Abstracts tagged "metabolomics"

Abstract Number: 1774 • ACR Convergence 2024
Metabolomics and Lipidomics in Juvenile Localized Scleroderma
Yuan Zhang¹, Angela Aquilani², Rebecca Nicolai³, Fabrizio De Benedetti⁴, Emiliano Marasco² and Cristina Maglio¹, ¹University of Gothenburg, Gothenburg, Sweden, ²Bambino Gesù Children’s Hospital, Immunology and Rheumatology Unit, Roma, Italy, ³Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, ⁴IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
Background/Purpose: Juvenile localised scleroderma (jLS) is a rare rheumatic disease in children characterized by inflammation and fibrosis in the skin [1, 2]. The cause and…
Abstract Number: 0053 • ACR Convergence 2024
Fasting Reduces an IL-17+/IFNg+ T Helper Cell-inducing Gut Pathobiont in Patients with Rheumatoid Arthritis
Márcia Pereira¹, Katja Stuhlträger², Natalie Scherff³, Anika Rajput Khokhar⁴, Sylvio Redanz¹, Hebah Ebid⁵, Bérénice Hansen⁵, Cédric C. Lacny⁵, Ulrike Löschberger², Stefan Bletz⁶, Jochen G. Schneider⁷, Paul Wilmes⁷, Christian S. Kessler⁴, Andreas Michalsen⁴, Alexander Mellmann³ and Martin Kriegel¹, ¹Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Münster, Germany, ²Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Muenster, Germany, ³Institute of Hygiene, University Hospital Münster, Münster, Germany, Muenster, Germany, ⁴Institute of Social Medicine, Epidemiology and Health Economics, Charité, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Berlin, Germany, ⁵4University of Luxembourg, Department of Life Sciences and Medicine (DLSM), 6, Avenue du Swing, L-4367 Belvaux, Luxembourg, Luxemburg, Luxembourg, ⁶Institute of Hygiene, University Hospital Münster, Germany, Muenster, Germany, ⁷University of Luxembourg, Department of Life Sciences and Medicine (DLSM), 6, Avenue du Swing, L-4367 Belvaux, Luxembourg, Luxemburg, Luxembourg
Background/Purpose: The mucosal origins hypothesis suggests rheumatoid arthritis (RA) is triggered at mucosal sites in genetically predisposed hosts1. Animal models support that microbiota‐induced Th17 cells are…
Abstract Number: 1785 • ACR Convergence 2024
Comparative Immuno-Metabolomics Shows Singular Changes in Systemic Lupus Erythematosus Metabolic Phenotype Induced by T-Cell Activation
Martin Stradner¹, Fernanda Monedeiro², Elmar Zuegner², Barbara Prietl³, Monika Oberhuber⁴, Michael Khalil⁵, Christoph Magnes², Hans-Peter Brezinsek¹, Angela Libiseller³ and Thomas Pieber³, ¹Div. of Rheumatology and Immunology, Medical University of Graz, Graz, Austria, ²Joanneum Research, Graz, Austria, ³Div. of Endocrinology, Medical University of Graz, Graz, Austria, ⁴CBmed, Graz, Austria, ⁵Dept. of Neurology, Medical University of Graz, Graz, Austria
Background/Purpose: Metabolic processes have a critical role in regulating immune cell function, therefore being relevant to understanding the pathogenesis and progression of autoimmune diseases. Here…
Abstract Number: 0070 • ACR Convergence 2024
Shared and Unique Fecal and Plasma Metabolic Signatures and Increased Inflammatory Markers in Ankylosing Spondylitis, Psoriatic Arthritis and Acute Anterior Uveitis
Sneha Couvillion¹, Javier Flores¹, Sean Davin², Kimberly Ogle², Emma Fale-Olsen², John Davis², Gina Many¹, Carley Shaut², Tammy Martin², Eric Suhler², Atul Deodhar³, James Rosenbaum⁴, Ernesto Nakayasu¹ and Tejpal Gill², ¹PNNL, Richland, WA, ²OHSU, Portland, OR, ³Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, ⁴Corvus Pharmaceuticals and Legacy Devers Eye Institute, Portland, OR
Background/Purpose: Spondyloarthritis (SpA) is a group of immune-mediated inflammatory disorders such as ankylosing spondylitis (AS) and psoriatic arthritis (PsA), along with acute anterior uveitis (AAU)…
Abstract Number: 1816 • ACR Convergence 2024
Paracrine WNT Signaling Drives Pro-fibrotic Metabolic Activation of Systemic Sclerosis Macrophages
Emily Morris¹, Helen Jarnagin², Heetaek Yang³, Alexandra Turnquist², Michael Whitfield⁴ and Patricia Pioli⁵, ¹Dartmouth College, Enfield, NH, ²Dartmouth College, Lebanon, NH, ³Dartmouth College, West Lebanon, NH, ⁴Geisel School of Medicine at Dartmouth, Hanover, NH, ⁵Geisel School of Medicine at Dartmouth, Lebanon, NH
Background/Purpose: While we have shown that systemic sclerosis (SSc) dermal fibroblasts and macrophages (MØs) engage in reciprocal activation mediated by exosomes via paracrine signaling, the…
Abstract Number: 0101 • ACR Convergence 2024
Metabolomic Profiling Reveals a Role for Citric Acid Cycle Dysfunction in Antiphospholipid Syndrome Neutrophils
Ajay Tambralli¹, Megan Radyk¹, Kaitlyn Sabb¹, Li Zhang¹, Harrison Wong¹, Emily Becker¹, Srilakshmi Yalavarthi¹, Claire Hoy¹, Cyrus Sarosh², Jacqueline Madison¹, Yu Zuo¹, Jason Knight¹ and Costas Lyssiotis¹, ¹University of Michigan, Ann Arbor, MI, ²University of Michigan, Temperance, MI
Background/Purpose: As early effectors of the immune response, neutrophils must access energy rapidly. Neutrophils rely on glycolysis for antimicrobial functions such as phagocytosis and reactive…
Abstract Number: 2085 • ACR Convergence 2024
The Effects of Pioglitazone on Metabolic Dysregulation in Inclusion Body Myositis: An Open-Label Pilot Study
Brittany Adler¹, Michael Bene¹, Cissy Zhang², Julie Paik¹, Christopher Mecoli¹, Thomas Lloyd³, Eleni Tiniakou⁴, Erika Darrah¹, Lisa Christopher-Stine¹, Albert Mears¹, Megan McGowan¹, Ruben Pagkatipunan¹, Anne Le² and Jemima Albayda⁵, ¹Johns Hopkins University, Baltimore, MD, ²Gigantest, Baltimore, MD, ³Baylor College of Medicine, Houston, TX, ⁴Johns Hopkins University, Lutherville Timonium, MD, ⁵Johns Hopkins School of Medicine, Baltimore, MD
Background/Purpose: Inclusion body myositis (IBM) is a progressive muscle disease for which there is no effective treatment. Mitochondrial dysregulation is a pathologic hallmark of IBM.…
Abstract Number: 0485 • ACR Convergence 2024
Biomarkers for Disease Activity and Response to Treatment in Early Rheumatoid Arthritis: Metabolomics and Machine Learning Analyses in NORD-STAR Cohort
Tahzeeb Fatima¹, Yuan Zhang², Georgios Vasileiadis², Araz Rawshani², Ronald Van Vollenhoven³, Jon Lampa⁴, Bjorn Gudbjornsson⁵, Espen Haavardsholm⁶, Dan Nordstrom⁷, Gerdur Gröndal⁵, Kim Hørslev-Petersen⁸, Kristina Lend⁹, Marte Heiberg¹⁰, Merete Hetland¹¹, Michael Nurmohamed¹², Mikkel Ostergaard¹³, Tillmann Uhlig⁶, Tuulikki Sokka-Isler¹⁴, Anna Rudin¹⁵ and Cristina Maglio², ¹University of Gothenburg, Göteborg, Sweden, ²University of Gothenburg, Gothenburg, Sweden, ³Department of Rheumatology and Clinical Immunology, Amsterdam University Medical Centers, Amsterdam, Netherlands, ⁴Karolinska University Hospital, Hässelby, Sweden, ⁵Landspitali University Hospital and University of Iceland, Reykjavik, Iceland, ⁶Diakonhjemmet Hospital, Oslo, Norway, ⁷Helsinki University Hospital, Helsinki, Finland, ⁸University Hospital of Southern Denmark, Sønderborg, Denmark, ⁹Amsterdam UMC, Karolinska Institute, Stockholm, Sweden, ¹⁰Diakonhjemmet Hospital, Oslo, Oslo, Norway, ¹¹Rigshospitalet Glostrup and University of Copenhagen, Glostrup, Denmark, ¹²Amsterdam University Medical Centers, Amsterdam, Netherlands, ¹³Department of Clinical Medicine, University of Copenhagen and Center for Rheumatology, Copenhagen Center for Arthritis Research, Glostrup, Denmark, ¹⁴Jyväskylä Central Hospital, Jyväskylä, Finland, ¹⁵Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
Background/Purpose: The variability in treatment response in people with rheumatoid arthritis (RA) warrants the prediction of patients at high risk of treatment failure. Identification of…
Abstract Number: 2319 • ACR Convergence 2024
Investigating the Association of Serum Metabolites with Psoriatic Arthritis Musculoskeletal Disease Patterns
Sheng Han Li¹, Nikita Looby², Max Kotiyar³, Lihi Eder⁴, Igor Jurisica⁵, Vathany Kulasingam⁶ and vinod Chandran⁷, ¹Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada, ²Psoriatic Arthritis Program Schroeder Arthritis Institute, Toronto, Canada, ³Data Science Discovery Centre for Chronic Dsiease, Krembil Research Institute, Toronto, Canada, ⁴University of Toronto, Women’s College Hospital and Department of Medicine, Toronto, ON, Canada, ⁵Data Science Discovery Centre, Krembil Research Institute, Toronto, Canada, ⁶Laboratory Medicine Program, Unviersity Health Network, Toronto, Canada, ⁷Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Accurate assessment of disease patterns may be important for appropriate management of psoriatic arthritis (PsA). Ultrasonography (USG) is a highly accurate, sensitive, and non-invasive…
Abstract Number: L18 • ACR Convergence 2023
Immune-metabolic Heterogeneity and Clinical Implications in Primary Sjogren’s Syndrome Revealed by Molecular Classification of Salivary Glands
Xiaobing Wang¹, Jing Luo², Senhong Ying³, Jingwei Hong⁴, Hui Cheng⁴, Ping Wang⁴, Yanran He⁵, Wenjing Ye⁶, Xiaofang Zhu⁷, Chengwei Zhu⁸, Langxiong Yang², Zhongshan Li⁹, Suxian Lin¹⁰, Dan Chen⁷, Xin Wu¹¹, Zhengwei Xie¹², Jinyu Wu¹³ and Huji Xu¹, ¹Department of Rheumatology and Immunology, Changzheng Hospital, Naval Medical University, Shanghai, China, ²School of Medicine, Tsinghua University, Beijing, China, ³Precision Medicine Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China, ⁴Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China, ⁵Committee on Cancer Biology, University of Chicago, Chicago, IL, ⁶Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China, ⁷Rheumatology Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China, ⁸Department of Ultrasonography, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China, ⁹Wenzhou Medical University, Wenzhou, China, ¹⁰Rheumatology Department, Wenzhou People's Hospital, Wenzhou, China, ¹¹Department of Rheumatology and Immunology,Changzheng Hospital, Naval Medical University, Shanghai, China, ¹²Peking University International Cancer Institute, Health Science Center, Peking University, Beijing, China, ¹³Institute of Genomic Medicine, Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou Medical University, Wenzhou, China
Background/Purpose: Primary Sjögren's syndrome (pSS) is a complex autoimmune disease with significant heterogeneity. Our study aimed to clarify the etiology and molecular variation of the…
Abstract Number: 0935 • ACR Convergence 2023
Sodium Pyruvate Improves Mitochondrial Fitness in SSc Fibroblasts to Prevent Fibroblast-to-myofibroblast Transition and Fibrotic Remodeling
Xiang Zhou¹, Thuong Trinh-Minh¹, Alexandru-Emil Matei¹, Honglin Zhu², Hermina Györfi¹, Cuong Tran Manh¹, Xuezhi Hong¹ and Joerg Distler¹, ¹Clinic for Rheumatology University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany; Hiller Research Center, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany, ²3 Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany. 4 Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany. 5 Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, China
Background/Purpose: Systematic sclerosis (SSc) is an autoimmune disease characteristic by fibroblast transition and overproduction of extracellular matrix, yet with limited treatment. Recent studies provided evidence…
Abstract Number: 1292 • ACR Convergence 2023
Active Rheumatoid Arthritis Patients Exhibit an Altered Serum Lipidomic Profile Directly Linked to Disease Activity, Which Is Reversed by Biologic and Targeted Synthetic DMARD
Chary Lopez-Pedrera¹, Laura Muñoz-Barrera², Beatriz Vellón², Rocio Guzman², Tomás Cerdó², Rafaela Ortega Castro³, Jerusalem Calvo⁴, Mª Angeles Aguirre⁵, Pedro Segui², Ivan Arias de la Rosa⁶, Maria del Carmen Abalos-Aguilera⁷, Desiree Ruiz-Vilchez², Christian Merlo-Ruiz², Jose Javier Perez-Venegas⁸, Javier Godoy⁹, Dolores Ruiz-Montesinos¹⁰, Carmen Dominguez⁸, Carlos Rodriguez-Escalera¹¹, Carmen Romero-Barco¹², Antonio Fernandez-Nebro¹², Natalia Mena Vazquez¹³, Julia Uceda Montañez¹⁴, Charo Santos¹⁴, Nuria Barbarroja¹⁵, Eduardo Collantes Estévez¹⁶, Mª del Mar Malagon², Alejandro Escudero Contreras⁴ and Carlos Perez-Sanchez¹⁷, ¹IMIBIC - Reina Sofia Hospital, Córdoba, Spain, ²IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ³Hospital Reina Sofía, Cordoba, Spain, ⁴Reina Sofia University Hospital, Córdoba, Spain, ⁵Reina Sofía University Hospital/ Rheumatology Department, Córdoba, Spain, ⁶IMIBIC/Reina Sofia Hospital/University of Cordoba. Rheumatology service. Cordoba. Spain, Cordoba, Spain, ⁷Rheumatology Department, Reina Sofia University Hospital/Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain, ⁸Virgen Macarena University Hospital, Sevilla, Spain, ⁹Jaen University Hospital, Jaen, Spain, ¹⁰Hospital Universitario Virgen Macarena, Sevilla, Spain, ¹¹Virgen de la Victoria Hospital, Malaga, Spain, ¹²Hospital Regional Universitario de Málaga, Malaga, Spain, ¹³IBIMA, Málaga, Spain, ¹⁴Hospital Virgen de Valme, Sevilla, Spain, ¹⁵University of Cordoba, Córdoba, Spain, ¹⁶Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/University of Cordoba, Cordoba, Spain, ¹⁷IMIBIC, Córdoba, Spain
Background/Purpose: Lipid metabolism impacts immune cell plasticity, activation, differentiation, and function, making the analysis of the lipidomic profile crucial in understanding chronic inflammatory diseases like…
Abstract Number: 1643 • ACR Convergence 2023
Exploring the Serum Metabolome for Potential Diagnostic Markers of Psoriatic Arthritis
Nikita Looby¹, Max Kotlyar², Chiara Pastrello², Darshini Ganatra¹, Vathany Kulasingam³, Igor Jurisica⁴ and Vinod Chandran⁵, ¹Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, ³Department of Laboratory Medicine and Pathobiology, University of Toronto and Division of Clinical Biochemistry, Laboratory Medicine Program, University Health Network, Toronto, ON, Canada, ⁴Schroeder Arthritis Institute, Krembil Research Institute and Departments of Medical Biophysics and Computer Science and Faculty of Dentistry, University of Toronto and Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia, ⁵Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory immune-mediated musculoskeletal skin disease that affects approximately 25% of psoriasis patients causing progressive disability. As a heterogeneous disease,…
Abstract Number: 1723 • ACR Convergence 2023
3,3-dimethyl-1-butanol and Its Metabolite 3,3-dimethylbutyrate Ameliorate Arthritis Severity in CIA Independent of Choline TMA Lyase Activity
Brendan Allen¹, Sabrina Fechtner², Meagan Chriswell³, Widian Jubair¹, M. Aaron Vrolijk¹, V. Michael Holers⁴ and kristine Kuhn¹, ¹University of Colorado School of Medicine, Aurora, CO, ²University of Colorado Anschutz Medical Campus, Aurora, CO, ³University of Colorado Anschutz SOM, Denver, CO, ⁴University of Colorado, Denver, CO
Background/Purpose: Both human and animal studies associate specific microbiota and microbial metabolic pathways with the development of RA and autoimmune arthritis, thereby providing a novel…
Abstract Number: 1753 • ACR Convergence 2023
Acylcarnitine Enrichment Is a Characteristic of Rheumatoid Arthritis Fibroblast-Like Synoviocyte Metabolic Fingerprint
Georgios Vasileiadis¹, Anna-Karin Hultgård Ekwall², Reshmi Sureshkumar¹, Monica Guma³, Anna Rudin⁴, Yuan Zhang¹ and Cristina Maglio¹, ¹Institute of Medicine, University of Gothenburg, Gothenburg, Sweden, ²Department of Rheumatology and Inflammation research, Sahlgrenska Academy, University of Gothenburg, Kullavik, Sweden, ³San Diego VA Healthcare Service, La Jolla, CA, ⁴Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Background/Purpose: Several metabolic pathways have been implicated in rheumatoid arthritis fibroblast-like synoviocytes (RA FLS) aggressive phenotype1,2. Here, we aimed to analyse the full spectrum of…

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