Abstracts tagged "Systemic sclerosis"

Abstract Number: 0397 • ACR Convergence 2020
Assessing Adherence to Screening of Systemic Sclerosis-Related Lung Disease
Matthew Herrmann¹ and Zineb Aouhab¹, ¹Loyola University Medical Center, Maywood, IL
Background/Purpose: Feared complications of systemic sclerosis (SSc) affect the pulmonary system, with pulmonary hypertension and interstitial lung disease being common causes of mortality. Baseline and…
Abstract Number: 1128 • ACR Convergence 2020
The Diagnosis of Systemic Sclerosis as a Traumatic Experience: Patients’ Reactions to the Diagnostic Process
Fennell Patricia¹, Lee Shapiro², Nancy Dorr³, Roberta Lukasiewicz⁴, Frank Houser⁵ and Madison Taylor⁶, ¹Albany Health Management Associates, Steffens Scleroderma Foundation, Albany, NY, ²Albany Medical College, Stillwater, NY, ³The College of Saint Rose, Albany, NY, ⁴Steffens Scleroderma Foundation, Albany, NY, ⁵The College of Saint Rose, Nassau, NY, ⁶The College of Saint Rose, Mississauga, ON, Canada
Background/Purpose: Both the process of being diagnosed with a chronic illness and the illness itself can be a traumatizing experience (1). The current study examined…
Abstract Number: 1905 • ACR Convergence 2020
Soluble Guanylate Cyclase Reduced the Gastrointestinal Fibrosis in Bleomycin-induced Mouse Model of Systemic Sclerosis
Yuzuru Yamamoto¹, Takaichi Okano², Takumi Nagamoto², Yoshikazu Fujikawa³, Yoshihide Ichise², Hirotaka Yamada², Ikuko Naka², Yo Ueda⁴, Kengo Akashi⁵, Sho Sendo⁶, Akira Onishi⁵, Jun Saegusa⁷ and Akio Morinobu⁵, ¹Kobe University, Kobe-city, Japan, ²Kobe University, Kobe, Japan, ³Kobe University, Kobe city, Japan, ⁴Kobe UniversityRheumatology and Clinical Immunology, Kobe University Hospital, Kobe, Japan, ⁵Rheumatology and Clinical Immunology, Kobe University Hospital, Kobe, Japan, ⁶Kobe University, Kobe, ⁷Department of Clinical Laboratory, Kobe University Hospital, Kobe, Japan
Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune-mediated connective tissue disorder. Although the etiology of the disease remains undermined, SSc is characterized by fibrosis and…
Abstract Number: 0398 • ACR Convergence 2020
Chest CT Ordering Practices at Expert Scleroderma Centers in the United States
Elana Bernstein¹, John VanBuren², Shervin Assassi³, Flavia Castelino⁴, Lorinda Chung⁵, Chase Correia⁶, Luke Evnin⁷, Tracy Frech⁸, Emily Startup², Jessica Gordon⁹, Faye Hant¹⁰, Laura Hummers¹¹, Nora Sandorfi¹², Ami Shah¹³, Victoria Shanmugam¹⁴, Virginia Steen¹⁵ and Dinesh Khanna¹⁶, ¹Columbia University, New York, NY, ²University of Utah, Salt Lake City, UT, ³University of Texas Houston McGovern Medical School, Division of Rheumatology and Clinical Immunogenetics, Houston, TX, ⁴Massachusetts General Hospital/Harvard Medical School, Boston, MA, ⁵Stanford University School of Medicine and Palo Alto VA Health Care System, Palo Alto, CA, ⁶Northwestern University, Chicago, IL, ⁷Scleroderma Research Foundation, Brisbane, CA, ⁸University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake City, UT, ⁹Hospital for Special Surgery, New York, NY, ¹⁰Medical University of South Carolina, Charleston, SC, ¹¹Johns Hopkins Univerisity, Ellicott City, MD, ¹²University of Pennsylvania, Philadelphia, PA, ¹³Johns Hopkins University School of Medicine, Ellicott City, MD, ¹⁴The George Washington University, Washington, DC, ¹⁵Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, ¹⁶University of Michigan, Ann Arbor, MI
Background/Purpose: Interstitial lung disease (ILD) is the leading cause of death in patients with systemic sclerosis (SSc). Although pulmonary function tests (PFTs) are commonly used…
Abstract Number: 1170 • ACR Convergence 2020
Exploring the Use of Von Willebrand Factor as a Disease Biomarker in a Cohort of Patients with Juvenile Scleroderma: A Pilot Study
Natalia Vasquez-Canizares¹, Beamon Agarwal², Tamar Rubinstein³, Dawn Wahezi¹ and Morayma Reyes-Gil¹, ¹Albert Einstein College of Medicine, Bronx, NY, ²GenomeRxUS LLC, Clifton Heights, PA, ³Albert Einstein College of Medicine / Montefiore Medical Center, White Plains, NY
Background/Purpose: Juvenile Scleroderma (JScl) is a heterogenous disease characterized by autoimmunity, vasculopathy, and fibrosis. Morbidity and mortality remain high in part due to the continuing…
Abstract Number: 1907 • ACR Convergence 2020
DNASE1L3 R206C Polymorphism, a Systemic Sclerosis Risk Factor, Causes Impaired Digestion of Genomic DNA in Apoptosis-derived Extracellular Vesicles
Brian Skaug¹, Julio Charles¹, Jacob Couturier², Dorothy Lewis², Maureen Mayes³ and Shervin Assassi³, ¹University of Texas Houston, McGovern Medical School, Division of Rheumatology and Clinical Immunogenetics, Houston, TX, ²University of Texas Houston McGovern Medical School, Division of Infectious Diseases, Houston, TX, ³University of Texas Houston McGovern Medical School, Division of Rheumatology and Clinical Immunogenetics, Houston, TX
Background/Purpose: Two independent studies on genetic risk factors for systemic sclerosis (SSc) identified a polymorphism of Deoxyribonuclease 1-like 3 (DNASE1L3) associated with increased SSc risk. …
Abstract Number: 0401 • ACR Convergence 2020
Prevalence and Characteristics of Systemic Sclerosis Patients Fulfilling the 2019 EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Ronald Bass¹, Duncan Moore² and Virginia Steen², ¹Georgetown University School of Medicine, Washington, DC, ²Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC
Background/Purpose: Literature describing the overlap syndrome of SSc and SLE is limited and has employed a range of case definitions. Our study sought to use…
Abstract Number: 1377 • ACR Convergence 2020
Raynaud’s Phenomenon and Systemic Sclerosis in Post-9/11 Deployed Veterans Receiving Care Veterans Health Administration Care
Tracy Frech¹, Maureen Murtaugh¹, Megan Amuan² and Mary Jo Pugh¹, ¹University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake City, UT, ²Veterans Affair Medical Center, Salt Lake City, UT
Background/Purpose: The purpose of this project was to describe Raynaud's phenomenon (RP), very early diagnosis of systemic sclerosis (VEDOSS), and systemic sclerosis (SSc) in Veterans…
Abstract Number: 1908 • ACR Convergence 2020
Establishment of iPSc and Differentiated Endothelial Cells of Systemic Sclerosis Associated Pulmonary Arterial Hypertension ; Functional and Molecular Analysis
Yuki Kudo¹, Masaru Kato², Yuhei Shibata¹, Michihito Kono², Yuichiro Fujieda², Olga Amengual², Kenji Oku² and Tatsuya Atsumi³, ¹Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ²Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, ³Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine, Hokkaido University, Sapparo, Hokkaido, Japan
Background/Purpose: Pulmonary arterial hypertension (PAH) occurs either primarily or in association with other diseases such as connective tissue diseases. PAH associated with systemic sclerosis (SSc-PAH)…
Abstract Number: 709 • 2019 ACR/ARP Annual Meeting
Structural Abnormalities of the Optic Nerve Head and Retinal Nerve Fiber Layer Using Optical Coherence Tomography in Patients with Systemic Sclerosis
Cecilia Agapito Tito¹, Izabela Almeida ², Elise Taniguchi ², Juliana Silvatti ², Tiago Prata ², Augusto Paranhos ² and CRISTIANE KAYSER ¹, ¹Universidade Federal de Sao Paulo, Sao Paulo, Sao Paulo, Brazil, ²Universidade Federal de Sao Paulo, sao paulo, Brazil
Background/Purpose: Vascular dysfunction, characterized by vasospasm and endothelial activation, represents a central and early event in systemic sclerosis (SSc). Ocular vasospasm may induce optic nerve…
Abstract Number: 736 • 2019 ACR/ARP Annual Meeting
Reduced Circulating Levels of Inorganic Pyrophosphate Are Associated with Ectopic Calcification in Scleroderma Spectrum Disorders
Vivien Hsu¹, Naomi Schlesinger ², Qiaoli Li ³ and John Varga ⁴, ¹Rutgers- RWJ Medical School, SOUTH PLAINFIELD, NJ, ²Rutgers Health- RWJ Medical School, New Brunswick, NJ, ³Thomas Jefferson University, Philadelphia, PA, ⁴Northwestern University, Chicago,, IL
Background/Purpose: Calcinosis cutis due to ectopic mineralization is a common and disabling complication of systemic sclerosis (SSc) that has poorly understood pathogenesis and no effective…
Abstract Number: 1050 • 2019 ACR/ARP Annual Meeting
Genome-Wide DNA Methylation Signatures in Classical Monocytes from African Ancestry Patients with Systemic Sclerosis
Peter Allen¹, Jena Wirth ², Nathan Wilson ², Jim Oates ³, Melissa Cunningham ², Devin Absher ⁴ and Paula Ramos ², ¹University of Alabama at Birmingham, Birmingham, AL, ²Medical University of South Carolina, Charleston, ³Division of Rheumatology & Immunology/Medical University of South Carolina, Charleston, SC, ⁴HudsonAlpha Institute for Biotechnology, Huntsville, AL
Background/Purpose: Systemic sclerosis (SSc) is a rare, fibrotic autoimmune disorder characterized by cutaneous and visceral fibrosis, immune dysregulation, and vasculopathy. It disproportionately affects individuals of…
Abstract Number: 1633 • 2019 ACR/ARP Annual Meeting
Relationship Between YKL-40, VEGF, and IL-5 in Borderline mPAP and Pulmonary Hypertension in Systemic Sclerosis
Tetsuya Furukawa¹, Yuichi Yokoyama ², Teppei Hashimoto ³, Naoto Azuma ⁴ and Kiyoshi Matsui ⁴, ¹Hyogo College of Medicine, Nishinomiya, Japan, ²Hyogo College of Medicine, Kyoto, Japan, ³Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Kobe, Hyogo, Japan, ⁴Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
Background/Purpose: Systemic sclerosis (SSc) is an intractable connective tissue disease that causes skin and organ fibrosis, and its prognosis is affected by pulmonary hypertension (PH).…
Abstract Number: 1830 • 2019 ACR/ARP Annual Meeting
Short- and Long-term Morbidity and Mortality Outcomes of African American Patients with Systemic Sclerosis-Related Interstitial Lung Disease
Elizabeth Volkmann¹, Virginia Steen ², Ning Li ³, Michael Roth ⁴, Philip Clements ³, Dinesh Khanna ⁵, Daniel Furst ⁶, Shervin Assassi ⁷, Grace Kim ³, Jonathan Goldin ³, Robert Elashoff ³ and Donald Tashkin ³, ¹University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, ²Georgetown University, Washington, D.C., USA, Georgetown, ³University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, ⁴University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁵Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, ⁶University of California, Los Angeles, CA, ⁷Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, Texas, USA, Houston, TX
Background/Purpose: Observational studies have demonstrated that African American (AA) patients with systemic sclerosis (SSc) have a more unfavorable prognosis compared with non-AA. However, no studies…
Abstract Number: 2602 • 2019 ACR/ARP Annual Meeting
Changes in Fecal Microbiota Composition After Fecal Microbiota Transplantation in Systemic Sclerosis
Anna Maria Hoffmann-Vold¹, Håvard Fretheim ², Brian Chung ³, Henriette Didriksen ³, Espen Bækkevold ³, Øyvind Midtvedt ³, Cathrine Brunborg ³, Kristian Holm ³, Anders Tennøe ³, Torhild Garen ³, Tore Midtvedt ⁴, Marius Trøseid ³, Johannes Hov ³, Knut Lundin ³ and Øyvind Molberg ², ¹Department of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ²University Hospital Oslo, Oslo, Norway, ³Oslo University Hospital, Oslo, Norway, ⁴Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: In the double-blind, placebo-controlled 16-week pilot including 10 systemic sclerosis (SSc) patients with upper and lower gastrointestinal (GI) symptoms we found that fecal microbiota…

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