ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 0219

Intra-Articular Mineralization on Knee CT and Risk of Cartilage Loss: The Multicenter Osteoarthritis Study

Jean Liew1, John Lynch2, Ali Guermazi1, Mohamed Jarraya3, David Felson1, Na Wang1, Cora Lewis4, James Torner5, Michael Nevitt6 and Tuhina Neogi7, 1Boston University, Boston, MA, 2University of California San Francisco, San Francisco, CA, 3Massachusetts General Hospital, Boston, MA, 4University of Alabama Birmingham, Birmingham, AL, 5University of Iowa, Iowa City, IA, 6University of California San Francisco, Orinda, CA, 7Boston University School of Medicine, Boston, MA

Meeting: ACR Convergence 2021

Keywords: Imaging, Magnetic resonance imaging (MRI), Osteoarthritis

  • Tweet
  • Email
  • Print
Session Information

Date: Saturday, November 6, 2021

Session Title: Osteoarthritis – Clinical Poster I (0210–0224)

Session Type: Poster Session A

Session Time: 8:30AM-10:30AM

Background/Purpose: Intra-articular (IA) mineralization due to crystal deposition may contribute to OA pathology through inflammation, release of pro-catabolic factors, or altered cartilage biomechanical properties. Prior conflicting studies regarding whether chondrocalcinosis (from IA mineralization) is associated with OA structural progression were limited by the use of insensitive radiographs for visualizing IA mineralization. We studied the relation of IA mineralization on CT (a more sensitive modality) to cartilage loss on knee MRI in older adults, with particular attention to potential joint location- and tissue-specific effects of mineralization on cartilage pathology.

Methods: Participants from the Multicenter Osteoarthritis (MOST) study, a longitudinal prospective cohort of older adults, who had knee CTs and MRIs, were included in this longitudinal analysis. IA mineralization was assessed on CT using the Boston University Calcium Knee Score (BUCKS), with semi-quantitative scoring of extent of crystal mineralization 0-3 in WORMS subregions. We categorized presence of mineralization as a BUCKS score >0 in the following tissues: 1) anywhere in the knee; 2) cartilage; 3) meniscus; 4) joint capsule. For cartilage and meniscus, we further classified mineralization as occurring in the medial and/or lateral tibiofemoral compartment. Cartilage worsening on MRI was defined as any increase in the semi-quantitative MOAKS score between baseline and two-year follow-up in a compartment-specific manner and for the whole knee. We evaluated the relation of IA mineralization (defined above) to the presence of MRI cartilage worsening using binomial regression, and with generalized estimating equations for compartment-specific analyses to account for correlations between compartments within a knee. Analyses were performed in a compartment-specific manner for cartilage and meniscus mineralization (i.e., relation of presence of medial mineralization to risk of medial cartilage worsening), and at the whole knee level for capsular mineralization. Analyses were adjusted for age, sex, and body mass index (BMI).

Results: We included 1673 participants (mean age 60.1±9.1, 56% female, mean BMI 28.6±5.0 kg/m2). Overall, 9.0% had any IA mineralization in the knee; mineralization in the cartilage, meniscus, and joint capsule was present in 6.3%, 7.1%, and 4.0%, respectively. 46.5% had cartilage loss on follow-up anywhere in the knee. In compartment-specific analyses, presence of cartilage mineralization was associated with a 1.40 higher risk of cartilage loss in the same compartment (95% CI, 1.04-1.88); no association was noted for mineralization of the meniscus (Table). Mineralization of any tissue in the knee, regardless of location or tissue type was not associated with cartilage worsening at any location in the knee.

Conclusion: IA mineralization in the cartilage, but not in the meniscus, was associated with higher risk of cartilage loss in the same compartment over two years. Mineralization of the joint capsule was also not associated with cartilage loss anywhere in the knee. These findings suggest potential tissue-specific and localized effects of IA mineralization on cartilage pathology in knee OA.


Disclosures: J. Liew, None; J. Lynch, None; A. Guermazi, Pfizer, MerckSerono, Regeneron, TissueGene, AstraZeneca, Novartis, 2, BICL, 8; M. Jarraya, None; D. Felson, None; N. Wang, None; C. Lewis, None; J. Torner, None; M. Nevitt, None; T. Neogi, Pfizer/Lilly, 2, Regeneron, 2, Novartis, 2.

To cite this abstract in AMA style:

Liew J, Lynch J, Guermazi A, Jarraya M, Felson D, Wang N, Lewis C, Torner J, Nevitt M, Neogi T. Intra-Articular Mineralization on Knee CT and Risk of Cartilage Loss: The Multicenter Osteoarthritis Study [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/intra-articular-mineralization-on-knee-ct-and-risk-of-cartilage-loss-the-multicenter-osteoarthritis-study/. Accessed June 1, 2023.
  • Tweet
  • Email
  • Print

« Back to ACR Convergence 2021

ACR Meeting Abstracts - https://acrabstracts.org/abstract/intra-articular-mineralization-on-knee-ct-and-risk-of-cartilage-loss-the-multicenter-osteoarthritis-study/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

© COPYRIGHT 2023 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences