Abstracts tagged "OA"

Abstract Number: 314 • 2016 ACR/ARHP Annual Meeting
The Clinical Efficacy and Safety of the Gumiganhwal-Tang in Knee Osteoarthritis: A Phase II Randomized Double Blind Placebo Controlled Study
Sung Hae Chang¹, Mi-Il Kang² and Seong-Su Nah³, ¹Internal Medicine, Rheumatology, Soonchunhyang University, College of Medicine, Cheonan, South Korea, ²Dankuk University Hospital, Cheonan, Korea, The Republic of, ³Soonchunhyang University, College of Medicine, Cheonan, South Korea
Background/Purpose: Gumiganghwal-tang (GMGHT) is a traditional herbal medicine consisted of nine different herbs. GMGHT inhibit the production and mRNA expression of inflammatory cytokine production TNF…
Abstract Number: 683 • 2016 ACR/ARHP Annual Meeting
Risk Factors of Uveitis in Ankylosing Spondylitis
Feng Wang¹, Qin Xue², Li Sun³ and Niansong Wang⁴, ¹Nephrology and Rheumatology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China, ²Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China, ³Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing, China, ⁴Shanghai Jiao Tong University Affiliated Sixth People's Hospital, shanghai, China
Background/Purpose: Uveitis is the most common extra-articular manifestation in patients with ankylosing spondylitis (AS).The prevalence and characteristics of uveitis in AS have been studied in previous literatures while…
Abstract Number: 1018 • 2016 ACR/ARHP Annual Meeting
Dietary Intake of Fiber and Risk of Knee Osteoarthritis
Zhaoli (Joy) Dai¹, Jingbo Niu¹, Yuqing Zhang², Paul Jacques³ and David T. Felson⁴, ¹Clinical epidemiology research and training unit, Boston University School of Medicine, Boston, MA, ²Clinical Epidemiology and Training Unit, Boston University School of Medicine, Boston, MA, ³Jean Mayer USDA Human Nutrition Research Center on Aging and Friedman School of Nutrition Science and Policy, Tufts University, Boston, Boston, MA, ⁴Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Dietary fiber reduced risks of metabolic diseases in part by reducing systemic inflammation and body weight. These factors are both likely to contribute to…
Abstract Number: 3249 • 2015 ACR/ARHP Annual Meeting
Pooled Efficacy and Safety from Phase 3 Controlled Studies of Tanezumab in Patients with Osteoarthritis
Leslie Tive¹, David Radin², Alfonso Bello³, Ha Nguyen¹, Mark T. Brown⁴, Christine R. West⁴ and Kenneth M. Verburg⁴, ¹Pfizer, Inc, New York, NY, ²Stamford Therapeutics Consortium, Stamford, CT, ³Illinois Bone & Joint Inst, Glenview, IL, ⁴Pfizer Inc., Groton, CT
Background/Purpose: Tanezumab (TNZ) significantly reduces pain and improves physical function and Patient's Global Assessment (PGA) in patients with chronic pain. From June 2010 to August…
Abstract Number: 2408 • 2015 ACR/ARHP Annual Meeting
The Quality of Community-Based Osteoarthritis Care Can be Improved. Results from a Systematic Review and Meta-Analysis
Kåre Birger Hagen¹, Geir Smedslund², Nina Østerås² and Gro Jamtvedt³, ¹National Advisory Unit on Rehabilitation in Rheumatology, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²National Advisory Unit on Rehabilitation in Rheumatology, Department of Rheumatology,, Diakonhjemmet Hospital, Oslo, Norway, ³The Norwegian Knowledge Center for the Health Services, Oslo, Norway
Background/Purpose: The burden of osteoarthritis (OA) is substantial and expected to increase because people are getting older and heavier. Health care providers need to monitor…
Abstract Number: 2405 • 2015 ACR/ARHP Annual Meeting
Knee Sounds May Predict Osteoarthritis Severity, Symptoms and Function: Pilot Investigation Toward a Novel Dynamic Imaging System
Victoria Manning¹, Costas Yiallourides², Mads Brevadt¹, Alastair Moore², Edouard Auvinet¹, Patrick Naylor² and Justin Cobb¹, ¹Musculoskeletal Lab, Imperial College London, London, United Kingdom, ²Communications and Signal Processing Group, Imperial College London, London, United Kingdom
Background/Purpose: Knee sounds (KS) may provide a low-cost, risk-free means of identifying presence and severity of knee osteoarthritis (KOA). Unlike static imaging, KS during dynamic…
Abstract Number: 2172 • 2015 ACR/ARHP Annual Meeting
Distribution of Clinical Osteoarthritis and Associations to Health-Related Quality of Life in a Population-Based Osteoarthritis Cohort
Guro Økelsrud Lombnæs¹, Karin Magnusson² and Kåre Birger Hagen¹, ¹National Advisory Unit on Rehabilitation in Rheumatology, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Department of Rheumatology, National Advisory Unit on Rehabilitation in Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Osteoarthritis (OA) is a major cause of musculoskeletal pain and disability, and is commonly reported to impair health-related quality of life (HRQoL). We aimed…
Abstract Number: 2169 • 2015 ACR/ARHP Annual Meeting
Low Education Is Associated with Mortality Among Individuals with Knee and/or Hip OA: The Johnston County Osteoarthritis Project
Rebecca J. Cleveland¹, Todd A. Schwartz², Jordan B. Renner³, Joanne M. Jordan⁴ and Leigh F. Callahan⁴, ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²School of Nursing, University of North Carolina, Chapel Hill, NC, ³Radiology, University of North Carolina, Chapel Hill, NC, ⁴Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: Low socioeconomic status (SES) is associated with an increased risk of death as well as knee and/or hip osteoarthritis (OA). SES and mortality has…
Abstract Number: 1266 • 2015 ACR/ARHP Annual Meeting
Rheumatologic Diagnoses, Characteristics and Needs of Somali Patients Referred to a Rheumatology Clinic Serving the Somali Population
Elizabeth Miller¹, Elie Gertner², Rosemary Quirk¹ and Maribet McCarty¹, ¹Hennepin County Medical Center, Minneapolis, MN, ²Section of Rheumatology, Regions Hospital and University of Minnesota, St. Paul, MN
Background/Purpose: With the growing immigrant and refugee population in the United States, the landscape of medicine is constantly changing. In order to provide quality healthcare,…
Abstract Number: 1136 • 2015 ACR/ARHP Annual Meeting
IL-1β-Induced Stress Granules Sequester COX-2 mRNA and Regulates Its Expression in Human OA Chondrocytes
Mohammad Ansari¹ and Tariq Haqqi², ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Stress granules (SGs) are ribonucleoprotein complexes assembled in the cytoplasm of eukaryotic cells to respond adequately to stress (e.g. heat shock, UV irradiation, oxidative…
Abstract Number: 339 • 2015 ACR/ARHP Annual Meeting
More Inflammatory Signs on Ultrasound, Severe Pain and Stiffness Are Associated with Erosive Than Non-Erosive Hand Osteoarthritis
Olga Sleglova¹, Olga Ruzickova², Karel Pavelka¹ and Ladislav Senolt², ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Hand osteoarthritis (HOA) causes considerable pain and disability. Radiographic HOA features show only a modest association with symptoms in HOA. Ultrasound is an easy…
Abstract Number: 334 • 2015 ACR/ARHP Annual Meeting
Lifetime Risk of Symptomatic Hand Osteoarthritis: The Johnston County Osteoarthritis Project
Jin Qin¹, Kamil E. Barbour¹, Louise Murphy¹, Charles G. Helmick¹, Nancy A. Baker², Kristina Theis¹, Todd Schwartz^3,4, Jordan B. Renner⁵, Amanda Nelson⁶, Kelli Allen⁷ and Joanne M. Jordan⁸, ¹Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ²University of Pittsburgh, Pittsburgh, PA, ³Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵UNC School of Medicine, University of North Carolina, Chapel Hill, NC, ⁶Division of Rheumatology, Allergy, and Immunology and Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ⁷University of North Carolina, Chapel Hill, NC, ⁸Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: Osteoarthritis (OA) affects 27 million adults in the United States. Symptomatic hand osteoarthritis (SHOA) is a common condition that affects hand strength and function.…
Abstract Number: 321 • 2015 ACR/ARHP Annual Meeting
Effects of Bariatric Surgery on Long-Term Quality of Life Outcomes for Obese Patients with Osteoarthritis
Ankita Satpute¹, Deepak L. Bhatt², Sangeeta Kashyap³, Philip Schauer⁴, Colin O'Rourke⁵, James Bena⁵ and M. Elaine Husni⁶, ¹Case Western Reserve University School of Medicine, Cleveland, OH, ²Brigham and Women’s Hospital Heart & Vascular Center, Boston, MA, ³Endocrinology, Diabetes and Metabolism, Cleveland Clinic Foundation, Cleveland, OH, ⁴General Surgery, Cleveland Clinic Foundation, Cleveland, OH, ⁵Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, ⁶Rheumatology Dept A50, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Osteoarthritis (OA) remains a debilitating burden for patients and a challenge to their physicians, as there is no known cure. Obesity has been linked…
Abstract Number: 2965 • 2014 ACR/ARHP Annual Meeting
Effects of Anti-NGF Strategies in Two Animal Models of Osteoarthritis (OA)
Lilian Ngozi Nwosu¹, Paul Mapp¹, Karyn Bouhana², Steven Andrews², Victoria Chapman³ and David Walsh⁴, ¹Academic Rheumatology, Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom, ²Array BioPharma, Boulder, CO, ³Life Sciences, Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom, ⁴Academic Rheum/Clin Sci Bldg, Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom
Background/Purpose Levels of endogenous nerve growth factor (NGF) are increased in osteoarthritic (OA) joints in patients and animal models and may be an important cause…
Abstract Number: 243 • 2014 ACR/ARHP Annual Meeting
Safety of Solumatrix Diclofenac in Adults with Osteoarthritis: Results of a 12-Month, Phase 3 Study
Roy Altman¹, Allan Gibofsky², Marc C. Hochberg³, Byron Cryer⁴, Alan J. Kivitz⁵, Vibeke Strand⁶, Olaolu Imasogie⁷ and Clarence Young⁸, ¹University of California–Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ²Medicine and Public Health, Hospital for Special Surgery, New York, NY, ³Division of Rheumatology & Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD, ⁴University of Texas Southwestern Medical Center, Dallas, TX, ⁵Altoona Center for Clinical Research, Duncansville, PA, ⁶Stanford University, Palo Alto, CA, ⁷Iroko Pharmaceuticals LLC, Philadelphia, PA, ⁸150 Rouse Boulevard, Iroko Pharmaceuticals, LLC, Phila, PA
Background/Purpose: Osteoarthritis (OA) is a frequent cause of disability in adults. NSAIDs such as diclofenac are often prescribed to treat OA pain. However, NSAIDs…