Abstracts tagged "Systemic sclerosis"

Abstract Number: 2599 • 2013 ACR/ARHP Annual Meeting
Safety and Effectiveness Of Mycophenolate In Systemic Sclerosis: A Systemic Review
Mohammed Omair¹, Abdulaziz Alahmadi² and Sindhu R. Johnson³, ¹Mount Sinai Hospital/University of Toronto, Toronto, ON, Canada, ²Medicine, Toronto Scleroderma Research Program, Division of Rheumatology, Mount Sinai Hospital, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada, ³Medicine, Toronto Western Hospital, Toronto General Hospital, Mount Sinai Hospital, and University of Toronto, Toronto, ON, Canada
Background/Purpose: Mycophenolate reduces chronic allograft nephropathy and interstitial fibrosis by inhibiting TGF-β, which is an important molecule in the pathogenesis of systemic sclerosis (SSc). The…
Abstract Number: 2600 • 2013 ACR/ARHP Annual Meeting
Shear Wave Elastography: A Novel Quantitative Approach For Evaluating Scleroderma Skin
Ingeborg Sacksen¹, Mark H. Wener², P. Scott Pollock³ and Manjiri K. Dighe⁴, ¹Rheumatology, University of Washington, Seattle, WA, ²Rheumatology & Lab Med, University of Washington, Seattle, WA, ³Internal Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ⁴Radiology, University of Washington, Seattle, WA
Background/Purpose: Systemic sclerosis (SSc) is a multi-system disease with both visceral and cutaneous fibrosis. Dermal elasticity is reduced and stiffness increased due to excessive dermal…
Abstract Number: 2601 • 2013 ACR/ARHP Annual Meeting
Modified Rodnan Ultrasound Skin Score: An Ultrasound Skin Scoring Approach In Systemic Sclerosis
Ingeborg Sacksen¹, P. Scott Pollock² and Mark H. Wener³, ¹Rheumatology, University of Washington, Seattle, WA, ²Internal Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ³Rheumatology & Lab Med, University of Washington, Seattle, WA
Background/Purpose: Systemic sclerosis (SSc) is a multi-organ disease characterized by thickening, hardening and tightening of the skin. Skin thickening is described by physical exam…
Abstract Number: 2603 • 2013 ACR/ARHP Annual Meeting
Are There Differences In Limited Systemic Sclerosis According To Extension Of Skin Involvement?
Marina Scolnik¹, Eliana Lancioni², Luis J. Catoggio¹, Mirtha Sabelli³, Zaida Bedran⁴, Carla Saucedo⁴, Josefina Marin³ and Enrique Soriano¹, ¹Rheumatology Section, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ²Rheumatology Unit, Internal Medicine Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ³Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁴Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Background/Purpose: There is consensus in classifying Systemic Sclerosis (SSc) according to extension of skin involvement as limited and diffuse, using the elbows and knees as…
Abstract Number: 2579 • 2013 ACR/ARHP Annual Meeting
Recommendations For Screening and Detection Of Connective-Tissue Disease Associated Pulmonary Arterial Hypertension
Dinesh Khanna¹, Heather Gladue², John D. FitzGerald³, Richard N. Channick⁴, Lorinda Chung⁵, Oliver Distler⁶, Daniel Furst⁷, Eric Hachulla⁸, Marc Humbert^9,10,11, David Langleben^12,13, Stephen C. Mathai¹⁴, Rajeev Saggar¹⁵, Scott H. Visovatti¹⁶ and Vallerie McLaughlin¹⁷, ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan, Ann Arbor, MI, ³Medicine/Rheumatology, UCLA School Med Rehab #32-59, Los Angeles, CA, ⁴Pulmonary Hypertension Program, Massachusetts General Hospital, Boston, MA, ⁵Rheumatology, Stanford Univ Medical Center, Palo Alto, CA, ⁶Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁷Rheumatology, University of California in Los Angeles, Los Angeles, CA, ⁸Department of Internal Medicine, Claude Huriez University Hospital, Lille, France, ⁹AP-HP Hôpital Antoine Béclère, Clamart, France, ¹⁰Université Paris-Sud, Le Kremlin-Bicêtre, France, ¹¹NSERM U999, Centre Chirurgical Marie-Lannelongue, Le Plessis-Robinson, France, ¹²Cardiology Division, Jewish General Hospital, Montreal, QC, Canada, ¹³McGill University, Montreal, QC, Canada, ¹⁴Medicine, Johns Hopkins University, Baltimore, MD, ¹⁵Critical Care Medicine, St. Joseph's Hospital and Medical Center, Phoenix, AZ, ¹⁶Internal Medicine, Division of Cardiology, The University of Michigan, Ann Arbor, MI, ¹⁷Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI
Background/Purpose: Pulmonary arterial hypertension (PAH) affects up to 15% of patients with connective tissue diseases (CTD) and is one of the leading causes of mortality…
Abstract Number: 2562 • 2013 ACR/ARHP Annual Meeting
Inhibition Of SOX9 Phosphorylation Abrogates The Increased Expression Of Profibrotic Genes In Systemic Sclerosis Dermal Fibroblasts
Sonsoles Piera-Velazquez, Alma Makul and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: SOX9, a high mobility group transcription factor is a master regulator of chondrogenesis and plays a crucial role in the regulation of chondrocyte gene…
Abstract Number: 2566 • 2013 ACR/ARHP Annual Meeting
Nilotinib Treatment Effect In The Skin As Measured By DNA Microarray In Patients With Diffuse Systemic Sclerosis
Jessica K. Gordon¹, Tammara A. Wood², Robert F. Spiera¹ and Michael L. Whitfield², ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Gene expression profiling by DNA microarray is used to identify potential biomarkers in Systemic Sclerosis (SSc). Discrete gene expression signatures have been observed to…
Abstract Number: 825 • 2013 ACR/ARHP Annual Meeting
Activating Transcription Factor 3 Regulates Canonical Transforming Growth Factor Beta Signaling In Experimental Fibrosis
Tatjana Mallano¹, Katrin Palumbo-Zerr¹, Christian Beyer¹, Clara Dees¹, Jingang Huang¹, Tsonwin Hai², Georg A. Schett³ and Joerg H. W. Distler¹, ¹Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²The Ohio State Biochemistry Program, The Ohio State University, Columbus, USA, Colombus, OH, ³Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Activating transcription factor 3 (ATF3), a member of the activating transcription factor/cAMP-responsive element binding protein (ATF/CREB) family of transcription factors is induced by various…
Abstract Number: 709 • 2013 ACR/ARHP Annual Meeting
Nilotinib (Tasigna™) In The Treatment Of Early Diffuse Systemic Sclerosis: A Single Group, Open Label Pilot Clinical Trial – One Year Results
Jessica K. Gordon¹, Cynthia Magro², Uzunma Udeh¹, Daniele Lerner¹, Horatio F. Wildman³, Wei-Ti Huang⁴, Mary K. Crow⁵ and Robert F. Spiera¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Dermatopathology, Weill-Cornell Medical Center, New York, NY, ³Dermatology, Weill-Cornell Medical Center, New York, NY, ⁴Biostatistics, Hospital for Special Surgery, New York, NY, ⁵Department of Medicine, Hospital for Special Surgery, New York, NY
Background/Purpose: Tyrosine kinase inhibitors (TKI) are under investigation for the treatment of diffuse cutaneous Systemic Sclerosis (dcSSc.) Nilotinib is a second-generation TKI which selectively antagonizes c-abl and…
Abstract Number: 676 • 2013 ACR/ARHP Annual Meeting
Early Systemic Sclerosis: Marker Autoantibody Positive Patients Have A Faster Pace Of The Disease
Gabriele Valentini¹, Antonella Marcoccia², Michele Iudici³, Serena Vettori¹ and Giovanna Cuomo³, ¹Department of Clinical and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ²Angiology Unit, Sandro Pertini Hospital, Rome, Italy, ³Department of Internal and Experimental Medicine, Second University of Naples, Naples, Italy
Background/Purpose: To investigate whether patients affected with any of the 3 subsets of early systemic sclerosis (SSc) i.e. Raynaud’s Phenomenon (RP) with SSc marker autoantibody…
Abstract Number: 683 • 2013 ACR/ARHP Annual Meeting
HRCT Predictors Of Decline In FVC% predicted—Implications For Cohort Enrichment For Scleroderma Lung Disease (SLD) Trials
Dinesh Khanna¹, Chi-hong Tseng², Robert D. Suh³, Fereidoun Abtin⁴, Athol U. Wells⁵, Donald Tashkin⁶ and Jonathan Goldin⁷, ¹University of Michigan, Ann Arbor, MI, ²Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ³UCLA Department of Radiological Sciences, Ronald Reagan UCLA Medical Center, Los Angeles, CA, ⁴Radiology, University of California Los Angeles Medical Center, Santa Monica, CA, ⁵Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, London, United Kingdom, ⁶Medicine, University of California at Los Angeles, Los Angeles, CA, ⁷Radiology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Moderate-to-severe HRCT-defined lung involvement (total lung involvement or fibrosis) is a predictor of decline in FVC% predicted and mortality in SLD. Various staging systems…
Abstract Number: 686 • 2013 ACR/ARHP Annual Meeting
Blood Flow In The Hands Of a Predefined Homogeneous Systemic Sclerosis Population: The Presence Of Digital Ulcers and The Improvement With Bosentan
Jessica Meijs¹, Annemie J.M. Schuerwegh¹, Alexandre E. Voskuyl², Joanne P.J. Bloemsaat-Minekus³ and Madelon C. Vonk⁴, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ³Actelion, Woerden, Netherlands, ⁴Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Digital ulcers (DU) are complications of systemic sclerosis (SSc) and arise as a result of ischaemia due to vasculopathy of the digital arteries (1).…
Abstract Number: 652 • 2013 ACR/ARHP Annual Meeting
Pirfenidone and BIBF1120 Suppress Collagen Synthesis In Skin Fibroblast From Patients With Systemic Sclerosis
Yuko Ota¹, Yasushi Kawaguchi¹, Kae Takagi¹, Hisae Ichida¹, Yasuhiro Katsumata¹, Takahisa Gono¹, Yuko Okamoto¹, Tomoaki Higuchi², Hidenaga Kawasumi¹ and Hisashi Yamanaka¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Institute Of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Pirfenidone (5-methyle-1-phenyl-2- [1H]-pyridone) and BIBF1120 (Nintedanib) are currently evaluated in clinical trials as a potential idiopathic pulmonary fibrosis (IPF). Pirfenidone was approved as the…
Abstract Number: 2919 • 2013 ACR/ARHP Annual Meeting
The Clinical Utility Of Flow-Mediated Dilation In Systemic Sclerosis
Tracy M. Frech¹, Ashley Walker², Zachary Barrett-Okeefe², Russell Richardson², D. Walter Wray² and Anthony Donato², ¹Internal Medicine, Salt Lake City VAMC, Salt Lake, UT, ²University of Utah, Salt Lake, UT
Background/Purpose: In systemic sclerosis (SSc, scleroderma) vasculopathy can result in the end-stage manifestation of a digital ulcer (DU). We hypothesized that bedside flow mediated dilatation…
Abstract Number: 2307 • 2012 ACR/ARHP Annual Meeting
Role of Endosomal and Cell Membrane Toll-Like Receptors in Keratinocyte Activation by Systemic Sclerosis Autoantibodies
James M. Watson¹, Joanna Nikitorowicz Buniak², Xu Shiwen³, David J. Abraham⁴, Christopher P. Denton⁵ and Richard J. Stratton², ¹Centre for Rheumatology & Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ³Rheumatology, Royal Free Hospital, London, United Kingdom, ⁴UCL Medical School, London, United Kingdom, ⁵Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune rare connective tissue disorder of unknown aetiology, heterogeneous clinical manifestations and an often progressive course which includes skin…

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