Abstracts tagged "pathogenesis"

Abstract Number: 480 • 2017 ACR/ARHP Annual Meeting
ANTI-Carbamylated Protein Antibodies (CARP) in Palindromic Rheumatism: Prevalence and Clinical Significance
Raul Castellanos-Moreira Sr.¹, Virginia Ruiz-Esquide¹, María José Gomara², Sonia Cabrera-Villalba¹, Sebastian C Rodriguez-Garcia¹, Georgina Salvador³, Andrea Cuervo¹, Julio Ramírez¹, M. Victoria Hernández¹, Juan Cañete¹, Isabel Haro² and Raimon Sanmartí¹, ¹Rheumatology Service, Hospital Clínic de Barcelona, Barcelona, Spain, ²Unit of Synthesis and Biomedical Applications of Peptides, IQAC-CSIC, Barcelona, Spain, ³Hospital Universitario Mutua Terrassa, Barcelona, Spain
Background/Purpose: Autoantibodies (RF or ACPA) are found in sera from patients with palindromic rheumatism (PR) but there are no studies analyzing the presence of Anti-carbamylated…
Abstract Number: 661 • 2017 ACR/ARHP Annual Meeting
Normal Human Enthesis Contains a Resident Population of γδT-Cells
Richard Cuthbert¹, Evangelos M. Fragkakis¹, Robert Dunsmuir², Peter Giannoudis³, Elena Jones¹, Darren Newton⁴ and Dennis McGonagle¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Department of Spinal Surgery, National Health Service, Leeds, United Kingdom, ³Academic Department of Trauma and Orthopaedics, University of Leeds, Leeds, United Kingdom, ⁴Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
Background/Purpose: Recent animal studies have suggested that γδT-cells accumulate at enthesis, secrete IL-17 and are responsible for driving the spondyloarthritis (SpA) phenotype resulting from IL-23…
Abstract Number: 967 • 2017 ACR/ARHP Annual Meeting
NF-κb-Inducing Kinase Regulates LTβR-Driven NF-κb Signaling and Inflammatory Activation of Endothelium
Paulina Kucharzewska¹, Chrissta Maracle², Jan Piet van Hamburg², Kim Jeucken², Henric Olsson¹ and Sander W. Tas³, ¹Bioscience, AstraZeneca, Göteborg, Sweden, ²2Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Sites of chronic inflammation, such as rheumatoid arthritis synovial tissue, are characterized by neovascularization and often contain tertiary lymphoid structures with characteristic features of…
Abstract Number: 1412 • 2017 ACR/ARHP Annual Meeting
Yra-1909 suppresses Production of Pro-Inflammatory Mediators and MMPs through Downregulating Akt, p38, JNK and NF-κb Activation in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Hyun Jung Yoo^1,2, Jeong Yeon Kim¹, Shin Eui Kang¹, Ji Seok Yoo³, Yong Nam Lee³, Dong Goo Lee³, Ji Soo Park¹, Eun Bong Lee⁴, Eun Young Lee⁴ and Yeong Wook Song^2,5, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Korea, Republic of (South), ³Central R&D Institute, Yungjin Pharm Co., Ltd., Suwon, Korea, Suwon, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁵Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South)
Background/Purpose: Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which mediates destruction of cartilage and bone. Fibroblast-like synoviocyte (FLS) are a key component…
Abstract Number: 1713 • 2017 ACR/ARHP Annual Meeting
Defining Genetic Risk for Scleroderma Renal Crisis in RNA-Polymerase III Antibody Positive Patients
Edward Stern¹, Sandra Guerra¹, Harry Chinque¹, David Gonzalez Serna², Markella Ponticos¹, Javier Martin², Maureen D. Mayes³, Shervin Assassi⁴, Carmen Fonseca¹ and Christopher Denton⁵, ¹UCL Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, ²Instituto de Parasitología y Biomedicina López-Neyra, Granada, Spain, ³Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁴University of Texas McGovern Medical School, Houston, TX, ⁵Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom
Background/Purpose: Scleroderma renal crisis (SRC), characterised by accelerated hypertension and acute kidney injury, is a life-threatening complication of systemic sclerosis (SSc). Most SSc cases have…
Abstract Number: 1736 • 2017 ACR/ARHP Annual Meeting
Deep Immunophenotyping of T-Lymphocytes with a 37-Channel Mass Cytometry (CyTOF) Panel for the Identification of Pathological Cell Functions and the Prediction of Response to Biologic Drugs in Rheumatoid Arthritis
Ben Mulhearn^1,2,3, Darren Plant², Ann W. Morgan^4,5, Anthony G. Wilson⁶, John D Isaacs^7,8, Jane Worthington⁹, Soumya Raychaudhuri^9,10,11,12, Tracy Hussell¹, Anne Barton^13,14 and Sebastien Viatte², ¹Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, United Kingdom, ²The University of Manchester, Arthritis Research UK Centre for Genetics and Genomics, , Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Medicine, Biology and Health, Manchester, United Kingdom, ³Kellgren Centre for Rheumatology, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁴Section of Musculoskeletal Disease, NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁶UCD School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland, ⁷Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom, ⁸National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle, United Kingdom, ⁹Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ¹⁰Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹¹Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute, Harvard University, Cambridge, MA, ¹²Partners Center for Personalized Genetic Medicine, Boston, MA, ¹³Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK, Manchester, United Kingdom, ¹⁴The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom
Background/Purpose: Pathogenic immune cell types and functions have not been identified yet in rheumatoid arthritis (RA). This is explained by the impact of disease heterogeneity…
Abstract Number: 178 • 2016 ACR/ARHP Annual Meeting
Alpha-Enolase Promotes Pro-Inflammatory Phenotype of Monocytes-Derived Macrophages
Pascal Rottenberg^1,2, Manuel Fréret^1,2, Sébastien Calbo¹ and Olivier Vittecoq^1,2, ¹INSERM U905 & Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France, ²Rheumatology, Rouen University Hospital, Rouen, France
Background/Purpose: Monocytes of healthy donors were cultured with M-CSF (gcultured with ENO1, or control BSA, to investigate its effect on monocytes differentiation and macrophages polarization.…
Abstract Number: 2558 • 2016 ACR/ARHP Annual Meeting
Dissociation of the Inhibitory Apoptosis Stimulating Protein of p53 (iASPP) Binding with Transcription Factor p73 Induces Synovial Fibroblast Apoptosis in the Rheumatoid Joint
Chrong-Reen Wang¹, Shih-Yao Chen¹, Ai-Li Shiau², Ming-Fei Liu¹ and Chao-Liang Wu³, ¹Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan, ²Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, ³Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan
Background/Purpose: Apoptosis-resistant synovial fibroblasts (SFs) constitute the major cell component of pannus tissues in rheumatoid arthritis (RA). In tumor cells, the binding of inhibitory…
Abstract Number: 179 • 2016 ACR/ARHP Annual Meeting
CD11b+Gr1dimcells, Which Are Induced By GM-CSF Produced By Th17 and Group3 Innate Lymphoid Cell, May Facilitate the Progression of Pneumonitis in SKG Mice
Sho Sendo¹, Jun Saegusa¹, Takaichi Okano², Soshi Takahashi³ and Akio Morinobu¹, ¹Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ³Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Rheumatoid lung disease is a prognostic factors of rheumatoid arthritis in human. The pathogenesis and the mechanism of rheumatoid lung disease is unclear. Zymosan…
Abstract Number: 2560 • 2016 ACR/ARHP Annual Meeting
Sputum Antibody to Malondialdehyde-Acetaldehyde Adduct in Subjects with Established Rheumatoid Arthritis
Bryant R. England^1,2, Peter Maloley³, Eric Daubach³, Michael J. Duryee⁴, M. Kristen Demoruelle⁵, Kevin D. Deane⁵, Geoffrey M. Thiele⁶ and Ted R Mikuls⁶, ¹Division of Rheumatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ²VA Nebraska-Western Iowa, Omaha, NE, ³University of Nebraska Medical Center, Omaha, NE, ⁴Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁵Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁶Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Anti-malondialdehyde-acetaldehyde adduct (MAA) antibodies target immunogenic products of oxidative stress, are detected in higher concentration in paired synovial fluid vs serum in RA, and…
Abstract Number: 488 • 2016 ACR/ARHP Annual Meeting
Exploring the Association Between Air Pollutant Exposure and Seropositivity in Rheumatoid Arthritis
Asha Mariam Alex^1,2, Gary A. Kunkel³, Jorge Flautero Arcos⁴, Richard Amdur⁵ and Gail S. Kerr⁶, ¹Rheumatology, Veterans Affairs Medical Center, Washington, DC, ²Rheumatology, Georgetown University Hospital, Washington, DC, ³Division of Rheumatology, George Wahlen VA Medical Center/University of Utah, Salt Lake City, UT, ⁴Rheumatology, Howard University Hospital, Washington, DC, ⁵Lead Biostatistician, Medical Faculty Associates Clinical Professor, Dept. of Surgery, George Washington University School of Medicine & Health Sciences, Washington, DC, ⁶Washington DC VAMC, Georgetown University Hospital, Howard University Hospital, Washington, DC
Background/Purpose: The etiology of rheumatoid arthritis (RA) is multi-factorial, with expression of HLA-DRB1 shared epitope (SE), smoking and socioeconomic status (SES) exerting influence. Prior studies…
Abstract Number: 2562 • 2016 ACR/ARHP Annual Meeting
Human Seroreactivity to Gut Microbiota Antigens in Rheumatoid Arthritis and Controls-Lack of Association with Rheumatoid Arthritis Autoantibodies
Carol Hitchon¹, Charles O. Elson², David Robinson³, Irene Smolik³ and Hani S. El-Gabalawy¹, ¹University of Manitoba, Winnipeg, MB, Canada, ²Dept of Medicine, University of Alabama at Birmingham, Birmingham, AL, ³Arthritis Center, University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: The human gut microbiome maintains normal immune homeostasis. Changes to the microbiota evolve with aging and have been implicated in the development of autoimmune…
Abstract Number: 568 • 2016 ACR/ARHP Annual Meeting
Triggering Receptor Expressed on Myeloid Cells (TREM) As a Novel Indicator of Disease Progression in ‘at-Risk’ Individuals
Laura Hunt¹, Sahar Musaad^1,2, John Stephenson³, Becki Burn², Isao Matsuura¹, Kulveer Mankia¹, Jackie L. Nam¹ and Paul Emery¹, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Microbiology, Calderdale & Huddersfield NHS Foundation Trust, Huddersfield, United Kingdom, ³Department Health Sciences, University of Huddersfield, Huddersfield, United Kingdom
Background/Purpose: Whilst the exact aetiology of rheumatoid arthritis (RA) remains unclear, current concepts suggest an environmental link with possible microbial triggers. Studying individuals at-risk of…
Abstract Number: 2578 • 2016 ACR/ARHP Annual Meeting
Plasma Levels of Bone Morphogenetic Protein (BMP) Subgroups and Their Inhibitors (noggin, sclerostin) in Rheumatoid Arthritis Patients and Correlation with Disease Activity, Clinical and Radiographic Progression
Ozge Kockara¹, Merve Sibel Gungoren², Erdem Karabulut³, Sebnem Ataman⁴ and Filiz Akbiyik², ¹Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey, ²Medical Biochemistry, Hacettepe University Faculty of Medicine, Ankara, Turkey, ³Biostatistics, Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁴Rheumatology Department, Ankara University Faculty of Medicine, Ankara, Turkey
Background/Purpose: Progressive bone destruction occurs in rheumatoid arthritis (RA) due to imbalance of osteoblast/osteoclast activity. Bone morphogenetic proteins (BMPs) regenerate bone damage by stimulating the…
Abstract Number: 570 • 2016 ACR/ARHP Annual Meeting
A Molecular Timeline for Preclinical RA Pathogenesis Defined By Dysregulated PTPN22, Hypercitrullination, and Aberrant Cytokine/Metabolic Profiles in PBMC of at-Risk Individuals
Hui-Hsin Chang¹, Nishant Dwivedi², Bo Sun², Deepak A. Rao³, Jeffrey A. Sparks³, Jennifer Kinslow⁴, Yuko Okamoto⁴, Kevin D. Deane⁵, M. Kristen Demoruelle⁶, Jill M. Norris⁷, Elizabeth Karlson², V. Michael Holers⁸ and I-Cheng Ho¹, ¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁴University of Colorado School of Medicine, Aurora, CO, ⁵Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁶Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁷Epidemiology, Colorado School of Public Health, Aurora, CO, ⁸Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: One unique feature of RA is the presence of ACPA. PTPN22 is a phosphatase that also acts to suppress citrullination independently of its phosphatase…