Abstracts tagged "Systemic sclerosis"

Abstract Number: 1652 • 2019 ACR/ARP Annual Meeting
Anticentromere Antibody Levels and Isotypes Associate with Disease Severity in Systemic Sclerosis
Nina van Leeuwen¹, Jaap Bakker ¹, Annette Grummels ¹, Corrie Wortel ¹, Suzana Jordan ², Oliver Distler ³, Håvard Fretheim ⁴, Anna Maria Hoffmann-Vold ⁵, Hans Ulrich Scherer ⁶, René Toes ¹, Thomas Huizinga ¹ and Jeska de Vries-Bouwstra ¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, Zurich, Switzerland, ³Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, ⁴University Hospital Oslo, Oslo, Norway, ⁵Department of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁶Leiden University Medical Center, Department of Rheumatology, Leiden, Netherlands
Background/Purpose: Although some studies suggest a possible association between clinical characteristics and isotypes of anticentromere antibodies (ACA) in patients with systemic sclerosis (SSc), characteristics of…
Abstract Number: 2593 • 2019 ACR/ARP Annual Meeting
Cyclophosphamide for the Treatment of Skin Fibrosis in Systemic Sclerosis: A Systematic Review
Marie Hudson ¹, Nancy Maltez², Catherine Ivory ² and Melissa Demery-Varin ³, ¹Jewish General Hospital, Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, QC, Canada, ²The Ottawa Hospital, Ottawa, ³University of Ottawa, Ottawa
Background/Purpose: Systemic sclerosis (SSc) is a chronic disease characterized by multi-organ involvement. Excess collagen deposition and fibrosis is thought to result from a complex interplay…
Abstract Number: 2614 • 2019 ACR/ARP Annual Meeting
Association of Body Composition in Scleroderma Patients with Disease Activity, Serum Levels of Inflammatory Cytokines and Parameters of Nutrition and Lipid Metabolism
Sabina Oreska¹, Maja Spiritovic ², Petr Cesak ³, Michal Cesak ³, Hana Storkanova ⁴, Hana Smucrova ⁵, Barbora Hermankova ³, Olga Ruzickova ⁴, Herman Mann ¹, Karel Pavelka ¹, Ladislav Senolt ¹, Jiří Vencovský ¹, Radim Becvar ¹ and Michal Tomcik ¹, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague 2, Czech Republic, ²Faculty of Physical Education and Sport, Department of Physiotherapy, Charles University, Prague, Czech Republic, Prague 2, Hlavni mesto Praha, Czech Republic, ³Faculty of Physical Education and Sport, Department of Physiotherapy, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁴Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague, Czech Republic, ⁵Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Fibrosis of the skin and visceral organs, especially digestive tract, and musculoskeletal involvement in systemic sclerosis (SSc) can have a negative impact on body…
Abstract Number: 725 • 2019 ACR/ARP Annual Meeting
Amniotic Membrane Dressings Provide an Effective Treatment for Systemic Sclerosis Digital Ulcers
Tracy Frech¹, Jan Pierce ², Greg Stoddard ³, Constance McNeill ⁴, Mislav Radic ⁵ and Jo -Anna Reems ⁶, ¹Division of Rheumatology, University of Utah and Salt Lake VAMC, Salt Lake City, UT, ²University of Utah Regenerative Medicine, Salt Lake City, United Kingdom, ³University of Utah Study Design and Biostatics Core, Salt Lake City, UT, ⁴University of Utah Hospitals and Clinics, Salt Lake City, UT, ⁵University Hospital Split, Split, Croatia, ⁶University of Utah Regenerative Medicine, Salt Lake City, UT
Background/Purpose: Systemic sclerosis (SSc)-related digital ulcers are a major burden for patients. The purpose of this study was to assess the effectiveness of amnion membrane…
Abstract Number: 1040 • 2019 ACR/ARP Annual Meeting
Proposition of a Novel Animal Model of Systemic Sclerosis Induced by Type V Collagen in C57BL/6 Mice Reproducing Fibrosis, Vasculopathy and Autoimmunity
Walcy Teodoro¹, Ana Paula Velosa ², Zelita Aparecida Queiroz ¹, Lais Araujo ³, Sergio Catanozi ¹, Antonio dos Santos Filho ⁴, Cleonice Bueno ⁴, Margarete Vendramini ⁴, Sandra Moraes Fernezlian ¹, Esmeralda Eher ⁴, Jurandir Tomaz de Miranda ¹, Fernanda Lopes ⁴, Sandra G. Pasoto ⁵, Percival Degrava Sampaio-Barros ⁶ and Vera Luiza Capelozzi ¹, ¹Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil, ²Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, São Paulo, Sao Paulo, Brazil, ³Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, São Paulo, Sao Paulo, Brazil, ⁴Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil, ⁵Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Brazil., Sao Paulo, Brazil, ⁶Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Brazil, Sao Paulo, Brazil
Background/Purpose: A better knowledge of the mechanisms and biomarkers of skin and lung damage in systemic sclerosis (SSc) related fibrosis remain a challenge. Our aim was…
Abstract Number: 1070 • 2019 ACR/ARP Annual Meeting
Cytokine Signatures Differentiate Systemic Sclerosis Patients at High versus Low Risk for Pulmonary Arterial Hypertension
Kathleen Kolstad¹, Avani Khatri ², Michele Donato ³, Sarah Chang ⁴, Shufeng Li ⁵, Virginia Steen ⁶, Paul Utz ⁴, Purvesh Khatri ³ and Lorinda Chung ⁷, ¹Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, ²Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, ³Institute for Immunity, Transplantation and Infection, Stanford University, Palo Alto, ⁴Division of Immunology and Rheumatology, Department of Medicine, Stanford, Palo Alto, ⁵Division of Immunology and Rheumatology, Department of Medicine, Stanford, Palo Alto, CA, ⁶Georgetown University, Washington, D.C., USA, Georgetown, ⁷Stanford University, Palo Alto, CA
Background/Purpose: Pulmonary arterial hypertension (PAH) affects approximately 10% of patients with systemic sclerosis (SSc) and is a leading cause of death. Screening algorithms using clinical…
Abstract Number: 1654 • 2019 ACR/ARP Annual Meeting
Esophageal Dilation and Other Clinical Factors Associated with Pulmonary Function Decline in Patients with Systemic Sclerosis
Kimberly Showalter¹, Aileen Hoffmann ², Carrie Richardson ³, Kimberly Koloms ², Gerald Rouleau ², David Aaby ², Julia (Jungwha) Lee ⁴, Jane Dematte ², Rishi Agrawal ², Xiaoping Wu ⁵, Rowland Chang ⁴ and Monique Hinchcliff ⁶, ¹Hospital for Special Surgery, New York, NY, ²Northwestern University Feinberg School of Medicine, Chicago, ³Rush University, Chicago, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵New York Presbyterian/Weill Cornell, New York, ⁶Yale University, Section of Rheumatology, Allergy and Immunology, New Haven, CT
Background/Purpose: Prior work has shown that Scl-70 positive autoantibody status and baseline c-reactive protein (CRP) are associated with more rapid pulmonary function decline in patients…
Abstract Number: 2596 • 2019 ACR/ARP Annual Meeting
The Contribution of Left Heart Disease in Patients with Systemic Sclerosis-associated Pulmonary Hypertension Having Normal Pulmonary Artery Wedge Pressure
Yoshioki Yamasaki¹, Kanako Suzuki ¹, Keiichi Sakurai ², Yusa Asari ¹, Hidehiro Yamada ³ and Kimito Kawahata ², ¹Rheumatology and Allergology, St. Marianna University School of Medicine, Kawasaki, Japan, ²Rheumatology and Allergology, St. Marianna University School of Medicine, Tokyo, Japan, ³Center for Rheumatic diseases, Seirei Yokohama Hospital, Kawasaki, Japan
Background/Purpose: Patients with systemic sclerosis (SSc) complicates variety of cardiopulmonary diseases which can result in pulmonary hypertension (PH). The types of PH are usually classified…
Abstract Number: 2618 • 2019 ACR/ARP Annual Meeting
Anti-RNPC-3 Antibodies Are Associated with Nuclear Speckled Immunofluorescence Pattern and Enriched in Triple Negative Systemic Sclerosis Patients
Michael Mahler¹, Fabrece Roup ¹, Chelsea Bentow ¹, Marie Hudson ², Murray Baron ³, May Choi ⁴ and Marvin Fritzler ⁵, ¹Inova Diagnostics, San Diego, CA, ²Jewish General Hospital, Lady Davis Institute for Medical Research, and Department of Medicine, McGill University, Montreal, QC, Canada, ³Jewish General Hospital, McGill University, Montreal, Canada, ⁴Cumming School of Medicine, University of Calgary, Calgary, Canada, ⁵Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Background/Purpose: Anti-nuclear antibodies (ANA) are present in approximately 90% of sera from systemic sclerosis (SSc) patients and play an important diagnostic and prognostic role in…
Abstract Number: 18 • 2019 ACR/ARP Annual Meeting
Undifferentiated Connective Tissue Disease at Risk for SSc: Potential Role of Circulating CXCL-10, CXCL-11 and IL-33 in Predicting Disease Evolution
Antonella Riccardi¹, Alessia Borgia ², Serena Fasano ¹, Valentina Messiniti ³, Rosaria Irace ³ and Gabriele Valentini ⁴, ¹Rheumatology Unit, Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy, Naples, Italy, ²University of Campania L. Vanvitelli, Naples, Italy, ³Rheumatology Unit, Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy, Naples, ⁴Dipartimento di Medicina di Precisione, II Policlinico U.O. Reumatologia, Napoli, Italy, Napoli, Italy
Background/Purpose: Higher levels of CXCL10 and CXCL11 in patients with a very early diagnosis of systemic sclerosis (SSc) subsequently shifted to SSc were pointed out…
Abstract Number: 726 • 2019 ACR/ARP Annual Meeting
Digital Blood Perfusion Differences Between Black Africans and Caucasians with Systemic Sclerosis
Claudia Ickinger¹, Valerie Lambrecht ², Eustasius Musenge ³, Mohammed Tikly ¹, Maurizio Cutolo ⁴ and Vanessa Smith ⁵, ¹Division of Rheumatology, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Joahnnesburg, South Africa, ²Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ³School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy, ⁵Dept. of Rheumatology, Ghent University Hospital, Ghent, Belgium; Dept. of Internal Medicine, Ghent University, Ghent, Belgium; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Ghent, Belgium, Gent, Belgium
Background/Purpose: Microvascular dysfunction is a prominent feature in SSc. Laser speckle contrast analysis (LASCA) has been shown to be a reliable tool to quantify skin…
Abstract Number: 1043 • 2019 ACR/ARP Annual Meeting
The Metabolic Intermediate Alpha-Ketoglutarate Suppresses the TGFβ-driven Profibrotic Responses of Dermal Fibroblasts
Blaž Burja¹, Gabriela Kania ², Matija Tomšič ³, Tea Janko ³, Snezna Sodin-Semrl ³, Oliver Distler ⁴, Katja Lakota ³ and Mojca Frank-Bertoncelj ⁵, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, Zurich, Switzerland, ²Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, LJUBLJANA, Slovenia, ⁴Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, ⁵University Hospital Zürich, Zürich, Switzerland
Background/Purpose: Metabolic perturbations are emerging as drivers of fibroblast activation in fibrosis. Transcriptomic analyses have shown the enrichment of glycolysis and suppression of tricarboxylic acid…
Abstract Number: 1072 • 2019 ACR/ARP Annual Meeting
CCR2+ Circulating Monocytes Contribute to the Survival of ADSC in Bleomycin-Induced Skin Fibrosis
Madhavi Latha Chalasani¹, Liyoung Kim ¹ and Theresa Lu ², ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, Weill Cornell Medicine (Microbiology and Immunology), New York
Background/Purpose: Monocytes and monocyte-derived cells play a crucial role during homeostasis and also during the development of various inflammatory diseases including skin fibrosis. Ly6Chi inflammatory…
Abstract Number: 1655 • 2019 ACR/ARP Annual Meeting
Histologic Features Correlate with the Modified Rodnan Skin Score, Serum Inflammatory Markers, and Patient Reported Outcomes in Patients with Early, Diffuse Cutaneous Systemic Sclerosis
Kimberly Showalter¹, Cynthia Magro ², Dana Orange ³, Yaxia Zhang ⁴, Phaedra Agius ⁵, Jackie Finik ⁶, Robert Spiera ¹ and Jessica Gordon ¹, ¹Hospital for Special Surgery, New York, NY, ²Weill Cornell Medicine, New York, ³Rockefeller University, New York, ⁴Hospital for Special Surgery, New York, ⁵New York Genome Center, New York City, ⁶Hospital for Special Surgery, New York, NY, New York, NY
Background/Purpose: The association between systemic sclerosis (SSc) skin histology and clinical findings is not fully characterized. In two SSc trials, we developed a scoring system…
Abstract Number: 2597 • 2019 ACR/ARP Annual Meeting
Prevalence and Clinical Associations of Degos Lesions in Systemic Sclerosis
Paula Song¹, Melody Chung ², Shufeng Li ³, David Fiorentino ⁴ and Lorinda Chung ², ¹Department of Medicine, Santa Clara Valley Medical Center, Palo Alto, CA, ²Stanford University, Palo Alto, CA, ³Division of Immunology and Rheumatology, Department of Medicine, Stanford, Palo Alto, CA, ⁴Department of Dermatology, Stanford University School of Medicine, Redwood City, CA
Background/Purpose: Degos disease, also known as malignant atrophic papulosis (MAP), is a rare small-vessel vasculopathy that has characteristic cutaneous manifestations consisting of erythematous telangiectatic rims…

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