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Abstracts tagged "Neutrophil Extracellular Traps"

  • Abstract Number: 573 • 2016 ACR/ARHP Annual Meeting

    Synovial Fibroblast-Neutrophil Interactions Promote Pathogenic Adaptive Immunity in Rheumatoid Arthritis

    Carmelo Carmona-Rivera1, Erica Moore2, Nithya Lingampalli3, Hannes Uchtenhagen4, Eddie James5, Kevin L. Bicker6, Heidi Wähämaa7, Victoria Hoffmann8, Anca I Catrina7, Paul Thompson9, Jane H. Buckner5, William Robinson10, David Fox11 and Mariana Kaplan2, 1Systemic Autoimmunity Branch/ NIAMS, National Institutes of Health, Bethesda, MD, 2Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 3Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 4Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, 5Benaroya Research Institute at Virginia Mason, Seattle, WA, 6Middle Tennessee State University, Murfreesboro, TN, 7Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 8Division of Veterinary Resources, National Institutes of Health, Bethesda, MD, 9University of Massachusetts, Worcester, MA, 10Stanford University School of Medicine, Stanford, CA, 11Department of Medicine [Division of Rheumatology], University of Michigan, Ann Arbor, MI

    Background/Purpose:   Methods:   Results:   Conclusion:  
  • Abstract Number: 1006 • 2016 ACR/ARHP Annual Meeting

    Immune Complex-Mediated TLR8 Activation Shifts Neutrophils from Phagocytosis to Netosis through Furin-Dependent Shedding of Fcgriia

    Christian Lood1, Sabine Arve2, Laura Durcan2, Jeffrey Ledbetter2 and Keith B. Elkon1, 1Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2University of Washington, Seattle, WA

    Background/Purpose:  Neutrophils, isolated from healthy individuals, were incubated with RNA-ICs and analyzed for phagocytosis and NETosis by flow cytometry and fluorimetry, respectively, in the presence…
  • Abstract Number: 1756 • 2016 ACR/ARHP Annual Meeting

    Novel Role of Rho Kinase in Neutrophil Netosis during UVB Induced-Skin Inflammation

    Ming-Lin Liu1,2, Meena Sharma2,3 and Victoria P. Werth4,5, 1Department of Dermatology,, Philadelphia V.A. Medical Center, Philadelphia, PA, 2Department of Dermatology, University of Pennsylvania, Philadelphia, PA, 3Department of Dermatology, Philadelphia V.A. Medical Center, Philadelphia, PA, 4Dermatology, University of Pennsylvania, Philadelphia, PA, 5Philadelphia V.A. Medical Center, Philidelphia, PA

    Background/Purpose:  Skin inflammation appears in cutaneous or systemic lupus erythematosus. Ultraviolet B (UVB) is an important environmental trigger of skin inflammation in lupus. Mechanisms linking…
  • Abstract Number: 1962 • 2016 ACR/ARHP Annual Meeting

    Antiphospholipid Syndrome Neutrophils Are Characterized By Overexpression of P-Selectin Glycoprotein Ligand 1, a Potential Therapeutic Target

    Jason S Knight1, Patrick S. Coit1, He Meng1, Srilakshmi Yalavarthi1, Paul Renauer1, Robert C Grenn1, Levi F Mazza1, Hui Wang2, Daniel T Eitzman2 and Amr H Sawalha1, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI

    Background/Purpose:  Treatment of the thrombotic manifestations of antiphospholipid syndrome (APS) primarily focuses on inhibiting clotting pathways. In an effort to identify upstream inflammatory targets that…
  • Abstract Number: 2058 • 2016 ACR/ARHP Annual Meeting

    Ectonucleotidase-Mediated Protection of Lupus Mice from Exaggerated Immune Responses and Arterial Vasculopathy

    Jason S Knight1, Levi F Mazza1, Srilakshmi Yalavarthi1, Yogen Kanthi2 and David J Pinsky2, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI

    Background/Purpose: CD39 and CD73 are so-called ectonucleotidases, surface enzymes expressed by leukocytes and endothelial cells that jut into the extracellular space. There, they mediate the…
  • Abstract Number: 3017 • 2016 ACR/ARHP Annual Meeting

    Elevated Neutrophil Extracellular Trap Levels Correlate with Anti-CCP3-IgG and Anti-CCP3-IgA Levels in the Sputum of Individuals at-Risk for Future Rheumatoid Arthritis

    M. Kristen Demoruelle1, Monica Purmalek2, Heather Rothfuss3, Michael Weisman4, Lindsay Kelmenson1, Michael Mahler5, Jill M. Norris6, Brian Cherrington3, Mariana Kaplan2, V. Michael Holers1 and Kevin D. Deane1, 1Rheumatology Division, University of Colorado Denver, Aurora, CO, 2Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 3Zoology and Physiology, University of Wyoming, Laramie, WY, 4Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 5Research and Development, Inova Diagnostics, San Diego, CA, 6Epidemiology, Colorado School of Public Health, Aurora, CO

    Background/Purpose: The initial site of anti-citrullinated protein antibody (ACPA) generation in RA has been proposed to be a mucosal site. We have previously demonstrated ACPA…
  • Abstract Number: 2121 • 2015 ACR/ARHP Annual Meeting

    Placentas of Lupus Pregnancies Are Characterized By Marked Inflammatory Changes Despite Good Disease Control

    Wendy Marder1, Jason S. Knight2, Mariana J. Kaplan3, Emily C. Somers4, Xu Zhang4, Alexander A. O'Dell5, Vasantha Padmanabhan4 and Richard W. Lieberman4, 1Div of Rheumatology, University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, University of Michigan, Ann Arbor, MI, 3National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4University of Michigan, Ann Arbor, MI, 5Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose:   Systemic lupus erythematosus (SLE) is associated with increased risk of adverse pregnancy outcomes (APO), including preeclampsia and intrauterine growth restriction.  While significant placental…
  • Abstract Number: 2598 • 2015 ACR/ARHP Annual Meeting

    Neutrophil Extracellular Trap Levels Measured By Cell Free Nucleosome ELISA in Serum Are Highly Specific and Sensitive for Rheumatoid Arthritis

    Paul Hasler1, Stavros Giaglis1, Ulrich A. Walker2, Erik Deman1, Christoph Hemmeler1, Christina Ryser1, Samuel Kretzschmar1, Guenther Schaefer3, Juliane Franz1 and Sinuhe Hahn4, 1Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, 2Rheumatology, University Hospital, Basel, Basel, Switzerland, 3Dept. of Biomedicine, Laboratory of Prenatal Medicine, University Hospital Basel, Basel, Switzerland, 4Dept. of Biomedicine, Laboratory for Prenatal Medicine, University Hospital Basel, Basel, Switzerland

    Background/Purpose: Rheumatoid factor (RF) or anti-citrullinated peptide antibody (ACPA) detection have limited clinical utility for the diagnosis of rheumatoid arthritis (RA), as the specificity and…
  • Abstract Number: 2709 • 2015 ACR/ARHP Annual Meeting

    Immediate  Release of Peripheral Neutrophil Myeloperoxidase and Elastase and Formation of Extracellular Traps to Cigarette Smoking in Rheumatoid Arthritis

    Juliane Franz1, Stavros Giaglis1,2, Guenther Schaefer3, Erik Deman1, Andreas Thueler4, Sinuhe Hahn2 and Paul Hasler1, 1Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, 2Biomedicine, Laboratory of Prenatal Medicine, University Hospital Basel, Basel, Switzerland, 3Dept. of Biomedicine, Laboratory of Prenatal Medicine, University Hospital Basel, Basel, Switzerland, 4Rheumatology, Kantonsspital Baden, Baden, Switzerland

    Background/Purpose: Smoking represents an independent risk factor for rheumatoid arthritis (RA) (1). In response to infectious agents, neutrophil granulocytes can extrude their nuclear contents as…
  • Abstract Number: 3032 • 2015 ACR/ARHP Annual Meeting

    Role of Adenosine and Neutrophils in Inflammation Associated with Mutations in CECR1 Gene

    Kyawt W. Shwin1,2, Carmelo Carmona-Rivera3, Wanxia Tsai4, Chya-chia Richard Lee5,6, Elaine Novakovich7, Deborah L. Stone8, Amanda K. Ombrello8, Raphaela Goldbach-Mansky9, Massimo Gadina10, Daniel Kastner11, Ivona Aksentijevich12,13, Mariana J. Kaplan7 and Peter C. Grayson14,15, 1NIAMS, National Institutes of Health, BETHESDA, MD, 2Translational Autoinflammatory Diseases Section, National Institutes of Health, Bethesda, MD, 3Systemic Autoimmunity Branch/ NIAMS, National Institutes of Health, Bethesda, MD, 4Translational Immunology, Office of Science and Technology, National Institutes of Health, Bethesda, MD, 5National Cancer Institute, National Institutes of Health, Bethesda, MD, 6Laboratory of Pathology, NCI, National Institutes of Health, BETHESDA, MD, 7Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD, 8National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 9Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD, 10Translational Immunology, Office of Science and Technology, NIAMS, National Institutes of Health, Bethesda, MD, 11Inflammatory Disease Section, NHGRI, National Institutes of Health, Bethesda, MD, 12NIH/NHGRI, Metabolic, Cardiovascular, and Inflammatory Disease Genomics Branch, Bethesda, MD, 13Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD, 14National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 15NIAMS Systemic Autoimmunity Branch, National Institutes of Health, Bethesda, MD

    Background/Purpose: The phenotype of patients afflicted by deficiency of adenosine deaminase 2 (DADA2) due to mutations in CECR1encoding ADA2 protein shares many features with idiopathic…
  • Abstract Number: 205 • 2015 ACR/ARHP Annual Meeting

    Mode of Action of Therapeutic Anti-Citrullinated Protein Antibodies Revealed: Inflammation Reduction Due to Inhibition of Netosis

    Renato G.S. Chirivi1,2, Jos W.G. van Rosmalen1, Gonny Schmets1, Helmuth van Es2 and Jos M.H. Raats1,2, 1ModiQuest BV, Oss, Netherlands, 2Citryll BV, Nijmegen, Netherlands

    Background/Purpose: Neutrophils together with aberrant Neutrophil Extracellular Trap (NET) formation contribute to the induction and propagation of inflammation. A growing number of studies indicate that…
  • Abstract Number: 208 • 2015 ACR/ARHP Annual Meeting

    Neutrophil-Mediated Mechanisms of Drug-Induced Autoimmunity

    Jorge Irizarry-Caro1, Carmelo Carmona-Rivera1, Elaine Novakovich1, Venkataraman Subramaniam2, Paul Thompson3, Mariana J. Kaplan4 and Peter C. Grayson5, 1National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 2Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, MA, 3University of Massachusetts, Worcester, MA, 4Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 5National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

    Background/Purpose: Certain medications are known to induce autoimmune disease in humans, triggering clinical features and autoantibody profiles that mirror idiopathic systemic lupus erythematosus (SLE) and/or…
  • Abstract Number: 209 • 2015 ACR/ARHP Annual Meeting

    Different Autoimmune Rheumatic Diease IgG Have Differential Effects upon Neutrophil Binding, Activation and Neutrophil Extracellular Trap Formation

    Akif A. Khawaja1,2, Charis Pericleous3, Vera M. Ripoll2, Joanna C. Porter4 and Ian Giles5, 1Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, 2Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, 3Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, 4Centre for Inflammation and Tissue Repair, Division of Medicine, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, 5Rayne Intitiute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom

    Background/Purpose: Dysregulation of neutrophil activation and function is important in the pathogenesis of various inflammatory and autoimmune rheumatic diseases (ARDs). Neutrophil dysfunction is well recognised…
  • Abstract Number: 933 • 2015 ACR/ARHP Annual Meeting

    DEK-Targeting DNA Aptamers As Novel Therapeutics for Inflammatory Arthritis

    Nirit Mor-Vaknin1, Anjan K. Saha2, Maureen Legendre1, Carmelo Carmona-Rivera3, M. Asif Amin4, Bradley J. Rabquer5, Marta J. Gonzalez-Hernandez6, Julie M. Jorns7, Srilakshmi Yalavarthi8, Smriti Mohan9, Dave Pai10, Kristine Angevine11, Barbara Adams12, Jason S. Knight8, Alisa E. Koch13,14,15, David Fox14, Dave Engelke16, Mariana J. Kaplan17 and David Markovitz4, 1Infectious Diseases, University of Michigan, Ann Arbor, MI, 2Medical School, University of Michigan, Ann Arbor, MI, 3Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4Internal Medicine, University of Michigan, Ann Arbor, MI, 5Albion College, Ann Arbor, MI, 6Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, 7Pathology, University of Michigan, Ann Arbor, MI, 8Division of Rheumatology, University of Michigan, Ann Arbor, MI, 9Pediatric Rheumatology, University of Michigan, Ann Arbor, MI, 10Scripps Research Institute, San Diego, CT, 11Appistry, Inc, St. Louis, MO, 12Pediatric Rheum PTD, Univ of Michigan Hlth System, Ann Arbor, MI, 13VA Medical Service, Ann Arbor, MI, 14Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 15Internal Medicine, Veteran's Affairs and University of Michigan, Ann Arbor, MI, 16Biochemistry, University Michigan, Ann Arbor, MI, 17Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD

    Background/Purpose: Aptamers are short single stranded DNA or RNA oligonucleotides that are specifically selected to bind and neutralize a wide range of biomedically relevant proteins.…
  • Abstract Number: 964 • 2015 ACR/ARHP Annual Meeting

    Neutrophil  Extracellular Traps Are Not Only Targets for ACPA-Positive IgG from Rheumatoid Arthritis Patients but Also Directly Trigger Pro- and Anti-Inflammatory Effects Partly Mediated By the C1q Complement Protein

    Matthieu Ribon1, Sarra Seninet1, Katarzyna Matyja1, Mireille Sebbag2, Cyril Clavel2, Julie Mussard1, Guy Serre2, Marie-Christophe Boissier3 and Patrice Decker1, 1Inserm UMR 1125, Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, 2University of Toulouse, UMR 5165 CNRS-1056 Inserm, Toulouse, France, 3Rheumatology Department, Avicenne Hospital, AP-HP, Bobigny, France

    Background/Purpose: Activated neutrophils (PMN) form neutrophil extracellular traps (NET). Those structures are expelled chromatin fibers composed of DNA and associated proteins. The process, NETosis, is…
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