Abstract Number: 1827 • ACR/ARP Annual Meeting 2019
Clinical Implications of Neutrophil Extracellular Traps in Systemic Lupus Erythematosus
Background/Purpose: Neutrophil activation, including formation of neutrophil extracellular traps (NETs), is essential in host defense. However, NET formation has also been linked to inflammation and…Abstract Number: 2789 • ACR/ARP Annual Meeting 2019
Neutrophil Extracellular Traps Induce Tissue-Invasive Macrophages in Granulomatosis with Polyangiitis Dominated by Ear, Nose and Throat Manifestations
Background/Purpose: Granulomatosis with polyangiitis (GPA) is a small vessel vasculitis characterized by acute and chronic tissue destruction in the nose, sinuses, lungs and kidneys. In…Abstract Number: 2790 • ACR/ARP Annual Meeting 2019
Platelet Mediates Neutrophil Extracellular Traps Formation via TLR Signaling in ANCA-associated Vasculitis
Background/Purpose: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease that affects small- to medium-sized blood vessels and causes vascular inflammation and multiple organ…Abstract Number: 2811 • ACR/ARP Annual Meeting 2019
The IRE1α Pathway Mediates Neutrophil Stress and NETosis in Lupus
Background/Purpose: Immune complex (IC)-activated neutrophils appear to amplify inflammation in lupus through the release of neutrophil extracellular traps (NETosis). There is presently no consensus as…Abstract Number: 31 • ACR/ARP Annual Meeting 2019
Regulation of Neutrophil Extracellular Traps by Apremilast (phosphodiesterase 4 Inhibition)
Background/Purpose: Increased propensity for neutrophil extracellular trap generation has been described in autoimmune diseases such as rheumatoid arthritis. Neutrophil extracellular traps are thought to contribute…Abstract Number: 489 • ACR/ARP Annual Meeting 2019
S100A11 (calgizzarin) Is Released During Neutrophil Extracellular Traps (NETs) Formation in Rheumatoid Arthritis (RA)
Background/Purpose: S100A11 protein, a member of S100 family, has been associated with several autoimmune inflammatory conditions such as rheumatoid arthritis (RA). Moreover, its pro-inflammatory effect…Abstract Number: 1226 • ACR/ARP Annual Meeting 2019
Neutrophil Activation Identifies Patients with Active Polyarticular Gout – a Role for Neutrophil Biomarkers in Monitoring Gout Disease Activity and Severity
Background/Purpose: Neutrophils are key immune cells participating in host defense through several mechanisms, including the formation of neutrophil extracellular traps (NETs). Excessive neutrophil activation has…Abstract Number: 1227 • ACR/ARP Annual Meeting 2019
A Neutrophil Signature Is Strongly Associated with Cardiovascular Risk in Gout
Background/Purpose: Patients with gout have an increased cardiovascular morbidity and mortality, not fully explained by traditional cardiovascular risk factors. Xanthine oxidase-induced oxidative stress, increased lipid…Abstract Number: 11 • ACR/ARHP Annual Meeting 2018
PAD4-Independent Interaction of ACPA with Nuclear Antigens in Apoptotic Cells and Neutrophil Extracellular Traps (NETs) Defines a Subset of Autoantibodies
Background/Purpose: Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) bind a wide range of citrullinated proteins with high cross-reactivity. Recent findings suggest that certain, but…Abstract Number: 77 • ACR/ARHP Annual Meeting 2018
Single Nucleotide Polymorphism in the Gene Encoding Peptidylarginine Deiminase 4 Correlates with Reduced Neutrophil Extracellular Traps and Anti-Histone Antibodies in Rheumatoid Arthritis
Background/Purpose: In neutrophils, peptidylarginine deiminase 4 (PAD4) citrullinates histones allowing chromatin unraveling and neutrophil extracellular trap (NET) formation. NETs are increased and display proteins targeted…Abstract Number: 106 • ACR/ARHP Annual Meeting 2018
Highly Elevated Levels of Anti-Mitochondrial Antibodies in Systemic Lupus Erythematosus and Rheumatoid Arthritis
Background/Purpose: We recently described the phenomenon in systemic lupus erythematosus (SLE) in which mitochondria are extruded into the extracellular space during formation of neutrophil extracellular…Abstract Number: 975 • ACR/ARHP Annual Meeting 2018
Alteration of Vascular Inflammatory Markers in SLE By Anifrolumab in the Phase IIb Muse Study
Background/Purpose: Cardiovascular disease is a leading cause of death for patients with systemic lupus erythematosus (SLE), and the disease is widely known to feature premature…Abstract Number: 1002 • ACR/ARHP Annual Meeting 2018
Pkcα Deficiency Protected Mice from UVB Induced-Skin Inflammation through Attenuation of Neutrophil Netosis
Background/Purpose: Neutrophil NETosis is a form of cell death characterized by nuclear envelope rupture, nuclear chromatin release, and neutrophil extracellular trap formation. NETosis is important…Abstract Number: 1004 • ACR/ARHP Annual Meeting 2018
Reevaluating Citrullination and Peptidylarginine Deiminases in Neutrophil Extracellular Trap-like Structures
Background/Purpose: Neutrophil extracellular traps (NETs) are webs of chromatin and proteins extruded from neutrophils during NETosis. NETs are increased and display citrullinated proteins that are…Abstract Number: 1085 • ACR/ARHP Annual Meeting 2018
Natural Gingerols Inhibit Neutrophil Extracellular Trap Release Elicited By Lupus Autoantibodies
Background/Purpose: Recent studies have revealed a role for neutrophils in the pathogenesis of lupus and antiphospholipid syndrome (APS). Indeed, neutrophils are activated by various disease-relevant…
ACR Meeting Abstracts