Abstracts tagged "Pediatric rheumatology"

Abstract Number: 1009 • ACR Convergence 2021
Expanded B Cell-Helper T Cells in ANA+ Oligoarticular Juvenile Idiopathic Arthritis
Amelie Jule¹, Maria Taylor², Kacie Hoyt³, Kevin Wei⁴, Maria Gutierrez-Arcelus¹, Siobhan Case¹, Mia Chandler¹, Margaret Chang², Ezra Cohen¹, Fatma Dedeoglu¹, Olha Halyabar¹, Jonathan Hausmann⁵, Melissa Hazen¹, Erin Janssen¹, Jeffrey Lo², Mindy Lo¹, Esra Meidan², Jordan Roberts¹, Mary Beth Son¹, Robert Sundel², Pui Lee⁶, Talal Chatila¹, Peter Nigrovic¹, Deepak Rao⁴ and Lauren Henderson⁷, ¹Boston Children's Hospital, Boston, MA, ²Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, ³Virginia Tech Carilion School of Medicine, Roanoke, VA, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Beth Israel Deaconess Medical Center, Boston, MA, ⁶Boston Children's Hospital, Newton, MA, ⁷Division of Genetics and Genomics, Boston Children’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Oligoarticular juvenile idiopathic arthritis (oligo JIA) is defined by limited joint involvement (< 5 joints) in the first 6 months of disease. A subgroup…
Abstract Number: 1619 • ACR Convergence 2021
Where Do Multisystem Inflammatory Syndrome in Children (MIS-C) and Pediatric COVID-19 Fit Under the Cytokine Storm Syndrome Umbrella?
Randy Cron and Daniel Reiff, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Although COVID-19 has been less severe in the pediatric population, with cases more likely to be mild or asymptomatic, there remains a proportion of…
Abstract Number: 1641 • ACR Convergence 2021
Long-term Cardiovascular Disease and Mortality Following Kawasaki Disease in Childhood: A Systematic Review
Francis Lao¹, Cal Robinson², Megan Schlorff¹, Jocelyne Ewusie³, Karen Beattie¹ and Michelle Batthish¹, ¹McMaster University, Hamilton, ON, Canada, ²The Hospital for Sick Children, Hamilton, ON, Canada, ³St Joseph's Healthcare, Hamilton, ON, Canada
Background/Purpose: Kawasaki Disease (KD) is a common vasculitis of childhood, with an annual North American incidence of 20-26 per 100,000 children (< 5 years of…
Abstract Number: 0261 • ACR Convergence 2021
Methotrexate Withdrawal and Outcomes in Participants with Well-controlled Non-systemic JIA Within the CARRA Registry
Marinka Twilt¹, Kevin Baszis², Sarah Ringold³, Timothy Beukelman⁴, Anne Dennos⁵, Peter Shrader⁶ and Daniel Horton⁷, ¹Alberta Children's Hospital, Calgary, AB, Canada, ²Washington University School of Medicine, St Louis, MO, ³Seattle Children's Hospital, Seattle, WA, ⁴University of Alabama at Birmingham, Birmingham, AL, ⁵Duke University, Durham, NC, ⁶Duke Clinical Research Institute, Durham, NC, ⁷Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ
Background/Purpose: Methotrexate (MTX) is currently the recommended first-line conventional DMARD for the treatment of JIA with oligo- or polyarthritis. There are limited data on how…
Abstract Number: 0774 • ACR Convergence 2021
The Impact of Patient/Provider Discordance on Changes on Mood and Behavior in Adolescents with Systemic Lupus Erythematosus
Zanab Mian¹, Terrence Calistro², Kimberly Rapoza², Shari Berkowitz², Tamar Rubinstein³, Kathleen Kenney-Riley² and Joyce Hui-Yuen⁴, ¹Cohen Children's Medical Center, New Hyde Park, NY, ²Mercy College, Dobbs Ferry, NY, ³Albert Einstein College of Medicine, White Plains, NY, ⁴Cohen Childrens Medical Center, New Hyde Park, NY
Background/Purpose: Discordance between physicians’ and patients’ perceptions of disease severity can negatively impact treatment and disease outcomes; this has not yet been studied in children…
Abstract Number: 1010 • ACR Convergence 2021
Proton Pump Inhibitors Suppress IL-1 Mediated Carditis in a Murine Model of Kawasaki Disease
Paul Tsoukas¹, Melissa Kleinau², Lysa Langevin², Lily Morikawa³, Trang Duong¹, Suzanne Tam⁴ and Rae Yeung⁵, ¹Hospital for Sick Children, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada, ³The Hospital for Sick Children, Toronto, ON, ⁴Hospital for Sick Children, Toronto, ON, ⁵The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Kawasaki disease (KD), is the leading cause of acquired heart disease in childhood. Up to 20% of patients may develop coronary artery lesions (CAL)…
Abstract Number: 1620 • ACR Convergence 2021
Pediatric Onset (< 16 Years) Non-infectious Uveitis: Results from Spanish National Registry
Pablo Mesa-del-Castillo B.¹, Ines Yago Ugarte¹, jose Miguel Bolarin², Berta Lopez Montesinos³, Honorio Barranco Gonzalez³, Daniel Clemente⁴, Isabel Valls Ferran⁴, Juan Carlos Lopez Robledillo⁴, Beatriz Bravo⁵, Marina Rubio Prats⁵, Carmen Alba Linero⁶, Laura Martin Pedraz⁶, Esmeralda Nuñez Cuadros⁶, Maria Concepción Mir Perelló⁷, Noelia Druetta⁷, Mari Carmen Pinedo Gago⁸, Alex Fonollosa Calduch⁸, Alex Souto⁹, Fernando Lopez Lopez¹⁰, Cristina Zarallo Reales¹¹, Maria Jerez Fidalgo¹¹, Jorge Solana Fajardo¹¹, NATALIA PALMOU FONTANA¹², Rosalía Demetrio-Pablo¹³, Maria Vega Jovani Casano¹⁴, Jose Juan Mondejar Garcia¹⁵, Anahy Maria Brandy-Garcia¹⁶, Alba Garcia Lopez¹⁷, Belen Sevilla¹⁸, Jose Luis Garcia Serrano¹⁹, Alfredo Tagarro²⁰, Mar Esteban²⁰, Joan Calzada²¹, Jesus Diaz Carrascosa²¹, Cesar Gavilan Martin²², Encarna Mengual Verdu²², Ester Carreño Salas²³, Sheila Recuero Diaz²³, Neus Quilis Marti²⁴, Mari Carmen Alvarado Valero²⁵, José Rosas²⁶, Juan Luis Sanchez Sevilla²⁷, Juan Carlos Nieto²⁸, Lucia Ibares²⁸, Jaime De Inocencio²⁹, Pilar Tejada²⁹ and Almudena Roman Pascual³⁰, ¹Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, ²CENTIC (Centro tecnológico de las TICs de Murcia), Murcia, Spain, ³Hospital Universitari i Politècnic La Fe, Valencia, Spain, ⁴Hospital Infantil Universitario Niño Jesús, Madrid, Spain, ⁵Hospital Universitario Virgen de las Nieves, Granada, Spain, ⁶Hospital Universitario Regional de Málaga, Malaga, Spain, ⁷Hospital Universitari Son Espases, Palma de Mallorca, Spain, ⁸Hospital Universitario de Cruces, Bilbao, Spain, ⁹Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain, ¹⁰Hospital Clínico Universitario de Santiago, Santiago de Compostela, South Georgia & South Sandwich Islands, ¹¹Hospital Universitario de Badajoz, Badajoz, Spain, ¹²UNIVERSITARY HOSPITAL MARQUES VALDECILLA, Santander, Spain, ¹³Hospital Universitario de Marqués de Valdecilla, Santander, Spain, ¹⁴National Health system, Alicante, Spain, ¹⁵Hospital General Universitario de Alicante, Alicante, Spain, ¹⁶Hospital Germans Trias i Pujol, Badalona, Spain, ¹⁷Hospital Universitario de Cabueñes, Gijón, Spain, ¹⁸Division of Paediatrics, Hospital Universitario San Cecilio, Granada, Spain, ¹⁹Hospital Universitario Clínico San Cecilio, Granada, ²⁰Hospital Universitario Infanta Sofía, Madrid, Spain, ²¹Hospital maternoinfantil Sant Joan de Déu, Barcelona, Spain, ²²Hospital Universitario San Juan de Alicante, Alicante, Spain, ²³Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, ²⁴Hospital del Vinalopó, Elche, Spain, ²⁵Hospital del Vinalopó, Elche, ²⁶Hospital Marina Baixa, Villajoyosa, ²⁷Hospital Marina Baixa, Villajoyosa, Spain, ²⁸Hospital General Universitario Gregorio Marañón, Madrid, Spain, ²⁹Hospital Universitario 12 de Octubre, Madrid, Spain, ³⁰Hospital Universitario Rey Juan Carlos, Madrid, Spain
Background/Purpose: Pediatric noninfectious uveitis is a major clinical challenge for Pediatric ophthalmologists and rheumatologists. The burden of disease is considerable and etiological diagnosis elusive in…
Abstract Number: 1642 • ACR Convergence 2021
Baseline Body-mass-index and Risk for Obesity in Children with Rheumatic Disease on Moderate to High-dose Prednisone Therapy
Roberta Berard¹, Michael Rieder², Erkan Demirkaya², Michael Miller³ and Renee Pang², ¹London Health Sciences Centre, London, ON, Canada, ²University of Western Ontario, London, ON, Canada, ³University of Western Ontario, Children's Research Institute, London, ON, Canada
Background/Purpose: Prednisone is a glucocorticoid (GC) medication commonly used in moderate ( >7.5 mg per day) to high doses (≥ 1 mg/kg/day) for children with…
Abstract Number: 0342 • ACR Convergence 2021
RAIL Distinguishes Responder and Non-Responder in Pediatric Lupus Nephritis
Ellen Cody¹, Scott Wenderfer², Qing Ma¹, Angela Merritt¹, Prasad Devarajan¹ and Hermine Brunner¹, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Baylor College of Medicine, Houston, TX
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a diagnostic and therapeutic challenge, particularly lupus nephritis (LN). We described a composite score, the Renal Activity Index for…
Abstract Number: 0777 • ACR Convergence 2021
Potential Biomarkers of Cognitive Impairment in the Context of Childhood-Onset Systemic Lupus Erythematosus
Santiago Arciniegas¹, Sarah Mossad², Tala El Tal³, Lawrence Ng⁴, Paris Moaf⁴, Helen Branson⁴, Adrienne Davis⁴, Linda Hiraki⁴, Deborah Levy⁴, Ashley Danguecan² and Andrea Knight², ¹University of Toronto/The Hospital for Sick Children, Toronto, ON, Canada, ²Hospital for Sick Children, Toronto, ON, Canada, ³University of Toronto/Hospital for Sick Children, Toronto, ON, Canada, ⁴The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Cognitive complaints are common in children with childhood-onset systemic lupus erythematosus (cSLE), but neuropsychiatric lupus (NPSLE) remains challenging to diagnose and treat. To increase…
Abstract Number: 1012 • ACR Convergence 2021
Altered T Cell Responses, and Synergistic Regulation of Synovial Fibroblasts Function in Children with Down’s Syndrome-Associated Arthritis
Serena Foo¹, Achilleas Floudas², Aisling O' Brien¹, Sharon Ansboro¹, Ronan Mullan³, Douglas Veale⁴, Emma MacDermott⁵, Derek Deely⁶, Charlene Foley⁶, Orla Killeen⁶ and Ursula Fearon¹, ¹Trinity College Dublin, Dublin, Ireland, ²Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Ireland, ³Tallaght University Hospital, Dublin, Ireland, ⁴University College Dublin, Dublin, Ireland, ⁵Children’s Health Ireland (CHI) at Crumlin, Dublin, Ireland, ⁶Children's Health Ireland, Crumlin, Dublin, Ireland
Background/Purpose: Juvenile idiopathic arthritis (JIA) was thought to be the most common inflammatory arthritis in children. However an aggressive, erosive arthritis of little-known immunologic mechanism…
Abstract Number: 1621 • ACR Convergence 2021
Self-reported Transition Readiness of Adolescent Patients with Rheumatologic Disease: Do the Parents Agree?
Christina Ma¹, Molly Dushnicky¹, Habeba Talaat¹, Steffy Thomas¹, Karen Beattie¹, Tania Cellucci², Stephanie Garner¹, Liane Heale¹, Mark Matsos¹ and Michelle Batthish¹, ¹McMaster University, Hamilton, ON, Canada, ²McMaster Children's Hospital, Hamilton, ON, Canada
Background/Purpose: The transition from pediatric to adult rheumatology care is associated with increased disease activity and morbidity. The parent-child relationship is a significant relationship in…
Abstract Number: 1643 • ACR Convergence 2021
Increased Incidence of Pediatric SLE and Other Interferon Activated Diseases During COVID-19 Pandemic
Xinyu Dou¹, David Kaelber² and Hulya Bukulmez¹, ¹MetroHealth Medical Center, Case Western Reserve, Cleveland, OH, ²The MetroHealth System Campus of Case Western Reserve University, Cleveland, OH
Background/Purpose: COVID-19, as a member of the Coronavirus family, has been described to trigger host immune response via type I interferon (IFN) signaling pathways with…
Abstract Number: 0171 • ACR Convergence 2020
Interferon Response Gene Expression Differs in Whole Blood, Peripheral Blood Mononuclear Cells, Monocytes, T Cells, B Cells, and NK Cells in Patients with the Autoinflammatory Interferonopathies, CANDLE and SAVI
Jacob Mitchell¹, Sara Alehashemi², Bernadette Marrero³, Yan Huang⁴, Sofia Torreggiani¹, Lena Bichell¹, Gina Montealegre Sanchez⁵, Raphaela Goldbach-Mansky⁶ and Adriana de Jesus⁷, ¹Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, MD, ²Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Clarksville, MD, ³Computational Systems Biology Section/NIAID/NIH, Bethesda, MD, ⁴NIH, Bethesda, ⁵NIAID/NIH, Rockville, MD, ⁶Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Potomac, MD, ⁷Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Silver Spring, MD
Background/Purpose: The disease progression of patients (pts.) with type-I interferon (IFN)-mediated diseases undergoing treatment with JAK1 and JAK2 inhibitors is monitored in part by measuring…
Abstract Number: 0721 • ACR Convergence 2020
Validation of New Antirheumatic Drug Use as a Proxy for Increased JIA Disease Activity
Avinash Gabbeta¹, Evan Mulvihill², Timothy Beukelman³, James Lewis⁴, Carlos Rose⁵, Brian Strom⁶ and Daniel Horton⁷, ¹St. Christopher's Hospital for Children, Philadelphia, PA, ²Nemours A.I. duPont Hospital for Children, Wilmington, DE, ³University of Alabama at Birmingham, Birmingham, AL, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Nemours A.I. duPont Hospital for Children, Wilmingon, DE, ⁶Rutgers University, Newark, NJ, ⁷Rutgers University, New Brunswick, NJ
Background/Purpose: Administrative claims databases are valuable tools for studying treatment effects in large JIA populations but do not contain direct measures of disease activity, limiting…

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