ACR Meeting Abstracts

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Abstracts tagged "Neuropsychiatry"

  • Abstract Number: 0094 • ACR Convergence 2024

    Small GTPase Rab4A Regulates Mouse Behavior Through Altered Serum Serotonin Levels and Microglial mTORC1 Activation in Lupus-prone B6.TC Mice

    Thomas Winans1, Xiaojing Wang2, Joshua Lewis2, Jessica Nolan1, Laurence Morel3 and Andras Perl4, 1SUNY Upstate Medical University, Syracuse, 2SUNY Upstate Medical University, Syracuse, NY, 3University of Texas health San Antonio, San Antonio, TX, 4SUNY, Syracuse, NY

    Background/Purpose: Rab4A is a small GTPase that is overexpressed in patients and mice with systemic lupus erythematosus (SLE, PubMed ID: 23897774; PubMed ID 31805010). Rab4A…
  • Abstract Number: 0654 • ACR Convergence 2024

    Corneal Confocal Microscopy: An Ophthalmic Imaging Biomarker for Small Fiber Neuropathy in Systemic Lupus Erythematosus

    Miral Gharib1, Georgios Baloglu Baloglu2, Soha Osman1, Rayaz A.Malik3 and Samar Alemadi4, 1hamad medical corporation, Doha, Qatar, 2Weill Cornell Medicine , Qatar, doha, 3Weill Cornell Medicine , Qatar, doha, Qatar, 4Hamad medical corporation, Doha, Qatar

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic multi-system autoimmune disease with frequent neuropsychiatric symptoms associated with poor outcomes. Small fiber neuropathy can cause intolerable…
  • Abstract Number: 2545 • ACR Convergence 2024

    Phosphodiesterase 1B Contributes to Neuropsychiatric Manifestations in Lupus-Prone Mice Through Microglial Activation

    Shuhei Takeyama1, Michihito Kono1, Kohei Karino1, Yuki Kudo1, Masatoshi Kanda2, Hiroyuki Nakamura2, Kenichi Miyamoto1, Kazuro Kamada3, Maria Tada1, Ryo Hisada1, Yuichiro Fujieda1, Masaru Kato1, Olga Amengual4 and Tatsuya Atsumi1, 1Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Sapporo, Japan, 2Department of Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan, Sapporo, Japan, 3Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Sapprp, Japan, 4Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

    Background/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the most severe organ manifestations in SLE and is associated with poor quality of life. We…
  • Abstract Number: 1459 • ACR Convergence 2023

    Unveiling the Impact of Neuropsychiatric Involvement in Systemic Lupus Erythematosus on Damage Accrual

    Dionysis Nikolopoulos1, Nursen Cetrez2, Julius Lindblom2 and Ioannis Parodis2, 1Karolinska Institutet and Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden, 2Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: The link between neuropsychiatric involvement in systemic lupus erythematosus (NPSLE) and heightened morbidity, mortality, and organ damage, as well as detrimental impacts on health-related…
  • Abstract Number: 2260 • ACR Convergence 2023

    Right Insular Cortex-Thalamic Functional Connectivity as a Potential Marker for Fatigue in Systemic Lupus Erythematosus and Primary Sjögren’s Syndrome

    Yuichiro fujieda1, Kodai Sakiyama1, Nobuya Abe1, Ryo Hisada1, Michihito Kono1, Masaru Kato1, Olga Amengual2, Khin Khin Tha3, Hisashi Shirakawa4 and Tatsuya Atsuma5, 1Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, 2Hokkaido University, Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Sapporo, Japan, 3Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University Hospital, Sapporo, Japan, 4Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto, Japan, 5Hokkaido University, Department of Rheumatology, Endocrinology and Nephrology, Sapporo, Japan

    Background/Purpose: Fatigue is a common symptom in patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS). Resting-state functional magnetic resonance imaging (rs-fMRI) has…
  • Abstract Number: 067 • 2023 Pediatric Rheumatology Symposium

    Clinical and Demographic Characteristics of Children with Anti-NMDAR Encephalitis

    Yike Jiang, Alexander Sandweiss, Timothy Erickson, Eyal Muscal and Kristy Murray, Baylor College of Medicine, Houston, TX

    Background/Purpose: The discovery of anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis heralded a new class of neuropsychiatric illnesses mediated by autoantibodies, known collectively as autoimmune encephalitis. The clinical…
  • Abstract Number: 0332 • ACR Convergence 2022

    Soluble Triggering Receptor Expressed on Myeloid Cells 2 (sTREM2) in Cerebrospinal Fluid Relating to Development of Diffuse Psychiatric/Neuropsychological Syndromes in Patients with Systemic Lupus Erythematosus (diffuse NPSLE)

    Yoshiyuki Arinuma1, Yasuhiro Hasegawa2, Yu Matsueda2, Kenji Oku3 and Kunihiro Yamaoka4, 1Kitasato University, Kanagawa, Japan, 2Kitasato University School of Medicine, Sagamihara, Japan, 3Kitasato University, Chigasaki, Japan, 4Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan

    Background/Purpose: Microglial activation is critical for behavioral abnormalities in a mouse model of diffuse NPSLE following anti-glutamate receptor subunit GluN2 antibody (anti-GluN2) exposure to neurons.…
  • Abstract Number: 1708 • ACR Convergence 2022

    A Role for the RAGE Receptor in Chronic Neurotoxicity After Exposure to SLE Antibodies That Cross React with dsDNA and the NMDA Receptor

    Bahtiyar Toz1, Jeffrey C wingard2, Bruce Volpe2 and Betty Diamond2, 1Resident in Queens Hospital Center, Jamaica, NY, 2Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: Neurologic dysfunction occurs in up to 80% of SLE patients. Cognitive impairment is one of the most frequent manifestations of neuropsychiatric SLE (NPSLE). There…
  • Abstract Number: 1934 • ACR Convergence 2021

    Intra-Individual Change in Cognitive Function Among Adults with Systemic Lupus Erythematosus: A Markov Analysis over 7 Years

    Stefan Perera1, Richard Cook2, Ker-Ai Lee2, Patricia Katz3 and Zahi Touma4, 1Division of General Internal Medicine, University of Toronto, Toronto, ON, Canada, 2Department of Statistics and Actuarial Sciences, University of Waterloo, Waterloo, ON, Canada, 3University of California San Francisco, San Francisco, CA, 4University of Toronto, Mississauga, ON, Canada

    Background/Purpose: Cognitive impairment is a prevalent neuropsychiatric manifestation of SLE. Studies have primarily focused on the prevalence of cognitive impairment cross-sectionally; however, there remain gaps…
  • Abstract Number: 0246 • ACR Convergence 2020

    Extreme Fatigue in Patients with Systemic Lupus Erythematosus and Neuropsychiatric Symptoms

    Rory Monahan1, Rolf Fronczek1, Jeroen Eikenboom1, Huub Middelkoop1, Liesbeth Beaart-van de Voorde1, Gisela Terwindt1, Nic van der Wee1, Thomas Huizinga1, Margreet Kloppenburg1 and Margreet Steup-Beekman1, 1Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Fatigue is commonly described in chronic illnesses, especially in auto-immune disorders such as systemic lupus erythematosus (SLE). We aim to study the prevalence of…
  • Abstract Number: 0835 • ACR Convergence 2020

    Pathogenic Effect of Chronic Stress-induced interleukin-12/23p40 on Neuropsychiatric System in Lupus-prone Mouse

    Nobuya Abe1, Kenji Oku1, Yuichiro Fujieda1, Nobuhiko Takahashi2, Kohei Karino1, Michihito Kono1, Masaru Kato1, Yuki Tanaka3, Rie Hasebe4, Olga Amengual1, Miwako Yamasaki5, Masahiko Watanabe5, Masaaki Murakami3 and Tatsuya Atsumi6, 1Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, 2Division of Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan, 3Division of Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, 4Biomedical Animal Research Laboratory, Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, 5Department of Anatomy, Faculty of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan, 6Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine, Hokkaido University, Sapparo, Hokkaido, Japan

    Background/Purpose:Neuropsychiatric system is one of the major organs affected in systemic lupus erythematosus (SLE). However, the pathogenesis of neuropsychiatric SLE (NPSLE) has not been fully…
  • Abstract Number: 1264 • ACR Convergence 2020

    Mortality in Patients with Systemic Lupus Erythematosus and Neuropsychiatric Symptoms

    Rory Monahan1, Rolf Fronczek1, Jeroen Eikenboom1, Huub Middelkoop1, Liesbeth Beaart-van de Voorde1, Gisela Terwindt1, Nic van der Wee1, Frits Rosendaal1, Thomas Huizinga1, Margreet Kloppenburg1 and Margreet Steup-Beekman1, 1Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Little is known about mortality in patients with systemic lupus erythematosus (SLE) presenting with neuropsychiatric (NP) symptoms. We aimed to evaluate all-cause and cause-specific…
  • Abstract Number: 1676 • ACR Convergence 2020

    Neuropsychiatric Involvement in Juvenile-onset Systemic Lupus Erythematosus (JSLE): Data from the UK JSLE Cohort Study

    Teresa Giani1, Eve Smith2, Rolando Cimaz3, Michael Beresford4 and Christian Hedrich2, 1AOU Meyer, Florence, Italy, 2University of Liverpool, Liverpool, United Kingdom, 3ASST Gaetano Pini-CTO Institute and Università degli Studi di Milano, Milan, Italy, Milan, Italy, 4Department of Women's & Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom

    Background/Purpose: Juvenile-onset systemic lupus erythematosus (JSLE) is a rare autoimmune/inflammatory disease, accounting for up to 20% of SLE cases. Though clinically similar to adult-onset disease,…
  • Abstract Number: 1677 • ACR Convergence 2020

    Schizophrenia Genetics and Neuropsychiatric Features in Childhood-Onset Systemic Lupus Erythematosus

    Ana C. Ulloa Baez1, Fangming Liao2, Raffaella Carlomagno3, Talia Diaz3, Daniela Dominguez4, Deborah Levy3, Lawrence Ng5, Earl D. Silverman6, Andrea Knight7 and Linda Hiraki8, 1Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada, 2Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, 3Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 4Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada, 5Division of Rheumatology, Hospital for Sick Children, Toronto, Canada, 6Division of Rheumatology, The Hospital for Sick Children, Translational Medicine, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada, 7Division of Rheumatology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 8Division of Rheumatology, The Hospital for Sick Children, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada

    Background/Purpose: Prior studies indicate that schizophrenia and systemic lupus erythematosus (SLE) share genetic risk loci. Despite overlapping phenotypic features such as psychosis, little is known…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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