Abstracts tagged "Systemic lupus erythematosus (SLE)"

Abstract Number: 2780 • 2019 ACR/ARP Annual Meeting
Identification of SLE Subgroups at Risk for Poor Outcomes After Hydroxychloroquine Taper or Discontinuation
Celline C. Almeida-Brasil ¹, Evelyne Vinet ², Christian Pineau ² and Sasha Bernatsky¹, ¹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: The risks and benefits of long-term hydroxychloroquine (HCQ) use in systemic lupus erythematosus (SLE), versus tapering or stopping, remain uncertain. We aimed to identify predictors of…
Abstract Number: 67 • 2019 ACR/ARP Annual Meeting
Dermal Lymphatic Dysfunction Is Associated with Disease Activity in the MRL/lpr Lupus Model
Noa Schwartz¹, Thomas Li ², Susan Chyou ², William Shipman ³ and Theresa Lu ⁴, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, ³Weill Cornell Tri-Institutional MD-PhD Program, New York, NY, ⁴Hospital for Special Surgery, Weill Cornell Medicine (Microbiology and Immunology), New York
Background/Purpose: Lymphatic vessels are important in limiting the extent and duration of peripheral immune response, both by transporting cellular debris, inflammatory cells and excess interstitial…
Abstract Number: 637 • 2019 ACR/ARP Annual Meeting
How Often Should SLE Patients Be Tested for Lupus Anticoagulant?
Laurence Magder¹ and Michelle Petri ², ¹University of Maryland School of Medicine, Baltimore, MD, ²Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: SLE patients with persistent lupus anticoagulant (LAC) have been observed to be at significantly higher risk of thrombosis. A common clinical definition of persistent…
Abstract Number: 686 • 2019 ACR/ARP Annual Meeting
Association Between the Soluble Terminal Complement Complex C5b-9 (sC5b-9) and Signs of Active Kidney Disease in a Swiss SLE Cohort
Kristin Schmiedeberg ¹, Ruediger B. Mueller ², Thomas Neumann ¹, Ian Pirker ¹, Philipp Rein ³, Camillo Ribi ⁴, Andrea Rubbert-Roth ⁵, Michael Kirschfink ⁶, Reinhard Voll ⁷ and Johannes von Kempis¹, ¹Division of Rheumatology and Immunolog, Kantonsspital St. Gallen, St. Gallen, Sankt Gallen, Switzerland, ²Clinic of Rheumatology, Medical University Hospital Aarau, Aarau, Aargau, Switzerland, ³Division of Rheumatology and Immunolog, Kantonsspital St. Gallen, St.Gallen, Sankt Gallen, Switzerland, ⁴Service of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, Vaud, Switzerland, ⁵Division of Rheumatology, Kantonsspital St. Gallen, St. Gallen, Sankt Gallen, Switzerland, ⁶Institute of Immunology, University of Heidelberg, Heidelberg, Germany, ⁷Division of Rheumatology and Clinical Immunology, Medical Centre - University of Freiburg, Freiburg, Germany
Background/Purpose: There is a lack of reliable biomarkers for disease activity in SLE. While C3a, an anaphylatoxin generated during of complement activation, could be predictive…
Abstract Number: 952 • 2019 ACR/ARP Annual Meeting
Rate of Thirty-Day Readmissions in Systemic Lupus Erythematosus Rivals Congestive Heart Failure and Exceeds the General Medicare Population
Ann Chodara¹, Xing Wang ¹, Fangfang Shi ¹, Shivani Garg ¹, Ryan Powell ¹, Maria Schletzbaum ¹, Ann Sheehy ¹, Amy Kind ¹ and Christie Bartels ¹, ¹University of Wisconsin School of Medicine and Public Health, Madison, WI
Background/Purpose: Medicare measures readmissions within 30 days of hospitalization across several conditions as a marker of care quality. While not currently a reporting condition, in…
Abstract Number: 1105 • 2019 ACR/ARP Annual Meeting
Relationships Among Cognitive Emotion Regulation, Body Image, Family and Marital Function and Quality of Life in Chinese Female Patients with Systemic Lupus Erythematosus
Huilin Zhang ¹, Lezhi Li ², Mengyue Chen ² and Qing Zhang³, ¹Clinical Nursing Teaching and Research Section, Second Xiangya Hospital, Central South University, Changsha, Hunan, China (People's Republic), ²Xiangya Nursing School, Central South University, Changsha, Hunan, China (People's Republic), ³Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China (People's Republic)
Background/Purpose: At present, there are few researches on cognitive emotional regulation, body image, family and marital function, and life quality of female patients with systemic…
Abstract Number: 1570 • 2019 ACR/ARP Annual Meeting
Can the Montreal Cognitive Assessment (MoCA) Improve the Automated Neuropsychological Assessment Metrics (ANAM) Performance in Screening for Cognitive Impairment in Lupus Patients?
Oshrat Tayer-Shifman¹, Robin Green ², Dorcas Beaton ³, Lesley Ruttan ², Joan Wither ⁴, Maria Tartaglia ⁵, Mahta Kakvan ¹, Sabrina Lombardi ², Nicole Anderson ¹, Jiandong Su ¹, Dennisse Bonilla ¹, Moe Zandy ¹, May Choi ⁶, Marvin Fritzler ⁶ and Zahi Touma ⁷, ¹University Health Network, University of Toronto, Toronto, ON, Canada, ²University Health Network, Toronto, ON, Canada, ³St. Michael's Hospital, Toronto, ON, Canada, ⁴University Health Network, Krembil Research Institute, Toronto, ON, Canada, ⁵University Health Network, University of Toronto, Toronto, ON, Canada, ⁶Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁷University Health Network, University of Toronto, Toronto, Canada
Background/Purpose: : In a related study, we have shown evidence to support the validity of the Automated Neuropsychological Assessment Metrics (ANAM) for the screening of…
Abstract Number: 1615 • 2019 ACR/ARP Annual Meeting
The Effects of Anti-glutamate Receptor Subunit Antiantibodies on Systemic Lupus Erythematosus Without Neuropsychiatric Involvement
Yoshiyuki Arinuma ¹, Yasuhiro Hasegawa ¹, Takumi Muramatsu¹, Yu Matsueda ¹ and Kunihiro Yamaoka ¹, ¹Department of Rheumatology and Infectious Diseaes, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
Background/Purpose: Autoantibodies against N-methyl-D-aspartate receptor subunit GluN2 (anti-GluN2) in the cerebrospinal fluid are known to be related with the development of diffuse psychiatric/neuropsychological manifestations in…
Abstract Number: 1825 • 2019 ACR/ARP Annual Meeting
Comparison of the Thrombosis Risk Score with Triple Positivity in SLE Thrombosis
Michelle Petri¹, Jessica Li ¹, John Conklin ², Tyler O'Malley ³, Jo-Anne Ligayon ², Leilani Wolover ² and Thierry Dervieux ², ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Exagen, Vista, CA, ³Exagen, Oceanside, CA
Background/Purpose: We previously developed a Thrombosis Risk Score, a sum of three factors: lupus anticoagulant (by RVVT confirm); low C3; and C4d bound to platelets.…
Abstract Number: 2033 • 2019 ACR/ARP Annual Meeting
IRAK4 Inhibition Suppresses TLR7, TLR9, and SLE Serum-Induced IFNA Production in Primary Human Plasmacytoid Dendritic Cells
Angie Hammond¹, Sean Parghi ¹, Nathan Wright ¹, Ethan Grant ¹, James Taylor ¹ and Matthew Warr ¹, ¹Gilead Sciences, Inc., Foster City, CA
Background/Purpose: A hallmark of lupus is the presence of antinuclear autoantibodies, including those against RNA-protein complexes and double-stranded DNA (dsDNA).1,2 FcγR-mediated internalization of these nucleic…
Abstract Number: 2518 • 2019 ACR/ARP Annual Meeting
Time to Lupus Low Disease Activity State: Role of African-American Ethnicity
Hakan Babaoglu¹, Jessica Li ², Daniel Goldman ³, Laurence Magder ⁴ and Michelle Petri ², ¹Gazi University School of Medicine, Ankara, Turkey, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD, ⁴University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Lupus Low Disease Activity State (LLDAS) is a potential treat to target goal in systemic lupus erythematosus (SLE). It is well established that SLE…
Abstract Number: 2553 • 2019 ACR/ARP Annual Meeting
Prescription Opioid Use and Osteoporotic Fractures in Systemic Lupus Erythematosus: The Michigan Lupus Epidemiology & Surveillance (MILES) Cohort
Emily Somers¹, Sioban Harlow ¹, Nina Zhou ¹, Lu Wang ¹, Kamil Barbour ², Charles Helmick ³, Caroline Gordon ⁴, Deeba Minhas ¹, Beth Wallace ¹, Afton Hassett ¹, Suzanna Zick ¹, W. Joseph McCune ⁵ and Wendy Marder ¹, ¹University of Michigan, Ann Arbor, ²Centers for Disease Control and Prevention, Atlanta, ³Centers for Disease Control and Prevention, Division of Population Health, Atlanta, GA, ⁴University of Birmingham, Birmingham, United Kingdom, ⁵University of Michigan, Ann Arbor, MI
Background/Purpose: We recently reported prescription opioid use in nearly one-third of systemic lupus erythematosus (SLE) patients in our population-based cohort. Data suggest that opioids may…
Abstract Number: 2781 • 2019 ACR/ARP Annual Meeting
Risk of Cardiovascular Disease Associated with the Use of Glucocorticoids in Patients with Incident Systemic Lupus Erytematosus: A Population-based Study
Lingyi Li¹, Hui Xie ², Eric Sayre ¹ and J. Antonio Avina-Zubieta ³, ¹Arthritis Research Canada, Vancouver, BC, Canada, ²Arthritis Research Canada and Simon Fraser University, Vancouver, BC, Canada, ³Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have an increased risk for cardiovascular disease (CVD). SLE itself predisposes patients to accelerated atherosclerosis. In addition, the…
Abstract Number: 68 • 2019 ACR/ARP Annual Meeting
Inactivation of Transaldolase and HRES-1/Rab4 Predisposes to Hepatitis in a Mouse Model of Systemic Lupus Erythematosus
Akshay Patel¹, Nick Huang ² and Andras Perl ³, ¹SUINY Upstate Medical University, Syracuse, NY, ²Upstate Medical University, Syracuse, NY, ³SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Deficiency of transaldolase (TAL) in systemic lupus erythematosus (SLE) predisposes to oxidative stress mediated autoimmune hepatitis[1, 2]. Along with TAL, HRES-1/Rab4 (Rab4A), a small…
Abstract Number: 638 • 2019 ACR/ARP Annual Meeting
Longitudinal Trends for Estimated Glomerular Filtration Rate and Predictors of Change in Patients with Systemic Lupus Erythematosus
Terry Cheuk Fung Yip ¹, Michelle Petri ² and Laurence Magder³, ¹Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: To characterize the longitudinal trajectory of estimated glomerular filtration rate (eGFR) in patients with systemic lupus erythematosus (SLE) and identify predictors of change in…

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