Abstracts tagged "pathogenesis"

Abstract Number: 1412 • 2017 ACR/ARHP Annual Meeting
Yra-1909 suppresses Production of Pro-Inflammatory Mediators and MMPs through Downregulating Akt, p38, JNK and NF-κb Activation in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Hyun Jung Yoo^1,2, Jeong Yeon Kim¹, Shin Eui Kang¹, Ji Seok Yoo³, Yong Nam Lee³, Dong Goo Lee³, Ji Soo Park¹, Eun Bong Lee⁴, Eun Young Lee⁴ and Yeong Wook Song^2,5, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Korea, Republic of (South), ³Central R&D Institute, Yungjin Pharm Co., Ltd., Suwon, Korea, Suwon, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of (South), ⁵Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South)
Background/Purpose: Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which mediates destruction of cartilage and bone. Fibroblast-like synoviocyte (FLS) are a key component…
Abstract Number: 1713 • 2017 ACR/ARHP Annual Meeting
Defining Genetic Risk for Scleroderma Renal Crisis in RNA-Polymerase III Antibody Positive Patients
Edward Stern¹, Sandra Guerra¹, Harry Chinque¹, David Gonzalez Serna², Markella Ponticos¹, Javier Martin², Maureen D. Mayes³, Shervin Assassi⁴, Carmen Fonseca¹ and Christopher Denton⁵, ¹UCL Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, ²Instituto de Parasitología y Biomedicina López-Neyra, Granada, Spain, ³Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁴University of Texas McGovern Medical School, Houston, TX, ⁵Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom
Background/Purpose: Scleroderma renal crisis (SRC), characterised by accelerated hypertension and acute kidney injury, is a life-threatening complication of systemic sclerosis (SSc). Most SSc cases have…
Abstract Number: 1736 • 2017 ACR/ARHP Annual Meeting
Deep Immunophenotyping of T-Lymphocytes with a 37-Channel Mass Cytometry (CyTOF) Panel for the Identification of Pathological Cell Functions and the Prediction of Response to Biologic Drugs in Rheumatoid Arthritis
Ben Mulhearn^1,2,3, Darren Plant², Ann W. Morgan^4,5, Anthony G. Wilson⁶, John D Isaacs^7,8, Jane Worthington⁹, Soumya Raychaudhuri^9,10,11,12, Tracy Hussell¹, Anne Barton^13,14 and Sebastien Viatte², ¹Manchester Collaborative Centre for Inflammation Research, University of Manchester, Manchester, United Kingdom, ²The University of Manchester, Arthritis Research UK Centre for Genetics and Genomics, , Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Medicine, Biology and Health, Manchester, United Kingdom, ³Kellgren Centre for Rheumatology, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁴Section of Musculoskeletal Disease, NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁶UCD School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland, ⁷Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom, ⁸National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle, United Kingdom, ⁹Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ¹⁰Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹¹Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute, Harvard University, Cambridge, MA, ¹²Partners Center for Personalized Genetic Medicine, Boston, MA, ¹³Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK, Manchester, United Kingdom, ¹⁴The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, United Kingdom
Background/Purpose: Pathogenic immune cell types and functions have not been identified yet in rheumatoid arthritis (RA). This is explained by the impact of disease heterogeneity…
Abstract Number: 1902 • 2017 ACR/ARHP Annual Meeting
A Pattern of Higher Serum Levels of IL-10 and MMP-3, Along with Lower IL-6R, Identify RA Patients with Interstitial Lung Disease
Jon T. Giles¹, Cheilonda Johnson², Elana J. Bernstein³, Erika Darrah⁴, Felipe Andrade⁵ and Sonye K. Danoff⁶, ¹Division of Rheumatology, Columbia University, College of Physicians and Surgeons, New York, NY, ²Medicine/Pulmonology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Rheumatology, Columbia University, New York, NY, ⁴Department of Medicine/Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Medicine/Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: The pathogenesis and prediction of RA-associated interstitial lung disease (ILD), an extra-articular manifestation with high morbidity and mortality, is poorly understood. We explored the…
Abstract Number: 2435 • 2017 ACR/ARHP Annual Meeting
Circulating Mirnas As Potential Biomarkers of Cardiovascular Disease in Rheumatoid Arthritis Patients
Chary Lopez-Pedrera¹, Nuria Barbarroja¹, Patricia Ruiz-Limon², Ivan Arias de la Rosa², Maria Carmen Abalos-Aguilera², Yolanda Jiménez-Gómez¹, Rafaela Ortega-Castro¹, Eduardo Collantes-Estévez¹, Alejandro Escudero-Contreras², Raquel Lopez-Mejías³, Miguel Angel González-Gay³ and Carlos Perez-Sanchez¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain
Background/Purpose: Extracellular microRNAs, circulating in the bloodstream and extracellular space, have been proposed as attractive candidates as both diagnostic and prognostic biomarkers in various diseases,…
Abstract Number: 78 • 2017 ACR/ARHP Annual Meeting
IL-37 Is Associated with Increased Atherogenesis in Patients with Rheumatoid Arthritis
Barbora Sumova^1,2, Tereza Lennerova^1,2, Lucie Andres Cerezo¹, Hana Hulejova¹, Romana Jandova¹, Karel Pavelka^1,2, Jiri Vencovsky^1,2 and Ladislav Senolt^1,2, ¹Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, ²Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Interleukin-37 (IL-37) is one of few anti-inflammatory cytokines belonging to the IL-1 cytokine family. It is mainly produced by immune cells of innate immunity…
Abstract Number: 480 • 2017 ACR/ARHP Annual Meeting
ANTI-Carbamylated Protein Antibodies (CARP) in Palindromic Rheumatism: Prevalence and Clinical Significance
Raul Castellanos-Moreira Sr.¹, Virginia Ruiz-Esquide¹, María José Gomara², Sonia Cabrera-Villalba¹, Sebastian C Rodriguez-Garcia¹, Georgina Salvador³, Andrea Cuervo¹, Julio Ramírez¹, M. Victoria Hernández¹, Juan Cañete¹, Isabel Haro² and Raimon Sanmartí¹, ¹Rheumatology Service, Hospital Clínic de Barcelona, Barcelona, Spain, ²Unit of Synthesis and Biomedical Applications of Peptides, IQAC-CSIC, Barcelona, Spain, ³Hospital Universitario Mutua Terrassa, Barcelona, Spain
Background/Purpose: Autoantibodies (RF or ACPA) are found in sera from patients with palindromic rheumatism (PR) but there are no studies analyzing the presence of Anti-carbamylated…
Abstract Number: 1213 • 2016 ACR/ARHP Annual Meeting
Targeted Next-Generation Sequencing of 128 Genes Associated with Rheumatoid Arthritis
Khai Pang Leong¹, Liuh Ling Goh², Edward Yu Wing Chee², Petrina Pei Qin Lim², Grace Li-Xian Toh², Ee Tzun Koh³ and Tan Tock Seng Hospital Rheumatoid Arthritis Study Group, ¹Rheumatology/Allerg/Immunology, Tan Tock Seng Hospital, Singapore, Singapore, ²Clinical Research & Innovation Office, Tan Tock Seng Hospital, Singapore, Singapore, ³Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, Singapore
Background/Purpose: Through genome-wide association scans (GWAS), more than 120 genes have been found to be associated with rheumatoid arthritis (RA). This study aims to search…
Abstract Number: 1247 • 2016 ACR/ARHP Annual Meeting
Diagnostic Modeling of Rheumatoid Arthritis in Oklahoma Tribal Members Using Soluble Mediators
Lucas Adams¹, Carla J. Guthridge¹, Tim Gross¹, Hua Chen¹, Krista M. Bean¹, Virginia C. Roberts¹, Julie M. Robertson², Melissa E. Munroe¹, Joel M. Guthridge³, Roger Montgomery⁴, M. Sohail Khan⁴, Fabio Mota⁵, Michael Peercy⁶, Bobby Saunkeah⁷ and Judith A. James^8,9, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Acelity, San Antonio, TX, ³Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Cherokee Nation Health Services, Tahlequah, OK, ⁵Chickasaw Nation Medical Center, Ada, OK, ⁶Epidemiology, Chickasaw Nation Department of Health, Ada, OK, ⁷Chickasaw Nation Department of Health, Ada, OK, ⁸Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁹Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Diagnosis of RA is difficult in American Indian (AI) patients who often have atypical autoantibodies (e.g. ANA) with erosive arthritis. Soluble mediators may serve…
Abstract Number: 1572 • 2016 ACR/ARHP Annual Meeting
Relationship Between KDR (VEGFR2) Gene Polymorphisms and Serum KDR Protein Levels in Patients with Rheumatoid Arthritis
Agnieszka Paradowska-Gorycka¹, Barbara Stypinska², Andrzej Pawlik³, Damian Malinowski³, Katarzyna Romanowska-Próchnicka⁴, Ewa Haladyj⁵, Malgorzata Manczak⁶ and Marzena Olesinska⁷, ¹Department of Biochemistry and Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland, ²Department of Biochemistry and Molecular Biology, National Institute of geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland, ³Department of Pharmacology, Pomeranian Medical University, Szczecin, Poland, ⁴Department of Pathophysiology, Medical University of Warsaw and Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland, ⁵Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland, ⁶Department of Epidemiology and Health Promotion, National Institute of geriatrics, Rheumatology and Rehabilitation,, Warsaw, Poland, ⁷Department of Connective Tissue Disease, National Institute of Geriatrics, Rheumatology and Rehabilitation,, Warsaw, Poland
Background/Purpose: Rheumatoid arthritis (RA) is one of the chronic autoimmune diseases, with genetic and environmental predisposition, and synovial angiogenesis is considered to be a notable…
Abstract Number: 1658 • 2016 ACR/ARHP Annual Meeting
Regulatory Role of the IL-9/IL-9R System on Pannus Formation in Psoriatic Arthritis
Siba P. Raychaudhuri^1,2 and Smriti K. Raychaudhuri³, ¹Davis, CA, ²Rheumatology, Univ of California, Davis & VAMC Sacramento, Davis, CA, ³Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA
Background/Purpose: Earlier we have reported that synovial tissues of psoriatic arthritis (PsA) and rheumatoid arthritis (RA) are enriched with the Th9 cells along…
Abstract Number: 2417 • 2016 ACR/ARHP Annual Meeting
High Dimensional Interrogation of the T Cell Immunome in Polyarticular Juvenile Idiopathic Arthritis Patients
Jing Yao Leong¹, Justin Tiong², Joo Guan Yeo^2,3, Liyun Lai¹, Phyllis Chen³, Loshinidevi D/O Thana Bathi³, Thaschawee Arkachaisri², Daniel J Lovell⁴ and Salvatore Albani^1,5, ¹SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ²Rheumatology and Immunology, KK Women's and Children's Hospital, Singapore, Singapore, ³Singhealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ⁴PRCSG Cincinnati Children's Hospital Medical Center, Cinncinnati, OH, ⁵Duke-National University of Singapore Medical School, Singapore, Singapore
Background/Purpose: Clinical management of polyarticular JIA with anti-TNF-alpha has been met with moderate success, with up to 50% of patients demonstrating clinically meaningful efficacy. Concerns…
Abstract Number: 178 • 2016 ACR/ARHP Annual Meeting
Alpha-Enolase Promotes Pro-Inflammatory Phenotype of Monocytes-Derived Macrophages
Pascal Rottenberg^1,2, Manuel Fréret^1,2, Sébastien Calbo¹ and Olivier Vittecoq^1,2, ¹INSERM U905 & Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France, ²Rheumatology, Rouen University Hospital, Rouen, France
Background/Purpose: Monocytes of healthy donors were cultured with M-CSF (gcultured with ENO1, or control BSA, to investigate its effect on monocytes differentiation and macrophages polarization.…
Abstract Number: 2558 • 2016 ACR/ARHP Annual Meeting
Dissociation of the Inhibitory Apoptosis Stimulating Protein of p53 (iASPP) Binding with Transcription Factor p73 Induces Synovial Fibroblast Apoptosis in the Rheumatoid Joint
Chrong-Reen Wang¹, Shih-Yao Chen¹, Ai-Li Shiau², Ming-Fei Liu¹ and Chao-Liang Wu³, ¹Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan, ²Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, ³Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan
Background/Purpose: Apoptosis-resistant synovial fibroblasts (SFs) constitute the major cell component of pannus tissues in rheumatoid arthritis (RA). In tumor cells, the binding of inhibitory…
Abstract Number: 179 • 2016 ACR/ARHP Annual Meeting
CD11b+Gr1dimcells, Which Are Induced By GM-CSF Produced By Th17 and Group3 Innate Lymphoid Cell, May Facilitate the Progression of Pneumonitis in SKG Mice
Sho Sendo¹, Jun Saegusa¹, Takaichi Okano², Soshi Takahashi³ and Akio Morinobu¹, ¹Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ³Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Rheumatoid lung disease is a prognostic factors of rheumatoid arthritis in human. The pathogenesis and the mechanism of rheumatoid lung disease is unclear. Zymosan…

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