ACR Meeting Abstracts

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Abstracts tagged "pathogenesis"

  • Abstract Number: 1412 • 2017 ACR/ARHP Annual Meeting

    Yra-1909 suppresses Production of Pro-Inflammatory Mediators and MMPs through Downregulating Akt, p38, JNK and NF-κb Activation in Rheumatoid Arthritis Fibroblast-like Synoviocytes

    Hyun Jung Yoo1,2, Jeong Yeon Kim1, Shin Eui Kang1, Ji Seok Yoo3, Yong Nam Lee3, Dong Goo Lee3, Ji Soo Park1, Eun Bong Lee4, Eun Young Lee4 and Yeong Wook Song2,5, 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, Seoul, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Korea, Republic of (South), 3Central R&D Institute, Yungjin Pharm Co., Ltd., Suwon, Korea, Suwon, Korea, Republic of (South), 4Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), 5Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South)

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which mediates destruction of cartilage and bone. Fibroblast-like synoviocyte (FLS) are a key component…
  • Abstract Number: 1713 • 2017 ACR/ARHP Annual Meeting

    Defining Genetic Risk for Scleroderma Renal Crisis in RNA-Polymerase III Antibody Positive Patients

    Edward Stern1, Sandra Guerra1, Harry Chinque1, David Gonzalez Serna2, Markella Ponticos1, Javier Martin2, Maureen D. Mayes3, Shervin Assassi4, Carmen Fonseca1 and Christopher Denton5, 1UCL Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, 2Instituto de Parasitología y Biomedicina López-Neyra, Granada, Spain, 3Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 4University of Texas McGovern Medical School, Houston, TX, 5Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom

    Background/Purpose: Scleroderma renal crisis (SRC), characterised by accelerated hypertension and acute kidney injury, is a life-threatening complication of systemic sclerosis (SSc). Most SSc cases have…
  • Abstract Number: 1736 • 2017 ACR/ARHP Annual Meeting

    Deep Immunophenotyping of T-Lymphocytes with a 37-Channel Mass Cytometry (CyTOF) Panel for the Identification of Pathological Cell Functions and the Prediction of Response to Biologic Drugs in Rheumatoid Arthritis

    Ben Mulhearn1,2,3, Darren Plant2, Ann W. Morgan4,5, Anthony G. Wilson6, John D Isaacs7,8, Jane Worthington9, Soumya Raychaudhuri9,10,11,12, Tracy Hussell1, Anne Barton13,14 and Sebastien Viatte2, 1Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, United Kingdom, 2The University of Manchester, Arthritis Research UK Centre for Genetics and Genomics, , Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Medicine, Biology and Health, Manchester, United Kingdom, 3Kellgren Centre for Rheumatology, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, 4Section of Musculoskeletal Disease, NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom, 5Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 6UCD School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland, 7Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom, 8National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle, United Kingdom, 9Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 10Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 11Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute, Harvard University, Cambridge, MA, 12Partners Center for Personalized Genetic Medicine, Boston, MA, 13Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK, Manchester, United Kingdom, 14The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom

    Background/Purpose: Pathogenic immune cell types and functions have not been identified yet in rheumatoid arthritis (RA). This is explained by the impact of disease heterogeneity…
  • Abstract Number: 1902 • 2017 ACR/ARHP Annual Meeting

    A Pattern of Higher Serum Levels of IL-10 and MMP-3, Along with Lower IL-6R, Identify RA Patients with Interstitial Lung Disease

    Jon T. Giles1, Cheilonda Johnson2, Elana J. Bernstein3, Erika Darrah4, Felipe Andrade5 and Sonye K. Danoff6, 1Division of Rheumatology, Columbia University, College of Physicians and Surgeons, New York, NY, 2Medicine/Pulmonology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Rheumatology, Columbia University, New York, NY, 4Department of Medicine/Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, 5Medicine/Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 6Medicine, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: The pathogenesis and prediction of RA-associated interstitial lung disease (ILD), an extra-articular manifestation with high morbidity and mortality, is poorly understood.  We explored the…
  • Abstract Number: 2435 • 2017 ACR/ARHP Annual Meeting

    Circulating Mirnas As Potential Biomarkers of Cardiovascular Disease in Rheumatoid Arthritis Patients

    Chary Lopez-Pedrera1, Nuria Barbarroja1, Patricia Ruiz-Limon2, Ivan Arias de la Rosa2, Maria Carmen Abalos-Aguilera2, Yolanda Jiménez-Gómez1, Rafaela Ortega-Castro1, Eduardo Collantes-Estévez1, Alejandro Escudero-Contreras2, Raquel Lopez-Mejías3, Miguel Angel González-Gay3 and Carlos Perez-Sanchez1, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain

    Background/Purpose: Extracellular microRNAs, circulating in the bloodstream and extracellular space, have been proposed as attractive candidates as both diagnostic and prognostic biomarkers in various diseases,…
  • Abstract Number: 78 • 2017 ACR/ARHP Annual Meeting

    IL-37 Is Associated with Increased Atherogenesis in Patients with Rheumatoid Arthritis

    Barbora Sumova1,2, Tereza Lennerova1,2, Lucie Andres Cerezo1, Hana Hulejova1, Romana Jandova1, Karel Pavelka1,2, Jiri Vencovsky1,2 and Ladislav Senolt1,2, 1Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 2Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Interleukin-37 (IL-37) is one of few anti-inflammatory cytokines belonging to the IL-1 cytokine family. It is mainly produced by immune cells of innate immunity…
  • Abstract Number: 480 • 2017 ACR/ARHP Annual Meeting

    ANTI-Carbamylated Protein Antibodies (CARP) in Palindromic Rheumatism: Prevalence and Clinical Significance

    Raul Castellanos-Moreira Sr.1, Virginia Ruiz-Esquide1, María José Gomara2, Sonia Cabrera-Villalba1, Sebastian C Rodriguez-Garcia1, Georgina Salvador3, Andrea Cuervo1, Julio Ramírez1, M. Victoria Hernández1, Juan Cañete1, Isabel Haro2 and Raimon Sanmartí1, 1Rheumatology Service, Hospital Clínic de Barcelona, Barcelona, Spain, 2Unit of Synthesis and Biomedical Applications of Peptides, IQAC-CSIC, Barcelona, Spain, 3Hospital Universitario Mutua Terrassa, Barcelona, Spain

    Background/Purpose: Autoantibodies (RF or ACPA) are found in sera from patients with palindromic rheumatism (PR) but there are no studies analyzing the presence of Anti-carbamylated…
  • Abstract Number: 1213 • 2016 ACR/ARHP Annual Meeting

    Targeted Next-Generation Sequencing of 128 Genes Associated with Rheumatoid Arthritis

    Khai Pang Leong1, Liuh Ling Goh2, Edward Yu Wing Chee2, Petrina Pei Qin Lim2, Grace Li-Xian Toh2, Ee Tzun Koh3 and Tan Tock Seng Hospital Rheumatoid Arthritis Study Group, 1Rheumatology/Allerg/Immunology, Tan Tock Seng Hospital, Singapore, Singapore, 2Clinical Research & Innovation Office, Tan Tock Seng Hospital, Singapore, Singapore, 3Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore

    Background/Purpose: Through genome-wide association scans (GWAS), more than 120 genes have been found to be associated with rheumatoid arthritis (RA). This study aims to search…
  • Abstract Number: 1247 • 2016 ACR/ARHP Annual Meeting

    Diagnostic Modeling of Rheumatoid Arthritis in Oklahoma Tribal Members Using Soluble Mediators

    Lucas Adams1, Carla J. Guthridge1, Tim Gross1, Hua Chen1, Krista M. Bean1, Virginia C. Roberts1, Julie M. Robertson2, Melissa E. Munroe1, Joel M. Guthridge3, Roger Montgomery4, M. Sohail Khan4, Fabio Mota5, Michael Peercy6, Bobby Saunkeah7 and Judith A. James8,9, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Acelity, San Antonio, TX, 3Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Cherokee Nation Health Services, Tahlequah, OK, 5Chickasaw Nation Medical Center, Ada, OK, 6Epidemiology, Chickasaw Nation Department of Health, Ada, OK, 7Chickasaw Nation Department of Health, Ada, OK, 8Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 9Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Diagnosis of RA is difficult in American Indian (AI) patients who often have atypical autoantibodies (e.g. ANA) with erosive arthritis. Soluble mediators may serve…
  • Abstract Number: 1572 • 2016 ACR/ARHP Annual Meeting

    Relationship Between KDR (VEGFR2) Gene Polymorphisms and Serum KDR Protein Levels in Patients with Rheumatoid Arthritis

    Agnieszka Paradowska-Gorycka1, Barbara Stypinska2, Andrzej Pawlik3, Damian Malinowski3, Katarzyna Romanowska-Próchnicka4, Ewa Haladyj5, Malgorzata Manczak6 and Marzena Olesinska7, 1Department of Biochemistry and Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland, 2Department of Biochemistry and Molecular Biology, National Institute of geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland, 3Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland, 4Department of Pathophysiology, Medical University of Warsaw and Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland, 5Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland, 6Department of Epidemiology and Health Promotion, National Institute of geriatrics, Rheumatology and Rehabilitation,, Warsaw, Poland, 7Department of Connective Tissue Disease, National Institute of Geriatrics, Rheumatology and Rehabilitation,, Warsaw, Poland

    Background/Purpose:  Rheumatoid arthritis (RA) is one of the chronic autoimmune diseases, with genetic and environmental predisposition, and synovial angiogenesis is considered to be a notable…
  • Abstract Number: 1658 • 2016 ACR/ARHP Annual Meeting

    Regulatory Role of  the IL-9/IL-9R System  on Pannus Formation in Psoriatic Arthritis

    Siba P. Raychaudhuri1,2 and Smriti K. Raychaudhuri3, 1Davis, CA, 2Rheumatology, Univ of California, Davis & VAMC Sacramento, Davis, CA, 3Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA

        Background/Purpose:  Earlier we have reported that synovial tissues of psoriatic arthritis (PsA) and rheumatoid arthritis (RA) are enriched with the Th9 cells along…
  • Abstract Number: 2417 • 2016 ACR/ARHP Annual Meeting

    High Dimensional Interrogation of the T Cell Immunome in Polyarticular Juvenile Idiopathic Arthritis Patients 

    Jing Yao Leong1, Justin Tiong2, Joo Guan Yeo2,3, Liyun Lai1, Phyllis Chen3, Loshinidevi D/O Thana Bathi3, Thaschawee Arkachaisri2, Daniel J Lovell4 and Salvatore Albani1,5, 1SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, 2Rheumatology and Immunology, KK Women's and Children's Hospital, Singapore, Singapore, 3Singhealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, 4PRCSG Cincinnati Children's Hospital Medical Center, Cinncinnati, OH, 5Duke-National University of Singapore Medical School, Singapore, Singapore

    Background/Purpose: Clinical management of polyarticular JIA with anti-TNF-alpha has been met with moderate success, with up to 50% of patients demonstrating clinically meaningful efficacy. Concerns…
  • Abstract Number: 178 • 2016 ACR/ARHP Annual Meeting

    Alpha-Enolase Promotes Pro-Inflammatory Phenotype of Monocytes-Derived Macrophages

    Pascal Rottenberg1,2, Manuel Fréret1,2, Sébastien Calbo1 and Olivier Vittecoq1,2, 1INSERM U905 & Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France, 2Rheumatology, Rouen University Hospital, Rouen, France

    Background/Purpose:  Monocytes of healthy donors were cultured with M-CSF (gcultured with ENO1, or control BSA, to investigate its effect on monocytes differentiation and macrophages polarization.…
  • Abstract Number: 2558 • 2016 ACR/ARHP Annual Meeting

    Dissociation of the Inhibitory Apoptosis Stimulating Protein of p53 (iASPP) Binding with Transcription Factor p73 Induces Synovial Fibroblast Apoptosis in the Rheumatoid Joint

    Chrong-Reen Wang1, Shih-Yao Chen1, Ai-Li Shiau2, Ming-Fei Liu1 and Chao-Liang Wu3, 1Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan, 2Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, 3Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan

    Background/Purpose:   Apoptosis-resistant synovial fibroblasts (SFs) constitute the major cell component of pannus tissues in rheumatoid arthritis (RA). In tumor cells, the binding of inhibitory…
  • Abstract Number: 179 • 2016 ACR/ARHP Annual Meeting

    CD11b+Gr1dimcells, Which Are Induced By GM-CSF Produced By Th17 and Group3 Innate Lymphoid Cell, May Facilitate the Progression of Pneumonitis in SKG Mice

    Sho Sendo1, Jun Saegusa1, Takaichi Okano2, Soshi Takahashi3 and Akio Morinobu1, 1Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 2Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 3Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: Rheumatoid lung disease is a prognostic factors of rheumatoid arthritis in human. The pathogenesis and the mechanism of rheumatoid lung disease is unclear. Zymosan…
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