Abstracts tagged "OA"

Abstract Number: 1185 • 2017 ACR/ARHP Annual Meeting
Acupotomy Therapy for Joint Pain Relief of Knee Osteoarthritis-Systematic Review and Meta-Analysis
Jia Li¹, Puwei Yuan², Rongqiang Zhang¹, Bin Chen³, Bo Dong¹, Wulin Kang¹, Xiaoliang Zhang³, Stephanie Hyon⁴, Raveendhara R. Bannuru⁵, William F. Harvey⁴ and Chenchen Wang⁴, ¹Shaanxi University of Chinese Medicine, Xianyang, China, ²Traditional Chinese Medicine College, Shaanxi University of Chinese Medicine, Xianyang, China, ³Integrative TCM and Western Medicine College, Shaanxi University of Chinese Medicine, Xianyang, China, ⁴Rheumatology, Center of Integrative Medicine and Division of Rheumatology, Tufts Medical Center, Boston, MA, Boston, MA, ⁵Center of Integrative Medicine and Division of Rheumatology, Tufts Medical Center, Boston, MA, Boston, MA
Background/Purpose: Knee osteoarthritis (KOA) is a major public health problem and a leading cause of long-term pain and disability. Few effective medical treatments for the…
Abstract Number: 1206 • 2017 ACR/ARHP Annual Meeting
Chondroitin Sulfate Reduces Pain and Improves Function in Knee Osteoarthritis Significantly Better Than Placebo, Independently of the Definition of Responders
J-Y Reginster, Bone Cartilage Unit, University of Liege, Liege, Belgium
Background/Purpose: In addition to the assessment of the two co-primary endpoints – pain and function – regulatory agencies recommend the use of responder rates in…
Abstract Number: 2019 • 2017 ACR/ARHP Annual Meeting
Structural Abnormalities in the Knee Detected By MRI in Middle-Aged Subjects without Radiographic Knee Osteoarthritis
Jaanika Kumm¹, Aleksandra Turkiewicz², Fan Zhang² and Martin Englund², ¹Department of Radiology, University of Tartu, Tartu, Estonia, ²Clinical Sciences Lund, Orthopedics, Clinical Epidemiology Unit, Lund University, Lund, Sweden
Background/Purpose: Early OA is a complex, poorly understood and still largely an unchartered “entity”. Thus, our purpose was evaluate the prevalence of findings suggestive of…
Abstract Number: 2196 • 2017 ACR/ARHP Annual Meeting
An Exploratory Analysis of Physical Activity Levels and the Presence of Bone Marrow Lesions in Adults with Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Amanda R. Canavatchel¹, Lori Lyn Price², Jeffrey B. Driban³, Ming Zhang¹, Grace H. Lo⁴ and Timothy E. McAlindon⁵, ¹Tufts Medical Center, Boston, MA, ²Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ³Rheumatology, Tufts Medical Center, Boston, MA, ⁴Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ⁵Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Many people with knee OA have bone marrow lesions (BMLs). BMLs are related with structural pathology and pain. Some investigators have found an association…
Abstract Number: 2198 • 2017 ACR/ARHP Annual Meeting
Combinatorial Peripheral Blood Inflammatory and MRI-Based Biomarkers Predict Radiographic Joint Space Narrowing in Knee OA
Svetlana Krasnokutsky Samuels¹, Hua Zhou², Mukundan Attur¹, Jonathan Samuels¹, Gregory Chang³, Jenny Bencardino⁴, Sisi Ma², Leon Rybak³ and Steven B. Abramson⁵, ¹Rheumatology, NYU Langone Medical Center, New York, NY, ²Bioinformatics, New York University, New York, NY, ³Department of Radiology, NYU Langone Medical Center, New York, NY, ⁴Radiology, NYU Langone Medical Center, New York, NY, ⁵Dept of Medicine, NYU Langone Medical Center, New York, NY
Background/Purpose: Inflammation contributes to OA disease pathogenesis. Subsets of knee OA patients with peripheral blood leukocyte (PBL) detected inflammatory gene expression profiles exhibit more rapid…
Abstract Number: 1124 • 2016 ACR/ARHP Annual Meeting
IL37 Rescues Human OA Cartilage Explants from GAG Release
Ellen van Geffen¹, Arjan van Caam², Henk van Beuningen², Elly Vitters², Esmeralda Blaney Davidson² and Peter M. van der Kraan², ¹Experimential Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: In healthy cartilage, there is a balance between anabolic and catabolic activities of chondrocytes that maintains the functional integrity of the extracellular matrix. However,…
Abstract Number: 1405 • 2016 ACR/ARHP Annual Meeting
Quality Measures in High Priority Rheumatologic Diseases: A Systematic Literature Review and Analysis
Melissa Wells¹, Stephanie Giattino¹, Malithi Jayasundara¹, Lisa Criscione-Schrieber¹, Arif Kamal² and Eugene William St.Clair¹, ¹Rheumatology, Duke University Medical Center, Durham, NC, ²Oncology, Duke University Medical Center, Durham, NC
Background/Purpose: To identify published quality measures in rheumatoid arthritis (RA), osteoarthritis (OA), osteoporosis, spondyloarthropathy (SpA) and gout for the purpose of summarizing the existing measures…
Abstract Number: 2029 • 2016 ACR/ARHP Annual Meeting
Risk of Knee Pain, Radiographic Osteoarthritis and Knee Arthroplasty in Retired Professional Footballers Compared to the General Population
Gwen Fernandes^1,2,3, Sanjay M Parekh^1,2, Jonathan P Moses^1,2, Colin Fuller⁴, Brigitte Scammell^1,2,3, Mark Batt^1,2,3, Weiya Zhang^1,2,3 and Michael Doherty^1,2,3, ¹Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ²Arthritis Research UK Centre for Sports, Exercise and Osteoarthritis, Nottingham, United Kingdom, ³Arthritis Research UK Pain Centre, Nottingham, United Kingdom, ⁴Colin Fuller Consultancy Ltd, Nottingham, United Kingdom
Background/Purpose: To determine the prevalence of knee pain (KP), radiographic knee osteoarthritis (RKOA) and total knee replacements (TKR) in ex-professional footballers compared to general population…
Abstract Number: 2128 • 2016 ACR/ARHP Annual Meeting
Autophagic Clearance of Dysfunctional Mitochondria Requires Parkin in Human Chondrocytes
Mohammad Y Ansari¹ and Tariq M. Haqqi², ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose:
Abstract Number: 2348 • 2016 ACR/ARHP Annual Meeting
Does Arthritis in Other Joints and Spine Influence the 1-Year Outcome of Total Hip Replacement? a Prospective European Multicenter Cohort Study Measuring the Influence of Musculoskeletal Morbidity
Joerg Huber¹, Paul Dieppe², Karsten Dreinhoefer³, Klaus-Peter Günther⁴, Georg Ruflin⁵ and Andrew Judge⁶, ¹Orthopedics, Triemli Spital, Zurich, Switzerland, ²Exeter Medical School, University of Exeter, Exeter, United Kingdom, ³Centre of Musculosceletal Surgery, Charité, Charite, Berlin, Berlin, Germany, ⁴University Center of Orthopedics and Traumatology, Technische Universität, Dresden, Germany, ⁵Orthopedics, Kantonsspital Aarau, Aarau, Switzerland, ⁶Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom
Background/Purpose: Whilst arthritis in other affected joints and back pain is known to lead to worse outcomes following total hip replacement surgery, these risk factors…
Abstract Number: 2354 • 2016 ACR/ARHP Annual Meeting
Pharmaceutical Grade Chondroitin Sulfate Improves Knee Osteoarthritis Symptoms More Than Placebo and As Much As Celecoxib: Results of the Chondroitin Vs Celecoxib Vs Placebo Trial (CONCEPT)
J-Y Reginster and CONCEPT Authors' Group, Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium
Background/Purpose: For the assessment of Symptomatic Slow Acting Drugs in Osteoarthritis (SYSADOAs), regulatory Agencies request the assessment of two co-primary endpoints: pain and function. They…
Abstract Number: 2364 • 2016 ACR/ARHP Annual Meeting
Swimming May Associate with Less Osteoarthritis: Data from the Osteoarthritis Initiative
Grace H. Lo¹, Jeffrey B. Driban², Timothy E. McAlindon³, Charles Eaton⁴, C. Kent Kwoh⁵, Andrea Kriska⁶, Richard Souza⁷, Nancy J. Petersen⁸, Kristi Storti⁹, Marc Hochberg¹⁰, Rebecca D. Jackson¹¹, Michael C. Nevitt¹² and Maria Suarez-Almazor¹³, ¹Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ²Rheumatology, Tufts Medical Center, Boston, MA, ³Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁴Brown University, Providence, RI, ⁵Rheumatology, University of Arizona, College of Medicine, Tucson, AZ, ⁶University of Pittsburgh, Pittsburgh, PA, ⁷University of California, San Francisco, San Francisco, CA, ⁸Medicine, Baylor College of Medicine, Houston, TX, ⁹Department of Kinesiology, Health and Sport Science, Indiana University of Pennsylvania, Indiana, PA, USA, Indiana, PA, ¹⁰Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, ¹¹Ohio State University, Columbus, OH, ¹²Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ¹³Section of Rheumatology and Clinical Immunology, Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Houston, TX
Background/Purpose: Swimming is a non-weight-bearing exercise often recommended to people with knee OA because it is viewed as being less harmful to the knee despite…
Abstract Number: 3058 • 2016 ACR/ARHP Annual Meeting
Varus Thrust and Incident and Progressive Knee Osteoarthritis
Leena Sharma¹, Alison H. Chang², Charles Eaton³, Marc Hochberg⁴, Rebecca D. Jackson⁵, C. Kent Kwoh⁶, Michael C. Nevitt⁷, Orit Almagor⁸, Kirsten C. Moisio⁸ and Joan S. Chmiel⁹, ¹Division of Rheumatology, Northwestern University, Chicago, IL, ²PT & Human Movement Sciences, Northwestern University, Chicago, IL, ³Brown University, Providence, RI, ⁴Department of Medicine, University of Maryland, Baltimore, MD, ⁵Ohio State University, Columbus, OH, ⁶Rheumatology, University of Arizona, College of Medicine, Tucson, AZ, ⁷Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁸Northwestern University, Chicago, IL, ⁹Preventive Medicine, Northwestern University, Chicago, IL
Background/Purpose: Varus thrust, bowing-out of the knee during gait, i.e., appearance (or worsening) of varus during stance improving in late stance or swing, was associated…
Abstract Number: 155 • 2016 ACR/ARHP Annual Meeting
Evaluation of Ultrasonography As Modality for Identification of Calcium Crystal Deposits in Patients of Primary Osteoarthritis of Knee Joint
Siddharth K. Das¹, Durgesh Srivastava², Urmila Dhakad³, Manju Singh², Ragini Srivastava⁴ and Archana Wakhlu², ¹Rheumatology, Prof. and Head, Rheumatology, K.G. Medical University, Lucknow, Lucknow, India, ²Rheumatology, King Georges Medical Univesity, Lucknow, India, ³Rheumatology, Asst Professor, K.G. Medical University, Lucknow, India, Lucknow, India, ⁴Rheumatology, Senior Research Officer, Rheumatology, K.G. Medical University, Lucknow, India, Lucknow, India
Background/Purpose: Calcium deposition diseases, the disordered calcification of cartilage and/or periarticular soft tissue, are associated with aging, degenerative joint disease, and genetic and metabolic disorders.…
Abstract Number: 307 • 2016 ACR/ARHP Annual Meeting
Visualizing Different Patterns of Cartilage Change: A Two-Year Study of Data from the Osteoarthritis Initiative
Amanda R. Canavatchel¹, Grace H. Lo², Michael P. LaValley³, Ming Zhang¹, Jeffrey B. Driban⁴, Lori Lyn Price⁵, Eric Miller⁶, Charles Eaton⁷ and Timothy E. McAlindon⁸, ¹Tufts Medical Center, Boston, MA, ²Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, ³Biostatistics, Boston University School of Public Health, Boston, MA, ⁴Rheumatology, Tufts Medical Center, Boston, MA, ⁵Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁶Department of Electrical and Computer Engineering, Tufts University, Medford, MA, ⁷Brown University, Providence, RI, ⁸Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Traditionally, regions of the knee that are assessed in clinical trials are selected based on anatomy or responsiveness to change. However, it is unclear…

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