ACR Meeting Abstracts

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Abstracts tagged "pulmonary"

  • Abstract Number: 0956 • ACR Convergence 2024

    Secreted Frizzled-Related Protein 2 (sFRP2) Regulates Wnt Signaling to Affect Mesenchymal Transition of Lung Epithelial Cells Participates in Interstitial Lung Disease

    Yinlan Wu1, Yanhong Li2 and Yi Liu3, 1West China Hospital of Sichuan University, Chengdu, Sichuan, China, 2West China School of Medicine and West China Hospital, Sichuan University, Cheng Du, Sichuan, China, 3West China Hospital, Sichuan University, Chengdu, China (People's Republic)

    Background/Purpose: Investigation of Transcriptional Changes in Interstitial Lung Disease (ILD) and Exploration of Functional Effects of Differential Genes and Expressed Proteins in the Development of…
  • Abstract Number: 1976 • ACR Convergence 2024

    Artificial Intelligence Analysis of HRCT Images Reflects Pulmonary Involvement in Systemic Sclerosis Interstitial Lung Disease

    Enrico De Lorenzis1, Lucy Elizabeth Thornton2, Stefano Di Donato3, Marco Minerba3, Lesley-Anne Bissell4, Riccardo Bixio5, Anand Devaraj6, Peter George7 and Francesco Del Galdo8, 1Catholic University of the Sacred Heart, Roma, Rome, Italy, 21. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2. NIHR Leeds Biomedical Research Centre, United Kingdom, Leeds, 31. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, 2. NIHR Leeds Biomedical Research Centre, United Kingdom, Leeds, United Kingdom, 4Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 5University of Verona, Verona, Verona, Italy, 6Department of Radiology, Royal Brompton Hospital, London, London, United Kingdom, 7Department of Interstitial Lung Disease, Royal Brompton Hospital London, London, United Kingdom, 8University of Leeds, Leeds, United Kingdom

    Background/Purpose: Interstitial lung disease (ILD) is the leading cause of mortality and morbidity in systemic sclerosis (SSc) patients. Current functional, imaging, and clinical measures of…
  • Abstract Number: 0253 • ACR Convergence 2024

    Outcomes of Respiratory Syncytial Virus Infection in Patients with Systemic Autoimmune Rheumatic Diseases

    Justine Enns1, Shruthi Srivatsan1, Bohang Jiang1, Miao Lin1, Emily Kowalski2, Naomi Patel1, Xiaosong Wang3, Zachary Williams1, Grace Qian3, Jennifer Hanberg1, Colebrook Johnson1, Madison Negron1, Katarina Bade2, Alene Saavedra2, Kevin Mueller2, Kathleen Vanni3, Jeffrey Sparks4 and Zachary Wallace5, 1Massachusetts General Hospital, Boston, MA, 2Brigham and Women's Hospital, Boston, MA, 3Brigham and Women’s Hospital, Boston, MA, 4Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA, 5Massachusetts General Hospital, Newton, MA

    Background/Purpose: Respiratory Syncytial Virus (RSV) can cause a severe respiratory illness, especially in older adults and those with significant comorbidities. In June 2023 the US…
  • Abstract Number: 0993 • ACR Convergence 2024

    Pulmonary Complications and Mortality Trends in Rheumatoid Arthritis Patients Aged 65 and Older in the United States: A CDC WONDER Database Analysis

    Muhammad Naveed1, Rabia Iqbal1, Kishan Patel2, Ahila Ali1, Simran Bhimani3, Bazil Azeem4, Yash Deshpande3, Muhammad Omer Rehan1, Faizan Ahmed5, Hussain Haider Shah1 and Nouman Shafique6, 1Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan, 2Riverside Community Hospital, Riverside, CA, 3The Wright Center for graduate medical education, Scranton, PA, 4Shaheed Mohtarma Benazir Bhutto Medical College Liyari, Karachi, Pakistan, 5Ameer-ud-Din Medical College, Lahore, Pakistan, 6AdventHealth Orlando, Orlando, FL

    Background/Purpose: Pulmonary complications in rheumatoid arthritis (RA) are an important cause of mortality among older adults. This study analyzes trends and demographic disparities in mortality…
  • Abstract Number: 2034 • ACR Convergence 2024

    Effectiveness and Tolerability of Tocilizumab in Systemic Autoimmune Rheumatic Disease Associated Intertistial Lung Disease

    Anne Dupont1, Clairelyne Dupin2, Esther Ebstein1, Marine Forien1, Sébastien Ottaviani1, Pierre Le Guen2, Quentin Philippot2, Raphaël Borie2, Bruno Crestani3, Philippe Dieudé1 and Pierre-Antoine Juge4, 1Departement of Rheumatology, AP-HP, Bichat Hospital, Paris, France, 2National Reference Center for Rare Pulmonary Diseases, Department of Pulmonology, AP-HP, Bichat Hospital, Paris, France, 3National Reference Center for Rare Pulmonary Diseases, Department of Pulmonology, AP-HP, Bichat Hospital, Paris, Ile-de-France, France, 4Departement of Rheumatology, AP-HP, Bichat Hospital, Boston, MA

    Background/Purpose: Interstitial lung diseases (ILD) are severe manifestations of systemic autoimmune diseases (SARD) that are associated with an increased mortality. Although the primary endpoint was not…
  • Abstract Number: 0263 • ACR Convergence 2024

    Characteristics and Coinfections of Diffuse Alveolar Hemorrhage in Rheumatic Patients

    Eduardo Briones-García1, Shaul Navarro-Lara2, Marco A Ortiz-Bustamante2, Iris Paola García Herrera3, Carla M Roman-Montes2 and Guillermo A Guaracha-Basañez4, 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Immunology and Rheumatology Department., Ciudad de México, Distrito Federal, Mexico, 2Departamento de Infectología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador-Zubirán., México city, Mexico, 3Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 4Instituto Nacional de Ciencias Medicas y Nutricion “Salvador Zubirán”, Mexico City, Distrito Federal, Mexico

    Background/Purpose: Diffuse alveolar hemorrhage (DAH) is a severe respiratory complication observed in certain rheumatic diseases, such as systemic lupus erythematosus (SLE), ANCA-associated vasculitides (AAV), and…
  • Abstract Number: 1070 • ACR Convergence 2024

    Evaluating & Improving Adherence to Pulmonary Hypertension Screening in Systemic Sclerosis Patients

    John Hickernell1 and Zineb Aouhab2, 1Loyola Univeristy Medical Center, Chicago, IL, 2Loyola University Medical Center, Oak Brook, IL

    Background/Purpose: Annual screening for pulmonary hypertension (PH) in patients with Systemic Sclerosis (SSc) has been shown to decrease mortality. The American College of Radiology, European…
  • Abstract Number: 2042 • ACR Convergence 2024

    Overview of Lung Manifestations in Sarcoidosis and Various Treatment Approaches at a University Center

    Aleeza Qamar1, Upasana Agrawal2, Karan Sachdeva3, Zara Hassan4, Alex Zamora1, Syeda Nida5, Sarwat Umer1, Samina Hayat1 and Kinza Muzaffar6, 1LSU Health-Shreveport, Shreveport, 2LSU Health, Shreveport, Shreveport, LA, 3Louisiana state university health shreveport LA, Shreveport, 4Louisiana State University Health Sciences, Shreveport, LA, 5LSU Healh-Shreveport, Shreveport, 6LSU HEALTH SHREVEPORT, SHREVEPORT, LA

    Background/Purpose: Sarcoidosis is a disease occurring in the form of non-caseating granulomas, with unclear etiology and multi-system manifestations. Pulmonary involvement in sarcoidosis is a cardinal…
  • Abstract Number: 0288 • ACR Convergence 2024

    Hypersensitivity Pneumonitis with Autoimmune Features: A New Entity?

    Pol Maymó1, Javier Narvaez-García2, Guadalupe Bermudo1, Vanesa Vicens-Zygmunt3, Santiago Bolivar4, Belen del Río5, Judith Palacios5, Martí Aguilar Coll2, Monserrat Roig Kim2, Laia De Daniel2, Paola Vidal1, Joan Miquel Nolla2 and María Molina1, 1Hospital Universtiario de Bellvitge, Barcelona, Spain, 2Hospital Universitario de Bellvitge, Barcelona, Spain, 3Hospital Universitario de Bellvitge., Barcelona, Spain, 4Bellvitge University Hospital, L'Hospitalet de Llobregat, Catalonia, Spain, 5Hospital Universtiario de Bellvitge, Hosptalet de Llobregat, Catalonia, Spain

    Background/Purpose: Hypersensitivity pneumonitis (HP) is an interstitial lung disease induced by inhaled antigens that trigger an interstitial and bronchoalveolar lymphocytic inflammatory response. This immune response…
  • Abstract Number: 1112 • ACR Convergence 2024

    Pleuroparenchymal Fibroelastosis Associated with Connective Tissue Diseases (PPFE-CTD)

    Maximiliano Diaz Menindez1, Alejandro Diaz Arumir Vergara2, Vivian Shing2, carolyn mead harvey3, Ana Zamora Martinez2 and Vivek Nagaraja4, 1Mayo Clinic School of Graduate Medical Education, Phoenix, AZ, 2Mayo Clinic, Phoenix, 3Mayo Clinic Florida, Jacksonville, FL, 4Mayo Clinic Arizona, Scottsdale, AZ

    Background/Purpose: Pleuroparenchymal Fibroelastosis (PPFE) is a rare idiopathic interstitial pneumonia characterized by fibrosis of the visceral pleura and subpleural parenchyma, predominantly affecting the upper lobes.…
  • Abstract Number: 2058 • ACR Convergence 2024

    Association of Anti-Synthetase Antibody Subtypes with Radiographic Progression of Interstitial Lung Disease in Anti-Synthetase Syndrome: An Analysis of the CLASS Project Database

    Daphne Rivero Gallegos1, Francisca Bozan2, Sangmee Bae3, Giovanni Zanframundo4, Sara Faghihi-Kashani5, Iazsmin Bauer Ventura6, Eduardo Dourado7, Gianluca sambataro8, Akira Yoshida9, Tamera J Corte10, Francesco Bonella11, Tracy J Doyle12, david fiorentino13, Miguel Angel Gonzalez-Gay14, marie Hudson15, Masataka Kuwana16, Antonella Notarnicola17, Andrew Mammen18, Neil McHugh19, Frederick Miller20, Carlomaurizio Montecucco21, Chester Oddis22, Jorge Rojas-Serrano23, Jens Schmidt24, Carlo A. Scire25, Albert Selva-O’Callaghan26, Victoria Werth27, Rohit Aggarwal28 and Lorenzo Cavagna29, and CLASS project participating investigators, 1INER, Ciudad de México, Mexico State, Mexico, 2Hospital Clinico Universidad de Chile, Santiago, Chile, 3UCLA, Los Angeles, CA, 4Università di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Milano, Italy, 5Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, San Francisco, CA, 6University of Chicago, Chicago, IL, 7Unidade Local de Saúde da Região de Aveiro, Aveiro, Portugal, 8University of Catania, Catania, Italy, 9Nippon Medical School Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan, 10Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia, 11Center for interstitial and rare lung diseases, Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany, 12Brigham and Women's Hospital, West Roxbury, MA, 13Department of Dermatology, Stanford University School of Medicine, Stanford, CA, Palo Alto, CA, 14University of Cantabria, Fundación Jimenez Díaz, Madrid, Madrid, Spain, 15McGill University, Montreal, QC, Canada, 16Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan, Tokyo, Japan, 17Karolinska University Hospital and Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, 18NIH, Bethesda, MD, 19University of Bath, Bath, United Kingdom, 20NIH, NIEHS, Chapel Hill, NC, 21IRCCS policlinico S. Matteo foundation, University of Pavia, Pavia, Italy, 22Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 23National Institute of Respiratory Diseases, Ismael Cosío Villegas, Mexico City, Mexico, 24University Medical Center Goettingen, Göttingen, Germany, 25University of Milano Bicocca, Milan, Italy, 26Systemic Autoimmune Disease Unit, Vall d’Hebron Institute of Research, Barcelona, Spain, 27University of Pennsylvania, Wynnewood, PA, 28Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA, Pittsburgh, PA, 29University of Pavia and Fondazione IRCCS Policlinico San Matteo Hospital of Pavia, Pavia, Pavia, Italy

    Background/Purpose: In anti-synthetase syndrome (ASSD), clinical presentations vary from isolated interstitial lung disease (ILD) to systemic multi-organ manifestations. Several studies emphasize the crucial role of…
  • Abstract Number: 0299 • ACR Convergence 2024

    Real-World Tolerability of Nintedanib in Connective Tissue Disease-Associated Interstitial Lung Disease

    Saloni Goyal, Briana DiSilvio and Joanna Marco, Allegheny Health Network, Pittsburgh, PA

    Background/Purpose: Nintedanib is an antifibrotic medication used to treat interstitial lung disease (ILD), including connective tissue disease-associated ILD (CTD-ILD). Clinical trials that led to its…
  • Abstract Number: 1114 • ACR Convergence 2024

    Nintedanib in Autoimmune Disease-related Interstitial Lung Disease: Real-life Effectiveness, Safety and Tolerance in a Spanish Multicenter Study

    paula pérez garcía1, Miriam Retuerto Guerrero2, yanira chuquimia mendoza3, Jesús Loarce4, Belén Atienza-Mateo5, Carolina Merino6, marina pavia pascual7, cristiana sieiro santos8, Clara Moriano9 and elvira Diez álvarez10, 1Complejo Asistencial Universitario de León, león, Spain, 2Complejo Asistencial Universitario de León, Leon, Spain, 3Complejo asistencial univeritario de león, león, Spain, 4Ramón y Cajal University Hospital, Madrid, Madrid, Spain, 5Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Cantabria, Spain, 6Hospital Universitario Puerta de Hierro Majadahonda., Majadahonda (Madrid), Spain, 7Hospital General Universitario Gregorio Marañon, madrid, Spain, 8Rheumatology Department, Complejo Asistencial Universitario de León, León, Spain, Leon, Spain, 9Hospital León, LEON, Spain, 10Complejo Asistencial Universitario de Leon, Leon

    Background/Purpose: Interstitial lung disease (ILD) is a severe complication of autoimmune diseases (AD). In recent years, new strategies for the treatment of progressive pulmonary fibrosis…
  • Abstract Number: 2059 • ACR Convergence 2024

    The Rs35705950 Promoter Variant of Muc5b Is Associated with Usual Interstitial Pneumonia in Antisynthetase Syndrome

    Daphne Rivero Gallegos1, Mayra Mejía2, Karol J. Nava-Quiroz2, Heidegger N. Mateos-Toledo3, Héctor I. Rocha-González4, Juan C. Huerta-Cruz3, Espiridion Ramos-Martínez5, Gloria Pérez-Rubio3, Ingrid Fricke-Galindo3, Jorge Rojas-Serrano6 and Ramcés Falfán-Valencia3, 1INER, Ciudad de México, Mexico State, Mexico, 2INER, Mexico, Distrito Federal, Mexico, 3INER, Mexico City, Distrito Federal, Mexico, 4Instituto Politècnico Nacional, Mexico City, Distrito Federal, Mexico, 5UNAM, Ciudad de Mexico, Distrito Federal, Mexico, 6National Institute of Respiratory Diseases, Ismael Cosío Villegas, Mexico City, Mexico

    Background/Purpose: Rs35705950 variant in the MUC5B gene promoter is a critical genetic risk factor in idiopathic pulmonary fibrosis (IPF). It has been associated with usual…
  • Abstract Number: 0308 • ACR Convergence 2024

    Interstitial Lung Disease as the First Clinical Manifestation of Connective Tissue Diseases

    Juan A. Meraz-Ostiz, Aina Puiggròs-Ferrer, Núria Bou, Irene Carrión-Barberà, Jordi Monfort, Carolina Pérez-García, Diana Badenes, Eva Balcells and Anna Pros-Simon, Hospital del Mar, Barcelona, Spain

    Background/Purpose: Interstitial lung disease (ILD) is a common complication of connective tissue diseases (CTDs), significantly influencing prognosis and mortality. The prevalence and characteristics of new…
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