Abstracts tagged "OA"

Abstract Number: 1986 • 2019 ACR/ARP Annual Meeting
Insights into Osteoarthritis Progression by Gene Expression and miRNA Profiling of Mesenchymal Stromal Cells from Medial and Lateral Femoral Condyles
Clara Sanjurjo-Rodríguez ¹, Rachel Crossland ², Thomas Baboolal ³, Monica Reis ⁴, Agata Burska ⁵, Frederique Ponchel ⁵, Jehan El-Jawhari ⁵, Dennis McGonagle⁶, Hemant Pandit ⁷, Xiao-nong Wang ⁸ and Elena Jones ⁹, ¹Grupo de investigación en Terapia Celular y Medicina Regenerativa. Departamento de Fisioterapia, Medicina y Ciencias Biomédicas. Universidade da Coruña. Agrupación estratégica CICA-INIBIC. A Coruña, España; University of Leeds; Newcastle University, A Coruña, Spain, ²2Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM)University of Leeds, Leeds, United Kingdom, ⁴Department of Pediatrics, Harvard Medical School, Boston, MA, USA, Boston, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁶University of Leeds, Leeds, United Kingdom, ⁷Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds. NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁸Institute of Cellular Medicine, Newcastle University, UK, Newcastle, United Kingdom, ⁹University of Leeds, Leeds, England, United Kingdom
Background/Purpose: Bone marrow multipotential stromal cells (MSC) are widely used in clinical trials to treat bone and cartilage diseases. However, there is limited information on…
Abstract Number: 2070 • 2019 ACR/ARP Annual Meeting
Co-morbidities in Patients with OA and RA: Results from a Large US Rheumatic Disease Registry
Sofia Pedro¹, Rebecca Schumacher ¹, Alyssa Dominique ², Yomei Shaw ¹, Kristin Wipfler ¹ and Kaleb Michaud ³, ¹FORWARD, The National Databank for Rheumatic Diseases, Wichita, KS, ²Bristol-Myers Squibb, Princeton, NJ, ³FORWARD, The National Databank for Rheumatic Diseases and University of Nebraska Medical Center, Wichita, KS
Background/Purpose: The burden of co-morbid conditions can impact the overall quality of life in patients with RA and OA. However, the presence of common co-morbidities…
Abstract Number: L20 • 2018 ACR/ARHP Annual Meeting
Efficacy and Safety of Subcutaneous Tanezumab for the Treatment of Osteoarthritis of the Hip or Knee
Thomas J. Schnitzer¹, Richard Easton², Shirley Pang³, Dennis Levinson⁴, Glenn Pixton⁵, Lars Viktrup⁶, Isabelle Davignon⁷, Mark T. Brown⁷, Kenneth M. Verburg⁷ and Christine R. West⁷, ¹Northwestern University, Chicago, IL, ²Michigan Orthopaedic & Spine Surgeons, Rochester Hills, MI, ³St. Jude Medical Center, Fullerton, CA, ⁴Chicago Clinical Research Institute, Chicago, IL, ⁵Pfizer, Inc., Morrisville, NC, ⁶Eli Lilly and Company, Indianapolis, IN, ⁷Pfizer, Inc., Groton, CT
Background/Purpose: Tanezumab is a humanized mAb that blocks nerve growth factor (NGF) and is in clinical development for chronic pain treatment. Tanezumab administered intravenously has…
Abstract Number: PP03 • 2018 ACR/ARHP Annual Meeting
Managing OsteoArthritis Pain with Daily Meditation
Raquel Masco, Patient/Volunteer, Arthritis Foundation, Atlanta, GA
Background/Diagnosis: Original diagnosis of OsteoArthritis in 2016 by family doctor (family medicine/general practitioner). There had been ongoing pain and symptoms for years. Original medications prescribed…
Abstract Number: 1204 • 2018 ACR/ARHP Annual Meeting
Experience Matters in Ultrasound Assessment of Gout
Burak Elkiran¹ and Eugene Y. Kissin², ¹Internal Medicine, Steward Carney Hospital, Boston, MA, ²Rheumatology, Boston University, Boston, MA
Background/Purpose: Ultrasound has emerged in the field of rheumatology as a diagnostic aid for gout and other similar forms of arthritis. While a number of…
Abstract Number: 1379 • 2018 ACR/ARHP Annual Meeting
Appraisal of the Educational Needs in Patients with Osteoarthritis Using the Educational Needs Assessment Tool Questionnaire
Adriana Garcia Coello¹, Oscar Rillo², Alejandro Brigante Jr.³, Maritza Quintero⁴, Yessica Ponce⁵, Rolando Espinoza⁶, Silvia Beatriz Papasidero⁷, Gonzalo Rodriguez⁸, Julia Sosa⁹, María Paula Kohan⁹, Dora Pereira¹⁰, Dafne Capelusnik¹¹, Lucy Heredia¹², Carlos Pineda¹³, Margarita González de Urizar¹⁴, Ana María Sapag Durán¹⁵, Cesar Rossi¹⁶, Pedro Santos-Moreno¹⁷, Vicente Juarez¹⁸, Jorge Esquivel-Valerio¹⁹, Vianna Khoury²⁰, Blanca Herrera Velasco²¹ and Renee Souto¹⁶, ¹Rheumatology Section, Hospital General de agudos Dr Ignacio Pirovano, Buenos Aires, Argentina, ²Hospital General de Agudos Dr Ignacio Pirovano, Argentina, Buenos Aires, Argentina, ³Sociedad Argentina de Reumatologia, Buenos Aires, Argentina, ⁴Rheumatology Section, Instituto Autónomo Hospital Universitario de Los Andes, Universidad de Los Andes, Venezuela, Mérida, Venezuela, ⁵Rheumatology Section, Hospital Genaral de agudos Dr Ignacio Pirovano, Argentina, Buenos Aires, Argentina, ⁶Rheumatology Section, Instituto Nacional de Rehabilitación, Luis Guillermo Ibarra Ibarra, Mexico, Mexico, Mexico, ⁷Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Argentina, Buenos Aires, Argentina, ⁸Hospital General de Agudos Dr Cosme Argerich, Argentina, Buenos Aires, Argentina, ⁹Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Argentina, CABA, Argentina, ¹⁰Rheumatology Section, Hospital Dr. Ricardo Gutiérrez, Argentina, Buenos Aires, Argentina, ¹¹Reumatology, Instituto de Rehabilitación Psicofísica, Argentina, CABA, Argentina, ¹²Hospital de Tercer Nivel Obrero Nº2 de la Caja Nacional de Salud, Bolivia, Cochabamba, Bolivia (Plurinational State of), ¹³Instituto Nacional de Rehabilitation, Mexico, Mexico, Mexico, ¹⁴Rheumatology, Hospital San Ramón, Paraguay, Ciudad del Este, Paraguay, ¹⁵Rheumatology, Hospital Universitario Japonés, Bolivia, Santa Cruz, Bolivia (Plurinational State of), ¹⁶Rheumatology Section, Cátedra de Reumatología de la Facultad de Medicina de la Universidad de la Republica, Uruguay, Montevideo, Uruguay, ¹⁷Biomab, Center for Arthritis, Bogota, Colombia, Bogota, Colombia, ¹⁸Rheumatology Section, Hospital Señor del Milagro de Salta, Argentina, Salta, Argentina, ¹⁹Rheumatology, University Hospital “Dr. José Eleuterio González”, UANL, Mexico, Monterrey, Mexico, ²⁰Rheumatology Section, Hospital Regional Universitario Presidente Estrella Ureña, República Dominicana, Santiago, Dominican Republic, ²¹Rheumatology, Centro Médico de Reumatología; Sucre, Bolivia, Sucre, Bolivia (Plurinational State of)
Background/Purpose: The SpENAT, a Spanish version of the Educational Needs Assessment Tool (ENAT), is a self-completed questionnaire that assesses educational needs (ENs) in ostheoathritis (OA)…
Abstract Number: 1993 • 2018 ACR/ARHP Annual Meeting
Evaluation of Cartilage Degeneration and Osteoarthritis Pain on Female and Male Mouse Model of Osteoarthritis
In Young Park, Jeong-Im Hong, Hyun Sook Hwang and Hyun Ah Kim, Hallym University Sacred Heart Hospital, Kyunggi-do, Korea, Republic of (South)
Background/Purpose: The prevalence of radiographic and symptomatic osteoarthritis (OA) is higher in women, but in animal study, male mice were more frequently used to explore…
Abstract Number: 2002 • 2018 ACR/ARHP Annual Meeting
Dynamic Compression of Articular Cartilage Explants Increases Formation and Decreases Degradation of Type II Collagen
Amalie Engstrøm^1,2, Anne C. Bay-Jensen², Morten A. Karsdal² and Christian S. Thudium², ¹Department of Biomedical Science, University of Copenhagen, København, Denmark, ²Nordic Bioscience, Herlev, Denmark
Background/Purpose: Mechanical loading is recognized as a major factor in initiation and progression of osteoarthritis (OA). Conversely loading is believed to play an essential role…
Abstract Number: 2047 • 2018 ACR/ARHP Annual Meeting
Synovial Fluid Cytokines /Chemokines and Proteins from the Knees of Symptomatic RA and OA Patients Which Correlate with the Magnitude of the Inflammatory Response As Measured By Synovial Fluid WBC Levels
Richard Meehan¹, Eric Hoffman², Mary Wolf³, Elizabeth Regan⁴, Prashant Parmar⁵, Karin Pacheco⁶, Jim Crooks⁷ and Vijaya Knight⁸, ¹MEDICINE, National Jewish Health, Denver, CO, ²Medicine/Rheumatology, National Jewish Health, Denver, CO, ³Pathology Department, National Jewish Health, Denver, CO, ⁴Medicine, National Jewish Health, Denver, CO, ⁵Internal Medicine, St Joseph Hospital, Denver, CO, ⁶MEDICINE/ Occupational Medince, National Jewish Health, Denver, CO, ⁷Biostatistics, National Jewish Health, Denver, CO, ⁸Pathology, ADX laboratory, National Jewish Health, Denver, CO
Background/Purpose: Synovial fluid (SF) provides nutritional support for cartilage and contains numerous catabolic and anabolic cytokines, chemokines and proteins. The precise role of these proteins…
Abstract Number: 1206 • 2017 ACR/ARHP Annual Meeting
Chondroitin Sulfate Reduces Pain and Improves Function in Knee Osteoarthritis Significantly Better Than Placebo, Independently of the Definition of Responders
J-Y Reginster, Bone Cartilage Unit, University of Liege, Liege, Belgium
Background/Purpose: In addition to the assessment of the two co-primary endpoints – pain and function – regulatory agencies recommend the use of responder rates in…
Abstract Number: 2019 • 2017 ACR/ARHP Annual Meeting
Structural Abnormalities in the Knee Detected By MRI in Middle-Aged Subjects without Radiographic Knee Osteoarthritis
Jaanika Kumm¹, Aleksandra Turkiewicz², Fan Zhang² and Martin Englund², ¹Department of Radiology, University of Tartu, Tartu, Estonia, ²Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Lund University, Lund, Sweden
Background/Purpose: Early OA is a complex, poorly understood and still largely an unchartered “entity”. Thus, our purpose was evaluate the prevalence of findings suggestive of…
Abstract Number: 2196 • 2017 ACR/ARHP Annual Meeting
An Exploratory Analysis of Physical Activity Levels and the Presence of Bone Marrow Lesions in Adults with Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Amanda R. Canavatchel¹, Lori Lyn Price², Jeffrey B. Driban³, Ming Zhang¹, Grace H. Lo⁴ and Timothy E. McAlindon⁵, ¹Tufts Medical Center, Boston, MA, ²Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ³Rheumatology, Tufts Medical Center, Boston, MA, ⁴Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ⁵Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Many people with knee OA have bone marrow lesions (BMLs). BMLs are related with structural pathology and pain. Some investigators have found an association…
Abstract Number: 2198 • 2017 ACR/ARHP Annual Meeting
Combinatorial Peripheral Blood Inflammatory and MRI-Based Biomarkers Predict Radiographic Joint Space Narrowing in Knee OA
Svetlana Krasnokutsky Samuels¹, Hua Zhou², Mukundan Attur¹, Jonathan Samuels¹, Gregory Chang³, Jenny Bencardino⁴, Sisi Ma², Leon Rybak³ and Steven B. Abramson⁵, ¹Rheumatology, NYU Langone Medical Center, New York, NY, ²Bioinformatics, New York University, New York, NY, ³Department of Radiology, NYU Langone Medical Center, New York, NY, ⁴Radiology, NYU Langone Medical Center, New York, NY, ⁵Dept of Medicine, NYU Langone Medical Center, New York, NY
Background/Purpose: Inflammation contributes to OA disease pathogenesis. Subsets of knee OA patients with peripheral blood leukocyte (PBL) detected inflammatory gene expression profiles exhibit more rapid…
Abstract Number: 2202 • 2017 ACR/ARHP Annual Meeting
Association between Oxidative Balance Score and Osteoarthritis in Korean Adults: The Korea National Health and Nutrition Examination Survey (2014–2015)
Young Bin Joo¹, Joo-Hyun Lee², Minkyung Han³, Seong-Ryul Kwon⁴, Won Park⁵, Kyung-Su Park⁶, Bo Young Yoon⁷ and Kyong-Hee Jung⁴, ¹Internal Medicine, Department of Rheumatology, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Gyeonggido, Korea, Republic of (South), ²Rheumatology, Inje University Ilsan Paik Hospital, Goyang, Korea, Republic of (South), ³Public health, Yonsei University graduate school, Seoul, Korea, Republic of (South), ⁴Rheumatology, Inha University, Incheon, Korea, Republic of (South), ⁵Medicine/Rheumatology, Inha University Hospital, Incheon, Korea, Republic of (South), ⁶Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea, Republic of (South), ⁷Rheumatology/Internal medicine, Inje Iniversity Ilsan Paik Hospital, Goyang, Korea, Republic of (South)
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, caused by a combination of systemic and local factors. Its multi-factorial etiology includes oxidative stress…
Abstract Number: 2212 • 2017 ACR/ARHP Annual Meeting
A Metabolite of C-Reactive Protein, a Marker of Disease Actvity, Is Prognostic of Radiographic Knee OA
Anne C. Bay-Jensen¹, Asger R. Bihlet², Inger Byrjalsen³, Jeppe Andersen⁴, Yi He⁵, Anne Sofie Siebuhr¹, Christian S. Thudium⁶, Bente J. Riis², Claus Christiansen² and Morten Asser Karsdal¹, ¹Rheumatology, Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience, Clinical Development, Herlev, Denmark, ³Nordic Bioscience, Herlev, Denmark, ⁴Clinical Development, Nordic Bioscience, Herlev, Denmark, ⁵Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ⁶Biomarkers and Research, Nordic Bioscience, Herlev, Denmark
Background/Purpose: There are two major needs in clinical DMOAD development: Identifying a population with an active and progressive disease to demonstrate significant improvements by an…

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