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Abstracts tagged "Monocytes/macrophages"

  • Abstract Number: 0068 • ACR Convergence 2020

    Single Cell RNA-seq to Characterize Monocyte Subtypes in the Autoinflammatory Interferonopathy, SAVI and the Inflammasomopathy, NOMID

    Ying Zhang1, Bernadette Marrero2, Adriana de Jesus3, Sara Alehashemi4, Jinguo Chen5, Rongye Shi6, Huizhi Zhou6, Clifton Dalgard7, Manfred Boehm8 and Raphaela Goldbach-Mansky9, 1Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, MD, 2Computational Systems Biology Section/NIAID/NIH, Bethesda, MD, 3Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Silver Spring, MD, 4Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, 5Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 6Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, 7Department of Anatomy, Physiology and Genetics, Uniformed Services University of Health Sciences, Bethesda, 8Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 9Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Potomac, MD

    Background/Purpose: Monocytes are pivotal producers of key inflammatory cytokines that drive autoinflammatory diseases. In SAVI, constitutive STING activation causes chronic activation with increased type-I IFN…
  • Abstract Number: 0294 • ACR Convergence 2020

    Tired T-Cells and Monocytes with Malaise: Investigating the Links Between Cellular Iron Deficiency and Mitochondrial Dysfunction in Systemic Lupus Erythematosus

    Chris Wincup1, Thomas McDonnell1, George Robinson2, Filipa Farinha1, Anna Radziszewska1 and Anisur Rahman1, 1University College London, London, United Kingdom, 2University College London, Hertford, United Kingdom

    Background/Purpose: Iron is vital for many physiological processes and is found within respiratory complexes of the mitochondrial electron transport chain, the key site of oxidative phosphorylation…
  • Abstract Number: 0450 • ACR Convergence 2020

    In Vitro Characterization of Inflammatory Arthritis Associated with Immune Check Point Inhibition

    Anne Sofie Sørensen1, Morten Nørgaard Andersen1, Kristian Juul-Madsen2, Cæcilie Deisting Skejø1, Henrik Schmidt1, Thomas Vorup-Jensen1 and Tue Wenzel Kragstrup1, 1Aarhus University, Aarhus, Denmark, 2Aarhus University, Aarhus, Midtjylland, Denmark

    Background/Purpose: During treatment with immune checkpoint inhibitors (ICI) such as the anti-PD-1 antibody pembrolizumab, 2-4% of cancer patients develop inflammatory arthritis as an immune-related adverse…
  • Abstract Number: 0496 • ACR Convergence 2020

    A Role of Lipid-Peroxidation in Systemic Lupus Erythematosus-Associated Cardiovascular Disease

    David Patrick1, Justin van Beusecum1, Michelle Ormseth2, Leslie J. Crofford2, Sean Davies3, Sergey Dikalov1 and David Harrison1, 1Vanderbilt University Medical Center, Nashville, 2Vanderbilt University Medical Center, Nashville, TN, 3Vanderbilt University, Nashville

    Background/Purpose: In SLE, cardiovascular complications are a significant contributor to morbidity and death. Importantly, there is an increased prevalence of hypertension in SLE patients compared…
  • Abstract Number: 0772 • ACR Convergence 2020

    Modification of THP-1 Cells with Malondialdehyde-Acetaldehyde Increases Cellular Calcium Load Rendering Cells Susceptible to Citrullination of Self-Proteins

    Nozima Aripova1, Michael Duryee1, Xiarepati Tieliwaerdi1, Xiaoting Jiang1, Lynell Klassen2, James O'Dell1, Bryant England1, Ted Mikuls1 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2Univerisity of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The post translational modification of self-proteins with malondialdehyde-acetaldehyde (MAA) has been shown to alter protein function and antibodies to MAA are increased in both…
  • Abstract Number: 0777 • ACR Convergence 2020

    CLEC12A Expression as a Potential Predictor of Disease Activity in Early Rheumatoid Arthritis

    Myriam Vaillancourt1, Philippe Desaulniers1, Guillaume Paré1, Nathalie Pagé1, Asmaa Lachaab1, Anthony Kerever1, Anne-Sophie Julien1, Nathalie Amiable1, Martin Pelletier1, Philippe Tessier1, Louis Bessette2, Paul Fortin3, Laetitia Michou1 and Maria Fernandes1, 1Université Laval, Québec, QC, Canada, 2Laval University, Quebec, Canada, 3CHU de Quebec - Universite Laval, Quebec, Canada

    Background/Purpose: Rheumatoid arthritis (RA) develops as a result of the dysregulation of immune activating and inhibitory pathways. Several lines of evidence indicate that inhibitory receptors…
  • Abstract Number: 0784 • ACR Convergence 2020

    Upregulation of Tyro3TK on CD14+CD16- Monocytes Promotes Osteoclast Formation in Rheumatoid Arthritis

    Jimeng Xue1, Liling Xu1, Fanlei Hu1 and Yin Su2, 1Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China, Beijing, China (People's Republic), 2Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing, China (People's Republic)

    Background/Purpose: The study aimed to investigate the expression and clinical significance of Tyro3TK on CD14+CD16+ and CD14+CD16- monocyte subsets and explore the effect of Tyro3TK…
  • Abstract Number: 0785 • ACR Convergence 2020

    Identification of Recruited CCR2+ Inflammatory Monocytes in a Mouse Model of RA-associated Lung Disease with Potential Role for resolvin-D1 in Reducing Monocyte Inflammatory Responses

    Austin Barry1, Geoffrey Thiele1, Ted Mikuls1, Michael Duryee1, Amy Nelson1, Rohit Gaurav1, Bryant England1 and Jill Poole1, 1University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Patients with rheumatoid arthritis (RA) are at an increased risk for comorbid chronic lung disease, with premature mortality. Therapies for RA-associated lung disease are…
  • Abstract Number: 0786 • ACR Convergence 2020

    A Combination of Dimensionality Reduction Techniques Reveals Novel HLA-DR+ ‘Candidate’ Antigen-Presenting Cell Subsets (cAPC) in Patients with Rheumatoid Arthritis (RA)

    Christian Geier1, Jon Giles1, Samantha Gaines2, Christopher Depender1, Joan Bathon1 and Robert Winchester1, 1Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 2Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York

    Background/Purpose: The presentation of MHC-peptide complexes to T lymphocytes via antigen-presenting cells (APC) is a crucial step in the initiation of immune responses. Dendritic cells…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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