ACR Meeting Abstracts

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Abstracts tagged "pathogenesis"

  • Abstract Number: 2435 • 2017 ACR/ARHP Annual Meeting

    Circulating Mirnas As Potential Biomarkers of Cardiovascular Disease in Rheumatoid Arthritis Patients

    Chary Lopez-Pedrera1, Nuria Barbarroja1, Patricia Ruiz-Limon2, Ivan Arias de la Rosa2, Maria Carmen Abalos-Aguilera2, Yolanda Jiménez-Gómez1, Rafaela Ortega-Castro1, Eduardo Collantes-Estévez1, Alejandro Escudero-Contreras2, Raquel Lopez-Mejías3, Miguel Angel González-Gay3 and Carlos Perez-Sanchez1, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain

    Background/Purpose: Extracellular microRNAs, circulating in the bloodstream and extracellular space, have been proposed as attractive candidates as both diagnostic and prognostic biomarkers in various diseases,…
  • Abstract Number: 78 • 2017 ACR/ARHP Annual Meeting

    IL-37 Is Associated with Increased Atherogenesis in Patients with Rheumatoid Arthritis

    Barbora Sumova1,2, Tereza Lennerova1,2, Lucie Andres Cerezo1, Hana Hulejova1, Romana Jandova1, Karel Pavelka1,2, Jiri Vencovsky1,2 and Ladislav Senolt1,2, 1Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 2Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Interleukin-37 (IL-37) is one of few anti-inflammatory cytokines belonging to the IL-1 cytokine family. It is mainly produced by immune cells of innate immunity…
  • Abstract Number: 480 • 2017 ACR/ARHP Annual Meeting

    ANTI-Carbamylated Protein Antibodies (CARP) in Palindromic Rheumatism: Prevalence and Clinical Significance

    Raul Castellanos-Moreira Sr.1, Virginia Ruiz-Esquide1, María José Gomara2, Sonia Cabrera-Villalba1, Sebastian C Rodriguez-Garcia1, Georgina Salvador3, Andrea Cuervo1, Julio Ramírez1, M. Victoria Hernández1, Juan Cañete1, Isabel Haro2 and Raimon Sanmartí1, 1Rheumatology Service, Hospital Clínic de Barcelona, Barcelona, Spain, 2Unit of Synthesis and Biomedical Applications of Peptides, IQAC-CSIC, Barcelona, Spain, 3Hospital Universitario Mutua Terrassa, Barcelona, Spain

    Background/Purpose: Autoantibodies (RF or ACPA) are found in sera from patients with palindromic rheumatism (PR) but there are no studies analyzing the presence of Anti-carbamylated…
  • Abstract Number: 661 • 2017 ACR/ARHP Annual Meeting

    Normal Human Enthesis Contains a Resident Population of γδT-Cells

    Richard Cuthbert1, Evangelos M. Fragkakis1, Robert Dunsmuir2, Peter Giannoudis3, Elena Jones1, Darren Newton4 and Dennis McGonagle1, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2Department of Spinal Surgery, National Health Service, Leeds, United Kingdom, 3Academic Department of Trauma and Orthopaedics, University of Leeds, Leeds, United Kingdom, 4Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Recent animal studies have suggested that γδT-cells accumulate at enthesis, secrete IL-17 and are responsible for driving the spondyloarthritis (SpA) phenotype resulting from IL-23…
  • Abstract Number: 967 • 2017 ACR/ARHP Annual Meeting

    NF-κb-Inducing Kinase Regulates LTβR-Driven NF-κb Signaling and Inflammatory Activation of Endothelium

    Paulina Kucharzewska1, Chrissta Maracle2, Jan Piet van Hamburg2, Kim Jeucken2, Henric Olsson1 and Sander W. Tas3, 1Bioscience, AstraZeneca, Göteborg, Sweden, 22Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: Sites of chronic inflammation, such as rheumatoid arthritis synovial tissue, are characterized by neovascularization and often contain tertiary lymphoid structures with characteristic features of…
  • Abstract Number: 1412 • 2017 ACR/ARHP Annual Meeting

    Yra-1909 suppresses Production of Pro-Inflammatory Mediators and MMPs through Downregulating Akt, p38, JNK and NF-κb Activation in Rheumatoid Arthritis Fibroblast-like Synoviocytes

    Hyun Jung Yoo1,2, Jeong Yeon Kim1, Shin Eui Kang1, Ji Seok Yoo3, Yong Nam Lee3, Dong Goo Lee3, Ji Soo Park1, Eun Bong Lee4, Eun Young Lee4 and Yeong Wook Song2,5, 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, Seoul, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Korea, Republic of (South), 3Central R&D Institute, Yungjin Pharm Co., Ltd., Suwon, Korea, Suwon, Korea, Republic of (South), 4Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), 5Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South)

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which mediates destruction of cartilage and bone. Fibroblast-like synoviocyte (FLS) are a key component…
  • Abstract Number: 1713 • 2017 ACR/ARHP Annual Meeting

    Defining Genetic Risk for Scleroderma Renal Crisis in RNA-Polymerase III Antibody Positive Patients

    Edward Stern1, Sandra Guerra1, Harry Chinque1, David Gonzalez Serna2, Markella Ponticos1, Javier Martin2, Maureen D. Mayes3, Shervin Assassi4, Carmen Fonseca1 and Christopher Denton5, 1UCL Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, 2Instituto de Parasitología y Biomedicina López-Neyra, Granada, Spain, 3Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 4University of Texas McGovern Medical School, Houston, TX, 5Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom

    Background/Purpose: Scleroderma renal crisis (SRC), characterised by accelerated hypertension and acute kidney injury, is a life-threatening complication of systemic sclerosis (SSc). Most SSc cases have…
  • Abstract Number: 2417 • 2016 ACR/ARHP Annual Meeting

    High Dimensional Interrogation of the T Cell Immunome in Polyarticular Juvenile Idiopathic Arthritis Patients 

    Jing Yao Leong1, Justin Tiong2, Joo Guan Yeo2,3, Liyun Lai1, Phyllis Chen3, Loshinidevi D/O Thana Bathi3, Thaschawee Arkachaisri2, Daniel J Lovell4 and Salvatore Albani1,5, 1SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, 2Rheumatology and Immunology, KK Women's and Children's Hospital, Singapore, Singapore, 3Singhealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, 4PRCSG Cincinnati Children's Hospital Medical Center, Cinncinnati, OH, 5Duke-National University of Singapore Medical School, Singapore, Singapore

    Background/Purpose: Clinical management of polyarticular JIA with anti-TNF-alpha has been met with moderate success, with up to 50% of patients demonstrating clinically meaningful efficacy. Concerns…
  • Abstract Number: 178 • 2016 ACR/ARHP Annual Meeting

    Alpha-Enolase Promotes Pro-Inflammatory Phenotype of Monocytes-Derived Macrophages

    Pascal Rottenberg1,2, Manuel Fréret1,2, Sébastien Calbo1 and Olivier Vittecoq1,2, 1INSERM U905 & Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France, 2Rheumatology, Rouen University Hospital, Rouen, France

    Background/Purpose:  Monocytes of healthy donors were cultured with M-CSF (gcultured with ENO1, or control BSA, to investigate its effect on monocytes differentiation and macrophages polarization.…
  • Abstract Number: 2558 • 2016 ACR/ARHP Annual Meeting

    Dissociation of the Inhibitory Apoptosis Stimulating Protein of p53 (iASPP) Binding with Transcription Factor p73 Induces Synovial Fibroblast Apoptosis in the Rheumatoid Joint

    Chrong-Reen Wang1, Shih-Yao Chen1, Ai-Li Shiau2, Ming-Fei Liu1 and Chao-Liang Wu3, 1Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan, 2Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, 3Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan

    Background/Purpose:   Apoptosis-resistant synovial fibroblasts (SFs) constitute the major cell component of pannus tissues in rheumatoid arthritis (RA). In tumor cells, the binding of inhibitory…
  • Abstract Number: 179 • 2016 ACR/ARHP Annual Meeting

    CD11b+Gr1dimcells, Which Are Induced By GM-CSF Produced By Th17 and Group3 Innate Lymphoid Cell, May Facilitate the Progression of Pneumonitis in SKG Mice

    Sho Sendo1, Jun Saegusa1, Takaichi Okano2, Soshi Takahashi3 and Akio Morinobu1, 1Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 2Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 3Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: Rheumatoid lung disease is a prognostic factors of rheumatoid arthritis in human. The pathogenesis and the mechanism of rheumatoid lung disease is unclear. Zymosan…
  • Abstract Number: 2560 • 2016 ACR/ARHP Annual Meeting

    Sputum Antibody to Malondialdehyde-Acetaldehyde Adduct in Subjects with Established Rheumatoid Arthritis

    Bryant R. England1,2, Peter Maloley3, Eric Daubach3, Michael J. Duryee4, M. Kristen Demoruelle5, Kevin D. Deane5, Geoffrey M. Thiele6 and Ted R Mikuls6, 1Division of Rheumatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 2VA Nebraska-Western Iowa, Omaha, NE, 3University of Nebraska Medical Center, Omaha, NE, 4Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 5Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 6Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Anti-malondialdehyde-acetaldehyde adduct (MAA) antibodies target immunogenic products of oxidative stress, are detected in higher concentration in paired synovial fluid vs serum in RA, and…
  • Abstract Number: 488 • 2016 ACR/ARHP Annual Meeting

    Exploring the Association Between Air Pollutant Exposure and Seropositivity in Rheumatoid Arthritis

    Asha Mariam Alex1,2, Gary A. Kunkel3, Jorge Flautero Arcos4, Richard Amdur5 and Gail S. Kerr6, 1Rheumatology, Veterans Affairs Medical Center, Washington, DC, 2Rheumatology, Georgetown University Hospital, Washington, DC, 3Division of Rheumatology, George Wahlen VA Medical Center/University of Utah, Salt Lake City, UT, 4Rheumatology, Howard University Hospital, Washington, DC, 5Lead Biostatistician, Medical Faculty Associates Clinical Professor, Dept. of Surgery, George Washington University School of Medicine & Health Sciences, Washington, DC, 6Washington DC VAMC, Georgetown University Hospital, Howard University Hospital, Washington, DC

    Background/Purpose: The etiology of rheumatoid arthritis (RA) is multi-factorial, with expression of HLA-DRB1 shared epitope (SE), smoking and socioeconomic status (SES) exerting influence. Prior studies…
  • Abstract Number: 2562 • 2016 ACR/ARHP Annual Meeting

    Human Seroreactivity to Gut Microbiota Antigens in Rheumatoid Arthritis and Controls-Lack of Association with Rheumatoid Arthritis Autoantibodies

    Carol Hitchon1, Charles O. Elson2, David Robinson3, Irene Smolik3 and Hani S. El-Gabalawy1, 1University of Manitoba, Winnipeg, MB, Canada, 2Dept of Medicine, University of Alabama at Birmingham, Birmingham, AL, 3Arthritis Center, University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: The human gut microbiome maintains normal immune homeostasis. Changes to the microbiota evolve with aging and have been implicated in the development of autoimmune…
  • Abstract Number: 568 • 2016 ACR/ARHP Annual Meeting

    Triggering Receptor Expressed on Myeloid Cells (TREM) As a Novel Indicator of Disease Progression in ‘at-Risk’ Individuals

    Laura Hunt1, Sahar Musaad1,2, John Stephenson3, Becki Burn2, Isao Matsuura1, Kulveer Mankia1, Jackie L. Nam1 and Paul Emery1, 1NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2Microbiology, Calderdale & Huddersfield NHS Foundation Trust, Huddersfield, United Kingdom, 3Department Health Sciences, University of Huddersfield, Huddersfield, United Kingdom

    Background/Purpose: Whilst the exact aetiology of rheumatoid arthritis (RA) remains unclear, current concepts suggest an environmental link with possible microbial triggers.  Studying individuals at-risk of…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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