Abstracts tagged "rheumatoid arthritis"

Abstract Number: 1713 • ACR Convergence 2023
Prevention of Arthritis Development by Mechanical Unloading Through Inhibition of CCL2 and YAP-mediated Inflammation in the Rat Adjuvant-induced Arthritis Model
Elisa Dalix¹, Mathieu Maalouf¹, Robin Caire², Guillaume Courbon¹, Virginie Dumas³, Sylvie Peyroche¹, Marie-Thérèse Linossier¹, Mireille Thomas¹, Charles-Antoine Arthaud¹, Arnaud Vanden-Bossche¹ and Hubert Marotte⁴, ¹Université Jean Monnet Saint-Étienne, Mines Saint-Etienne, INSERM, Saint-Etienne, France, ²Department of Molecular Medicine, University of Padua School of Medicine, Padua, Italy, ³Laboratory of Tribology and Systems Dynamics, Ecole Nationale d'Ingénieurs de Saint Etienne, Ecole Centrale de Lyon, University of Lyon, Saint-Etienne, France, ⁴CHU Saint-Etienne, Saint-Etienne, France
Background/Purpose: Rheumatoid arthritis (RA) is the most common chronic inflammatory rheumatic disease, characterized by synovitis associated with progressive bone loss and joint degradation. The adjuvant-induced…
Abstract Number: 1736 • ACR Convergence 2023
The Effect of Resolvin E1 and Resolvin D1 Specialised Pro-resolving Mediators on the Inhibition of Osteoclastogenesis
Patricia Riedlova¹, Kieran Woolcock², Cecilia Ansalone² and Carl Goodyear², ¹University of Glasgow - School of Infection & Immunity, Glasgow, United Kingdom, ²University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Osteoclasts (OCs) are multinucleated bone-resorbing cells playing a key role in rheumatoid arthritis (RA). Under physiological conditions, OCs are in balance with bone-forming osteoblasts,…
Abstract Number: 1752 • ACR Convergence 2023
Fibroblast Expression of Neurotransmitter Receptor HTR2A Associates with Inflammation in Rheumatoid Arthritis Joint
Chunyan Xiang¹, Soomin Hong¹, Bingjiao Zhao², Hui Pi³, Fang Du⁴, Xingyu Lu⁵, Yuanjia Tang¹, Nan Shen⁶, Chunxi Yang⁷ and Runci Wang⁸, ¹Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University (SJTUSM), Shanghai, China, ²Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China, ³Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China, ⁴Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University (SJTUSM), Shanghai, China, ⁵Department of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁶Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁷Department of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiao Tong University (SJTUSM), Shanghai, China, ⁸Renji hospital, Shanghai Jiaotong University, Pudong Xinqu, China
Background/Purpose: Peripheral neuroimmune crosstalk plays a crucial role in the inflammatory process and bone metabolism in joint. Serotonin receptor HTR2A was reported to be expressed…
Abstract Number: 1768 • ACR Convergence 2023
The Dynamics of the Gut Microbiome in Rheumatoid Arthritis Susceptibility: A Cross-Sectional and Longitudinal Observational Study
Christopher Rooney¹, Ian Jeffery², Kulveer Mankia³, Mark Wilcox¹ and Paul Emery⁴, ¹University of Leeds, Leeds, United Kingdom, ²4D Pharma plc, Cork, Ireland, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Multiple compositional shifts of gut microbiota have been identified within the rheumatoid arthritis (RA) disease continuum, encompassing both established RA and at-risk individuals (including…
Abstract Number: 1867 • ACR Convergence 2023
Peripheral Volumetric Bone Mineral Density and Erosive Disease in Patients with Established Rheumatoid Arthritis: A Cross-Sectional Study Using High-Resolution Peripheral Quantitative Computed Tomography
Mathias Hänel¹, Rasmus Klose-Jensen², Josephine Therkildsen³, Anne-Birgitte Garm Blavnsfeldt³, Bente Langdahl³, Stinus Gadegaard Hansen⁴, Kresten Keller⁵ and Ellen Margrethe Hauge³, ¹Rheumatollogy, Aarhus University Hospital, Aarhus, Denmark, ²Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ³Aarhus University Hospital, Aarhus, Denmark, ⁴Odense University Hospital, Svendborg Sygehus, Svendborg, Denmark, ⁵Department of Rheumatology, Aarhus University Hospital; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Background/Purpose: High resolution peripheral quantitative computed tomography (HR-pQCT) is a promising imaging modality for assessing volumetric bone mineral density (BMD) in rheumatoid arthritis (RA), and…
Abstract Number: 2021 • ACR Convergence 2023
Beliefs, Attitudes, and Preferences of Patients with Rheumatoid Arthritis (RA) and Concomitant Cancer with Respect to RA Therapy
Juan Ruiz¹, Sheneze Madramootoo², Maria A. Lopez-Olivo¹, Namrata Singh³ and Maria Suarez-Almazor⁴, ¹The University of Texas, MD Anderson Cancer Center, Houston, TX, ²The University of Texas MD Anderson Cancer Center, Houston, TX, ³University of Washington, Bellevue, WA, ⁴MD Anderson Cancer Center, Houston, TX
Background/Purpose: Treatment of rheumatoid arthritis (RA) in patients with cancer could potentially result in poor cancer outcomes because of immunosuppression. Adequate data for shared decision-making…
Abstract Number: 2106 • ACR Convergence 2023
Evaluation of the Construct of Constitutional Stiffness (CS) in Anti-CCP-Antibody-Positive Rheumatoid Arthritis (ACPA+RA) and Controls
Stephen Oakley¹, Samantha Stott¹, Kerri Gill¹, Chan Virgil¹, Lyanne Weston² and Theo de Malmanche¹, ¹John Hunter Hospital, New Lambton, Australia, ²Australian Red Cross Blood Service, Alexandria, Australia
Background/Purpose: The risk of developing ACPA+RA, predictors of severity and causes of excess cardiovascular disease (CVD) are incompletely understood. We have observed that RA patients…
Abstract Number: 2122 • ACR Convergence 2023
Coronary Calcium and Carotid Artery Stiffness as Predictors of Cardiovascular Events and Mortality in Patients with Rheumatoid Arthritis: A 10-year Prospective Follow-up Study
Cristina Corrales Selaya¹, Nuria Vegas Revenga², Jose Antonio Parra³, Virginia Portilla⁴, Ricardo Blanco⁵, Miguel A Gonzalez-Gay⁶, Ivan Ferraz Amaro⁷ and Alfonso Corrales⁴, ¹Hospital Universitario Marqués de Valdecilla, Santander, Spain, ²Hospital Galdakao- Usansolo, Galdakao, Spain, ³Hospital Universitario Marques de Valdecilla, Santander, Spain, ⁴Rheumatology Department, Immunopathology Group, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain, ⁵Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ⁶IDIVAL and School of Medicine, UC, Santander; Department of Rheumatology, IIS-Fundación Jiménez Díaz, Madrid, Santander, Spain, ⁷Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
Background/Purpose: The risk of mortality is increased in patients with RA compared to the general population. Different non-invasive surrogate markers of atherosclerosis have been implemented…
Abstract Number: 2138 • ACR Convergence 2023
Frailty Is a Predictor of Incident Osteoporotic Fractures in Veterans with Rheumatoid Arthritis
K Wysham¹, Hannah Brubeck², Aaron Baraff³, Punyasha Roul⁴, Namrata Singh⁵, James Andrews⁶, Grant Cannon⁷, Gary Kunkel⁸, Ted R Mikuls⁹, Bryant England⁴, Dolores Shoback¹⁰, Patti Katz¹¹, Jose Garcia¹², Ariela Orkaby¹³ and Joshua Baker¹⁴, ¹VA Puget Sound/University of Washington, Seattle, WA, ²VA Puget Sound Health Care System, Seattle, WA, ³VA Puget Sound Seattle, Seattle, WA, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵University of Washington, Bellevue, WA, ⁶University of Washington, Seattle, WA, ⁷University of Utah and Salt Lake City VA, Salt Lake City, UT, ⁸University of Utah, Salt Lake City, UT, ⁹Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, ¹⁰San Francisco VA Medical Center, San Francisco, CA, ¹¹University of California San Francisco, San Rafael, CA, ¹²VA Puget Sound Healthcare System, Seattle, WA, ¹³Veterans Affairs Boston Healthcare System & Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; VA Geriatric Research Education and Clinical Center, Boston, MA, ¹⁴University of Pennsylvania, Philadelphia, PA
Background/Purpose: Frailty occurs prematurely in RA. Levels of frailty are higher in Veteran populations than civilians1. Frailty has been shown to predict osteoporotic fractures in…
Abstract Number: 2154 • ACR Convergence 2023
Two-Year Persistence of First-Line Biological or JAK Inhibitor Treatment in Patients with Long-Standing Rheumatoid Arthritis and Failure of Triple Therapy with Synthetic DMARDs
Sebastian Ibanez Vodnizza¹, María Paz Poblete², María Francisca Valenzuela³, María Magdalena Canals², Dominga García² and Carla Jaque³, ¹Clinica Alemana de Santiago / Facultad de Medicina Universidad del Desarrollo-CAS, Santiago, Chile, ²Hospital Padre Hurtado / Facultad de Medicina Universidad del Desarrollo-CAS, Santiago, Chile, ³Hospital Padre Hurtado, Santiago, Chile
Background/Purpose: In Chile, patients with rheumatoid arthritis (RA) can apply to receive state-funded biological or JAK inhibitor treatment if they have failed (defined as a…
Abstract Number: 2171 • ACR Convergence 2023
Common IL-6 Signaling Is Inhibited by IL-6 Inhibitors and JAK Inhibitors, but Which Is Better at Preventing Bone Destruction in RA?
Yoshinobu Koyama¹, Yoshiharu Sato², Moe Tokunaga(Sakamoto)³ and Yu Nakai³, ¹Japanese Red Cross Okayama Hospital, Okayama, Japan, ²DNA Chip Research Inc, Tokyo, Japan, ³Rheumatology, Center for Autoimmune diseases, Japanese Red Cross Okayama Hospital, Okayama, Japan
Background/Purpose: To date, there are no head-to-head clinical trials directly comparing the effects between IL-6i and JAKi on bone destruction in RA. In recent years,…
Abstract Number: 2451 • ACR Convergence 2023
TET2 Clonal Hematopoiesis and Incident Rheumatoid Arthritis: Results from the UK Biobank
Karen Costenbader¹, Zhi Yu², Emily G. Oakes³, Michelle Robinette⁴, Mridul Agarwal⁵, Buu Truong⁶, Md Mesbah Uddin⁶, Alexander Bick⁷, Abhishek Niroula⁶, Daniel Solomon³ and Pradeep Natarajan⁸, ¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Broad Institute; Massachusetts General Hospital, Cambridge, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Brigham and Women's Hospital; Dana-Farber Cancer Institute, Boston, MA, ⁵Dana-Farber Cancer Institute, Boston, MA, ⁶Broad Institute, Cambridge, MA, ⁷Broad Institute; Vanderbilt University Medical Center, Nashville, TN, ⁸Broad Institute; Massachusetts General Hospital, Boston, MA
Background/Purpose: Clonal hematopoiesis (CH), the clonal expansion of somatically mutated blood cells in people without hematologic malignancy, is found in ~10% of people age ≥…
Abstract Number: 2541 • ACR Convergence 2023
Differential Responses to Initial Treatment Strategies for Rheumatoid Arthritis Among Those with Lower Body Mass and Adiposity
Joshua Baker¹, James O'Dell², Bryant England², Jon Giles³, Jefferey Newcomb⁴, Michael George¹, Geoffrey Thiele², Larry Moreland⁵, S. Louis Bridges⁶, Jeffrey R Curtis⁷ and Ted R Mikuls⁸, ¹University of Pennsylvania, Philadelphia, PA, ²University of Nebraska Medical Center, Omaha, NE, ³Columbia University, New York, NY, ⁴University of Nebraska, Omaha, NE, ⁵University of Colorado, Denver, CO, ⁶Hospital for Special Surgery, New York, NY, ⁷Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham, AL, ⁸Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: The identification of measures that help predict who is likely to benefit most from early escalation to biologic therapy would inform personalized care among…
Abstract Number: 0029 • ACR Convergence 2023
Post-translationally Modified Fibrinogen Activated Macrophages Drive the Expression of Fibrotic Genes in Human Lung Fibroblasts
Nozima Aripova¹, Michael Duryee¹, Carlos Hunter¹, Breanna Butler¹, Amy Nelson¹, Bryant England¹, James O'Dell¹, Jill Poole¹, Geoffrey Thiele¹ and Ted R Mikuls², ¹University of Nebraska Medical Center, Omaha, NE, ²Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Cellular interactions between alveolar macrophages (MΦ) and human lung fibroblasts (HLFs) contribute to excessive pro-inflammatory and pro-fibrotic responses in rheumatoid arthritis interstitial lung disease…
Abstract Number: 0094 • ACR Convergence 2023
Granzyme K Elicits a New Pathway for Complement Activation in RA Synovium
Anna Helena Jonsson¹, Carlos Donado², Erin Theisen², Dominique Jones¹, Aparna Nathan³, Fan Zhang⁴, Accelerating Medicines Partnership (AMP): RA/SLE¹, Soumya Raychaudhuri¹ and Michael Brenner², ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Harvard Medical School, Boston, MA, ⁴University of Colorado, Aurora, CO
Background/Purpose: T cells are major drivers of rheumatoid arthritis (RA) pathogenesis. While most research has focused on CD4+ T cells, we have found that CD8+…

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