Abstracts tagged "Osteoarthritis"

Abstract Number: 428 • 2018 ACR/ARHP Annual Meeting
Significant Pain Reduction with Oral Methotrexate in Knee Osteoarthritis; Results from a Randomised Controlled Phase III Trial of Treatment Effectiveness
Sarah R. Kingsbury¹, Puvan Tharmanathan², Ada Keding², Belen Corbacho², Fiona E Watt³, David L Scott⁴, Edward Roddy⁵, Fraser Birrell⁶, Nigel K Arden⁷, Catherine Arundel², Sarah Ronaldson², Lema Vernon⁸, Catherine Hewitt², Michael Doherty⁹, David Torgerson² and Philip G. Conaghan¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, United Kingdom, Leeds, United Kingdom, ²York Trials Unit, University of York, York, United Kingdom, ³Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ⁴Department of Rheumatology, King's College London, London, United Kingdom, ⁵Staffordshire and Stoke on Trent Partnership NHS Foundation Trust, Newcastle Under Lyme, United Kingdom, ⁶Northumbria Healthcare NHS Foundation Trust, North Shields, United Kingdom, ⁷Arthritis Research UK Centre for Sports, Exercise and Osteoarthritis, University of Oxford, Oxford, United Kingdom, ⁸Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁹The University of Nottingham, Nottingham, United Kingdom
Background/Purpose: Current treatments for osteoarthritis (OA) are severely limited. Synovitis is prevalent in OA and is associated with pain. The slow-acting anti-rheumatic drug methotrexate (MTX)…
Abstract Number: 1211 • 2018 ACR/ARHP Annual Meeting
Contribution of Ultrasonography Examination in Symptomatic Radiographic Knee OA
Oriane BAZIN¹, Willy Ngueyon Sime², Alexandra Desvignes³, Emmanuel Spitz⁴, Francis Guillemin⁵, Anne-Christine Rat⁵, Isabelle Chary-Valckenaere⁶ and Damien Loeuille⁷, ¹service de Rhumatologie, CHU Nancy, Vandoeuvre les Nancy, France, ²Université de Lorraine, Nancy, France, ³service de Rhumatologie, Groupement hospitalier Eaubonne -Montmorency, EAUBONNE, France, ⁴Rheumatology Strasbourg, Strasbourg, France, ⁵Université de Lorraine, EA4360, APEMAC, Nancy, France, ⁶Rheumatology, CHRU Nancy, Vandoeuvre les Nancy, France, ⁷Rheumatology, University Hospital of Nancy, NANCY, France
Background/Purpose: To evaluate and to compare ultrasonographic (US) features to clinical data and structural damage in symptomatic radiographic (RX) knee osteoarthritis (OA). Methods: Patients with…
Abstract Number: 1983 • 2018 ACR/ARHP Annual Meeting
Mutations Associated with Clonal Hematopoiesis of Indeterminate Potential Are Found in Peripheral Blood and Synovial Fluid Macrophages from Patients with Rheumatoid and Psoriatic Arthritis
Maria De Santis¹, Matteo Zampini², Natasa Isailovic¹, Elena Generali¹, Giacomo Maria Guidelli¹, Matteo Della Porta² and Carlo Selmi^1,3, ¹Rheumatology and Clinical Immunology Unit, Humanitas Research Hospital, Rozzano (MI), Italy, ²Oncology and Hematology Unit, Humanitas Research Hospital, Humanitas University, Rozzano (MI), Italy, ³BIOMETRA Department, University of Milan, Milan, Italy
Background/Purpose: Myeloidmutations commonly associated to neoplasia in patients who do not meet the diagnostic criteria for myelodysplastic syndrome are coined as clonal hematopoiesis of indeterminate…
Abstract Number: 433 • 2018 ACR/ARHP Annual Meeting
Impact of Bariatric Surgery on Rheumatic Diseases: A Systematic Review and Meta-Analysis
Marie Moly¹, Bernard Combe¹, Thomas Barnetche², Claire Daien¹, Jacques Morel³, Cédric Lukas¹, Cécile Gaujoux-Viala⁴ and Charlotte Hua⁴, ¹Rheumatology, University Hospital Lapeyronie, Montpellier, Montpellier, France, ²Rheumatology, University Hospital Pellegrin, Bordeaux, Bordeaux, France, ³Department of Rheumatology, University Hospital Lapeyronie, Montpellier, Montpellier, France, ⁴Rheumatology, University Hospital Carémeau , Nimes, Nimes, France
Background/Purpose: Obesity increase the incidence of rheumatic diseases (1-3). Bariatric surgery (BS) improve obesity-related comorbidities (4). The aim of our study was to assess currently…
Abstract Number: 1357 • 2018 ACR/ARHP Annual Meeting
Flexion Contractures Are Associated with Worse Pain, Stiffness, and Function in Patients with Knee Osteoarthritis
T Mark Campbell¹, Marc Monsour² and Guy Trudel³, ¹Physical Medicine and Rehabilitation, Elisabeth Bruyere Hospital, Ottawa, ON, Canada, ²Medicine, University of Ottawa, Ottawa, ON, Canada, ³Medicine, The Ottawa Hospital Rehabilitation Centre, Ottawa, ON, Canada
Background/Purpose: Knee osteoarthritis (OA) causes pain, disability, and affects ~20% of the population in the United States [Wallace 2017]. Knee flexion contractures (FCs) are limitations…
Abstract Number: 2008 • 2018 ACR/ARHP Annual Meeting
Vascular Adhesion Protein-1 (VAP-1) As Predictor of Radiographic Severity in Symptomatic Knee Osteoarthritis
Eirini Bournazou¹, Jonathan Samuels², Hua Zhou³, Svetlana Krasnokutsky Samuels⁴, Jyoti Patel⁵, Jenny Bencardino⁶, Leon Rybak⁷, Steven Abamson⁸, Uwe Junker⁹, Karen Brown¹ and Mukundan Attur⁵, ¹Roche Innovation Center, New York, NY, ²Department of Medicine, Divison of Rheumatology, NYU Langone Health, New York, NY, ³Bioinformatics, New York University, New York, NY, ⁴NYU School of Medicine, New York, NY, ⁵Rheumatology Research, NYU Langone Orthopedic Hospital, New York, NY, ⁶Radiology, NYU Langone Medical Center, New York, NY, ⁷Department of Radiology, NYU Langone Medical Center, New York, NY, ⁸Rheumatology, NYU Langone Health, New York, NY, ⁹Roche Innovation Center, Basel, Switzerland
Background/Purpose: To investigate the expression of vascular adhesion protein -1 (VAP-1) in joint tissues and serum in knee osteoarthritis (OA) patients and examine whether VAP-1…
Abstract Number: 438 • 2018 ACR/ARHP Annual Meeting
What Characterizes Osteoarthritis: Ultrasound-Detected Inflammation but Not Osteophytes Is More Common in Hand Osteoarthritis Than in Painless Bony Enlargements
Nina Gasperi¹, Antonella Adinolfi², Arnd Kleyer³, Melanie Hagen³, Christiane Gasperi⁴, Martin Weger⁵, Stefan Kiechl⁶, Johann Willeit⁶, Georg Schett³, Annamaria Iagnocco⁷, Arno Gasperi⁸, Agnes Mayr⁹ and Christian Dejaco^10,11, ¹Medical University of Graz, Graz, Austria, Graz, Austria, ²Department of Medicine, surgery and Neurosciences, University of Siena, Siena, Italy, Siena, Italy, ³Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen–Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, ⁴Department of Neurology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany, Munich, Germany, ⁵Department of Internal Medicine, Bruneck Hospital, Bruneck, Italy, Bruneck, Italy, ⁶Department of Neurology, Medical University of Innsbruck, Austria, Innsbruck, Austria, ⁷Academic Rhematology Center, University of Torino, Turin, Italy, Turin, Italy, ⁸Department of Neurology, Bruneck Hospital, Bruneck, Italy, Bruneck, Italy, ⁹Department of Laboratory Medicine, Bruneck Hospital, Italy, Bruneck, Italy, ¹⁰Rheumatology Service, South tyrolean Health trust, Hospital of Bruneck, Bruneck, Italy, Bruneck, Italy, ¹¹Department of Rheumatology and Immunology, Medical University Graz, Graz, Austria, Graz, Austria
Background/Purpose: To study structural and inflammatory ultrasound lesions in elderly subjects with hand osteoarthritis (HOA) as well as in pain-free subjects with bony enlargements of…
Abstract Number: 1359 • 2018 ACR/ARHP Annual Meeting
A Machine Learning Approach to Knee OA Phenotyping: The Johnston County Osteoarthritis Project
Amanda Nelson¹, Matthew Fuller², Becki Cleveland³, Todd Schwartz⁴, Joanne M. Jordan¹, Leigh F. Callahan¹, J.S. Marron² and Richard Loeser¹, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Knee osteoarthritis (KOA) is a heterogeneous condition characterized by changes in a variety of joint tissues and driven by a number of different potential…
Abstract Number: 2009 • 2018 ACR/ARHP Annual Meeting
A Novel Role of ZCCHC6 in the Regulation of MMP13 in Experimental Osteoarthritis in Mice
Mohammad Y Ansari¹, Nashrah Ahmad² and Tariq M Haqqi³, ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, ²School of Biomedical Science, Kent State University, kent, OH, ³Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Zinc Finger CCHC Domain Containing Protein 6 (ZCCHC6) or Terminal Uridylyltransferase 7 (TUT7) is a member of terminal uridylyltransferase family that mediate terminal uridylation…
Abstract Number: 452 • 2018 ACR/ARHP Annual Meeting
Features of Peripheral and Central Sensitization and Neuropathic Pain Are Seen in Both Osteoarthritis and Rheumatoid Arthritis
Jacquelin R. Chua¹, Shingo Ishihara², Mariam Riad¹, Isabel Castrejón¹, Rachel E. Miller³, Anne-Marie Malfait⁴, Joel A. Block¹, Theodore Pincus¹ and Najia Shakoor¹, ¹Division of Rheumatology, Rush University Medical Center, Chicago, IL, ²Internal Medicine, Rush University Medical Center, Chicago, IL, ³Biochemistry, Rush University Medical Center, Chicago, IL, ⁴Biochemistry & Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: OA and RA are among the most common chronic painful rheumatic diseases. Appreciation of the role of pain sensitization in OA has revolutionized the…
Abstract Number: 1363 • 2018 ACR/ARHP Annual Meeting
Progression of Pain, Stiffness, Function Changes, and Ultrasound Detected Synovitis and Osteophyte Formation in Patients with Hand Osteoarthritis over Three Years
Olga Sleglova¹, Olga Ruzickova², Karel Pavelka¹ and Ladislav Šenolt¹, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ²Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Hand osteoarthritis (HOA) is a common and frequent cause of pain. HOA is a heterogeneous group of disorders with two main subsets including non-erosive…
Abstract Number: 2345 • 2018 ACR/ARHP Annual Meeting
Systematic Review of Patient Decision Aids for Chronic Musculoskeletal Pain
Rabih Nayfe¹, Emily Bowen², Nathaniel Milburn², Helen Mayo², Ethan Halm², MC. Reid³, Liana Fraenkel⁴ and Una E. Makris⁵, ¹Department of Medicine, UT Southwestern Medical Center, Dallas, TX, ²UT Southwestern Medical Center, Dallas, TX, ³Weill Cornell Medicine, New York, NY, ⁴Yale University School of Medicine, New Haven, CT, ⁵UT Southwestern Medical Center and Dallas VA, Dallas, TX
Background/Purpose: Chronic musculoskeletal (MSK) pain is common and disabling; it is among the top reasons for doctor’s visits in the US. Most treatment decisions for…
Abstract Number: 484 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patients Have Lower Preoperative Expectations but Greater Clinical Improvement after Total Knee Arthroplasty Compared to Osteoarthritis Patients
Jason Blevins¹, Yu-fen Chiu², Stephen Lyman³, Susan M. Goodman¹, Lisa A. Mandl⁴, Peter K. Sculco⁵, Mark P. Figgie⁶ and Alexander McLawhorn², ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, new york, NY, ³Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁴Rheumatology, Hospital for Special Surgery, New York, NY, ⁵Orthopaedic Surgery, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁶Surgery, Hospital for Special Surgery, New York, NY
Background/Purpose: Preoperative patient expectations of Total Knee Arthroplasty (TKA) influence postoperative outcomes and satisfaction. Rheumatoid Arthritis (RA) may lower preoperative expectations after TKA compared to…
Abstract Number: 1367 • 2018 ACR/ARHP Annual Meeting
Efficacy of Intra-Articular Cntx-4975 for Knee OA Pain Varies with Radiographic Presence of OA in the Opposite Knee
Randall Stevens¹, James Campbell¹, Kimberly Guedes¹, Robin Burges¹, Valerie Smith² and Peter Hanson¹, ¹Centrexion Therapeutics, Boston, MA, ²Premier Research, Durham, NC
Background/Purpose: Nearly 60% of patients with knee OA have unilateral OA; most of those patients develop bilateral OA. CNTX-4975 is a highly purified, synthetic trans-capsaicin…
Abstract Number: 2909 • 2018 ACR/ARHP Annual Meeting
Diagnostic and Prognostic Value of Ultrasound Compared with Plain Radiography in Knee Osteoarthritis
Annie Yang¹, Fernando Bomfim², Kristen Lee², Mukundan Attur³, Steven B. Abramson⁴ and Jonathan Samuels⁵, ¹Department of Medicine, NYU Langone Health, New York, NY, ²NYU Langone Health, New York, NY, ³Rheumatology, NYU Langone Health, New York, NY, ⁴Dept of Medicine, NYU Langone Health, New York, NY, ⁵Department of Medicine, Divison of Rheumatology, NYU Langone Health, New York, NY
Background/Purpose: Plain radiography of knee osteoarthritis (OA) has inherent diagnostic and prognostic limitations, especially in early disease. Ultrasound (US) examination sheds light on disease activity…

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