ACR Meeting Abstracts

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Abstracts tagged "metabolomics"

  • Abstract Number: 1622 • ACR Convergence 2024

    18F-FDG PET/CT in LVV During Active and Inactive Disease Phases Is Associated with the Metabolic Profile, but Not with Macrophage-related Cytokines: Results of an Integrated Analysis

    Dimitrios Anastasios Palamidas1, Georgios Kalykakis2, Dimitra Benaki3, Loukas chatzis1, Ourania Argyropoulou4, Panagiota Palla4, Antonia Kollia5, Pavlos Kafouris5, Marinos Metaxas5, Andreas Goules6, Emmanuel Mikros7, Konstantinos Kambas8, Constantinos Anagnostopoulos5 and Athanasios Tzioufas9, 1Pathophysiology Department, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Cholargos Athens, Greece, 2Department of Informatics, Ionian University, Kerkyra, Greece, Athens, Greece, 3Department of Pharmaceutical Chemistry, School of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece, Athens, Greece, 4Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece., Athens, Greece, 5PET-CT Department & Preclinical Imaging Unit, Center for Experimental Surgery, Clinical & Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece., Athens, Greece, 6GENERAL HOSPITAL LAIKO ATHENS, Athens, Greece, 7Department of Pharmaceutical Chemistry, School of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece., Athens, Greece, 8Laboratory of Molecular Genetics, Department of Immunology, Hellenic Pasteur Institute, Athens, Greece., Athens, Greece, 9LAIKO HOSPITAL, Athens, Greece

    Background/Purpose: Giant cell arteritis (GCA) may affect temporal arteries (cranial-GCA) or may present as a systemic disease extended to the large vessels [Large Vessel Vasculitis…
  • Abstract Number: 1651 • ACR Convergence 2024

    Unlocking the Secrets of Breg Dysfunction in Lupus: Glycosylation Patterns as Therapeutic Targets

    Pauline Kerleroux-Trébaol1, Marie Morel1, Sandrine Jousse-Joulin2, Divi Cornec3, Pierre Pochard1 and Anne Bordron1, 1Université de Bretagne Occidentale, brest, France, 2cavale blanche hospital, brest, France, 3Service de Rhumatologie, CHU de Brest, Brest, France

    Background/Purpose: The immune system is a complex network of cells preventing the invasion of the organism from external particles. The break in the homeostasis will…
  • Abstract Number: 1711 • ACR Convergence 2024

    Identification of Psoriatic Arthritis-related Pathways Using Multi-omics Data Integration

    Sreemoyee Ghosh1, Chiara Pastrello2, Omar F. Cruz-Correa3, Darshini Ganatra4, Katerina Oikonomopoulou3, Melanie Anderson5, Igor Jurisica6 and Vinod Chandran7, 1Institute of Medical Science, University of Toronto and Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 2Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, 3Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 4University Health Network, Toronto, ON, Canada, 5The Institute for Education Research, Library and Information Services, University Health Network, Toronto, ON, Canada, 6Departments of Medical Biophysics and Computer Science and Faculty of Dentistry, University of Toronto and Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia, Toronto, ON, Canada, 7University of Toronto, Toronto, ON, Canada

    Background/Purpose: Psoriasis (Pso) is a chronic immune mediated inflammatory skin disease. Up to 24% of Pso patients develop psoriatic arthritis (PsA). Pathophysiology of PsA is…
  • Abstract Number: 1774 • ACR Convergence 2024

    Metabolomics and Lipidomics in Juvenile Localized Scleroderma

    Yuan Zhang1, Angela Aquilani2, Rebecca Nicolai3, Fabrizio De Benedetti4, Emiliano Marasco2 and Cristina Maglio1, 1University of Gothenburg, Gothenburg, Sweden, 2Bambino Gesù Children’s Hospital, Immunology and Rheumatology Unit, Roma, Italy, 3Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, 4IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy

    Background/Purpose: Juvenile localised scleroderma (jLS) is a rare rheumatic disease in children characterized by inflammation and fibrosis in the skin [1, 2]. The cause and…
  • Abstract Number: 0053 • ACR Convergence 2024

    Fasting Reduces an IL-17+/IFNg+ T Helper Cell-inducing Gut Pathobiont in Patients with Rheumatoid Arthritis

    Márcia Pereira1, Katja Stuhlträger2, Natalie Scherff3, Anika Rajput Khokhar4, Sylvio Redanz1, Hebah Ebid5, Bérénice Hansen5, Cédric C. Lacny5, Ulrike Löschberger2, Stefan Bletz6, Jochen G. Schneider7, Paul Wilmes7, Christian S. Kessler4, Andreas Michalsen4, Alexander Mellmann3 and Martin Kriegel1, 1Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Münster, Germany, 2Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Muenster, Germany, 3Institute of Hygiene, University Hospital Münster, Münster, Germany, Muenster, Germany, 4Institute of Social Medicine, Epidemiology and Health Economics, Charité, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Berlin, Germany, 54University of Luxembourg, Department of Life Sciences and Medicine (DLSM), 6, Avenue du Swing, L-4367 Belvaux, Luxembourg, Luxemburg, Luxembourg, 6Institute of Hygiene, University Hospital Münster, Germany, Muenster, Germany, 7University of Luxembourg, Department of Life Sciences and Medicine (DLSM), 6, Avenue du Swing, L-4367 Belvaux, Luxembourg, Luxemburg, Luxembourg

    Background/Purpose: The mucosal origins hypothesis suggests rheumatoid arthritis (RA) is triggered at mucosal sites in genetically predisposed hosts1. Animal models support that microbiota‐induced Th17 cells are…
  • Abstract Number: 1785 • ACR Convergence 2024

    Comparative Immuno-Metabolomics Shows Singular Changes in Systemic Lupus Erythematosus Metabolic Phenotype Induced by T-Cell Activation

    Martin Stradner1, Fernanda Monedeiro2, Elmar Zuegner2, Barbara Prietl3, Monika Oberhuber4, Michael Khalil5, Christoph Magnes2, Hans-Peter Brezinsek1, Angela Libiseller3 and Thomas Pieber3, 1Div. of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, 2Joanneum Research, Graz, Austria, 3Div. of Endocrinology, Medical University of Graz, Graz, Austria, 4CBmed, Graz, Austria, 5Dept. of Neurology, Medical University of Graz, Graz, Austria

    Background/Purpose: Metabolic processes have a critical role in regulating immune cell function, therefore being relevant to understanding the pathogenesis and progression of autoimmune diseases.  Here…
  • Abstract Number: 0070 • ACR Convergence 2024

    Shared and Unique Fecal and Plasma Metabolic Signatures and Increased Inflammatory Markers in Ankylosing Spondylitis, Psoriatic Arthritis and Acute Anterior Uveitis

    Sneha Couvillion1, Javier Flores1, Sean Davin2, Kimberly Ogle2, Emma Fale-Olsen2, John Davis2, Gina Many1, Carley Shaut2, Tammy Martin2, Eric Suhler2, Atul Deodhar3, James Rosenbaum4, Ernesto Nakayasu1 and Tejpal Gill2, 1PNNL, Richland, WA, 2OHSU, Portland, OR, 3Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, 4Corvus Pharmaceuticals and Legacy Devers Eye Institute, Portland, OR

    Background/Purpose: Spondyloarthritis (SpA) is a group of immune-mediated inflammatory disorders such as ankylosing spondylitis (AS) and psoriatic arthritis (PsA), along with acute anterior uveitis (AAU)…
  • Abstract Number: 1816 • ACR Convergence 2024

    Paracrine WNT Signaling Drives Pro-fibrotic Metabolic Activation of Systemic Sclerosis Macrophages

    Emily Morris1, Helen Jarnagin2, Heetaek Yang3, Alexandra Turnquist2, Michael Whitfield4 and Patricia Pioli5, 1Dartmouth College, Enfield, NH, 2Dartmouth College, Lebanon, NH, 3Dartmouth College, West Lebanon, NH, 4Geisel School of Medicine at Dartmouth, Hanover, NH, 5Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: While we have shown that systemic sclerosis (SSc) dermal fibroblasts and macrophages (MØs) engage in reciprocal activation mediated by exosomes via paracrine signaling, the…
  • Abstract Number: 0101 • ACR Convergence 2024

    Metabolomic Profiling Reveals a Role for Citric Acid Cycle Dysfunction in Antiphospholipid Syndrome Neutrophils

    Ajay Tambralli1, Megan Radyk1, Kaitlyn Sabb1, Li Zhang1, Harrison Wong1, Emily Becker1, Srilakshmi Yalavarthi1, Claire Hoy1, Cyrus Sarosh2, Jacqueline Madison1, Yu Zuo1, Jason Knight1 and Costas Lyssiotis1, 1University of Michigan, Ann Arbor, MI, 2University of Michigan, Temperance, MI

    Background/Purpose: As early effectors of the immune response, neutrophils must access energy rapidly. Neutrophils rely on glycolysis for antimicrobial functions such as phagocytosis and reactive…
  • Abstract Number: 2085 • ACR Convergence 2024

    The Effects of Pioglitazone on Metabolic Dysregulation in Inclusion Body Myositis: An Open-Label Pilot Study

    Brittany Adler1, Michael Bene1, Cissy Zhang2, Julie Paik1, Christopher Mecoli1, Thomas Lloyd3, Eleni Tiniakou4, Erika Darrah1, Lisa Christopher-Stine1, Albert Mears1, Megan McGowan1, Ruben Pagkatipunan1, Anne Le2 and Jemima Albayda5, 1Johns Hopkins University, Baltimore, MD, 2Gigantest, Baltimore, MD, 3Baylor College of Medicine, Houston, TX, 4Johns Hopkins University, Lutherville Timonium, MD, 5Johns Hopkins School of Medicine, Baltimore, MD

    Background/Purpose: Inclusion body myositis (IBM) is a progressive muscle disease for which there is no effective treatment. Mitochondrial dysregulation is a pathologic hallmark of IBM.…
  • Abstract Number: 0485 • ACR Convergence 2024

    Biomarkers for Disease Activity and Response to Treatment in Early Rheumatoid Arthritis: Metabolomics and Machine Learning Analyses in NORD-STAR Cohort

    Tahzeeb Fatima1, Yuan Zhang2, Georgios Vasileiadis2, Araz Rawshani2, Ronald Van Vollenhoven3, Jon Lampa4, Bjorn Gudbjornsson5, Espen Haavardsholm6, Dan Nordstrom7, Gerdur Gröndal5, Kim Hørslev-Petersen8, Kristina Lend9, Marte Heiberg10, Merete Hetland11, Michael Nurmohamed12, Mikkel Ostergaard13, Tillmann Uhlig6, Tuulikki Sokka-Isler14, Anna Rudin15 and Cristina Maglio2, 1University of Gothenburg, Göteborg, Sweden, 2University of Gothenburg, Gothenburg, Sweden, 3Department of Rheumatology and Clinical Immunology, Amsterdam University Medical Centers, Amsterdam, Netherlands, 4Karolinska University Hospital, Hässelby, Sweden, 5Landspitali University Hospital and University of Iceland, Reykjavik, Iceland, 6Diakonhjemmet Hospital, Oslo, Norway, 7Helsinki University Hospital, Helsinki, Finland, 8University Hospital of Southern Denmark, Sønderborg, Denmark, 9Amsterdam UMC, Karolinska Institute, Stockholm, Sweden, 10Diakonhjemmet Hospital, Oslo, Oslo, Norway, 11Rigshospitalet Glostrup and University of Copenhagen, Glostrup, Denmark, 12Amsterdam University Medical Centers, Amsterdam, Netherlands, 13Department of Clinical Medicine, University of Copenhagen and Center for Rheumatology, Copenhagen Center for Arthritis Research, Glostrup, Denmark, 14Jyväskylä Central Hospital, Jyväskylä, Finland, 15Institute of Medicine, University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: The variability in treatment response in people with rheumatoid arthritis (RA) warrants the prediction of patients at high risk of treatment failure. Identification of…
  • Abstract Number: 2319 • ACR Convergence 2024

    Investigating the Association of Serum Metabolites with Psoriatic Arthritis Musculoskeletal Disease Patterns

    Sheng Han Li1, Nikita Looby2, Max Kotiyar3, Lihi Eder4, Igor Jurisica5, Vathany Kulasingam6 and vinod Chandran7, 1Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada, 2Psoriatic Arthritis Program Schroeder Arthritis Institute, Toronto, Canada, 3Data Science Discovery Centre for Chronic Dsiease, Krembil Research Institute, Toronto, Canada, 4University of Toronto, Women’s College Hospital and Department of Medicine, Toronto, ON, Canada, 5Data Science Discovery Centre, Krembil Research Institute, Toronto, Canada, 6Laboratory Medicine Program, Unviersity Health Network, Toronto, Canada, 7Toronto Western Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Accurate assessment of disease patterns may be important for appropriate management of psoriatic arthritis (PsA). Ultrasonography (USG) is a highly accurate, sensitive, and non-invasive…
  • Abstract Number: 0491 • ACR Convergence 2024

    Small Molecule Metabolites, Potential Disease-specific Biomarkers for Predicting Treatment Response in Rheumatoid Arthritis

    Jiayi Xu1, Yi Zhao2, Chenxi Zhu3, Yi Liu4, Tao Chen1, Rui Sun3, Huifang Hu5, Zhen Zhou1 and Yan Liu1, 1Department of Rheumatology and Immunology, West China Hospital,Sichuan University, Chengdu, Sichuan, China, Cheng du, China (People's Republic), 2Department of Rheumatology and Immunology, West China Hospital,Sichuan University, Chengdu, Sichuan, China, Sichuan, China (People's Republic), 3Department of Rheumatology and Immunology, West China Hospital,Sichuan University, Chengdu, Sichuan, China, chengdu, China (People's Republic), 4Department of Rheumatology and Immunology, West China Hospital,Sichuan University, Chengdu, Sichuan, China, chengdu, 5Department of Rheumatology and Immunology, West China Hospital,Sichuan University, Chengdu, Sichuan, China, Chengdu, Sichuan, China (People's Republic)

    Background/Purpose: Rheumatoid arthritis (RA) is a complex chronic inflammatory condition primarily affecting joints, presenting a challenge in understanding its causes, varied subtypes, diagnostic indicators, and…
  • Abstract Number: 2323 • ACR Convergence 2024

    The Effect of Biologic Therapies on Serum Metabolic Biomarkers in Patients with Psoriatic Arthritis

    Keith Colaco1, laura bumbulis2, Vinod Chandran1, Richard Cook3, Dafna Gladman4 and Lihi Eder5, 1University of Toronto, Toronto, ON, Canada, 2University of Waterloo, Waterloo, ON, Canada, 3University of Waterloo, Waterloo, Canada, 4University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 5University of Toronto, Women’s College Hospital and Department of Medicine, Toronto, ON, Canada

    Background/Purpose: Biologic therapies, such as tumor necrosis factor-alpha inhibitors (TNFi) and interleukin-17 inhibitors (IL-17i) may affect the cardio-metabolic profile of patients with psoriatic arthritis (PsA).…
  • Abstract Number: 0846 • ACR Convergence 2024

    Three Novel Metabolomic Signatures of Inflammation for Female Gout Risk: A Prospective Cohort Study over 26 Years

    Sharan Rai1, Hyon K. Choi2, Chio Yokose1 and Natalie McCormick1, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Lexington, MA

    Background/Purpose: Only 20% of those with hyperuricemia develop clinically evident gout, suggesting that other, likely inflammatory, factors influence NLRP3 inflammasome activation and progression to gout.…
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