmedizin Berlin, Berlin, Germany, 4Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin / DRFZ Berlin, Berlin, Germany

    Background/Purpose: Uric acid is controversially discussed regarding its effect on bone health. Higher uric acid levels have been associated with higher T-scores and fewer bone…
  • Abstract Number: 1132 • ACR Convergence 2022

    Interaction of LOC100507053, ADH1B, and ADH1C with Alcohol Consumption for Elevated Serum Urate Levels and Gout in People of European Ethnicity

    Min Hui Chuah1, Ruth Topless2, Gregory Gamble1, Nicholas Sumpter3, Lisa Stamp4, Tony Merriman2 and Nicola Dalbeth1, 1University of Auckland, Auckland, New Zealand, 2University of Otago, Dunedin, New Zealand, 3University of Alabama at Birmingham, Birmingham, AL, 4University of Otago, Christchurch, New Zealand

    Background/Purpose: Alcohol consumption is a risk factor for hyperuricaemia and gout. Multiple single nucleotide polymorphisms (SNPs) have been identified as associated with both habitual alcohol…
  • Abstract Number: 1829 • ACR Convergence 2022

    Efficacy and Safety of Allopurinol and Febuxostat in Patients with Gout and Chronic Kidney Disease: A Subgroup Analysis of the STOP Gout Study

    Lindsay Helget1, Anne Davis-Karim2, James O'Dell1, Ted Mikuls3, Jeff Newcomb1, Maria Androsenko4, Mary Brophy4, Bryant England1, Ryan Ferguson4, Michael Pillinger5, Tuhina Neogi6, Hongsheng Wu4 and Paul Palevsky7, 1University of Nebraska Medical Center, Omaha, NE, 2VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, NM, 3Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 4VA Boston Cooperative Studies Program Coordinating Center, Boston, MA, 5NYU Grossman School of Medicine, New York, NY, 6Boston University School of Medicine, Boston, MA, 7University of Pittsburgh School of Medicine, Pittsburgh, Pittsburgh

    Background/Purpose: Urate lowering therapy (ULT) is a cornerstone in the treatment of gout, which afflicts over 2 million individuals with chronic kidney disease (CKD) in…
  • Abstract Number: 1206 • ACR Convergence 2022

    Association Between Different Alcoholic Beverages and Serum Urate Level: A Cross-Sectional Study Using Large Medical Checkup Data

    Sho Fukui1, Masato Okada2, Mahbubur Rahman3, Takehiro Nakai2, Hiromichi Tamaki2, Hiroki Matsui4, Atsushi Shiraishi5, Mitsumasa Kishimoto6, Hiroshi Hasegawa7, Takeaki Matsuda7 and Kazuki Yoshida8, 1Kyorin University Hospital, Tokyo, Japan, 2St. Luke's International Hospital, Tokyo, Japan, 3Graduate School of Public Health, St. Luke’s International University, Tokyo, Japan, 4Clinical Research Support Office, Kameda Medical Center, Kamogawa, Japan, 5Emergency and Trauma Center, Kameda Medical Center, Kamogawa, Japan, 6Kyorin University School of Medicine, Yokohama, Japan, 7Kyorin University, Tokyo, Japan, 8Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Alcohol consumption is associated with increased serum urate levels. However, data regarding the differences in the extent of the association between various types of…
  • Abstract Number: 1410 • ACR Convergence 2022

    Subclinical Atherosclerosis Is Not Related with Acid Uric in Rheumatoid Arthritis: Study of 1005 Patients of a Single University Hospital

    Fabricio Benavides Villanueva1, Cristina Corrales1, Ivan Ferraz Amaro2, Nuria Vegas Revenga3, Ricardo Blanco4, Miguel Angel Gonzalez Gay5 and Alfonso Corrales6, 1Hospital Universitario Marqués de Valdecilla, Santander, Spain, 2Division of Rheumatology. Hospital Universitario de Canarias. Spain., Santa Cruz de Tenerife, Spain, 3Hospital Galdakao- Usansolo, Galdakao, Spain, 4Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 5Hospital Universitario Marques de Valdecilla, Lugo, Spain, 6Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain

    Background/Purpose: Rheumatoid Arthritis (RA) and Gout are related with increased cardiovascular (CV) disease. Carotid plaques and increased carotid intima-media thickness (cIMT) are surrogate markers of…
  • Abstract Number: 1579 • ACR Convergence 2022

    The TICOG Study: Tight Control of Gout – A Randomized, Controlled Trial of Targeted versus Conventional Treatment for Gout Including Ultrasonography

    Sarah Black, Natalie McKee, Jonathan McKnight, Annmarie McShane, Adrian Pendleton, Taggart Alister and Gary Wright, Musgrave Park Hospital, Belfast Health and Social Care Trust, Belfast, Northern Ireland, United Kingdom

    Background/Purpose: Gout is a common inflammatory arthritis triggered by deposition of monosodium urate crystals in joints, bone and soft tissues, with a prevalence of 1-4%…
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