ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "pathogenesis"

  • Abstract Number: 34 • 2019 ACR/ARP Annual Meeting

    The Role of NFAT5-p65 Complex Enhanceosome in the Inflammatory Responses of Rheumatoid Arthritis Synovial Fibroblasts via TLR4 Signaling

    Kunihiko Umekita1, Yumi Kariya 1, Chihiro Iwao 1, Masatoshi Kimura 1, Risa Kudo 1, Yuki Rikitake 1, Shunichi Miyauchi 2 and Akihiko Okayama 1, 1University of Miyazaki, Miyazaki, Japan, 2University of Miyazaki, Miyazaki

    Background/Purpose: Transcription factors belonging to the family of nuclear factors of activated T cells (NFAT) play an essential role in diverse biological processes, such as…
  • Abstract Number: 35 • 2019 ACR/ARP Annual Meeting

    Mass Cytometry Identifies Enhanced Histone H3 Citrullination and TNFα Production by CD14 Monocytes in Subjects At-Risk for Future Development of Rheumatoid Arthritis

    Yuko Okamoto1, Elena W.Y. Hsieh 2, Ronald P. Schuyler 3, Jennifer Seifert 4, Marie Feser 5, Jill Norris 6, M. Kristen Demoruelle 7, Kevin Deane 5 and V. Michael Holers 4, 1University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA and Tokyo Women’s Medical University School of Medicine, Department of Rheumatology, Tokyo, Japan, Denver, 2University of Colorado School of Medicine, Department of Immunology and Microbiology, Aurora, CO, USA and University of Colorado School of Medicine, Children’s Hospital Colorado, Department of Pediatrics, Section of Allergy & Immunology, Aurora, CO, USA, Denver, 3University of Colorado School of Medicine, Department of Immunology and Microbiology Aurora, CO, USA, Denver, 4University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, 5University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, 6Colorado School of Public Health, Department of Epidemiology, Aurora, CO, USA, Denver, 7University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora

    Background/Purpose: Our group previously demonstrated that sputum neutrophils from subjects At-Risk for future rheumatoid arthritis (RA) spontaneously form neutrophil extracellular traps with elevated histone H3…
  • Abstract Number: 34 • 2018 ACR/ARHP Annual Meeting

    Microbiome-Drived Aberration of Hematopoietic Stem Cell Development Facilitates Immune Deregulation on the Onset of Collagen-Induced Arthritis in Mice

    Peiqing Yang1, Lingchong Su1, Yanhong Li1, Yi Liu2 and Yubin Luo3, 1West China Hospital, Sichuan University, Chengdu, China, 2Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, China, Chengdu, China, 3Department of Rheumatology & Immunology,, West China Hosptial, Sichuan University, Chengdu, China

    Background/Purpose: Increasing studies indicate that immune deregulation occurs prior to symptom in Rheumatoid arthritis (RA). Hematopoietic stem cell (HSC) gives rise to multipotent progenitors differentiating…
  • Abstract Number: 152 • 2018 ACR/ARHP Annual Meeting

    Polymorphonuclear Neutrophils and Regulatory T Lymphocytes (Treg) Cooperate to Sustain Treg Activity in Normal and Arthritic Contexts

    Maxime Batignes1, François Santinon1, Marie-Christophe Boissier2,3, Patrice Decker4 and Natacha Bessis1, 1INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 2University of Paris 13,Sorbonne Paris Cité, Bobigny, France, 3Rheumatology Department, Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Bobigny, France, 4Inserm UMR 1125, Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France

    Background/Purpose: Polymorphonuclear neutrophils (PMN) are abundant and activated in rheumatoid arthritis (RA) joints. In addition to their pro-inflammatory role, PMN exert immunoregulatory functions and may…
  • Abstract Number: 929 • 2018 ACR/ARHP Annual Meeting

    Transcriptional Profiling of the Subcutaneous Rheumatoid Nodule: An Insight into Pathogenic Mechanisms and Cellular Content

    Judith Marsman1, Melanie J Millier1, John Highton1, Lisa K. Stamp2 and Paul A Hessian1, 1Department of Medicine, University of Otago, Dunedin, New Zealand, 2University of Otago, Christchurch, New Zealand

    Background/Purpose: Rheumatoid nodules are the most common cutaneous manifestation in patients with RA, often associated with longstanding and a more severe disease course. Paradoxically, therapy…
  • Abstract Number: 1332 • 2018 ACR/ARHP Annual Meeting

    Proteomic Discovery Analysis Identifies Unique Proteins and Pathways Correlating with Different Clinical Activity and Damage Measures in Juvenile Dermatomyositis (JDM)

    Hanna Kim1, Angelique Biancotto2, Foo Cheung2, Terrance P. O'Hanlon3, Yan Huang4, Frederick W. Miller3, Raphaela Goldbach-Mansky4 and Lisa G. Rider5, 1Pediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD, 2Center for Human Immunology Autoimmunity and Inflammation (CHI), NIAID, NIH, Bethesda, MD, 3Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, 4Translational Autoinflammatory Disease Section (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, 5Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD

    Background/Purpose: JDM is a complex heterogeneous autoimmune disease.  To define biomarkers and better understand JDM pathogenesis, aptamer-based proteomic technology was used to mine the serum…
  • Abstract Number: 1981 • 2018 ACR/ARHP Annual Meeting

    A Molecular Bayesian Network for Rheumatoid Arthritis Reveals Multiple Candidate Key Regulators for Disease Severity

    Wenhui Wang1, Amit Lahiri2, Teresina Laragione2, Jun Zhu1 and Percio S. Gulko2,3, 1Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, 2Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, 3Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a common and chronic autoimmune joint disease. RA is pathologically heterogeneous with multiple contributing factors. While there has been a…
  • Abstract Number: 1982 • 2018 ACR/ARHP Annual Meeting

    An Integrative Rheumatoid Arthritis Network for Elucidating Molecular Mechanisms Underlying RA Severity

    Wenhui Wang1, Teresina Laragione2, Amit Lahiri2, Jun Zhu1 and Percio S. Gulko3, 1Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, 2Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, 3Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a pathologically heterogeneous disease with multiple contributing factors. Many models have been developed to study RA severity and progression, and…
  • Abstract Number: 2035 • 2018 ACR/ARHP Annual Meeting

    Effect of Baricitinib on Joint-Related Biomarkers in Patients with Moderate-to-Severe Rheumatoid Arthritis

    Christian S. Thudium1, Anne C. Bay-Jensen1, Suntara Cahya2, Ernst R. Dow2, Morten A. Karsdal1, Alisa E. Koch2, Wenling Zhang2 and Robert J. Benschop2, 1Nordic Bioscience, Herlev, Denmark, 2Eli Lilly and Company, Indianapolis, IN

    Background/Purpose: Baricitinib (bari) is an oral selective inhibitor of Janus kinase (JAK) 1 and JAK2. In the phase 3 study RA-BUILD (NCT01721057), once-daily bari yielded…
  • Abstract Number: 2050 • 2018 ACR/ARHP Annual Meeting

    B and T Cell Phenotypes of First Degree Relatives of RA Patients in an Indigenous North American Cohort

    Stacy Tanner1, Christine Zhang2, Irene Smolik3, Aaron Marshall2 and Hani El-Gabalawy4, 1Rheumatology, University of Manitoba, Winnipeg, MB, Canada, 2Immunology, University of Manitoba, Winnipeg, MB, Canada, 3Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, 4University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: First degree relatives (FDR) of patients with RA are known to have approximately 4 times increased risk of developing RA and prevalence of RA…
  • Abstract Number: 2053 • 2018 ACR/ARHP Annual Meeting

    Global Mirna Expression and Transcriptomic Profiling of Monocytes from RA Patients

    Marzena Ciechomska1, Krzysztof Bonek2, Piotr Gluszko2, Marzena Olesinska2, Bartosz Wojtas3, Vladimir Benes4 and Wlodzimierz Maslinski1, 1Department of Pathophysiology and Immunology, National Institute of Geriatrics Rheumatology and Rehabilitation, Warsaw, Poland, Warsaw, Poland, 2Department of Rheumatology, National Institute of Geriatrics Rheumatology and Rehabilitation, Warsaw, Poland, Warsaw, Poland, 3Nencki Institute of Experimental Biology, Warsaw, Poland, Warsaw, Poland, 4The European Molecular Biology Laboratory, Heidelberg, Germany, Heidelberg, Germany

    Background/Purpose: Infiltration of the synovium by mononuclear cells, including monocytes, is one of the main features of RA. Monocytes are the first immune cells which…
  • Abstract Number: 2084 • 2018 ACR/ARHP Annual Meeting

    Targeting the Voltage-Gated K+ Channels: T Cell Targeted Therapies for Spondyloarthritis

    Siba P. Raychaudhuri1, Smriti K. Raychaudhuri2 and Heike Wulff3, 1Rheumatology Section, Sacramento Veterans Affairs Medical Center, Sacramento, CA, 2Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA, 3Pharmacology, School of Medicine, University of California Davis, Davis, CA

    Background/Purpose: TCR (T cell receptor) engagement triggers intracellular Ca++ influx through voltage-independent Ca2+ channels. This crucial Ca2+-influx is only possible by a counterbalancing K+ efflux…
  • Abstract Number: 2791 • 2018 ACR/ARHP Annual Meeting

    Characterization of Monoclonal Anti-PAD4 Autoantibodies from Rheumatoid Arthritis Patients: Functional Implications for Citrullination and Disease Progression

    Alejandro Gomez, Sarah Kongpachith, Nithya Lingampalli, Cecilia Cisar and William H. Robinson, Department of Medicine, Stanford University, Stanford, CA

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are present in two-thirds of patients with rheumatoid arthritis (RA), and target proteins that have been post-translationally modified by the…
  • Abstract Number: 1736 • 2017 ACR/ARHP Annual Meeting

    Deep Immunophenotyping of T-Lymphocytes with a 37-Channel Mass Cytometry (CyTOF) Panel for the Identification of Pathological Cell Functions and the Prediction of Response to Biologic Drugs in Rheumatoid Arthritis

    Ben Mulhearn1,2,3, Darren Plant2, Ann W. Morgan4,5, Anthony G. Wilson6, John D Isaacs7,8, Jane Worthington9, Soumya Raychaudhuri9,10,11,12, Tracy Hussell1, Anne Barton13,14 and Sebastien Viatte2, 1Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, United Kingdom, 2The University of Manchester, Arthritis Research UK Centre for Genetics and Genomics, , Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Medicine, Biology and Health, Manchester, United Kingdom, 3Kellgren Centre for Rheumatology, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, 4Section of Musculoskeletal Disease, NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom, 5Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 6UCD School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland, 7Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom, 8National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle, United Kingdom, 9Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 10Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 11Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute, Harvard University, Cambridge, MA, 12Partners Center for Personalized Genetic Medicine, Boston, MA, 13Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK, Manchester, United Kingdom, 14The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom

    Background/Purpose: Pathogenic immune cell types and functions have not been identified yet in rheumatoid arthritis (RA). This is explained by the impact of disease heterogeneity…
  • Abstract Number: 1902 • 2017 ACR/ARHP Annual Meeting

    A Pattern of Higher Serum Levels of IL-10 and MMP-3, Along with Lower IL-6R, Identify RA Patients with Interstitial Lung Disease

    Jon T. Giles1, Cheilonda Johnson2, Elana J. Bernstein3, Erika Darrah4, Felipe Andrade5 and Sonye K. Danoff6, 1Division of Rheumatology, Columbia University, College of Physicians and Surgeons, New York, NY, 2Medicine/Pulmonology, Johns Hopkins University School of Medicine, Baltimore, MD, 3Rheumatology, Columbia University, New York, NY, 4Department of Medicine/Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, 5Medicine/Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 6Medicine, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: The pathogenesis and prediction of RA-associated interstitial lung disease (ILD), an extra-articular manifestation with high morbidity and mortality, is poorly understood.  We explored the…
  • « Previous Page
  • 1
  • 2
  • 3
  • 4
  • …
  • 10
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology