ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: 336 • 2012 ACR/ARHP Annual Meeting

    Preclinical Development of ALX-0061, an Anti-IL-6R Nanobody® For Therapeutic Use in Rheumatoid Arthritis with a High in Vitro Affinity and Potency and a Competitive in Vivo Pharmacological Profile

    Maarten Van Roy1, Hans Ulrichts2, Stefaan Rossenu2, Sandy Jacobs2, Sofie Poelmans3, Gert Verheyden2, Michel Vierboom4, Bert 't Hart4, Judith Baumeister1 and Josefin-Beate Holz5, 1Department of Pharmacology, Ablynx N.V., Zwijnaarde, Belgium, 2Pharmacology, Ablynx N.V., Zwijnaarde, Belgium, 3Pharmacology, Ablynx NV, Gent, Belgium, 4Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, Netherlands, 5Chief Medical Officer, Ablynx N.V., Zwijnaarde, Belgium

    Background/Purpose: Interleukin-6 (IL-6) is a pleiotropic cytokine inducing a wide range of biological activities via its receptor IL-6R. IL-6 plays an important role in the…
  • Abstract Number: 2083 • 2012 ACR/ARHP Annual Meeting

    New Treatment Approach of Rheumatoid Arthritis Based On Inhibition of Cyclin Dependent Kinase-9

    Annelie Hellvard1, Lutz Zeitlmann2, Ulrich Heiser3, André Niestroj3, Hans-Ulrich Demuth3, Jan Potempa4 and Piotr Mydel1, 1Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway, 2Ingenium Pharmaceuticals GmbH, Martinsried, Germany, 3Probiodrug AG, Halle/Saale, Germany, 4Microbiology Department, Jagiellonian University, Krakow, Poland

    Background/Purpose: Cyclin dependent kinase-9 (cdk-9) is transcription regulator of the carboxyterminal domain of RNA polymerase II. The usage of pan-cdk inhibitors such as flavopiridol has…
  • Abstract Number: 1636 • 2012 ACR/ARHP Annual Meeting

    Commensal Gut-Derived Bacteria As Therapy for Systemic Autoimmune Disease

    David Luckey1, Eric Marietta1, Harvinder S. Luthra2, Robin Patel3, Joseph A. Murray4, Ashutosh Mangalam1 and Veena Taneja1, 1Immunology, Mayo Clinic, Rochester, MN, 2Medicine/Division of Rheum, Mayo Clinic, Rochester, MN, 3Medicine, Mayo Clinic, Rochester, MN, 4Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that leads to destruction of joints. Although etiology of RA is unknown, both genetic and environmental factors…
  • Abstract Number: 823 • 2012 ACR/ARHP Annual Meeting

    Positive Effects of Tocilizumab On Bone Remodeling in Patients with Rheumatoid Arthritis

    Karine Briot1, Thierry Schaeverbeke2, Fabien Etchepare3, Philippe Gaudin4, Aleth Perdriger5, Muriel Vray6, Stephanie Rouanet7, Ghislaine Steinberg8 and Christian Roux1, 1Cochin hospital, Paris Descartes University, Paris, France, 2Service de Rhumatologie, Groupe Hospitalier Pellegrin, Bordeaux, France, 3G.H. Pitié-Salpêtrière, Paris, France, 4Rheumatology Department, CHU Hôpital Sud, Grenoble Teaching Hospital, Echirolles, France, 5Rheumatology, Hôpital Sud, Rennes, France, 6Institut Pasteur, Paris, France, 7Medical Department, Roche, Boulogne-Billancourt, France, 8Medical Department, Roche, Neuilly sur Seine, France

    Background/Purpose: The anti-IL6-R antibody tocilizumab (TCZ) is an effective treatment of rheumatoid arthritis (RA). Previous studies showed that TCZ has a positive effect on bone…
  • Abstract Number: 346 • 2012 ACR/ARHP Annual Meeting

    Sclerostin Protects Against Inflammatory Bone Loss by Regulating Tnfalpha Mediated p38-Mapkinase Activation

    Corinna Wehmeyer1, Christina Wunrau1, Athanasios Stratis1, Ina Kramer2, Michaela Kneissel2, Thomas Pap3 and Berno Dankbar1, 1Institute of Experimental Musculoskeletal Medicine (IEMM), University Hospital Muenster, Muenster, Germany, 2Novartis Institutes for Biomedical Research, CH-4056 Basel, Switzerland, 3Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany

    Background/Purpose: Progressive loss of joint structure is a hallmark of rheumatoid arthritis (RA). TNFα has been shown to promote the destruction of bone by increasing…
  • Abstract Number: 2073 • 2012 ACR/ARHP Annual Meeting

    Green Tea Epigallocatechin-3-Gallate Ameliorates Murine Arthritis by Inducing IDO Producing Dendritic Cells Via Nrf2 Antioxidant Pathway

    Soyoun Min1, Mei Yan1, Kamala Vanarsa2, Anna Bashmakov1 and Chandra Mohan1, 1Internal Medicine/Division of Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, 2Internal Medicine - Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: To examine the immunomodulatory effects and mechanisms of Green Tea (−)-epigallocatechin-3-gallate (EGCG) on experimental arthritis in mice, we investigated whether EGCG can afford therapeutic…
  • Abstract Number: 1561 • 2012 ACR/ARHP Annual Meeting

    Factors Influencing Implementation of Intensive Treatment Strategies for Early Rheumatoid Arthritis

    Sabrina Meyfroidt1, Diederik De Cock1, Kristien Van der Elst2, Laura van Hulst3, Marlies Hulscher3, Johan Joly4, Rene Westhovens5 and Patrick Verschueren5, 1Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium, 2Department of Development and Regeneration, Neuro-musculo-skeletal Research Unit, University Hospitals KULeuven, Leuven, Belgium, 3Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 4University Hospitals Leuven on behalf of the CareRA Study Group, Leuven, Belgium, 5Rheumatology, University Hospitals KULeuven, Leuven, Belgium

    Background/Purpose: Despite the availability and demonstrated effectiveness of intensive treatment strategies for early rheumatoid arthritis (RA), a discrepancy seems to exist between theoretical acceptance and…
  • Abstract Number: 772 • 2012 ACR/ARHP Annual Meeting

    Tocilizumab Monotherapy Compared with Adalimumab Monotherapy in Patients with Rheumatoid Arthritis: Results of a 24-Week Study

    Arthur Kavanaugh1, Paul Emery2, Ronald F. van Vollenhoven3, Ara H. Dikranian4, Rieke Alten5, Micki Klearman6, David Musselman7, Sunil Agarwal7, Jennifer Green8 and Cem Gabay9, 1UCSD School of Medicine, La Jolla, CA, 2Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, 3Karolinska Institute, Stockholm, Sweden, 4San Diego Arthritis Medical Clinic, San Diego, CA, 5Teaching Hospital of the Charité, University of Berlin, Berlin, Germany, 6Roche, South San Francisco, CA, 7Genentech Inc, South San Francisco, CA, 8Roche, Welwyn Garden City, United Kingdom, 9Rheumatology, Geneva University Hospitals, Geneva, Switzerland

    Background/Purpose: Approximately one-third of RA pts treated with biologics receive them as monotherapy (ie, without other DMARDs).1-3 Although tocilizumab (TCZ), an IL-6 receptor inhibitor, has…
  • Abstract Number: 349 • 2012 ACR/ARHP Annual Meeting

    Preliminary Results From a Controlled Study Assessing the Humoral Immune Response to Vaccines in Rheumatoid Arthritis Patients Treated with Tocilizumab

    Clifton O. Bingham III1, Warren C. Rizzo2, Micki Klearman3, Azra Hassanali4, Ruchi Upmanyu5 and Alan J. Kivitz6, 1Rheumatology, Johns Hopkins University, Baltimore, MD, 2Advanced Arthritis Care & Research, Scottsdale, AZ, 3Genentech Inc, South San Francisco, CA, 4Genentech Inc, San Francisco, CA, 5Roche, Welwyn Garden City, United Kingdom, 6Altoona Center for Clinical Research, Duncansville, PA

    Background/Purpose: Tocilizumab (TCZ) is an IL-6–receptor inhibitor for treatment of rheumatoid arthritis (RA) patients (pts). Because TCZ may impact how IL-6 modulates T-cell activation and…
  • Abstract Number: 2074 • 2012 ACR/ARHP Annual Meeting

    Combined Effects of a c-Fos/AP-1 Inhibitor T-5224 and Methotrexate On Collagen-Induced Arthritis in Mice

    Tomomi Date1, Yukihiko Aikawa1, Tetsuya Yamamoto1, Hirokazu Narita1, Shuichi Hirono2 and Shunichi Shiozawa3, 1Research Laboratories, Toyama Chemical Co., Ltd, Toyama, Japan, 2Department of Pharmaceutical Sciences, School of Pharmacy, Kitasato University, Tokyo, Japan, 3Department of Medicine & Rheumatology, Kyushu University Beppu Hospital, Beppu, Japan

    Background/Purpose: Activator protein-1 (AP-1) is an important transcription factor for cytokine production and joint destruction in rheumatoid arthritis (RA), and a potential target for the…
  • Abstract Number: 1302 • 2012 ACR/ARHP Annual Meeting

    Early Neutropenia Is Associated with Clinical Response in Patients Receiving Tocilizumab in Rheumatoid Arthritis

    Marie Kostine1, Thomas Barnetche2, Elodie Ardouin3, Marlene Joly4, Emilie Rabois5, Baptiste Glace Sr.6, Delphine Nigon7, Thierry Schaeverbeke8 and Christophe Richez9, 1Rheumatology, CHU Pellegrin, Bordeaux, France, 2Rheumatology, CHU Bordeaux Pellegrin, Bordeaux, France, 3Rheumatology, Limoges University Hospital, Limoges, France, 4Rheumatology, Montpellier University Hospital, Montpellier, France, 5Rheumatology, CHU Gabriel Montpied, Clermont-Ferrand, France, 6Rheumatology, Rheumatology CHU Gabriel Montpied, Clermont-Ferrand, France, 7CHU Purpan, Toulouse, France, 8Service de Rhumatologie, Groupe Hospitalier Pellegrin, Bordeaux, France, 9Hôpital Pellegrin and Université Victor Segalen Bordeaux, France

    Background/Purpose: A reduction in peripheral blood neutrophils count is usually observed with the anti-interleukin (IL) 6 receptor antibody tocilizumab. This often appears few days after…
  • Abstract Number: 470 • 2012 ACR/ARHP Annual Meeting

    Concomitant Assessment of Clinical and Ultrasound Efficacy and Safety of Tocilizumab in Patients with Moderate to Severe Rheumatoid Arthritis: The Torpedo Study

    Thierry Schaeverbeke1, Philippe Gaudin2, Aleth Perdriger3, Christian Roux4, Muriel Vray5, Stephanie Rouanet6, Ghislaine Steinberg7 and Fabien Etchepare8, 1Service de Rhumatologie, Groupe Hospitalier Pellegrin, Bordeaux, France, 2Rheumatology Department, CHU Hôpital Sud, Grenoble Teaching Hospital, Echirolles, France, 3Rheumatology, Hôpital Sud, Rennes, France, 4Rheumatology, Paris Descartes University, Paris, France, 5Institut Pasteur, Paris, France, 6Medical Department, Roche, Boulogne, France, 7Medical department, Roche, Boulogne, France, 8G.H. Pitié-Salpêtrière, Paris, France

    Background/Purpose: The anti-IL6-R tocilizumab (TCZ), indicated for the treatment of moderate to severe rheumatoid arthritis (RA), has demonstrated its clinical and structural efficacy in phase…
  • Abstract Number: 326 • 2012 ACR/ARHP Annual Meeting

    Silencing Intraarticular Snail Expression Ameliorates Rat Collagen-Induced Arthritis Through Induction of Mesenchymal-Epithelial Transition in Synovial Fibroblasts

    Chrong-Reen Wang1, Shih-Yao Chen2, Ai-Li Shiau3, Yuan-Tsung Li4, Ming-Fei Liu5 and Chao-Liang Wu2, 1Section of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 2Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, 3Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, 4Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 5Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan

    Background/Purpose: Morphological characteristics of rheumatoid arthritis (RA) synovial fibroblasts (SF) are similar to transformed cells. We hypothesized that epithelial-mesenchymal transition (EMT) of SF regulated by…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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