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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: L04 • ACR Convergence 2020

    Influenza Adverse Events in Patients with Rheumatoid Arthritis in the Tofacitinib Clinical Program

    Kevin L Winthrop1, Arne Yndestad2, Dan Henrohn3, Hyejin Jo4, Sara Marsal5, Maria Galindo6, Annette Diehl7, Andrea B Shapiro8 and Stanley B Cohen9, 1Oregon Health & Science University, Portland, OR, 2Pfizer Inc, Oslo, Norway, 3Pfizer Inc, Sollentuna, Sweden, 4Syneos Health, Raleigh, NC, 5Vall d’Hebron Hospital, Barcelona, Spain, 6Rheumatology Unit, Hospital Universitario 12 de Octubre, Madrid, Spain, 7Pfizer Inc, Collegeville, PA, 8Pfizer Inc, Peapack, NJ, 9Metroplex Clinical Research Center, Dallas, TX

    Background/Purpose: Patients (pts) with RA have increased susceptibility to seasonal influenza and its complications.1 The COVID-19 pandemic highlights the need to understand acute respiratory RNA…
  • Abstract Number: 0033 • ACR Convergence 2020

    Pre-pregnancy Long Non-coding RNA Expression Signatures Among Women with Rheumatoid Arthritis Who Improve or Worsen During Pregnancy

    Matthew Wright1, Mette Kiel Smed2, J Lee Nelson3, Jørn Olsen4, Merete Hetland5, Vibeke Zoffmann2 and Damini Jawaheer6, 1UCSF Children's Hospital Oakland Research Institute, Oakland, CA, 2The Juliane Marie Center, Copenhagen, Denmark, 3Fred Hutchinson Cancer Res Ctr and U of WA, Seattle, WA, 4Aarhus University Hospital, Aarhus, Denmark, 5The DANBIO Registry, Rigshospitalet, Glostrup, Denmark, 6UCSF Benioff Children's Hospital Oakland Research Institute, Oakland, CA

    Background/Purpose: Pregnancy is known to have disease-modifying effects on rheumatoid arthritis (RA). A role for long non-coding (lnc) RNAs in the improvement or worsening of…
  • Abstract Number: 0105 • ACR Convergence 2020

    Use of Peripheral Quantitative Computed Tomography in the Assessment of Bone Mineral Density in Anti-TNF-treated Rheumatoid Arthritis and Ankylosing Spondylitis Patients

    Balázs Juhász1, Katalin Gulyás1, Ágnes Horváth1, Edit Végh1, Anita Pusztai2, Ágnes Szentpétery3, Zsófia Pethő1, Nóra Bodnár1, Attila Hamar1, Levente Bodoki1, Harjit Bhattoa1, Éva Szekanecz1, Katalin Hodosi1, Andrea Domján1, Szilvia Szamosi1, Csaba Horváth4, Sándor Szántó1, Gabriella Szűcs1, Hennie Raterman5, Oliver FitzGerald6 and Zoltán Szekanecz1, 1University of Debrecen, Debrecen, Hungary, 2University of Debrecen Faculty of Medicine, Department of Rheumatology, Debrecen, Hungary, 3Uppsala University Hospital, Uppsala, Sweden, 4Semmelweis University, Budapest, Hungary, 5Northwest Clinics, Alkmaar, Netherlands, 6Conway Institute for Biomolecular Research, University College Dublin, Dublin, Ireland

    Background/Purpose: Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) have both been associated with generalized and localized bone loss. Inflammatory cytokines like tumor necrosis factor (TNF)…
  • Abstract Number: 0152 • ACR Convergence 2020

    Veterans with RA and Gout Identify Their Goals and How They Can Work with Clinicians to Achieve Their Goals

    Swathi Reddy1, Aricca Van Citters2, Rashmi Arora1, Kyawt Shwin1, Lisa Johnson2, Jabeen Ahmad2, Guy Eakin3, Eugene Nelson2, Andreas Reimold1 and Salahuddin Kazi1, 1Veterans Affairs North Texas Healthcare System / UT Southwestern Medical Center, Dallas, TX, 2The Dartmouth Institute for Health Policy & Clinical Practice, Lebanon, NH, 3Arthritis Foundation, Atlanta, GA

    Background/Purpose: Understanding patient goals and concerns is essential for aligning treatment decisions with patient preferences and supporting effective patient-clinician partnerships. Yet, little is known about…
  • Abstract Number: 0187 • ACR Convergence 2020

    Regional and Widespread Patterns of Non-articular Pain Are Common at RA Diagnosis and Contribute to Poor Outcomes at 12 Months: A Prospective Study of Pain Patterns in Canadians with RA

    Vivian Bykerk1, Orit Schieir2, Marie-France Valois3, Louis Bessette4, Gilles Boire5, Glen Hazlewood6, Carol Hitchon7, Edward C Keystone8, Diane Tin9, Carter Thorne9, Janet Pope10, Susan Bartlett3 and Canadian Early Arthritis Cohort (CATCH) Investigators11, 1Hospital for Special Surgery, New York, NY, 2Canadian Early Arthritis Cohort Study, Montreal, Canada, 3McGill University, Montreal, Canada, 4Laval University, Quebec, Canada, 5Universite de Sherbrooke, Sherbrooke, Canada, 6University of Calgary, Calgary, AB, Canada, 7University of Manitoba, Winnipeg, MB, Canada, 8Mount Sinai Hospital, Toronto, ON, Canada, 9Southlake Regional Health Centre, Newmarket, ON, Canada, 10Department of Medicine, University of Western Ontario, St. Joseph's Health Centre, London, ON, Canada, 11Canadian Early Arthritis Cohort (CATCH) Study, Toronto, Canada

    Background/Purpose: Persistent pain can occur in early RA patients, despite improvement in synovitis and may be due to coexisting non-articular pain (NAP). Though NAP is…
  • Abstract Number: 0203 • ACR Convergence 2020

    Safety of Baricitinib in Patients with Rheumatoid Arthritis: Interim Report from All-Case Post‑Marketing Study in Clinical Use

    Tatsuya Atsumi1, Nami Okamoto2, Nobunori Takahashi3, Naoto Tamura4, Atsuo Nakajima5, Ayako Nakajima6, Takao Fujii7, Hiroaki Matsuno8, Yuko Takahashi9, Fumie Inui9, Naoto Tsujimoto9, Atsushi Nishikawa9, Taeko Ishii9, Tsutomu Takeuchi10, Masataka Kuwana11 and Michiaki Takagi12, 1Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine, Hokkaido University, Sapparo, Hokkaido, Japan, 2Department of Rheumatology and Allergy of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan, 3Department of Orthopaedics/Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan, 4Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Bunkyō, Tokyo, Japan, 5Ueno Touseki Clinic, Kitasaku District, Nagano, Japan, 6Center for Rheumatic Diseases, Mie University Hospital, Tsu, Mie, Japan, 7Department of Rheumatology and Clinical Immunology, Wakayama Medical University, Wakayama, Wakayama, Japan, 8Matsuno Clinic for Rheumatic Diseases, Toyama, Toyama, Japan, 9Eli Lilly, Kobe, Hyogo, Japan, 10Division of Rheumatology, Department of internal Medicine, School of Medicine, Keio University, Tokyo, Japan, 11Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Tokyo, Japan, 12Department of Orthopaedic Surgery, Yamagata University Faculty of Medicine, Yamagata, Yamagata, Japan

    Background/Purpose: To evaluate the safety of baricitinib in rheumatoid arthritis (RA) patients in clinical use.Methods: An all-case post-marketing study of baricitinib, started in September 2017,…
  • Abstract Number: 0219 • ACR Convergence 2020

    Is It Realistic to Stop Prednisone in Early Rheumatoid Arthritis? A Subanalysis from the BeSt and IMPROVED Studies

    Raquel Dos-Santos1, Sytske Anne Bergstra2, J. M. Maassen2, Thomas Huizinga2 and CF Allaart2, 1Clinical University Hospital in Santiago de Compostela, Santiago de Compostela, Galicia, Spain, 2Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Glucocorticoids are widely used in the treatment of rheumatoid arthritis (RA) patients. It is internationally recommended to taper and stop glucocorticoids as rapidly as…
  • Abstract Number: 0236 • ACR Convergence 2020

    Safety and Usability of Infliximab Administration by Auto-injector (AI) and Pre-filled Syringe (PFS) in Patients with Active Rheumatoid Arthritis (RA): Patient-reported Experience from a Multicenter, Randomized Controlled Pivotal Trial

    Rene Westhovens1, DaeHyun Yoo2, Piotr Wiland3, Marek Zawadzki4, Delina Ivanova5, Alfredo Berrocal Kasay6, Elias Chalouhi7, Eva Balázs8, SangJoon Lee9, SungHyun Kim9, JeeHye Suh9, NooRi Han9 and HoJae Lee9, 1University Hospitals Leuven, Belgium, Leuven, Belgium, 2Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, 3Medical Univeristy, Wroclaw, Poland, 4Medical Univeristy, Dpt of Rheumatology , Wroclaw, Wroclaw, Poland, 5Diagnostic-Consultative Center Aleksandrovska EOOD, Sofia, Bulgaria, 6ABK Reuma SRL, LIMA, Peru, 7Clinica Internacional Sede Lima, Lima, Peru, 8Dr. Bugyi István Hospital, Szentes, Hungary, 9Celltrion, Inc., Incheon, Republic of Korea

    Background/Purpose: The subcutaneous (SC) formulation of CT-P13 received marketing authorization for RA from the EMA by demonstrating non-inferiority compared to CT-P13 intravenous for efficacy in…
  • Abstract Number: 0480 • ACR Convergence 2020

    Impact of Targeting Remission or Low Disease Activity on 10-year Severity in Rheumatoid Arthritis : Data from ESPOIR Cohort

    Julia Dupont1, Gregory Guernec2, Yannick Degboé3, Frédéric Lioté4, Olivier Vittecoq5, Arnaud Constantin6 and Adeline Ruyssen Witrand7, 1University Hospital of Thoulouse, Toulouse, 2Inserm UMR 1027, TOULOUSE CEDEX 9, France, 3University Hospital of Toulouse, Toulouse, 4AP-HP, Paris, France, 5University Hospital of Rouen, Rouen, France, 6Rheumatology Department, Toulouse University Hospital, Toulouse, France, 7Rheumatology center, University Hospital of Toulouse, Inserm 1027, University Paul Sabatier, Toulouse, France, Toulouse, France

    Background/Purpose: The aim of rheumatoid arthritis (RA) treatment is to target remission or at least low disease activity (LDA). We previously showed that SDAI remission…
  • Abstract Number: 0567 • ACR Convergence 2020

    Rheumatologist’s Perception of the Efficacy, Safety and Willingness to Prescribe Infliximab and Use Alternate Drug Supply Programs to Lower Cost of Rheumatoid Arthritis Care

    Cesar Galan1, Alan Puric2, Guy Cozzi2, Michele Hamburger3, Elisea Avalos-Reyes4 and Kjel Johnson1, 1CVS Health, Lincoln, RI, 2CVS Health, Northbrook, IL, 3Frances Hamburger Institute, Hauppauge, NY, 4CVS Health, Irving, TX

    Background/Purpose: There is interest in employing biosimilar therapies for patients with rheumatoid arthritis (RA), which have been shown comparable to originator biologics in safety and…
  • Abstract Number: 0745 • ACR Convergence 2020

    Development of Functional Assays to Pre-qualify Human Mesenchymal Stem Cells for Rheumatoid Arthritis Treatment

    Maya Breitman1, Tracey Bonfield2, Arnold Caplan3, Hillard Lazarus4, Maricela Haghiac5, Jane Reese6 and Nora Singer1, 1The MetroHealth System, Case Western Reserve University School of Medicine, Cleveland, OH, 2National Center of Regenerative Medicine Case Western Reserve University School of Medicine, Cleveland, OH, 3Skeletal Research Center Case Western Reserve University School of Medicine, Cleveland, OH, 4Case Western Reserve University School of Medicine, Cleveland, OH, 5The MetroHealth System, Cleveland, OH, 6University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH

    Background/Purpose: Sero-positive rheumatoid arthritis (RA) is a chronic autoimmune disease that without effective treatment, leads to joint damage and disability. Not all patients respond to…
  • Abstract Number: 0762 • ACR Convergence 2020

    Anti-Protein-Arginine Deiminase (PAD) 1 IgG Is a Promising Novel Autoantigen in Rheumatoid Arthritis (RA) and Increases Diagnostic Performance in Combination with Anti-PAD4 IgG Using a Composite Biomarker Score

    Marcos Lopez-Hoyos1, Chelsea Bentow2, Andy Ishii2, Laura Martinez-Prat3 and Michael Mahler2, 1Marques de Valdecilla University Hospital-IDIVAL, Santander, Spain, 2Research and Development, Inova Diagnostics, San Diego, CA, 3Research and Development, Inova Diagnostics, Barcelona, Spain

    Background/Purpose: Over the past years, novel biomarkers have been identified in the sera of rheumatoid arthritis (RA) patients, including autoantibodies to the protein-arginine deiminase (PAD)…
  • Abstract Number: 0779 • ACR Convergence 2020

    Antibody Responses to Epstein-Barr Virus Are Altered in the Pre-Clinical Period of Rheumatoid Arthritis

    Sabrina Fechtner1, Heather Berens2, Elizabeth Bemis3, M Kristen Demoruelle2, Carla J. Guthridge4, John Harley5, Judith James6, Jess Edison7, Kevin D. Deane8, Jill Norris9 and V. Michael Holers2, 1University of Colorado, Aurora, CO, 2University of Colorado, Denver, CO, 3Colorado School of Public Health Anschutz Medical Campus, Aurora, CO, 4Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Cincinnati, OH, 6Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK, 7Walter Reed National Military Medical Center, Bethesda, 82 Division of Rheumatology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA, Colorado, 9Colorado School of Public Health, Aurora, CO

    Background/Purpose: Viral infections, including infection with Epstein-Barr virus (EBV), have been suggested as environmental risk factors for rheumatoid arthritis (RA). EBV infections are known to…
  • Abstract Number: 0796 • ACR Convergence 2020

    Development of a Tool to Assess Synovial Tissue Infiltrates and Derive Histological Pathotype in Inflammatory Arthritis: Relationship to Clinical and Ultrasound Variables

    Hayley Carr1, Ilfita Sahbudin1, Mark Maybury1, Bernard Dyke2, Jason Turner3, Nicola Gullick4, Karim Raza5, Dagmar Scheel-Toellner1 and Andrew Filer1, 1Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 2Institute of Inflammation and Ageing, University of Birmingham, Birmingham, England, United Kingdom, 3Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom, 4University Hospitals Coventry & Warwickshire, Coventry, United Kingdom, 5Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom

    Background/Purpose: Evidence suggests that histological pathotypes are linked to pathogenic mechanisms in inflammatory arthritis and may be useful as biomarkers of outcome. The frequently used…
  • Abstract Number: 0812 • ACR Convergence 2020

    Real-World Utilization of Infliximab (IFX) and Its Biosimilars in Patients (Pts) with Rheumatoid Arthritis (RA) Since the First Biosimilar Approval in the US

    Simon Helfgott1, Janna Radtchenko2, Nehad Soloman3, Kent Kwas Huston4, Jasvinder Singh5 and Colin Edgerton6, 1BWH- HMS, Boston, MA, 2Trio Health, Louisville, CO, 3Arizona Arthritis & Rheumatology Associates, P.C., Peoria, AZ, 4Kansas City Physician Partners, Kansas City, MO, 5University of Alabama at Birmingham, Birmingham, AL, 6Articularis Healthcare, Summerville, SC

    Background/Purpose: Biologics have revolutionized the treatment of autoimmune diseases, though costs and payer restrictions have limited who are treated and when these agents are used. …
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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