ACR Meeting Abstracts

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Abstracts tagged "rheumatoid arthritis"

  • Abstract Number: 988 • 2019 ACR/ARP Annual Meeting

    Translational Imaging of Treatment Effects for a Novel Anti-TNF-Steroid Antibody Drug Conjugate in a Rat Model of Rheumatoid Arthritis

    Bradley Hooker1, Xiaomeng Zhang 2, Todd Cole 2, Ann Tovcimak 2, Shaughn Bryant 3, Lucy Phillips 3, David Blanchard 2, Dustin Wooten 2, Qi Guo 2, Melanie Ruzek 3, Adrian Hobson 3, Michael McPherson 3, Robert Stoffel 3, Wendy Waegell 3 and Yanping Luo 2, 1AbbVie, North Chicago, IL, 2AbbVie, North Chicago, 3AbbVie, Worcester

    Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory joint disease of autoimmune etiology.  If insufficiently treated, RA leads to joint damage and irreversible disability.  Although there…
  • Abstract Number: 1401 • 2019 ACR/ARP Annual Meeting

    Australian Rheumatoid Arthritis (RA) Biologic Treatment Pathways: An Australian Rheumatology Association Database (ARAD) Analysis

    Ashley Fletcher 1, Marissa Lassere2, Lyn March 3, Catherine Hill 4, Claire Barrett 5, Graeme Carroll 6 and Rachelle Buchbinder 1, 1Cabrini Health/Monash University, Melbourne, Australia, 2St George Hospital, University of New South Wales, Sydney, Australia, 3University of Sydney, Sydney, Australia, 4Royal Adelaide Hospital/The University of Adelaide/The Queen Elizabeth Hospital, Adelaide, Australia, 5Redcliffe Hospital, University of Queensland, Redcliffe, Australia, 6Fiona Stanley Hospital, Perth, Australia

    Background/Purpose: To describe current biologic disease-modifying antirheumatic drug (bDMARD) treatment patterns for Australian Rheumatology Association Database (ARAD) participants with Rheumatoid Arthritis (RA) including switching and…
  • Abstract Number: 2004 • 2019 ACR/ARP Annual Meeting

    Protein Profiling and Network Enrichment Analysis in Individuals Before and After the Onset of Rheumatoid Arthritis

    Mikael Brink 1, Anders Lundquist 1, Andrey Alexeyenko 2, Kristina Lejon 1 and Solbritt Rantapää-Dahlqvist1, 1Umeå University, Umeå, Sweden, 2SciLife lab, Stockholm, Sweden

    Background/Purpose: Antibodies and up-regulated cytokines and chemokines predate the onset of symptoms of rheumatoid arthritis (RA). The aims with this study was to identify pathways…
  • Abstract Number: 2381 • 2019 ACR/ARP Annual Meeting

    Baseline Characteristics Associated with Sustained SDAI Remission Following Treatment with Abatacept in Combination with MTX Compared with Abatacept Placebo in Combination with MTX in ACPA Positive Patients with Early RA

    Paul Emery1, Yoshiya Tanaka 2, Vivian Bykerk 3, Clifton Bingham 4, Thomas Huizinga 5, Gustavo Citera 6, Kuan-Hsiang Gary Huang 7, Sean Connolly 7, Yedid Elbez 8, Karissa Lozenski 9 and Roy Fleischmann 10, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, 2University of Occupational and Environmental Health Japan, Kitakyushu, Japan, 3Hospital for Special Surgery, New York City, NY, 4Johns Hopkins University, Baltimore, MD, 5Leiden University Medical Center, Leiden, Netherlands, 6Instituto de Rehabilitación Psicofísica, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 7Bristol-Myers Squibb, Princeton, NJ, 8Excelya, Boulogne-Billancourt, France, 9Bristol-Myers Squibb, Princeton, 10Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: The Phase IIIb Assessing Very Early Rheumatoid arthritis Treatment (AVERT)-2 trial (NCT02504268) is evaluating SC abatacept (ABA) + MTX versus ABA placebo (PBO) +…
  • Abstract Number: 504 • 2019 ACR/ARP Annual Meeting

    A Subgroup Analysis of the Efficacy of Filgotinib in Demographic and Clinical Subgroups of Patients with Refractory Rheumatoid Arthritis

    Kenneth Kalunian1, Mark Genovese 2, Jacques-Eric Gottenberg 3, Beatrix Bartok 4, Alena Pechonkina 4, Ying Guo 4, Chantal Tasset 5, John Sundy 4, Kurt de Vlam 6, David Walker 7 and Tsutomu Takeuchi 8, 1Division of Rheumatology, Allergy, and Immunology, University of California San Diego, La Jolla, CA, 2Stanford University, Stanford, CA, 3Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 4Gilead Sciences, Inc., Foster City, CA, 5Galapagos NV, Mechelen, Belgium, 6Department of Rheumatology, Universitair Ziekenhuis Leuven, Leuven, Belgium, 7Northumbria Healthcare, Northumbria, United Kingdom, 8Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: RA patients who have failed biologic DMARDs represent an unmet medical need. We explored the impact of baseline demographics and clinical characteristics on filgotinib…
  • Abstract Number: 539 • 2019 ACR/ARP Annual Meeting

    A Randomized Double-Blind Study Comparing Pharmacokinetics (PK) and Pharmacodynamics (PD) of ABP 798 with Rituximab in Subjects with Moderate to Severe RA

    Gerd Burmester1, Stanley Cohen 2, David Chien 3, Vincent Chow 3 and Zhiying Pan 3, 1Charité—University Medicine Berlin, Berlin, Germany, 2Metroplex Clinical Research Center, Dallas, TX, 3Amgen, Thousand Oaks, CA

    Background/Purpose: ABP 798 is being developed as a biosimilar to rituximab, a CD20-directed cytolytic antibody that is approved in the US and EU for treatment…
  • Abstract Number: 989 • 2019 ACR/ARP Annual Meeting

    Lineage Tracing of Murine Lymphatic Smooth Muscle Cells to Determine the Role of the Lymphatic System in Inflammatory Arthritis

    H. Mark Kenney1, Richard Bell 2 and Edward Schwarz 1, 1University of Rochester, Rochester, NY, 2University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Dysfunction of lymphatic vessel contraction has been implicated in inflammatory arthritis progression and arthritic flare in murine models. Previous studies have demonstrated that tumor…
  • Abstract Number: 1404 • 2019 ACR/ARP Annual Meeting

    Treatments Patterns Among Patients with Rheumatoid Arthritis Treated with a Biologic Disease-modifying Anti-rheumatic Drug: A Nation-wide Study in Korea

    Min Jung Kim1, Anna Shin 2, Seonghwan Shin 2, You-Jung Ha 3, Yun Jong Lee 4, Eun Bong Lee 5, Yeong-Wook Song 1 and Eun Ha Kang 3, 1Seoul National University Hospital, Seoul, Republic of Korea, 2Seoul National University Bundang Hospital, Seongnam, Republic of Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, Seongnam, Republic of Korea, 4Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, 5Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, seoul

    Background/Purpose: Limited data are available on whether patients with rheumatoid arthritis (RA) are treated with conventional disease-modifying anti-rheumatic drugs (cDMARDs) according to the current recommendations…
  • Abstract Number: 2008 • 2019 ACR/ARP Annual Meeting

    Histone Lysine Methyltransferase MLL1 Regulates the Expression of Cytokines and Chemokines in Rheumatoid Arthritis Synovial Fibroblasts

    Yasuto Araki1, Keita Okamoto 1, Yoshimi Aizaki 1, Hiromi Oda 2 and Toshihide Mimura 1, 1Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 2Department of Orthopedic Surgery, Faculty of Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease that primarily affects the joints. The inflammatory process causes the activation of synovial fibroblasts (SFs) and…
  • Abstract Number: 2387 • 2019 ACR/ARP Annual Meeting

    Management of Patients with Incident Rheumatoid Arthritis in Rheumatology Clinical Practice

    isabel Hernandez Rodriguez1, Zulema Rosales Rosado 1, pia Lois 1, Cristina Lajas 1, Judit Font Urgelles 2, Juan Angel Jover Jover 1 and lydia Abasolo Alcazar 1, 1HOSPITAL CLINICO SAN CARLOS, MADRID, Spain, 2HOSPITAL CLINICO SAN CARLOS, MADRID, Madrid, Spain

    Background/Purpose: Treatment of Rheumatoid Arthritis (RA) has changed drastically in the last two decades in strategies and objectives, as well as in therapeutic options, especially…
  • Abstract Number: 507 • 2019 ACR/ARP Annual Meeting

    Inhibition of Joint Destruction in Patients with Rheumatoid Arthritis Treated with Peficitinib in Combination with Methotrexate: A Randomized, Double-Blind, Placebo-Controlled Trial in Japan

    Tsutomu Takeuchi1, Yoshiya Tanaka 2, Mitsuhiro Rokuda 3, Hiroyuki Izutsu 3, Yuichiro Kaneko 3, Musashi Fukuda 3, Daisuke Kato 3 and Désirée van der Heijde 4, 1Keio University School of Medicine, Tokyo, Japan, 2University of Occupational and Environmental Health Japan, Kitakyushu, Japan, 3Astellas Pharma, Inc., Tokyo, Japan, 4Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Peficitinib (PEF), a novel oral Janus kinase (JAK) inhibitor, has demonstrated efficacy in Phase 3 studies of patients with RA (NCT02305849).1 We report the…
  • Abstract Number: 543 • 2019 ACR/ARP Annual Meeting

    Cytokine Signaling Pathways Inhibited by Different Biologics in Rheumatoid Arthritis Patients

    Sergio Duran-Barragan1, Efrain Chavarria-Avila 1, Marisol Esesarte-Rodriguez 1, Rosal Valenzuela-Marrufo 1, Karla Arrona-Ríos 1, Jorge Aguilar-Arreola 1, Oscar Pizano Martínez 1 and Monica Vazquez-del Mercado 1, 1Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

    Background/Purpose: Different types of cells play pathogenic roles in Rheumatoid Arthritis (RA). The immunogenetics of RA suggests a key role of aberrant pathways of T…
  • Abstract Number: 991 • 2019 ACR/ARP Annual Meeting

    Identification of Citrullinated Peptide Specific T-cells in Humanized Mice Immunized with Citrullinated Peptides

    Matthew McElwee1, Thamotharampillai Dileepan 1 and Marc Jenkins 1, 1University of Minnesota, Minneapolis, MN

    Background/Purpose: Seropositive rheumatoid arthritis (RA) is a T-cell mediated disease that is characterized by the presence of antibodies to proteins that have undergone the post-translational…
  • Abstract Number: 1411 • 2019 ACR/ARP Annual Meeting

    Positivity of Anti-Ro/SSA Antibody Confer Poor Response and Persistence with Abatacept Therapy

    Yushiro Endo1, Tomohiro Koga 1, Shin-ya Kawashiri 1, Ayako Nishino 1, Momoko Okamoto 1, Shimpei Morimoto 2, Sosuke Tsuji 1, Ayuko Takatani 1, Toshimasa Shimizu 1, Remi Sumiyoshi 1, Takashi Igawa 1, Naoki Iwamoto 1, Kunihiro Ichinose 1, Mami Tamai 1, Hideki Nakamura 1, Tomoki Origuchi 3, Yukitaka Ueki 4, Tamami Yoshitama 5, Nobutaka Eiraku 6, Naoki Matsuoka 7, Akitomo Okada 8, Keita Fujikawa 9, Hiroaki Hamada 10, Tomomi Tsuru 11, Shuji Nagano 12, Yojiro Arinobu 13, Toshihiko Hidaka 14, Yoshifumi Tada 15 and Atsushi Kawakami 16, 1Nagasaki University Graduate School of Biomedical Sciences, Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki, Japan, 2Nagasaki University Hospital Clinical Research Centre, Nagasaki, Japan, 3Nagasaki University School of health sciences, Division of physical therapy, Nagasaki, Japan, 4Sasebo Chuo Hospital Rheumatic and Collagen Disease Center, Sasebo, Japan, 5Yoshitama Clinic for Rheumatic Diseases, Kirishima, Japan, 6Eiraku Clinic for Rheumatic Diseases, Kagoshima, Japan, 7Nagasaki Medical Hospital of Rheumatology, Nagasaki, Japan, 8Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan, 9JCHO Isahaya General Hospital Department of Rheumatology, Isahaya, Japan, 10Miyazaki University Hospital, Miyazaki, Japan, 11PS clinic, Fukuoka, Japan, 12Aso Iizuka Hospital, Iizuka, Japan, 13Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Fukuoka, Japan, Fukuoka, Japan, 14Zenjinkai Shimin-no-Mori Hospital, Miyazaki, Japan, 15Saga University Hospital, Saga, Japan, 16Nagasaki University Graduate School of Biomedical Sciences, Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki

    Background/Purpose: Rheumatoid arthritis (RA) occasionally overlaps Sjogren’s syndrome (SS), and RA patients with secondary SS have a higher disease activity of RA and worse joint…
  • Abstract Number: 2009 • 2019 ACR/ARP Annual Meeting

    Biomarkers Identified by Serum Inflammatory Profile Analysis to Predict Biologic Treatment Response in Rheumatoid Arthritis Patients

    Chary Lopez-Pedrera1, Nuria Barbarroja 2, Carlos Perez-Sanchez 3, Pilar Font 4, Alejandro Ibañez-Costa 1, Maria Luque-Tevar 1, Alejandra Patiño-Trives 1, Ivan Arias de la Rosa 4, Maria del Carmen Abalos-Aguilera 1, Rafaela Ortega 1, Alejandro Escudero 5, Laura Pérez-Sanchez 6, Jerusalem Calvo-Gutierrez 1, Rocío Segura-Ruiz 7, Carlos Rodriguez Escalera 8, Dolores Ruiz-Montesinos 9, Carmen Romero Barco 10, N. Mena-Vazquez 11, Julia Uceda Montañez 12, Mª Dolores Toledo Coello 13, M Angeles Aguirre 14 and Eduardo Collantes-Estevez 4, 1IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2University of Cordoba/IMIBIC/Reina Sofia Hospital and CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain, 3Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, Cordoba, Spain, 4University of Cordoba/IMIBIC/Reina Sofia Hospital, Cordoba, Spain, 5IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, 6MIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, 7Reina Sofia University Hospital/IMIBIC, Córdoba, Spain, 8Hospital Universitario de Jaén, Jaen, Spain, 9Hospital Virgen Macarena, Sevilla, 10Hospital Marítimo de Torremolinos, Málaga, Málaga, Spain, 11HU Malaga., Malaga, 12Hospital Universitario Virgen de Valme, Sevilla, Sevilla, Spain, 13Hospital Universitario de Jerez de la Frontera, Cádiz, Cádiz, Spain, 14IMIBIC/Reina Sofia Hospital/University of Cordoba,, Córdoba, Spain

    Background/Purpose: Biologic disease modifying antirheumatic drugs (b-DMARDs) have revolutionized the management of Rheumatoid Arthritis (RA). Despite this success, a high percentage of the patients undergoing…
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