ACR Meeting Abstracts

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Abstracts tagged "metabolomics"

  • Abstract Number: 1292 • ACR Convergence 2023

    Active Rheumatoid Arthritis Patients Exhibit an Altered Serum Lipidomic Profile Directly Linked to Disease Activity, Which Is Reversed by Biologic and Targeted Synthetic DMARD

    Chary Lopez-Pedrera1, Laura Muñoz-Barrera2, Beatriz Vellón2, Rocio Guzman2, Tomás Cerdó2, Rafaela Ortega Castro3, Jerusalem Calvo4, Mª Angeles Aguirre5, Pedro Segui2, Ivan Arias de la Rosa6, Maria del Carmen Abalos-Aguilera7, Desiree Ruiz-Vilchez2, Christian Merlo-Ruiz2, Jose Javier Perez-Venegas8, Javier Godoy9, Dolores Ruiz-Montesinos10, Carmen Dominguez8, Carlos Rodriguez-Escalera11, Carmen Romero-Barco12, Antonio Fernandez-Nebro12, Natalia Mena Vazquez13, Julia Uceda Montañez14, Charo Santos14, Nuria Barbarroja15, Eduardo Collantes Estévez16, Mª del Mar Malagon2, Alejandro Escudero Contreras4 and Carlos Perez-Sanchez17, 1IMIBIC - Reina Sofia Hospital, Córdoba, Spain, 2IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, 3Hospital Reina Sofía, Cordoba, Spain, 4Reina Sofia University Hospital, Córdoba, Spain, 5Reina Sofía University Hospital/ Rheumatology Department, Córdoba, Spain, 6IMIBIC/Reina Sofia Hospital/University of Cordoba. Rheumatology service. Cordoba. Spain, Cordoba, Spain, 7Rheumatology Department, Reina Sofia University Hospital/Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain, 8Virgen Macarena University Hospital, Sevilla, Spain, 9Jaen University Hospital, Jaen, Spain, 10Hospital Universitario Virgen Macarena, Sevilla, Spain, 11Virgen de la Victoria Hospital, Malaga, Spain, 12Hospital Regional Universitario de Málaga, Malaga, Spain, 13IBIMA, Málaga, Spain, 14Hospital Virgen de Valme, Sevilla, Spain, 15University of Cordoba, Córdoba, Spain, 16Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/University of Cordoba, Cordoba, Spain, 17IMIBIC, Córdoba, Spain

    Background/Purpose: Lipid metabolism impacts immune cell plasticity, activation, differentiation, and function, making the analysis of the lipidomic profile crucial in understanding chronic inflammatory diseases like…
  • Abstract Number: 1643 • ACR Convergence 2023

    Exploring the Serum Metabolome for Potential Diagnostic Markers of Psoriatic Arthritis

    Nikita Looby1, Max Kotlyar2, Chiara Pastrello2, Darshini Ganatra1, Vathany Kulasingam3, Igor Jurisica4 and Vinod Chandran5, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 2Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, 3Department of Laboratory Medicine and Pathobiology, University of Toronto and Division of Clinical Biochemistry, Laboratory Medicine Program, University Health Network, Toronto, ON, Canada, 4Schroeder Arthritis Institute, Krembil Research Institute and Departments of Medical Biophysics and Computer Science and Faculty of Dentistry, University of Toronto and Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia, 5Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory immune-mediated musculoskeletal skin disease that affects approximately 25% of psoriasis patients causing progressive disability. As a heterogeneous disease,…
  • Abstract Number: 1723 • ACR Convergence 2023

    3,3-dimethyl-1-butanol and Its Metabolite 3,3-dimethylbutyrate Ameliorate Arthritis Severity in CIA Independent of Choline TMA Lyase Activity

    Brendan Allen1, Sabrina Fechtner2, Meagan Chriswell3, Widian Jubair1, M. Aaron Vrolijk1, V. Michael Holers4 and kristine Kuhn1, 1University of Colorado School of Medicine, Aurora, CO, 2University of Colorado Anschutz Medical Campus, Aurora, CO, 3University of Colorado Anschutz SOM, Denver, CO, 4University of Colorado, Denver, CO

    Background/Purpose: Both human and animal studies associate specific microbiota and microbial metabolic pathways with the development of RA and autoimmune arthritis, thereby providing a novel…
  • Abstract Number: 1753 • ACR Convergence 2023

    Acylcarnitine Enrichment Is a Characteristic of Rheumatoid Arthritis Fibroblast-Like Synoviocyte Metabolic Fingerprint

    Georgios Vasileiadis1, Anna-Karin Hultgård Ekwall2, Reshmi Sureshkumar1, Monica Guma3, Anna Rudin4, Yuan Zhang1 and Cristina Maglio1, 1Institute of Medicine, University of Gothenburg, Gothenburg, Sweden, 2Department of Rheumatology and Inflammation research, Sahlgrenska Academy, University of Gothenburg, Kullavik, Sweden, 3San Diego VA Healthcare Service, La Jolla, CA, 4Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Several metabolic pathways have been implicated in rheumatoid arthritis fibroblast-like synoviocytes (RA FLS) aggressive phenotype1,2. Here, we aimed to analyse the full spectrum of…
  • Abstract Number: 1786 • ACR Convergence 2023

    Newly Identified Gut Commensal Clostridium Fessum AM100 for Treating Ankylosing Spondylitis

    Lu Bai1, Chengkai Zhu1, Yihong Xu2, Kunhai Tang1, Dachun Zhuo1, Qing Zhang1, Chengchun Geng1, Weidong Xu2, Hao Wu1, Xingdong Chen1 and Jiucun Wang1, 1Fudan University, Shanghai, China, 2Changhai Hospital, Shanghai, China

    Background/Purpose: Ankylosing spondylitis (AS) is an inflammatory disease of the spinal joints leading to progressive loss of spinal mobility and chronic pain. Gutdysbiosis has been…
  • Abstract Number: 1795 • ACR Convergence 2023

    Multi-Omics Analyses Identify Metabolic Pathways That Differentiate Psoriatic Arthritis from Psoriasis

    Chiara Pastrello1, Darshini Ganatra2, Max Kotlyar1, Nikita Looby2, Quan Li3, Lihi Eder4, Dafna Gladman5, Proton Rahman3, Igor Jurisica6 and Vinod Chandran7, 1Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 3Craig Dobbin Research Institute, Memorial University, St. John's, NL, Canada, 4Women’s College Research Institute, Division of Rheumatology, University of Toronto, Toronto, ON, Canada, 5Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, ON, Canada, 6Schroeder Arthritis Institute, Krembil Research Institute and Departments of Medical Biophysics and Computer Science and Faculty of Dentistry, University of Toronto and Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia, 7Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis (PsA) is a form of inflammatory arthritis that occurs in patients with cutaneous psoriasis. Due to the lack of clinically useful diagnostic…
  • Abstract Number: 0044 • ACR Convergence 2023

    Aberrant Mevalonate Metabolite Farnesyl Pyrophosphate-Induced Neutrophil Hyperactivation in Behçet’s Disease Pathogenesis

    Menghao Zhang1, Na Kang2, Xin Yu1, Wanli Liu2 and Wenjie Zheng1, 1Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China, 2Beijing Key Lab for Immunological Research on Chronic Diseases, School of Life Sciences, Institute for Immunology, Tsinghua University, Beijing, China

    Background/Purpose: Behçet’s disease (BD) is a chronic vasculitis characterized by polymorphonuclear neutrophils (PMNs) hyperactivation with unknown etiology. The over-productions of neutrophil extracellular traps (NETs) and…
  • Abstract Number: 2149 • ACR Convergence 2023

    Biologic IRL201805 Drives Differential Cell-contact and Metabolism Transcriptional Profiles in Monocytes from RA Patients Compared to Healthy Donors

    Yuriko Yamamura1, Kieran Woolcock2, Valerie Corrigall3, Lara Ravanetti4, Jorge De Alba4, Roly Foulkes5, Paul Eggleton6 and Carl Goodyear2, 1School of Infection & Immunity, University of Glasgow, Glasgow, United Kingdom, 2University of Glasgow, Glasgow, United Kingdom, 3Revolo Biotherapeutics, Tadworth, United Kingdom, 4Revolo Biotherapeutics, London, United Kingdom, 5Revolo Biotherapeutics, Slough, United Kingdom, 6Revolo Biotherapeutics, Exeter, United Kingdom

    Background/Purpose: IRL201805 is a novel biologic derived from Binding Immunoglobulin Protein (BiP) that has been developed for the treatment of Rheumatoid arthritis (RA) (P Eggleton,…
  • Abstract Number: 0116 • ACR Convergence 2023

    Integrated Metabolomic and Proteomic Analyses Stratified Patients with Antiphospholipid Syndrome According to Their Atherothrombotic Risk

    Chary Lopez-Pedrera1, Beatriz Vellón2, Mª Angeles Aguirre3, Ismael Sanchez-Pareja2, Laura Muñoz-Barrera2, Tomás Cerdó2, Pedro Segui2, Christian Merlo-Ruiz2, Desiree Ruiz-Vilchez2, Maria del Carmen Abalos-Aguilera4, Nuria Barbarroja5, Alejandro Escudero Contreras6, Rafaela Ortega-Castro2 and Carlos Perez-Sanchez7, 1IMIBIC - Reina Sofia Hospital, Córdoba, Spain, 2IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, 3Reina Sofía University Hospital/ Rheumatology Department, Córdoba, Spain, 4Rheumatology Department, Reina Sofia University Hospital/Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain, 5University of Cordoba, Córdoba, Spain, 6Reina Sofia University Hospital, Córdoba, Spain, 7IMIBIC, Córdoba, Spain

    Background/Purpose: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by a hypercoagulable state, leading to arterial, venous, or microvascular thrombosis and accelerated atherosclerosis. Timely diagnosis…
  • Abstract Number: 2218 • ACR Convergence 2023

    Exploring Metabolite Markers Associated with Treatment Response of Biologic Disease Modifying Antirheumatic Drugs in Psoriatic Arthritis Patients

    John Koussiouris1, Nikita Looby1, Max Kotlyar2, Vathany Kulasingam3, Igor Jurisica4, Ashish J Mathew5, Proton Rahman6 and Vinod Chandran7, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 2Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, 3Department of Laboratory Medicine and Pathobiology, University of Toronto and Division of Clinical Biochemistry, Laboratory Medicine Program, University Health Network, Toronto, ON, Canada, 4Schroeder Arthritis Institute, Krembil Research Institute and Departments of Medical Biophysics and Computer Science and Faculty of Dentistry, University of Toronto and Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia, 5Christian Medical College, Vellore, India, 6Craig Dobbin Research Institute, Memorial University, St. John's, NL, Canada, 7Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON, Canada

    Background/Purpose: The use of biologic disease-modifying anti-rheumatic drugs (bDMARDS) is the current standard of care for severe diseases like psoriatic arthritis (PsA) which affects approximately…
  • Abstract Number: 0486 • ACR Convergence 2023

    Identifying Serum Metabolomic Markers Associated with Psoriasis Skin Disease Activity

    Hani Choksi1, Sheng Han Li2, Nikita Looby2, Max Kotlyar3, Vathany Kulasingam4, Igor Jurisica5 and Vinod Chandran6, 1Schroeder Arthritis Institute, Krembil Research Institute, Krembil Research Institute, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 3Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, 4Department of Laboratory Medicine and Pathobiology, University of Toronto and Division of Clinical Biochemistry, Laboratory Medicine Program, University Health Network, Toronto, ON, Canada, 5Schroeder Arthritis Institute, Krembil Research Institute and Departments of Medical Biophysics and Computer Science and Faculty of Dentistry, University of Toronto and Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia, 6Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Psoriasis is a chronic, immune-mediated inflammatory skin disease that affects over 2.5% of the global population. Approximately 25% of psoriasis patients also have a…
  • Abstract Number: 2468 • ACR Convergence 2023

    Association Between Gut Microbiome-related Metabolites and Symptomatic Hand Osteoarthritis in Two Independent Cohorts

    Jie Wei1, Zidan Yang2, Jiatian Li3, Yuqing Zhang4, Weiya Zhang5, Michael Doherty5, Tuo Yang6, Yuanheng Yang3, Hui Li3, Yilun Wang3, Ziying Wu3, Changjun Li7, Guanghua Lei3 and Chao Zeng3, 1Health Management Center, Xiangya Hospital Central South University, Changsha, China, 2Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China, 3Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China, 4Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 5Academic Rheumatology, Clinical Sciences Building, University of Nottingham, City Hospital, Nottingham, United Kingdom, 6Department of Health Management Center, Xiangya Hospital, Central South University, Changsha, China, 7National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

    Background/Purpose: Since gut microbiome dysbiosis can cause inflammatory disorders by affecting host metabolism, we postulate that the gut microbiome and related metabolites could play a…
  • Abstract Number: 0750 • ACR Convergence 2023

    Multispectral Optoacoustic Tomography of the Entheses Reveals Common Metabolic and Architectural Tissue Patterns in Psoriasis and Psoriatic Arthritis Independent of Inflammation

    Filippo Fagni1, Koray Tascilar1, Rita Noversa de Sousa2, Sara Bayat1, Lukas Sollfrank3, Arnd Kleyer4, Michael Sticherling5, Adrian Regensburger6, Ferdinand Knieling6, Georg Schett7, Maximilian Waldner8 and David Simon1, 1Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology / Deutsches Zentrum Immuntherapie, Erlangen, Germany, 2Department of Internal Medicine 3, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, 3Department Dermatology, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, 4University Hospital Erlangen, Erlangen, Germany, 5Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Dermatology, Erlangen, Germany, 6Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany, 7Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 8Department of Internal Medicine 1, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany

    Background/Purpose: Multispectral optoacoustic tomography (MSOT) is a novel imaging platform that combines ultrasound (US) with optoacoustic imaging to allow non-invasive in vivo quantification of key…
  • Abstract Number: 2508 • ACR Convergence 2023

    Chronic IL-6 Trans-Signaling Enhances Stem Cell-Like Characteristics of Rheumatoid Arthritis Synovial Fibroblasts

    Anil Singh and Salahuddin Ahmed, Washington State university, Spokane, WA

    Background/Purpose: Chronic exposure to IL-6 trans-signaling has been shown to significantly impact the characteristics of rheumatoid arthritis synovial fibroblasts (RASFs). Previous studies have demonstrated that…
  • Abstract Number: 0794 • ACR Convergence 2023

    Microbiota-dependent Indole Production Is Required for the Development of Collagen-induced Arthritis

    Brenda Seymour1, Brandon Trent2, Brendan Allen3, Sucai Liu3, Sunny Sneed4, Robert Anthony4 and kristine Kuhn3, 1University of Colorado School of Medicine, Denver, CO, 2University of Colorado School of Medicine, Eugene, OR, 3University of Colorado School of Medicine, Aurora, CO, 4Harvard Medical School, Boston, MA

    Background/Purpose: While alterations in tryptophan (Trp) metabolism have been broadly implicated across autoimmune diseases (including RA, SpA, SLE, and MS), the specific role(s) of Trp…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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