Abstracts tagged "synovium"

Abstract Number: 1383 • ACR/ARHP Annual Meeting 2013
Validation Of Popliteal Lymph Node Phenotype and Bin Expansion As Biomarkers Of Rheumatoid Arthritis Knee Flare
Homaira Rahimi¹, Ronald Wood², Igor Kuzin³, Wakenda Tyler⁴, Gregory Dieudonne⁵, Stephen Kates⁶, Christopher T. Ritchlin³ and Edward M. Schwarz⁷, ¹Pediatrics, University of Rochester, Rochester, NY, ²Department of Urology, University of Rochester Medical Center, Rochester, NY, ³Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁴Orthopedics, University of Rochester, Rochester, NY, ⁵Radiology, University of Rochester, Rochester, NY, ⁶Orthopedic Surgery, University of Rochester Medical Center, Rochester, NY, ⁷Center for Musculoskeletal Research, University of Rochester, Rochester, NY
Background/Purpose: Factors precipitating joint flare in rheumatoid arthritis (RA) patients are poorly understood. Contrast enhanced (CE) MRI studies in murine models have identified popliteal lymph…
Abstract Number: 1314 • ACR/ARHP Annual Meeting 2013
Synovial Ectopic Lymphoneogenesis Predicts Clinical Response To Certolizumab Pegol In Patients With Rheumatoid Arthritis
Maria Di Cicco¹, Stephen Kelly¹, Frances Humby², Nora Ng¹, Sabrina Dadoun³, Rebecca Hands², Vidalba Rocher², Alessandra Nerviani¹, Michele Bombardieri² and Costantino Pitzalis⁴, ¹William Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, ²Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ³APHP, Pitié-Salpêtrière University Hospital, Paris, France, ⁴Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, QMUL, London, United Kingdom
Background/Purpose: Predicting response to anti-TNF alpha inhibitors (TNFi) in rheumatoid arthritis (RA) patients is challenging. Therefore there is a high need for identification of biomarkers…
Abstract Number: 2342 • ACR/ARHP Annual Meeting 2012
Synovial Tissue Analysis in the Pre-Clinical Phase of Arthritis: T-Cell Infiltration Preceding the Development of Arthritis
Maria J. H. de Hair¹, Marleen G. H. van de Sande¹, Tamara H. Ramwadhdoebe², Robert B. M. Landewé³, Christiaan van der Leij⁴, Mario Maas⁵, Dirkjan van Schaardenburg⁶, Danielle Marie Gerlag¹, Lisa G.M. van Baarsen² and Paul P. Tak⁷, ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Division of Clinical Immunology and Rheumatology and Department of Experimental Immunology , Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ³Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam & Atrium Medical Center, Amsterdam, Netherlands, ⁴Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Department of Radiology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁶Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ⁷Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: We have previously shown in a pilot study that there is no evident synovial inflammation in autoantibody-positive individuals who are at risk of developing…
Abstract Number: 901 • ACR/ARHP Annual Meeting 2012
Colony-Stimulating Factor (CSF) Receptor 1 Blockade Overcomes Overlapping Effects of M-CSF and Interleukin-34 On Myeloid Differentiation and Gene Expression to Reduce Inflammation in Human and Murine Models of Rheumatoid Arthritis
Samuel Garcia¹, Linda M. Hartkamp², Inge E. van Es², Haishan Lin³, Li Long³, Emma L. Masteller³, Brian R. Wong³, Paul P. Tak⁴ and Kris A. Reedquist², ¹Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Five Prime Therapeutics, Inc., South San Francisco, CA, ⁴Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: Disease activity and response to therapy in RA correlates with changes in synovial macrophage numbers and their products. M-CSF or IL-34 stimulation of their…
Abstract Number: 874 • ACR/ARHP Annual Meeting 2012
TNFα Induces Sustained Signaling and a Prolonged and Unremitting Inflammatory Response in Synovial Fibroblasts
Angela Lee¹, Galina Grigoriev¹, Janice Chen¹, Lionel B. Ivashkiv² and George D. Kalliolias¹, ¹Medicine, Hospital for Special Surgery, New York, NY, ²Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: The non resolving character of synovial inflammation in rheumatoid arthritis (RA) is a conundrum. To identify the contribution of fibroblast-like synoviocytes (FLS) to the…
Abstract Number: 413 • ACR/ARHP Annual Meeting 2012
α(1,2)-Linked Fucosylated Cytokines Are Upregulated in Rheumatoid Arthritis
Takeo Isozaki¹, Jeffrey H. Ruth², M. Asif Amin¹, Phillip L. Campbell¹, Christine M. Ha² and Alisa E. Koch³, ¹Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ²Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Glycosylation is a common post-translational modification of proteins in eukaryotes. Fucosylated glycans are synthesized by fucosyltransferases (futs). We previously reported that sialyl Lewisx, synthesized…
Abstract Number: 418 • ACR/ARHP Annual Meeting 2012
Immediate Early Response Gene X-1 Is Over-Expressed and Regulates Apoptosis and Cytokine Production in Rheumatoid Arthritis Synovial Fibroblasts
Akio Morinobu¹, Masaaki Fujita², Shino Tanaka³, Jun Saegusa⁴ and Shunichi Kumagai⁵, ¹Department of clinical pathology and immunology, Kobe university graduate school of medicine, Kobe 650-0017, Japan, ²Kobe University Graduate School of Medicine, Kobe, Japan, ³Department of Clinical Pathology and Immunology, Rheumatology and Clinical Immunology, Kobe, Japan, ⁴Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁵Center of rheumatic diseases, Shinko hospital, Kobe, Japan
Background/Purpose: Histone deacetylase inhibitors (HDACi) are potential therapeutic drugs for the treatment of rheumatoid arthritis (RA). We found that an HDACi up-regulates the gene expression…
Abstract Number: 132 • ACR/ARHP Annual Meeting 2012
FDG-PET Evaluation of Axillary Lymph Nodes and Large Joints of Patients with Rheumatoid Arthritis Treated with Anti-TNF Drugs
Koichi Okamura¹, Yukio Yonemoto², Tetsuya Kaneko³, Kimihiko Takeuchi⁴, Tsutomu Kobayashi¹ and Kenji Takagishi¹, ¹Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan, ²Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan, ³Department of Orthopaedic Surgery, Inoue Hospital, Takasaki, Gunma, Japan, ⁴Department of Rheumatology, Isesaki Fukushima Hospital, Isesaki, Gunma, Japan
Background/Purpose: F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) can be used to image synovial inflammation in patients with rheumatoid arthritis (RA). The development of molecular…