ACR Meeting Abstracts

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Abstracts tagged "osteoclast"

  • Abstract Number: 1719 • ACR Convergence 2023

    Exploring the Link Between Osteitis and Bone Microstructure Changes in Rheumatoid Arthritis: Role of JAK-STAT Signaling Pathway

    Tsuneyasu Yoshida1, Yoichi Nakayama1, Masao Katsushima2, Yuri Nishida3, Mirei Shirakashi1, Ran Nakashima1, Ryu Watanabe2, Kosaku Murakami4, Hajime Yoshifuji1, Akio Morinobu1 and Motomu Hashimoto2, 1Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Department of Clinical Immunology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan, 3Department of Endocrinology and Rheumatology, Kurashiki Central Hospital, Kurashiki, Japan, 4Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Background/Purpose: Osteitis on MRI and bone microstructure changes (BMC) on high-resolution peripheral quantitative CT are the earliest signs of arthritis, preceding the development of bone…
  • Abstract Number: 2014 • ACR Convergence 2023

    The Role of Orosomucoid 2 in the Regulation of Bone Remodeling by Inhibiting Osteoclastogenesis and Promoting Osteogenesis

    CHONG HYUK CHUNG1, Myeung-Su Lee1 and Chang-hoon Lee2, 1Wonkwang University Hospital, Iksan, South Korea, 2Wonkwang University Hospital, Iksan Jeonbuk, South Korea

    Background/Purpose: Orosomucoid (ORM) is one of the acute phase reactant protein family and is expressed in hepatocytes and secreted into plasma under stress conditions such…
  • Abstract Number: 0588 • ACR Convergence 2022

    S-nitrosoglutathione Reductase (GSNOR) Regulates Osteoclast Differentiation

    Toshihiro Tanioka1, Kohei Maeda1, Rei Takahashi1 and Takeo Isozaki2, 1Division of Pathogenesis and Translational Medicine, Department of Clinical Pharmacy, Showa University School of Pharmacy, Tokyo, Japan, 2Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan

    Background/Purpose: S-nitrosoglutathione (GSNO) reductase (GSNOR) is an enzyme which decomposes GSNO and downregulates protein S-nitrosylation. It has been reported that GSNOR KO mice have enhanced…
  • Abstract Number: 0604 • ACR Convergence 2022

    Altered Metabolic State in Myeloid Precursors and Mature Cells Within Rheumatoid Arthritis

    Patricia Riedlova1, Luís Almeida2, Cecilia Ansalone3, Shatakshi Sood1, Bart Everts2 and Carl Goodyear1, 1University of Glasgow, Glasgow, Scotland, United Kingdom, 2Leiden University Medical Center, Leiden, Netherlands, 3UCSD and University of Glasgow, Glasgow, Scotland, United Kingdom

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterised by synovial inflammation and joint destruction. Prior research has revealed perturbation in the myeloid compartment of…
  • Abstract Number: 0030 • ACR Convergence 2021

    Interleukin-9 Enhances the Osteoclastogenesis in Rheumatoid Arthritis

    Santanu Kar1, Dipendra Mitra2, Vijay Kumar D1 and Sushmita Chakraborty1, 1AIIMS, New Delhi, India, 2ALL INDIAN INSTITUTE OF MEDICAL SCIENCES, New Delhi, India

    Background/Purpose: Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation leading to bone destruction. Bone erosion in RA results from excessive resorption…
  • Abstract Number: 0044 • ACR Convergence 2021

    Autoantibodies Against Malondialdehyde-modifications Promote Osteoclast Development by Reprogramming Cellular Metabolism

    Koji Sakuraba1, Akilan Krishnamurthy1, Alexandra Circiumaru2, Jitong Sun1, Vijay Joshua1, Heidi Wähämaa1, Marianne Engström1, Meng Sun1, Xiaowei Zheng1, Cheng Xu1, khaled amara1, Vivianne Malmström1, Sergiu Catrina1, Caroline Grönwall1, Anca Catrina1 and Bence Réthi1, 1Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, 2Division for Rheumatology, Karolinska Institutet; Center for Rheumatology, Academic Specialist Center, Stockholm Region, Stockholm, Sweden

    Background/Purpose: Malondialdehyde (MDA) is a highly reactive compound generated during lipid-peroxidation in conditions associated with oxidative stress. MDA can irreversibly modify proteins (e.g. lysine, arginine…
  • Abstract Number: 1890 • ACR Convergence 2021

    Cellular Origin and Functions of Osteoclasts in Inflammatory Arthritis

    Hannah Nelson1, Ellen Gravallese2, Julia Charles1 and Christian Jacome-Galarza1, 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: Inflammatory arthritis (IA) is an autoimmune disease targeting multiple joints and characterized by joint destruction caused by osteoclasts (OC), leading to physical disability. However,…
  • Abstract Number: 0117 • ACR Convergence 2020

    Development of an In Vitro Trabecular Human Bone Model to Recapitulate Features of Glucocorticoid-induced Osteoporosis

    Annemarie Lang1, Karoline Diesing1, Alexandra Damerau1, Moritz Pfeiffenberger1, Timo Gaber1 and Frank Buttgereit2, 1Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, 2Charité University Medicine, Berlin, Germany

    Background/Purpose: The bone matrix consists of inorganic and organic components and a variety of specialized cells such as osteoblasts, osteocytes and osteoclasts. The bone-forming osteoblasts…
  • Abstract Number: 0784 • ACR Convergence 2020

    Upregulation of Tyro3TK on CD14+CD16- Monocytes Promotes Osteoclast Formation in Rheumatoid Arthritis

    Jimeng Xue1, Liling Xu1, Fanlei Hu1 and Yin Su2, 1Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China, Beijing, China (People's Republic), 2Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing, China (People's Republic)

    Background/Purpose: The study aimed to investigate the expression and clinical significance of Tyro3TK on CD14+CD16+ and CD14+CD16- monocyte subsets and explore the effect of Tyro3TK…
  • Abstract Number: 1105 • ACR Convergence 2020

    RANK-L Activity: Understanding the Pathogenesis of Erosive Osteoarthritis

    Kalyna Jakibchuk1, Javier Rangel-Moreno1, Bethany Marston2, Jennifer Anolik1 and Allen Anandarajah1, 1University of Rochester Medical Center, Rochester, NY, 2University of Rochester Medical Center, Rochester

    Background/Purpose: Erosive osteoarthritis (EOA) is characterized by osteoarthritic findings with central erosions and collapse of the interphalangeal joint subchondral bone plate.  A number of studies…
  • Abstract Number: 977 • 2019 ACR/ARP Annual Meeting

    Conditional Deletion of MKL1 Inhibits Osteoclast Formation and Bone Erosions in Collagen Induced Arthritis Mice

    Wenfeng Tan1, Aishu Luo 1, Yong Xu 2, Shiyu Lin 3, Miaojia Zhang 4 and Fang Wang 3, 1the First Affiliated Hospital of Nanjing Medical University, Nanjing, China (People's Republic), 2Nanjing Medical University, NANJING, China (People's Republic), 3the First Affiliated Hospital of Nanjing Medical University, Nanjing, 4the First Affiliated Hospital of Nanjing Medical University, Najing, China (People's Republic)

    Background/Purpose: Excessively osteoclasts (OCs) activation play an essential role in bone erosions in rheumatoid arthritis (RA). Thus, controlling OCs would be an effective strategy to…
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