Abstracts tagged "Osteoarthritis"

Abstract Number: 887 • 2019 ACR/ARP Annual Meeting
Critical Role of the Cholinergic System Involvement in Osteoarthritis
Alice Courties¹, Ariane Do ¹, Sarah Leite ², Audrey Pigenet ², Morgane Belle ³, Geoffroy Nourissat ⁴, Alain Sautet ⁵, Alain Chedotal ³, Uwe Maskos ⁶, Francis Berenbaum ⁷ and Jérémie Sellam ¹, ¹Service de Rhumatologie, AP-HP Hôpital Saint-Antoine, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France, ²Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France, ³Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France, Paris, France, ⁴Chirurgie orthopédique, Clinique Maussins, Groupe Ramsay générale de santé, 67 rue de Romainville, 75019, Paris, Paris, France, ⁵Chirurgie orthopédique, AP-HP Hôpital Saint-Antoine, Paris, Paris, France, ⁶Unité de neurobiologie intégrative des systèmes cholinergiques, CNRS UMR 3571, Institut Pasteur, Paris, Paris, France, ⁷Sorbonne Université-Inserm CDR Saint-Antoine, AP-HP, Paris, France
Background/Purpose: The efferent vagus nerve can regulate inflammation via its principal neurotransmitter acetylcholine (ACh), a concept referred as the 'cholinergic anti-inflammatory pathway'. ACh interacts with members of…
Abstract Number: 1310 • 2019 ACR/ARP Annual Meeting
Osteoarthritis: What’s in a Name?
Warren A Katz¹, ¹Penn Medicine; University of Pennsylvania School of Medicine, Upper Gwynedd, PA
Background/Purpose: The nomenclature of "osteoarthritis" (OA) has been a source of confusion and likely misdiagnosis for centuries. Prior to 1759, most patients with joint diseases…
Abstract Number: 1760 • 2019 ACR/ARP Annual Meeting
Six-week Treatment with Low-dose Prednisolone in Patients with Painful Hand Osteoarthritis (HOPE): Results from a Randomised Double-blind Placebo-controlled Trial
Féline Kroon¹, Marion Kortekaas ¹, Annelies Boonen ², Stephan Böhringer ³, Monique Reijnierse ¹, Frits R Rosendaal ³, Naghmeh Riyazi ⁴, Mirian Starmans ⁵, Franktien Turkstra ⁶, Jende van Zeben ⁷, CF Allaart ⁸ and Margreet Kloppenburg ³, ¹Leiden University Medical Center, Leiden, Netherlands, ²Maastricht University Medical Center, Maastricht, Netherlands, ³Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, ⁴Haga Hospital, The Hague, Netherlands, ⁵Zuyderland Medical Center, Heerlen, Netherlands, ⁶Amsterdam Rheumatology and immunology Center | Reade, Amsterdam, Netherlands, ⁷Sint Franciscus Vlietland Groep, Rotterdam, Netherlands, ⁸Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands
Background/Purpose: Hand osteoarthritis (OA) is a prevalent joint disease with high disease-burden in need for effective therapeutic options. Studies have shown that synovial inflammation is…
Abstract Number: 1985 • 2019 ACR/ARP Annual Meeting
Divergent Mononuclear Cell Participation and Cytokine Release Profiles Define Hip and Knee Osteoarthritis
Ricardo Grieshaber-Bouyer¹, Till Kämmerer ², Nils Rosshirt ², Philipp Koniezke ², Sebastien Hagmann ², Elena Tripel ², Johannes Kirsch ², Tobias Gotterbarm ² and Babak Moradi ², ¹Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Department of Orthopedics, Heidelberg University Hospital, Heidelberg, Germany, Boston, MA, ²Department of Orthopedics, Heidelberg University Hospital, Heidelberg, Germany, Heidelberg, Germany
Background/Purpose: Osteoarthritis (OA) is a progressive joint disease driven by a blend of inflammatory and biomechanical processes. Studies using human samples to understand inflammatory mechanisms…
Abstract Number: 2184 • 2019 ACR/ARP Annual Meeting
A Flexion Contracture Is a Risk Factor for Radiographic Progression and Earlier Need for Arthroplasty in Knee Osteoarthritis: Data from the Osteoarthritis Initiative
T Mark Campbell¹ and Dennis McGonagle ², ¹Elisabeth Bruyere Hospital, Ottawa, ON, Canada, ²University of Leeds, Leeds, United Kingdom
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis. Knee OA is often accompanied by a knee flexion contracture (FC), but the impact of…
Abstract Number: 2410 • 2019 ACR/ARP Annual Meeting
Using External Data to Estimate Omitted Variables in Observational Data: A Plasmode Simulation Study Investigating the Relationship Between Osteoarthritis and Cardiovascular Diseases to Compare Alternative Approaches in Imputing the Body Mass Index Variable
Mohammad Atiquzzaman¹, Mohammad Karim ², Jacek Kopec ³, Hubert Wong ⁴, Mary De Vera ⁵ and Aslam Anis ², ¹Faculty of Pharmaceutical Sciences, University of British Columbia, Surrey, BC, Canada, ²School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada, ³Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada, ⁴University of British Columbia, Vancouver, BC, Canada, ⁵Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: BMI is a well-known confounding factor in the association between osteoarthritis (OA) and cardiovascular diseases (CVD). However, BMI is not usually recorded in administrative…
Abstract Number: 888 • 2019 ACR/ARP Annual Meeting
Mitochondrial DNA Impact on Joint Degeneration Process Using DMM OA and Spontaneous Aging Conplastic Mice Models
Morena Scotece¹, Ignacio Rego-Pérez ², Ana Victoria Lechuga-Vieco ³, María Concepción Jiménez Gómez ³, Purificación Filgueira-Fernández ⁴, José Antonio Enriquez ³ and Francisco J. Blanco ², ¹Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ³Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Madrid, Spain, ⁴Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Galicia, Spain
Background/Purpose: Accumulated data indicated that osteoarthritis has a strong genetic component with a prevalent role of mitochondria and mtDNA variations. In the present work, we…
Abstract Number: 1311 • 2019 ACR/ARP Annual Meeting
Prevalence of Symptomatic Axial Osteoarthritis and Poliarticular Phenotypes in Spain: EPISER 2016 Study
Maite Silva-Díaz¹, Francisco J. Blanco ², Victor Quevedo Vila ³, Daniel Seoane-Mato ⁴, Sagrario Bustabad-Reyes ⁵ and on behalf of the Working Group Proyecto EPISER2016 ⁶, ¹Servicio de Reumatología. Complexo Hospitalario Universitario A Coruña (CHUAC)-INIBIC, A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ³Unidad de Reumatología. Hospital Comarcal Monforte de Lemos., Lugo, Spain, ⁴Unidad de Investigación. Sociedad Española de Reumatología., Madrid, Spain, ⁵eumatología. Hospital Universitario de Canarias., La Laguna, Santa Cruz de Tenerife, Spain, ⁶Grupo de trabajo del proyecto EPISER2016, Madrid, Spain
Background/Purpose: Osteoarthritis (OA) is a heterogeneous group of diseases with common clinical and radiographic manifestations involving the peripheral and axial skeletal. OA is the most…
Abstract Number: 1846 • 2019 ACR/ARP Annual Meeting
Does Cartilage Loss Cause Pain in Osteoarthritis?
KATHRYN BACON¹, Lavalley Michael ² and David Felson ³, ¹Boston University School of Medicine, Boston, MA, ²Boston University, Boston, ³Boston University School of Medicine, Department of Rheumatology, Boston
Background/Purpose: Treatment development in osteoarthritis continues to focus on chondroprotection, but it is unclear if delaying cartilage loss would reduce joint pain. In published studies,…
Abstract Number: 1988 • 2019 ACR/ARP Annual Meeting
Establishing an in Vitro Model of Hand Osteoarthritis by Generating Induced Pluripotent Stem Cells (iPSc) That Carry Single Nucleotide Polymorphisms Associated with Hand Osteoarthritis Risk
Rocío Castro-Viñuelas¹, Clara Sanjurjo-Rodríguez ², María Piñeiro-Ramil ¹, Silvia Rodríguez-Fernández ¹, Tamara Hermida-Gómez ³, Francisco J. De Toro ⁴, Isaac Fuentes-Boquete ¹, Francisco J. Blanco ⁵ and Silvia Díaz-Prado ¹, ¹Grupo de investigación en Terapia Celular y Medicina Regenerativa. Departamento de Fisioterapia, Medicina y Ciencias Biomédicas. Universidade da Coruña. Agrupación estratégica CICA-INIBIC. A Coruña, España., A Coruña, Spain, ²Grupo de investigación en Terapia Celular y Medicina Regenerativa. Departamento de Fisioterapia, Medicina y Ciencias Biomédicas. Universidade da Coruña. Agrupación estratégica CICA-INIBIC. A Coruña, España; University of Leeds; Newcastle University, A Coruña, Spain, ³Unidad de Bioingeniería Tisular y Terapia Celular (GBTTC-CHUAC). Grupo de Investigación en Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC). Sergas. Centro de Investigaciones Científicas Avanzadas (CICA), A Coruña, Spain, ⁴University Hospital A Coruña, A Coruña, Spain, ⁵Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain
Background/Purpose: Knowledge and research results in the field of hand osteoarthritis (hOA) are currently limited, mainly due to the unavailability of tissue samples to develop…
Abstract Number: 2185 • 2019 ACR/ARP Annual Meeting
MRI-detected Abnormalities in Prediction Models of Incident Radiographic Knee Osteoarthritis over 10 Years of Follow-up
C. Kent Kwoh¹, Frank Roemer ², Erin Ashbeck ³, ChengCheng Hu ¹, Edward Bedrick ¹, Leena Sharma ⁴ and Ali Guermazi ⁵, ¹University of Arizona, Tucson, AZ, ²University of Erlangen-Nuremberg, Erlangen, Germany, ³The University of Arizona Arthritis Center, University of Arizona, Tuccson, AZ, Tucson, AL, ⁴Northwestern University, Chicago, IL, ⁵Boston Medical Center, Boston
Background/Purpose: MRI Osteoarthritis Knee Score (MOAKS) is a semi-quantitative scoring system used to assess MRI-detected structural abnormalities including over 100 raw scores representing multiple joint…
Abstract Number: 2756 • 2019 ACR/ARP Annual Meeting
Subcutaneous Tanezumab versus NSAID for the Treatment of Osteoarthritis: Joint Safety Events in a Randomized, Double-Blind, Active-Controlled, 80-Week, Phase-3 Study
Marc C. Hochberg¹, John Carrino ², Thomas Schnitzer ³, Ali Guermazi ⁴, David Walsh ⁵, Alexander White ⁶, Satoru Nakajo ⁷, Robert Fountaine ⁸, Anne Hickman ⁸, Glenn Pixton ⁹, Lars Viktrup ¹⁰, Mark T. Brown ⁸, Christine R. West ⁸ and Kenneth M. Verburg ⁸, ¹University of Maryland School of Medicine, Baltimore, MD, ²Hospital for Special Surgery, New York, NY, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Boston Medical Center, Boston, ⁵Sherwood Forest Hospitals NHS Foundation Trust, Nottingham, United Kingdom, ⁶Progressive Medical Research, Port Orange, FL, ⁷Nakajo Orthopaedic Clinic, Miyagi, Japan, ⁸Pfizer Inc, Groton, CT, ⁹Pfizer Inc, Morrisville, NC, ¹⁰Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Tanezumab, a monoclonal antibody inhibiting nerve growth factor (NGF), is under investigation for the treatment of chronic pain conditions. In prior osteoarthritis (OA) studies,…
Abstract Number: 891 • 2019 ACR/ARP Annual Meeting
Lorecivivint (SM04690), a Potential Disease-Modifying Osteoarthritis Drug, Inhibits CLK2 and DYRK1A, Novel Molecular Regulators of Wnt Signaling, Chondrogenesis, and Inflammation
Vishal Deshmukh¹, Alyssa O'Green ¹, Carine Bossard ¹, Tim Seo ¹, Lisa Lamangan ¹, Maureen Ibanez ¹, Abdullah Ghias ¹, Carolyn Lai ¹, Long Do ¹, Shawn Cho ¹, Joseph Cahiwat ¹, Kevin Chiu ¹, Melinda Pedraza ¹ and Yusuf Yazici ¹, ¹Samumed, LLC, San Diego, CA
Background/Purpose: In the synovial joint, Wnt pathway upregulation contributes to osteoarthritis (OA) by increasing osteocyte differentiation, cartilage thinning, and inflammation. Lorecivivint (LOR; SM04690), a novel…
Abstract Number: 1312 • 2019 ACR/ARP Annual Meeting
Knee Morphology Associates with Tibio-Femoral and Patello-Femoral Osteoarthritis: A Case-Control Study
Anand Ramachandran Nair¹, Weiya Zhang ², Michael Doherty ² and Abhishek Abhishek ³, ¹Academic Rheumatology, School of Medicine, University of Nottingham, Nottingham, UK, Nottingham, England, United Kingdom, ²Academic Rheumatology, Division of Rheumatology,School of Medicine, University of Nottingham, Nottingham, UKArthritis Research UK Pain Centre, Nottingham, UKNational Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham, UK, Nottingham, England, United Kingdom, ³Academic Rheumatology, School of Medicine, University of Nottingham,Nottingham,UK National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham,UK, Nottingham, England, United Kingdom
Background/Purpose: Although several morphological features of the hip joint predispose to hip osteoarthritis (OA), only a few are known to associate with knee OA. The…
Abstract Number: 1878 • 2019 ACR/ARP Annual Meeting
Quantifying the Placebo Effect After Intra-Articular Injections: Implications for Trials and Practice
Sebastian Rodriguez-Garcia¹, Raul Castellanos-Moreira ², Jacqueline Uson-Jaeger ³, ESPERANZA NAREDO ⁴ and Loreto Carmona ⁵, ¹Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Spain, ²Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Catalonia, Spain, ³Hospital Universitario de Mostoles, Madrid, Spain, ⁴Rheumatology Department, Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz, Universidad Autónoma, MADRID, Spain, ⁵Instituto de Salud Musculoesquelética - Inmusc., Madrid, Spain
Background/Purpose: In recent years, diverse compounds for intra-articular (IA) administration were brought into the market with a subsequent significant and heterogeneous literature production. Understanding the efficacy…

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