ACR Meeting Abstracts

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Abstracts tagged "Magnetic resonance imaging (MRI)"

  • Abstract Number: 1923 • ACR Convergence 2020

    Angiographic Progression of Disease in Large-Vessel Vasculitis

    Kaitlin Quinn1, Himanshu Dashora2, Mark Ahlman3, Elaine Novakovich2 and Peter C. Grayson2, 1Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Washington, DC, 2Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD, 3National Institutes of Health, Clinical Center, Radiology and Imaging Sciences, Bethesda, MD

    Background/Purpose: Angiography is essential to detect vascular disease in patients with large-vessel vasculitis (LVV).  Guidelines differ on the role of periodic angiography to monitor patients…
  • Abstract Number: 1358 • ACR Convergence 2020

    Certolizumab Pegol Efficacy in Patients with Non-Radiographic Axial Spondyloarthritis Stratified by Baseline MRI and C-Reactive Protein Status

    Atul Deodhar1, Lianne Gensler2, Stephen Hall3, Philip Robinson4, Bengt Hoepken5, Lars Bauer5, Thomas Kumke5 and Walter Maksymowych6, 1Oregon Health & Science University, Portland, OR, 2University of California San Francisco, San Francisco, CA, 3Cabrini Medical Centre, Monash University and Emeritus Research, Malvern, Victoria, Australia, 4University of Queensland, Herston, Queensland, Australia, 5UCB Pharma, Monheim am Rhein, Germany, 6University of Alberta, Edmonton, AB, Canada

    Background/Purpose: This post-hoc analysis from the phase 3 C-axSpAnd study aimed to evaluate whether the response to certolizumab pegol (CZP) in non-radiographic axial spondyloarthritis (nr-axSpA)…
  • Abstract Number: 1995 • ACR Convergence 2020

    Non-invasive Vagus Nerve Stimulation Improves Signs and Symptoms of Rheumatoid Arthritis: Results of a Pilot Study

    Sara Marsal1, Hector Corominas2, Juan Jose De Agustin De Oro3, Carolina Perez Garcia4, Maria Lopez Lasanta3, Helena Borrell3, Delia Reina5, Raimon Sanmartí6, Francisco Javier Narváez7, Clara Franco-Jarava8, Charles Peterfy9, Jose Antonio Narvaez10, Vivek Sharma11, Konstantinos Alataris11, Mark Genovese12 and Matthew Baker13, 1Hospital Universitari Vall d'Hebron, Barcelona, Spain, 2Institut Rec. Hospital de la Santa Creu I Sant Pau., Barcelona, Spain, 3Hospital Universitari Vall d’Hebron, Barcelona, Spain, 4Hospital Universitari Parc Salut Mar, Barcelona, Spain, 5Hospital Moises Broggi, Barcelona, Spain, 6Hospital Universitari Clínic de Barcelona, Barcelona, Catalonia, Spain, 7Hospital Bellvitge, BARCELONA, Spain, 81Hospital Universitari Vall d’Hebron, Barcelona, Spain, 9Spire Sciences, Inc., Boca Raton, FL, 10Clinica Diagonal, Barcelona, Spain, 11Vorso Corp, Redwood CIty, CA, 12Stanford University Medical Center, Palo Alto, CA, 13Stanford University, Menlo Park, CA

    Background/Purpose: Vagus nerve stimulation (VNS) has been shown to improve rheumatoid arthritis (RA) disease severity in patients with refractory disease (1,2). A multi-center pilot study…
  • Abstract Number: 1365 • ACR Convergence 2020

    Machine Learning-based Berlin Scoring of Magnetic Resonance Images of the Spine in Patients with Ankylosing Spondylitis: Analysis of Data from a Phase 3 Trial with Secukinumab

    Amir Jamaludin1, Rhydian Windsor1, Sarim Ather1, Timor Kadir1, Andrew Zisserman1, Juergen Braun2, Lianne Gensler3, Pedro Machado4, Mikkel Østergaard5, Denis Poddubnyy6, Thibaud Coroller7, Brian Porter7, Shephard Mpofu8 and Aimee Readie7, 1University of Oxford, Oxford, United Kingdom, 2Rheumazentrum Ruhrgebiet and Ruhr-University, 44649 Herne, Germany, 3University of California San Francisco, San Francisco, CA, 4University College London, London, United Kingdom, 5Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, 6Charité – Universitätsmedizin Berlin, Berlin, Germany, 7Novartis Pharmaceuticals Corporation, East Hanover, NJ, 8Novartis Pharma AG, Basel, Switzerland

    Background/Purpose: Magnetic resonance imaging (MRI) offers a non-invasive and objective method of early diagnosis and classification, monitoring disease burden and treatment response for patients (pts)…
  • Abstract Number: 2012 • ACR Convergence 2020

    A Phase IIb, Randomized, Double-blind Study in Patients with Rheumatoid Arthritis Evaluating the Safety and Efficacy of Evobrutinib Compared with Placebo in Patients with an Inadequate Response to Methotrexate

    Charles Peterfy1, Maya Buch2, Ernest Choy3, Georg Schett4, Dana Parsons-Rich5, Anand Patel6, Yulia Zima5, Claire Le Bolay7 and Mark Genovese8, 1Spire Sciences, Inc., Boca Raton, FL, 2Centre of Musculoskeletal Research, School of Biological Sciences, University of Manchester, Manchester, United Kingdom, 3CREATE Centre, Cardiff University, Cardiff, Wales, United Kingdom, 4Friedrich-Alexander-Universität Erlangen- Nuremberg, Erlangen, Germany, 5EMD Serono (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 6EMD Serono (a business of Merck KGaA, Darmstadt, Germany), Billerica, 7Merck KGaA, Darmstadt, Germany, 8Division of Immunology and Rheumatology, Stanford University, Palo Alto, CA

    Background/Purpose: Bruton’s tyrosine kinase (BTK) is involved in multiple signalling pathways potentially implicated in rheumatoid arthritis (RA). Evobrutinib is a highly selective, oral BTK inhibitor.…
  • Abstract Number: 0317 • ACR Convergence 2020

    Axial Involvement in Psoriatic Arthritis in a Comprehensive Rapid Diagnosis Program (Reuma-check PsA). Analysis of Its Characteristics

    Rodrigo Garcia Salinas1, Santiago Ruta2, Jessica Torres Chichande1, Einer Sanchez Prado1, Facundo Salvatori1 and Sebastian Magri1, 1Hospital Italiano La Plata, La Plata, Argentina, 2Hospital Italiano La Plata, Buenos Aires, Argentina

    Background/Purpose: To date, there is no consensus that allows an appropriate definition of axial involvement in PsA, that ranges between 25 to 70%. To estimate…
  • Abstract Number: 1366 • ACR Convergence 2020

    Secukinumab Improved Signs and Symptoms in Patients with Non-radiographic Axial Spondyloarthritis: Results from a Randomized Controlled Phase III Study Stratified by Baseline Objective Signs of Inflammation

    Juergen Braun1, Ricardo Blanco2, Helena Marzo-Ortega3, Lianne Gensler4, Filip Van den Bosch5, Hideto Kameda6, Denis Poddubnyy7, Marleen van de Sande8, Anna Wiksten9, Brian Porter10, Santiago Moreno9, Abhijit Shete9, Hanno Richards9, Sibylle Haemmerle9 and Atul Deodhar11, 1Rheumazentrum Ruhrgebiet Herne, and Ruhr-University Bochum, 44649 Herne, Germany, 2Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain, 3The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom, 4University of California San Francisco, San Francisco, CA, 5Ghent University Hospital, Ghent, Belgium, 6Toho University, Tokyo, Japan, 7Charité – Universitätsmedizin Berlin, Berlin, Germany, 8Amsterdam UMC, AMC/University of Amsterdam, Department of Rheumatology and Clinical Immunology, Amsterdam Infection & Immunity Institute and Amsterdam Rheumatology and Immunology Center (ARC), Amsterdam, Netherlands, 9Novartis Pharma AG, Basel, Switzerland, 10Novartis Pharmaceuticals Corporation, East Hanover, NJ, 11Oregon Health & Science University, Portland, OR

    Background/Purpose: Active non-radiographic axial spondyloarthritis (nr-axSpA) is often determined on the basis of objective signs of inflammation (elevated C-reactive protein [CRP] and/or evidence of sacroiliitis…
  • Abstract Number: 2019 • ACR Convergence 2020

    Preliminary Definition of a Positive MRI for Active Lesions in the Sacroiliac Joints Typical of Axial Spondyloarthritis

    Walter Maksymowych1, Xenofon Baraliakos2, Ulrich Weber3, Pedro M Machado4, Susanne J Pedersen5, Joachim Sieper6, Stephanie Wichuk1, Denis Poddubnyy7, Martin Rudwaleit8, Désirée van der Heijde9, Robert Landewé10, Joel Paschke11, Mikkel Østergaard12 and Robert G Lambert13, 1University of Alberta, Edmonton, AB, Canada, 2Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, 3University of South Denmark, Odense, Denmark, 4University College London, London, United Kingdom, 5Rigshospitalet University, Copenhagen, Denmark, 6Charité Universitätsmedizin Berlin, Berlin, Germany, 7Charité – Universitätsmedizin Berlin, Berlin, Germany, 8Department of Internal Medicine and Rheumatology, Klinikum Bielefeld, Germany, 9Leiden University Medical Center, Leiden, Netherlands, 10Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands, 11CARE Arthritis, Edmonton, AB, Canada, 12Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, 13University of Alberta and CARE Arthritis, Edmonton, AB, Canada

    Background/Purpose: The ASAS definition of a positive MRI for inflammation (ASAS-MRI+) is intended for classification of patients as having axSpA but is often misused for…
  • Abstract Number: 0444 • ACR Convergence 2020

    Chronological Order of Decrease of Synovitis, Osteitis and Tenosynovitis in Early Arthritis Patients Receiving First DMARD-treatment

    Xanthe Matthijssen1, Ellis Niemantsverdriet1, Saskia le Cessie1 and Annette van der Helm - van Mil2, 1Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center, Erasmus Medical Center, Leiden, Netherlands

    Background/Purpose: Advanced imaging modalities have shown that not only joints but also bones and tendon sheaths can be inflamed at diagnosis of rheumatoid arthritis. We…
  • Abstract Number: 1396 • ACR Convergence 2020

    Digital Artery Volume Index (Davix©) Predicts Onset of Future Digital Ulcers in Patients with Systemic Sclerosis

    Klodian Gjeloshi1, Giovanni Lettieri2, Fiammetta Danzo1, Giuseppina Abignano3, Mark Hinton4, Anne-Maree Dean5, Giovanna Cuomo6, Olga Kubassova7 and Francesco Del Galdo5, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK and Internal Medicine Department, University of Campania Luigi Vanvitelli, Naples, Italy, Leeds, United Kingdom, 2Radiology Department, San Carlo Hospital, Potenza, Italy, Potenza, Italy, 3Rheumatology Institute of Lucania (IReL), Rheumatology Department of Lucania, San Carlo Hospital, Potenza, Italy; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, England, United Kingdom, 4IAG CEO, London, United Kingdom, London, United Kingdom, 5Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom, 6Internal Medicine Department, University of Campania Luigi Vanvitelli, Naples, Italy, Naples, Italy, 7Image Analysis Group, London, United Kingdom

    Background/Purpose: Neointima proliferation is a key pathologic feature of Systemic Sclerosis (SSc), causing arterial vessel narrowing. It is a recognised culprit pathological lesion in Digital…
  • Abstract Number: 2020 • ACR Convergence 2020

    Preliminary Definition of a Positive MRI for Structural Lesions in the Sacroiliac Joints in Axial Spondyloarthritis

    Walter Maksymowych1, Xenofon Baraliakos2, Ulrich Weber3, Pedro M Machado4, Susanne J Pedersen5, Joachim Sieper6, Stephanie Wichuk1, Denis Poddubnyy7, Martin Rudwaleit8, Désirée van der Heijde9, Robert Landewé10, Joel Paschke11, Robert G Lambert12 and Mikkel Østergaard13, 1University of Alberta, Edmonton, AB, Canada, 2Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, 3University of South Denmark, Odense, Denmark, 4University College London, London, United Kingdom, 5Rigshospitalet University, Copenhagen, Denmark, 6Charité Universitätsmedizin Berlin, Berlin, Germany, 7Charité – Universitätsmedizin Berlin, Berlin, Germany, 8Department of Internal Medicine and Rheumatology, Klinikum Bielefeld, Germany, 9Leiden University Medical Center, Leiden, Netherlands, 10Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands, 11CARE Arthritis, Edmonton, AB, Canada, 12University of Alberta and CARE Arthritis, Edmonton, AB, Canada, 13Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

    Background/Purpose: There is lack of international consensus as to what defines a structural lesion on MRI of the sacroiliac joints (SIJ) typical of axial spondyloarthritis…
  • Abstract Number: 0481 • ACR Convergence 2020

    Subclinical Synovitis in Arthralgia: How Often Does It Result in Clinical Arthritis? A Longitudinal Study to Reflect on Starting Points for DMARD Treatment

    Cleo Rogier1, Fenne Wouters2, Laurette van Boheemen3, Dirkjan van Schaardenburg4, Pascal de Jong1 and Annette van der Helm - van Mil5, 1Erasmus MC, Rotterdam, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Amsterdam Rheumatology and immunology Center | Reade, Amste, Netherlands, 4Amsterdam Rheumatology and immunology Center | Reade and Amsterdam UMC, Amsterdam, Netherlands, 5Leiden University Medical Center, Erasmus Medical Center, Leiden, Netherlands

    Background/Purpose: According to guidelines, clinical arthritis is mandatory for diagnosing rheumatoid arthritis (RA). However, in the absence of clinical synovitis, imaging-detected subclinical synovitis is increasingly…
  • Abstract Number: 1470 • ACR Convergence 2020

    Machine Learning-Based Prediction of Knee Replacement in Persons with and Without Radiographic Osteoarthritis Using Clinical and Imaging Features of Osteoarthritis: The Multicenter Osteoarthritis Study

    S. Reza Jafarzadeh1, David Felson1, Michael Nevitt2, James Torner3, Cora Lewis4, Frank Roemer5, Ali Guermazi1 and Tuhina Neogi1, 1Boston University School of Medicine, Boston, MA, 2University of California, San Francisco, San Francisco, CA, 3University of Iowa, Iowa City, IA, 4University of Alabama Birmingham, Birmingham, AL, 5Boston University School of Medicine, Boston, MA, and Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany

    Background/Purpose: Prior studies of predictors of knee replacement (KR) have often included only a limited set of risk factors, been conducted primarily in knees with…
  • Abstract Number: 2022 • ACR Convergence 2020

    Effects of Anti-TNF-therapy on Osteoblastic Activity in Ankylosing Spondylitis – Results from a Prospective Study Using PET-MRI of SIJ and Spine

    Xenofon Baraliakos1, Styliani Tsiami2, Christoph Rischpler3, Nils-Martin Bruckmann4, Wolfgang Fendler3, Julian Kirchner5, Ken Herrmann3, Lino Morris Sawicki5 and Juergen Braun6, 1Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany, 2Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 3Department of Nuclear Medicine, University Essen-Duisburg, Essen, Germany, 4Department of Radiology, University Duesseldorf, Düsseldorf, Germany, 5Department of Radiology, University Duesseldorf, Duesseldorf, Germany, 6Rheumazentrum Ruhrgebiet Herne, and Ruhr-University Bochum, 44649 Herne, Germany

    Background/Purpose: The clinical efficacy of TNFi in patients with axSpA is well established but its effect on new bone formation is still unclear. Positron emission…
  • Abstract Number: 061 • 2020 Pediatric Rheumatology Symposium

    Perspectives of Radiologist Physicians in the Imaging of Chronic Nonbacterial Osteomyelitis

    Farzana Nuruzzaman1, Mingqian Huang 2, Christian Hedrich 3, Hermann Girschick 4, Julie Cherian 1, Karen Onel 5, T. Shawn Sato 6, Polly Ferguson 7 and Yongdong Zhao 8, 1Stony Brook Children's Hospital, Stony Brook, 2Mount Sinai Hospital, New York, New York, 3University of Liverpool, Liverpool, United Kingdom, 4Wuerzburg, Germany, 5Hospital for Special Surgery, New York, 6University of Iowa, Iowa City, 7University of Iowa Carver College of Medicine, Iowa City, 8University of Washington, Seattle

    Background/Purpose: Radiological imaging is integral to the diagnosis of chronic nonbacterial osteomyelitis (CNO) and has been included as a central component in suggested diagnostic criteria…
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