ACR Meeting Abstracts

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Abstracts tagged "synovium"

  • Abstract Number: 2911 • 2019 ACR/ARP Annual Meeting

    A Randomised, Open Labelled Clinical Trial to Investigate Synovial Mechanisms Determining Response – Resistance to Rituximab versus Tocilizumab in Rheumatoid Arthritis Patients Failing TNF Inhibitor Therapy

    Frances humby 1, Maya H. Buch 2, Patrick Durez 3, Myles Lewis 1, Michele Bombardieri 1, Hasan Rizvi 4, Stephen Kelly 4, Liliane Fosatti 1, Rebecca Hands 1, Giovanni Giorli 1, Arti Mahto 1, Carlomaurizio Montecucco 5, Bernard Lauwerys 6, Vasco Romao 7, Arthur Pratt 8, Serena Bugatti 9, Nora Ng 10, Felice Rivellese 1, Pauline Ho 11, Mattia Bellan 12, Mattia Congia 13, Patrick Verschueren 14, Pier Paolo Sainaghi 12, Nagui Gendi 15, Bhaskar Dasgupta 16, Alberto Cauli 17, Piero Reynolds 18, Juan Cañete 19, Robert J. Moots 20, Peter Taylor 21, Christopher Edwards 22, John Isaacs 8, Peter Sasieni 23, João Eurico Fonseca 24, Ernest Choy 25 and Costantino Pitzalis26, 1Queen Mary University of London, London, United Kingdom, 2University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, 3Pôle de Recherche en Rhumatologie, Institut de Recherche Expérimentale et Clinique, UCL Saint-Luc, Brussels, Belgium, 4Barts Health NHS Trust, London, United Kingdom, 5Department of Rheumatology, IRCCS Policlinico S. Matteo Foundation, University of Pavia, Pavia, Italy, Pavia, Italy, 6University of Louvain, Louvain, Belgium, 7University of Lisbon, Lisbon, Portugal, 8University of Newcastle, Newcastle, United Kingdom, 9University of Pavia, Pavia, Italy, 10Guys and St Thomas NHS Trust, London, United Kingdom, 11University of Manchester, Manchester, United Kingdom, 12University of Novara, Novara, Italy, 13University of Cagliari, Cagliari, Italy, 14University of Leuven, Leuven, Belgium, 15Basildon Hospital NHS Trust, Basildon, United Kingdom, 16Southend University Hospital, NHS Foundation Trust, Westcliff-on-Sea, United Kingdom, 17Rheumatology Unit, University Clinic AOU and University of Cagliari, Cagliari, Italy, 18Homerton University NHS Trust, London, United Kingdom, 19Rheumatology Department, Hospital Clínic and IDIBAPS,, Barcelona, Spain, 20Institute of Ageing and Chronic Disease, Liverpool, United Kingdom, 21University of Oxford, Oxford, United Kingdom, 22University of Southampton, Southampton, United Kingdom, 23Kings College London, London, United Kingdom, 24Rheumatology and Bone Diseases Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte; Unidade de Investigação em Reumatologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa; Centro Académico de Medicina de Lisboa; Lisbon, Portugal., Lisbon, Portugal, 25Cardiff University School of Medicine, Cardiff, United Kingdom, 26Centre for Experimental Medicine & Rheumatology, Queen Mary University of London, London, United Kingdom

    Background/Purpose: Although biologic therapies have transformed the outlook for rheumatoid arthritis (RA), the lack of a major treatment response in over 50% of patients, the…
  • Abstract Number: 44 • 2019 ACR/ARP Annual Meeting

    Validation of New Genes Identified in a Molecular Bayesian Network of Rheumatoid Arthritis Synovitis

    Teresina Laragione1, Carolyn Harris 1, Wenhui Wang 1, Jun Zhu 1 and Percio Gulko 1, 1Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: We have previously identified new key regulators of Rheumatoid arthritis (RA) synovial pathology using a systems biology approach that combined RA gene expression datasets,…
  • Abstract Number: 49 • 2019 ACR/ARP Annual Meeting

    Towards a Single Cell Portrait of Rheumatoid Arthritis – Development of a Single Cell Multiomics Pipeline for Phase 2 of the Accelerating Medicine Partnership (AMP) – RA Network

    Kevin Wei1, Anna Helena Jonsson 1, Fan Zhang 2, Aparna Nathan 3, Joseph Mears 2, Gerald Watts 2, Zhu Zhu 2, ilya Korsunsky 2, Laura Donlin 4, Deepak Rao 2, Andrew Filer 5, Accelerating Medicine Partnership (AMP) 6, Brendan Boyce 7, Ellen Gravallese 8, V. Michael Holers 9, Larry Moreland 10, Peter Gregersen 11, Vivian Bykerk 12, Jennifer Anolik 7, Soumya Raychaudhuri 2 and Michael Brenner 13, 1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Harvard Medical School, Boston, MA, 4Hospital For Special Surgery, New York, NY, 5Institute of Inflammation and Ageing College of Medical and Dental Sciences University of Birmingham, Birmingham, United Kingdom, 6Brigham and Women's Hospital, Boston, 7University of Rochester Medical Center, Rochester, NY, 8University of Massachusetts Medical School, Worcester, MA, 9University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, 10University of Pittsburgh, PITTSBURGH, PA, 11Feinstein Institutes for Medical Research, Manhasset, NY, 12Hospital for Special Surgery, New York City, NY, 13Brigham and Women’s Hospital:, Boston

    Background/Purpose: The goal of the Accelerating Medicines Partnership (AMP) program is to study synovial tissue from individuals with rheumatoid arthritis (RA) using high-dimensional analyses.  During…
  • Abstract Number: 996 • 2019 ACR/ARP Annual Meeting

    The Role of Flip in Differentiation and Survival of Synovial Tissue Resident Macrophages

    Qi Huang1, Renee Doyle 1, Shang-Yang Chen 2, Alexander Misharin 3, Deborah Winter 4 and Richard Pope 5, 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2Northwestern University, Chicago, 3Northwestern University Feinberg School of Medicine, chicago, 4Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, 5Northwestern University Feinberg School of Medicine, Division of Rheumatology, chicago, IL

    Background/Purpose: We previously identified that under homeostatic conditions Flip was necessary for macrophage (MΦ) survival.  The mechanisms responsible for the differentiation of monocyte-derived MΦs into…
  • Abstract Number: 1996 • 2019 ACR/ARP Annual Meeting

    Bromodomain Inhibitor, I-BET762 Inhibits Production of Pro-inflammatory in Rheumatoid Arthritis Fibroblast-like Synoviocytes and Differentiation of Osteoclast

    Ra Ham Kim1, Hyun Jung Yoo 2, Shin Eui Kang 3, Ji soo Park 4, Seon Uk Kim 5, Eun Young Lee 6, Jin Kyun Park 6 and Yeong-Wook Song 7, 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Republic of Korea, Seoul, Republic of Korea, 2Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Repulbic of Korea, Seoul, Republic of Korea, 3Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Republic of Korea, Seoul, Republic of Korea, 4Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea., Seoul, Republic of Korea, 5Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Republic of Korea, 6Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Republic of Korea, 7Seoul National University Hospital, Seoul, Republic of Korea

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disorder, characterized by joint inflammation and bone destruction. The fibroblast-like synoviocyte(FLS) contributes to the pathogenesis of RA…
  • Abstract Number: 2002 • 2019 ACR/ARP Annual Meeting

    Presence of the MerTK Receptor on Human Synovial Tissue Macrophages Lowers Inflammatory Cytokine Production and Activation of the MerTK+CD206+ Subpopulation Limits the Inflammatory Response of Synovial Fibroblasts

    Samuel Finlay1, Stefano Alivernini 2, Aziza Elmesmari 3, Barbara Tolusso 2, Luca Petricca 2, Clara Di Mario 4, Annunziata Capacci 2, Andrew Filer 5, Gianfranco Ferraccioli 2, Iain McInnes 1, Elisa Gremese 2 and Mariola Kurowska-Stolarska 1, 1Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, 2Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, 3Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom, 4Institute of Rheumatology - Università Cattolica del Sacro Cuore, Rome, Italy, 5Institute of Inflammation and Ageing College of Medical and Dental Sciences University of Birmingham, Birmingham, United Kingdom

    Background/Purpose: Background: A substantial proportion of Rheumatoid Arthritis patients do not respond to treatment and only a small proportion achieve sustained disease remission. We showed…
  • Abstract Number: 2010 • 2019 ACR/ARP Annual Meeting

    Individual Functions of Histone-acetyltransferases CBP and p300 in Regulating Autophagy and Proteasomal Degradation in Synovial Fibroblasts

    Monika Krošel1, Marcel Gabathuler 2, Matija Tomšič 1, Oliver Distler 3, Caroline Ospelt 4 and Kerstin Klein 5, 1Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, Ljubljana, Slovenia, 2Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland, Schlieren, 3Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, 4University Hospital Zürich, Zürich, Switzerland, 5Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland., Zürich, Switzerland

    Background/Purpose: Tight control of the two major catabolic pathways proteasomal degradation and autophagy is critical for the maintenance of cellular homeostasis and cell survival. Here…
  • Abstract Number: 2741 • 2019 ACR/ARP Annual Meeting

    Integration of Single Cells from Inflammatory Disease Tissues Reveals Common and Unique Pathogenic Cell States

    Fan Zhang1, Joseph Mears 1, ilya Korsunsky 1, Kevin Wei 2, Anna Helena Jonsson 2, Deepak Rao 1, Edy Kim 3, Laura Donlin 4, Jill Buyon 5, Michelle Petri 6, Chaim Putterman 7, Thomas Tuschl 8, Nir Hacohen 9, Betty Diamond 10, Michael Brenner 11 and Soumya Raychaudhuri 1, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Brigham and Women's Hospital, Boton, MA, 4Hospital For Special Surgery, New York, NY, 5New York University School of Medicine, New York, NY, 6Johns Hopkins University School of Medicine, Baltimore, MD, 7Albert Einstein College of Medicine, New York, NY, 8Rockefeller Research Laboratories, New York, 9Broad Institute, Cambridge, 10Feinstein Institutes for Medical Research, Manhasset, 11Brigham and Women’s Hospital:, Boston

    Background/Purpose: Different autoimmune diseases can co-exist in an individual and share similar genetic associations, autoimmune signaling pathways, and clinical manifestations. However, autoimmune diseases present varied…
  • Abstract Number: 2848 • 2019 ACR/ARP Annual Meeting

    Semiquantitative Assessment of Synovial Inflammation on US-Guided Synovial Membrane Biopsy Is Contingent to Disease Phase, Autoimmune Profile and Treatment Response in Rheumatoid Arthritis: Large Single Center Experience (SYNGem Cohort)

    Stefano Alivernini1, Barbara Tolusso 1, Marco Gessi 2, Maria Rita Gigante 1, Luca Petricca 1, Clara Di Mario 3, Simone Perniola 1, Anna Laura Fedele 1, Giusy Peluso 4, Laura Bui 2, Annunziata Capacci 1, Francesco Federico 2, Gianfranco Ferraccioli 3 and Elisa Gremese 1, 1Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, 2Division of Pathology - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, 3Institute of Rheumatology - Università Cattolica del Sacro Cuore, Rome, Italy, 4Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy, Italy

    Background/Purpose: Ultrasound (US)-guided minimally-invasive Synovial Tissue (ST) biopsy is a well tolerated procedure for basic and translational studies on chronic inflammatory joint diseases as Rheumatoid…
  • Abstract Number: 70 • 2018 ACR/ARHP Annual Meeting

    Colocalization of Malondialdehyde-Acetaldehyde Adducts (MAA) and Extracellular Matrix Proteins in Joint and Lung Tissues from Rheumatoid Arthritis Patients

    Geoffrey M. Thiele1, Michael J. Duryee2, Jacob D. McGowan1, Logan M. Duryee1, Lynell W. Klassen3, James R. O'Dell3, Bryant R. England4 and Ted R. Mikuls5, 1University of Nebraska Medical Center, Omaha, NE, 2Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 4Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, 5Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE

    Background/Purpose:   Malondialdehyde-acetaldehyde adducts (MAA) are products of oxidative stress that modify self-proteins and stimulate potent cellular and humoral immune responses. We have previously demonstrated…
  • Abstract Number: 1073 • 2018 ACR/ARHP Annual Meeting

    Connective Tissue Growth Factor Associates with Angiogenesis through Notch-1 Activation in Rheumatoid Arthritis

    Kazuhisa Nozawa1, Takuya Hirai2, Hiroshi Tsushima2, Ken Yamaji3, Naoto Tamura3 and Iwao Sekigawa4, 12-1-1 Hongo Bunkyo-ku, Juntendo University, Tokyo, Japan, 2Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan, 3Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 4Institute for Environment and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan

    Background/Purpose: Aberrant angiogenesis has been considered as one of important factors for pathogenesis of rheumatoid arthritis (RA). Several angiogenetic mediators are reported to be massively…
  • Abstract Number: 1201 • 2018 ACR/ARHP Annual Meeting

    Finger Extensor Tendon Involvement Is Frequent in Early Rheumatoid Arthritis

    Mihaela Maruseac1, Patrick Durez2,3, Adrien Nzeusseu Toukap4 and Maria Stoenoiu5, 1Rheumatology, Cliniques Universitaires Saint-Luc, Brussels, Belgium, 2Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, 3Pôle de Recherche en Rhumatologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium, 4Department of Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, 5Rheumatology, Cliniques Universitaires Saint-Luc, Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium

    Background/Purpose: Finger extensor involvement (FET) at ultrasound examination (US) was previously described in patients suffering from early psoriatic arthritis. Contradictory results were published in patients…
  • Abstract Number: 1933 • 2018 ACR/ARHP Annual Meeting

    Histological Features and Tissue-Macrophage Phenotype of Synovial Biopsies Identify RA Patients in Sustained Remission at Risk of Disease Flare after Treatment Tapering or Discontinuation

    Stefano Alivernini1, Barbara Tolusso1, Aziza Elmesmari2, Laura Bui3, Giusy Peluso1, Maria Rita Gigante1, Samuel Finlay2,4, Luca Petricca1, Clara Di Mario1, Simone Perniola1,5, Anna Laura Fedele1, Francesco Federico3, Iain B. McInnes2,4, Gianfranco Ferraccioli1, Mariola Kurowska-Stolarska2,6 and Elisa Gremese1, 1Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University of the Sacred Heart, Rome, Italy, 2Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 3Institute of Pathology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Catholic University of the Sacred Heart, Rome, Italy, 4Rheumatoid Arthritis Pathogenesis Centre of Excellence (RACE), Glasgow, United Kingdom, 5Department of Verona - University of Verona (ITALY), Verona, Italy, 6Rheumatoid Arthritis Pathogenesis Centre of Excellence (RACE), Rome, Italy

    Background/Purpose: Flares of immune-mediated inflammatory diseases, as Rheumatoid Arthritis (RA) occur unpredictably representing a major burden for patients and clinicians. We aimed to dissect the…
  • Abstract Number: 1959 • 2018 ACR/ARHP Annual Meeting

    Stability of DNA Methylation Signature in Primary RA Synovial Fibroblasts Compared with Cultured Fibroblast-like Synoviocytes

    Rizi Ai1, Deepa Hammaker2, Wei Wang3 and Gary S. Firestein4, 1University of California San Diego, La Jolla, CA, 2Medicine, UC San Diego, La Jolla, CA, 3Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 4Medicine, University of California San Diego, La Jolla, CA

    Background/Purpose: Rheumatoid arthritis (RA) is an aggressive immune-mediated joint disease with synovial inflammation and joint destruction. Fibroblast-like synoviocytes (FLS) play a key role in mediating…
  • Abstract Number: 2798 • 2018 ACR/ARHP Annual Meeting

    Expanded T-Cell Clones Are Present in the Synovium before the Clinical Onset of Rheumatoid Arthritis

    Giulia Balzaretti1,2,3, Paul L. Klarenbeek4, Marieke E. Doorenspleet5, Maria JH de Hair6, Barbera C.D. van Schaik7, Rebecca Esveldt2, Marleen van de Sande1, Danielle Gerlag8, Antoine H.C. van Kampen7, Frank Baas2,9, Paul-Peter Tak10 and Niek de Vries3,5, 1Clinical Immunology & Rheumatology, ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 2Dept. of Genome Analysis, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 3Dept. of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 4Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 5Amsterdam Rheumatology and immunology Center | Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 6Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands, Utrecht, Netherlands, 7Bioinformatics Laboratory, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 8GlaxoSmithKline, Stevenage, United Kingdom, 9Dept. of Genome Diagnostics, Leiden University, Leiden, Netherlands, 10GlaxoSmithKline, Cambridge, United Kingdom

    Background/Purpose: In healthy individuals with arthralgia and RA-specific autoantibodies (so called at-risk individuals) the presence of expanded B-cell receptor (BCR) clones in peripheral blood (PB)…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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