ACR Meeting Abstracts

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Abstracts tagged "pulmonary"

  • Abstract Number: L10 • ACR Convergence 2021

    A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients with Rheumatoid Arthritis Interstitial Lung Disease

    joshua solomon1, Felix Woodhead2, Sonye Danoff3, Shana Haynes-Harp4, Tanvi Naik5, Cathie Spino5, Shelley Hurwitz6, Rie Maurer6, Daniel Chambers7, Martin Kolb8, Hiliary Goldberg6 and Ivan Rosas4, 1National Jewish Health, Denver, CO, 2University of Leicester, Leicester, United Kingdom, 3Johns Hopkins University, Baltimore, MD, 4Baylor College of Medicine, Houston, TX, 5University of Michigan, Ann Arbor, MI, 6Brigham and Womens Hospital, Boston, MA, 7University of Queensland, Brisbane, Australia, 8McMaster University, Hamilton, ON, Canada

    Background/Purpose: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a prevalent and morbid condition leading to premature death in 10% of those affected. The TRAIL1 trial…
  • Abstract Number: 0288 • ACR Convergence 2021

    Demographic, Lifestyle, and Clinical Risk Factors for Rheumatoid Arthritis-Associated Bronchiectasis: Role of RA-related Autoantibodies

    Gregory McDermott1, Ritu Gill2, Staci Gagne3, Suzanne Byrne3, Weixing Huang3, Lauren Prisco4, Alessandra Zaccardelli3, Lily Martin3, Nancy Shadick5, Paul Dellaripa3, Tracy Doyle6 and Jeffrey Sparks3, 1Brigham and Women's Hospital, Brookline, MA, 2Beth Israel Deaconess Medical Center, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4Brigham and Women's Hospital, Pound Ridge, MA, 5Brigham & Women's Hospital, Boston, MA, 6Brigham and Women's Hospital, West Roxbury, MA

    Background/Purpose: Bronchiectasis is a known extra-articular manifestation of rheumatoid arthritis (RA) characterized by bronchial damage and excessive mucus production that predispose patients to risk of…
  • Abstract Number: 0290 • ACR Convergence 2021

    Prevalence and Predictors of Mortality in Rheumatoid Arthritis-Related Lung Disease: Results from a Single Center Study

    Didem Sahin Eroglu1, Anil Colaklar2, Serdar Baysal3, Murat Torgutalp1, Asaf Baygul4, Serdar Sezer1, Emine Aydemir Guloksuz1, Mehmet Yuksel1, Mucteba Yayla1, Emine Uslu yurteri5, Caglar Uzun2, Ozlem Ozdemir kumbasar4, Murat Turgay1, Kinikli Gulay1 and Askin Ates1, 1Ankara University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, 2Ankara University Faculty of Medicine, Department of Radiology, Ankara, Turkey, 3Ankara University Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey, 4Ankara University Faculty of Medicine, Department of Pulmonology, Ankara, Turkey, 5Hatay Training and Research Hospital, Hatay, Turkey

    Background/Purpose: Rheumatoid arthritis-related lung disease (RA-LD) is a common manifestation of rheumatoid arthritis (RA) and associated with excess mortality. Many studies to date were focused…
  • Abstract Number: 0291 • ACR Convergence 2021

    IgA Anti-Cyclic Citrullinated Peptide Antibodies in Bronchoalveolar Lavage Fluid from Patients with Idiopathic Pulmonary Fibrosis Are Associated with Reduced Mortality

    Scott Matson1, Candace Cephers2, Timothy Wilson3, Valerie Minarchick3, Kevin Brown4, Joshua Solomon4 and Kristen Demoruelle5, 1University of Kansas, Kansas City, MO, 2St Joseph Hospital, Internal Medicine, Denver, CO, 3University of Colorado, Denver, CO, 4National Jewish Health, Denver, CO, 5University of Colorado Anschutz Medical Campus, Aurora, CO

    Background/Purpose: Idiopathic pulmonary fibrosis (IPF) is a form of interstitial lung disease (ILD) that shares many clinical features with rheumatoid arthritis (RA) associated ILD. Our…
  • Abstract Number: 0497 • ACR Convergence 2021

    Efficacy in Patient Subgroups in the INCREASE Trial, a Phase III Trial to Evaluate Inhaled Treprostinil in Patients with Pulmonary Hypertension Due to Parenchymal Lung Disease

    Victor Tapson1, Steven Nathan2, Reda Girgis3, James Runo4, Remzi Bag5, Arunabh Talwar6, Peter Smith7, Lisa Edwards7, Christine Park7 and Aaron Waxman8, 1Cedars-Sinai, Los Angeles, CA, 2Inova Fairfax, Falls Church, VA, 3Michigan State University, Lansing, MI, 4University of Wisconsin, Madison, WI, 5University of Chicago, Chicago, IL, 6Hofstra Northwell School of Medicine, Hempstead, NY, 7United Therapeutics Corporation, Durham, NC, 8Brigham and Women's Hospital, Boston, MA

    Background/Purpose: INCREASE was a 16-week trial evaluating the safety and efficacy of inhaled treprostinil (iTRE) in patients with pulmonary hypertension associated with interstitial lung disease…
  • Abstract Number: 0505 • ACR Convergence 2021

    Risk of Venous and Arterial Thromboembolism in Patients with Giant Cell Arteritis And/or Polymyalgia Rheumatica: A Veterans Health Administration Population-Based Study in the United States

    Despina Michailidou1, Tianyu Zhang2, Pavlos Stamatis3 and Bernard Ng4, 1Division of Rheumatology, University of Washington, Seattle, WA, 2Department of Biostatistics, University of Washington, Seattle, WA, 3Lund University, Lund, Sweden, 4Rheumatology Section, VA Puget Sound HCS, University of Washington, Seattle, WA

    Background/Purpose: Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two chronic systemic inflammatory diseases that primarily affect elderly women. Both diseases can be complicated…
  • Abstract Number: 1002 • ACR Convergence 2021

    Nerve and Airway-associated Tissue Resident Pulmonary Macrophages Limit Infiltration and Alter Phenotype of Infiltrating Monocytes and Fibrocytes to Reduce Pulmonary Fibrosis

    Robert Freilich1 and Kamal Khanna2, 1New York University Department of Rheumatology, New York, NY, 2New York University Department of Rheumatology & Microbiology, New York, NY

    Background/Purpose: Macrophages and monocytes are increasingly implicated in the pathogenesis of autoimmune induced pulmonary fibrosis. In addition to the well-recognized classes of tissue resident macrophages…
  • Abstract Number: 1100 • ACR Convergence 2021

    Pulmonary Arterial Hypertension in Adult-Onset Still’s Disease: A Case Series of 13 Patients

    Stéphane Mitrovic1, athénaïs Boucly2, Estibaliz Lazaro3, Nicolas SCHLEINITZ4, Coralie Bloch-Queyrat5, Christine Christides6, Jacques Pouchot7, marc humbert2, David Montani2, laurent savale2, Xavier Jaïs2, Olivier Sitbon2 and Bruno Fautrel8, 1Pitié Salpêtrière Hospital - Institut Mutaliste Montsouris, Paris, France, 2Pneumology Department, Bicêtre Hospital, Assistance Publique – Hôpitaux de Paris, Kremlin-Bicêtre, France, 3Internal Medicine Department, CHU Bordeaux, Pessac, France, 4Internal Medicine Department, Hôpital Timone, APHM, Marseille, France, 5Internal Medicine Department, Avicennes Hospital, APHP, Bobigny, France, 6Internal Medicine Department, CH Avignon, Avignon, France, 7AP-HP, RUEIL-MALMAISON, France, 8Pitié Salpêtrière Hospital, APHP, Sorbonne Université, Paris, France

    Background/Purpose: Pulmonary Arterial Hypertension (PAH) is a rare but potentially fatal complication of Adult-Onset Still's Disease (AOSD). To date, only isolated observations have been published.…
  • Abstract Number: 1370 • ACR Convergence 2021

    Complement Factor D and Factor H Represent Disease and Severity Biomarkers for Systemic Sclerosis Associated Pulmonary Arterial Hypertension (SSc-PAH)

    Roberta G Marangoni1, Changyong Feng1, Ashley Frazer-Abel2, Stephen Tomlinson3, Amy Wielgosz1, Katie Lutz4, Michael Pauciulo4, William Nichols4, V. Michael Holers5, Christopher Ritchlin6, R James White III1 and Benjamin Korman1, 1University of Rochester, Rochester, NY, 2University of Colorado Denver, Colorado, CO, 3Medical University of South Carolina, Charleston, SC, 4Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5University of Colorado, Denver, CO, 6Division of Allergy, Immunology, and Rheumatology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Pulmonary arterial hypertension (PAH) is a severe vascular complication of systemic sclerosis (SSc) and a major cause of mortality. Despite significant advances in the…
  • Abstract Number: 1379 • ACR Convergence 2021

    Serum Levels of the Soluble Receptor for Advanced Glycation Endproducts Are Prospectively Associated with Pulmonary Arterial Hypertension in Systemic Sclerosis

    Isabella Atzeni1, Yehya Al-Adwi2, Berber Doornbos-van der Meer2, Anniek Van Roon2, Caroline Roozendaal1, Andries Smit2, Alja J. Stel2, Harry Van Goor2, Tji-Joong Gan1, Johanna Westra2 and Douwe J Mulder2, 1University of Groningen, University Medical Centre Groningen, Groningen, Groningen, Netherlands, 2University of Groningen, University Medical Centre Groningen, Groningen, Netherlands

    Background/Purpose: Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) are the leading causes of death in Systemic Sclerosis (SSc). Markers for early detection of…
  • Abstract Number: 1385 • ACR Convergence 2021

    Overall Survival in Patients with Systemic Autoimmune Diseases Following Lung or Heart-Lung Transplantation at a Single High-Volume Academic Transplant Center: A Comparative Cohort Study

    Jason Melehani1, Shufeng Li2, Joshua Mooney3 and Lorinda Chung2, 1Stanford University, San Jose, CA, 2Stanford University, Palo Alto, CA, 3Stanford University, Stanford, CA

    Background/Purpose: Lung manifestations of systemic autoimmune diseases are a frequent cause of early death. For many patients, current treatments cannot arrest the inexorable progression to…
  • Abstract Number: 1386 • ACR Convergence 2021

    Measurement of TIMP-1 in Pulmonary Vessels May Be a Novel Marker of Reflecting mPAP in CTD-PH

    Shusaku Nakashima1, Kaori Ishikawa1, Kiyo Ueeda1, Tomohiro Kameda1, Hiromi Shimada1, Risa Wakiya1, Mansour mai1, Mikiya Kato1, Taichi Miyagi2, Koichi Sugihara1, Rina Semba1, Mao Mizusaki1 and Hiroaki Dobashi3, 1Kagawa University, Takamatsu, Japan, 2Kagawa University, Kidagun, Japan, 3Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan

    Background/Purpose: CTD is a disease with immune abnormalities which could alter normal cytokine profile. CTD-PH has a different pathogenesis from that of iPAH, and immunosuppressive…
  • Abstract Number: 1662 • ACR Convergence 2021

    Unrecognised, Subclinical, Structural or Functional Lung Changes in Rheumatoid Arthritis Is Associated with a Higher Risk of Developing Serious Respiratory Tract Infection

    Benjamin Worcester1, Dorothy Wang2, Susan Morton3 and Michelle Leech4, 1Monash Health, Melbourne, Australia, 2Melbourne Health, Clayton, Australia, 3Monash Health, Clayton, Australia, 4Monash Medical Centre, Australia, Australia

    Background/Purpose: The incidence of lung disease within the rheumatoid arthritis is well described and likely underestimated. Additionally, RA patients are at higher risk for developing…
  • Abstract Number: 1855 • ACR Convergence 2021

    Up-regulation of TNFα Gene in Peripheral Blood Is Useful for Predicting the Development of Exercise-induced Pulmonary Hypertension, Which Is Early Stage of Pulmonary Vascular Disease Associated with Systemic Sclerosis

    Yoshinobu Koyama1, Yoshiharu Sato2, Tatsuma Shoji2, Soichiro Fuke1, Takatsune Umayahara1 and Moe Sakamoto1, 1Japanese Red Cross Okayama Hospital, Okayama, Japan, 2DNA Chip Research Inc, Tokyo, Japan

    Background/Purpose: Pulmonary hypertension (PH) is prominent as a vascular involvement of systemic sclerosis (SSc), which remains a leading cause of death in spite of current…
  • Abstract Number: 0084 • ACR Convergence 2021

    COVID-19 Pneumonia in Two Hospitals: Similar Outcomes Despite Differential Use of Tocilizumab

    Leanna Wise1, Lauren Mathias2, Wendy Mack2, Aarya Kafi3, Yash Kothari2, Omkar Rao3 and William Stohl4, 1LAC+USC/Keck Medicine of USC, Pasadena, CA, 2University of Southern California, Los Angeles, CA, 3University of California San Diego, San Diego, CA, 4University of Southern California Keck School of Medicine, Los Angeles, CA

    Background/Purpose: A substantial number of patients with COVID-19 pneumonia develop a hyperinflammatory state. The anti-IL-6 receptor (IL-6R) mAb tocilizumab (TCZ) has been used in such…
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