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Abstract Number: 1638

Sexual Health in 60 Female Patients with Systemic Sclerosis

Barbora Hermankova 1, Maja Spiritovic 2, Hana Storkanova 3, Sabina Oreska 4, Petr Cesak 1, Karel Pavelka 4, Jiří Vencovský 4, Ladislav Senolt 4, Radim Becvar 4 and Michal Tomcik4, 1Faculty of Physical Education and Sport, Department of Physiotherapy, Charles University, Prague, Czech Republic, Prague, Czech Republic, 2Faculty of Physical Education and Sport, Department of Physiotherapy, Charles University, Prague, Czech Republic, Prague 2, Hlavni mesto Praha, Czech Republic, 3Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague, Czech Republic, 4Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague 2, Czech Republic

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: scleroderma and quality of life, Systemic sclerosis

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Session Information

Date: Monday, November 11, 2019

Session Title: Systemic Sclerosis & Related Disorders – Clinical Poster II

Session Type: Poster Session (Monday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Systemic sclerosis (SSc) is a chronic, multisystem, connective tissue disorder characterized by fibrosis of the skin and internal organ involvement, which can influence all aspects of life including sexual life. The aim of this study was to assess sexual functioning in female SSc patients compared to age-/sex-matched healthy controls (HC) and to determine the association between sexual health impairment and disease activity, treatment, physical and psychological aspects of the disease.

Methods: In total, 60 women (45 currently have a partner) with SSc (mean age: 49.5, disease duration: 6.2 years, lcSSc/dcSSc: 38/22, mRSS: 11.0, ESSG activity index: 2.4), who fulfilled the ACR/EULAR 2013 criteria, and 60 healthy controls (54 currently have a partner, mean age: 49.5) without rheumatic diseases filled in 12 well-established and validated questionnaires assessing sexual function (FSFI, SFQ28, BISFW, PISQ-12), quality of sexual life (SQoL-F), pelvic floor function (PFIQ-7), fatigue (FIS, MAF), physical activity (HAP), severity of functional impairment (SHAQ – only in SSc patients) and depression (BDI-II). A standard laboratory testing was performed. Data are presented as mean ± SEM.

Results: Patients with SSc had significantly higher prevalence and greater severity of sexual dysfunction (FSFI, BISF-W, SFQ28, PISQ-12 – in all subscales as well as total scores) and worse sexual quality of life (SQoL-F) compared to HC (table). Worse scores in SSc patients were associated with increased inflammation [CRP: FSFI (r=-0.260, p=0.0499), BISF-W (r=-0.273, p=0.0398), SFQ28 Pain Domain (r=-0.362, p=0,0056], disease activity [ESSG activity score: FSFI Pain Domain (r=-0.297, p=0.0210), FSFI Satisfaction Domain (r=-0.263, p=0.0423), PISQ-12 (r=0.403, p=0.0024)], more severe functional impairment [SHAQ: FSFI (r=-0.526, p< 0.0001), BISF-W (r=-0.477, p< 0.0001], greater fatigue [FIS: FSFI (r=-0.490, p< 0.0001), BISF-W (r=-0.458, p=0.0002), MAF: FSFI (r=-0.358, p=0.0011), BISF-W (r=-0.378, p=0.0030)], more severe depression [BDI-II: FSFI (r=-0.411, p< 0.0001), BISF-W (r=-0.419, p=0.0008)], deteriorated quality of life [HAQ: FSFI (r=-0.342, p=0.0073)], and worse ability to perform physical activities [HAP: FSFI (r=0.509, p< 0.0001), BISF-W (r=0.474, p=0.0002)]. No associations were found with disease duration, current prednisone equivalent dose or skin score.

Conclusion: Conclusion: Women with SSc reported significantly impaired sexual function and sexual quality of life and pelvic floor function than healthy controls with identical age. Worse scores in SSc were associated with disease activity, increased inflammation, more severe functional impairment, physical inactivity, fatigue, depression and decreased quality of life.

Acknowledgements: Supported by MHCR 023728 and GA UK 1578119


Table1_Results_SSc_ACR2019


Disclosure: B. Hermankova, None; M. Spiritovic, None; H. Storkanova, None; S. Oreska, None; P. Cesak, None; K. Pavelka, AbbVie, 8, Abbvie, 5, 8, Amgen, 5, 8, BMS, 8, Egis, 5, 8, Lilly, 5, 8, MSD, 8, Novartis, 5, 8, Pfizer, 5, 8, Roche, 5, 8, UCB, 8; J. Vencovský, projeMinistry of Health, Czech Republic, project 00023728, 2; L. Senolt, None; R. Becvar, None; M. Tomcik, None.

To cite this abstract in AMA style:

Hermankova B, Spiritovic M, Storkanova H, Oreska S, Cesak P, Pavelka K, Vencovský J, Senolt L, Becvar R, Tomcik M. Sexual Health in 60 Female Patients with Systemic Sclerosis [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/sexual-health-in-60-female-patients-with-systemic-sclerosis/. Accessed January 30, 2023.
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