ACR Meeting Abstracts

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Abstracts tagged "macrophages"

  • Abstract Number: 0071 • ACR Convergence 2020

    Significant Enrichment of Transcriptionally Distinct CD206+CD163+ Macrophage Population in Rheumatoid Arthritis Synovial Tissue

    Megan Hanlon1, Mary Canavan2, Qingxuan Song3, Candice Low4, Phil Gallagher5, Ronan Mullan6, Conor Hurson7, Sunil Nagpal8, Douglas Veale9 and Ursula Fearon2, 1Molecular Rheumatology, Trinity College Dublin, Dublin 2, Dublin, Ireland, 2Molecular Rheumatology, Trinity College Dublin, Dublin, Dublin, Ireland, 3Janssen Research & Development, LLC, Spring House, PA, USA, Spring House, PA, 4EULAR Centre for Arthritis and Rheumatic diseases, St Vincents University Hospital, UCD, Dublin, Ireland, 5St Vincents University Hospital, UCD, Dublin, Ireland, 6Adelaide and Meath Hospital, Dublin, Dublin, Ireland, 7St Vincents University Hospital, UCD, Dublin, Dublin, Ireland, 8Janssen Research & Development, Collegeville, PA, 9EULAR Centre for Arthritis and Rheumatic Diseases, St Vincents University Hospital, UCD, Dublin, Dublin, Ireland

    Background/Purpose: Synovial tissue macrophages are an exquisitely plastic pool of innate cells that play a key role in RA disease progression. However, the precise nature,…
  • Abstract Number: 0072 • ACR Convergence 2020

    Characterizing Heterogeneity of Synovial Macrophages in Rheumatoid Arthritis Patients

    Shang-Yang Chen1, Yidan Wang2, Anna Montgomery2, Salina Dominguez2, Carla Cuda2, Gaurav Gadhvi1, Harris Perlman2 and Deborah Winter3, 1Northwestern University, Chicago, IL, 2Northwestern University, Chicago, 3Northwestern University Division of Rheumatology, Chicago, IL

    Background/Purpose: Macrophages in the synovial lining of the joint are critical players in the pathogenesis of rheumatoid arthritis (RA). While they are potent producers of…
  • Abstract Number: 0669 • ACR Convergence 2020

    Calcium Pyrophosphate Crystal Deposition in Gouty Tophi

    Hang-Korng Ea1, Alan Gauffenic2, Quand Nguyen3, Nhu Pham3, Oceane Olivier2, Vincent Frochot4, Dominique Bazin5, Nghia Le3, Caroline Marty2, Agnès Ostertag2, Martine Cohen-Solal1, Jean-Denis Laredo6, Pascal Richette7 and Thomas Bardin8, 1Université de Paris, INSERM UMR 1132, BIOSCAR, AP-HP, DMU Locomoteur, Paris, France, 2Université de Paris, INSERM UMR 1132, BIOSCAR, Paris, France, 3Vien Gut Medical Center and French-Vietnamese research center on gout and chronic diseases, Ho Chi Ming, Vietnam, 4Hôpital Tenon, Service des explorations fonctionnelles multidisciplinaires, Sorbonne université, UMR_S1155, Paris, France, 5Institut de Chimie Physique, Université Paris-Saclay et CNRS - UMR8000, Orsay, France, 6AP-HP Université de Paris, Paris, 7Department of Rheumatology, Lariboisière Hospital, AP-HP Université de Paris, INSERM U1132, Paris, 8Université de Paris, INSERM U1132 and Hôpital Lariboisièe, Paris, France, Paris, France

    Background/Purpose: The coexistence of calcium pyrophosphate (CPP) and monosodium urate crystals is rarely reported in gouty tophi. We investigated CPP crystal deposits in a series…
  • Abstract Number: 0738 • ACR Convergence 2020

    Systemic Administration of Novel Hydroxyl Dendrimers to Target Inflammation in Arthritic Tissues

    Jeffrey Cleland1, Rishi Sharma2, Minghao Sun3, Santiago Appiani La Rosa3 and Rangaramanujam M. Kannan4, 1Ashvattha Therapeutics, Inc, Redwood City, CA, 2Ashvattha Therapeutics, Baltimore, MD, 3Ashvattha Therapeutics, Inc, Baltimore, MD, 4Johns Hopkins School of Medicine, Baltimore, MD

    Background/Purpose: Chronic inflammation observed in arthritis and other autoimmune disorders is mediated primarily by pro-inflammatory reactive macrophages.  Systemic administration of anti-inflammatory agents does not selectively…
  • Abstract Number: 0787 • ACR Convergence 2020

    MerTK Synovial Expression Correlates with Disease Activity and Treatment Response in Rheumatoid Arthritis Patients

    Alessandra Nerviani1, Marie-Astrid Boutet1, Giulia Maria Ghirardi2, Gloria Lliso-Ribera2, Felice Rivellese1, Myles Lewis1, Michele Bombardieri2, Frances Humby2 and Costantino Pitzalis2, 1Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, 2Queen Mary University of London, London, United Kingdom

    Background/Purpose: Despite valuable improvements in long-term clinical outcomes, a significant portion of rheumatoid arthritis (RA) patients still do not adequately respond to available treatments, and…
  • Abstract Number: 0839 • ACR Convergence 2020

    Single-Cell Transcriptomics of Mouse and Human Lupus Nephritis Identifies Conserved Myeloid Populations Across Species

    Paul Hoover1, Michael Peters2, David Lieb3, Rakesh Mishra4, Nir Hacohen2 and Anne Davidson5, 1Brigham and Women's Hospital, Boston, MA, 2Broad Institute, Boston, 3Broad Institute, Boston, MA, 4Feinstein Institute, Manhasset, NY, 5Northwell Health, New York

    Background/Purpose: We recently identified novel immune cell states in the kidneys of lupus nephritis patients (Arazi et al, Nature Immunology 2019). To determine the similarities…
  • Abstract Number: 0979 • ACR Convergence 2020

    The Identification of Shared and Unique Myeloid Cell States in Pre- and Post-nephritic Lupus Mouse Models, Sle.Yaa1 and NZBW

    Paul Hoover1, Michael Peters2, David Lieb3, Heather Geiger4, Rakesh Mishra5, Nir Hacohen2 and Anne Davidson6, 1Brigham and Women's Hospital, Boston, MA, 2Broad Institute, Boston, 3Broad Institute, Boston, MA, 4New York Genome Center, New York, NY, 5Feinstein Institute, Manhasset, NY, 6Northwell Health, New York

    Background/Purpose:Poor renal prognosis in lupus nephritis (LN) is associated with an abundance of renal macrophages and dendritic cells (DCs) but the role of these cells…
  • Abstract Number: 1531 • ACR Convergence 2020

    Characterization of Cytokine/chemokine Profile in Patient-derived M1/ M2 Macrophages to Identify Biomarkers for Genetically-defined Systemic Autoinflammatory Diseases

    Farzana Bhuyan1, Adriana Almeida de Jesus2, Kim Johnson3, Jacob Mitchell4, Yan Huang5 and Raphaela Goldbach-Mansky5, 1NIH, bhetesda, MD, 2Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, 3NIH, NIAID, Bethesda, 4Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, MD, 5NIH, Bethesda

    Background/Purpose: Genetic mutations in key regulatory molecules of the innate immune system cause autoinflammatory diseases through propagation of hyperinflammatory responses. Monocytes/ macrophages regulate inflammatory processes…
  • Abstract Number: 1544 • ACR Convergence 2020

    Tc99m Tilmanocept Imaging Is an Early Predictor of Clinical Response in Rheumatoid Arthritis Patients Beginning New Anti-TNFα Therapy

    Mara Leach1, David Ralph1, Beth Potter1, Bonnie Abbruzzese1, Rachael Hershey1, Jessica Fitzpatrick1, Katherine Repp1, Haya Shakhtra1, Madison Palmer1, Nicole Korczak1, Audrey Villarosa1, Michael Blue1, Martin Jacobs2, Yelliann Ruis3, Debbie Foley4, Alan Kivitz5 and Michael Rosol1, 1Navidea Biopharmaceuticals, Dublin, 2Kettering Medical Center, Kettering, 3Innovation Medical Research Center, Palmetto Bay, 4Premier Rheumatology of Oklahoma, Tulsa, 5Altoona Center for Clinical Research/Altoona Arthritis and Osteoporosis Center, Duncansville, PA

    Background/Purpose: Rheumatoid Arthritis (RA) is a serious and potentially debilitating disease, but low disease activity and even clinical remission can be obtained if an effective…
  • Abstract Number: 1969 • ACR Convergence 2020

    The Dynamics of Macrophage Sub-Populations in the Inflammatory Phase Following Joint Trauma

    Samuel Hamilton1, Anna Montgomery1, Niamh Fahy2, Maximilian Mayr1, Shang-Yang Chen1, Gaurav Gadhvi1, Yvonne Bastiaansen-Jenniskens2 and Deborah Winter3, 1Northwestern University, Chicago, IL, 2Erasmus MC, Rotterdam, Netherlands, 3Northwestern University Division of Rheumatology, Chicago, IL

    Background/Purpose: Macrophages fulfill critical functions in maintaining tissue homeostasis in steady-state, as well as in inflammation and immune response.  In the joint synovium, we have…
  • Abstract Number: 0037 • ACR Convergence 2020

    Lipoprotein-associated Phospholipase A2: A New Biomarker for Lymphoma Development in Sjögren’s Syndrome

    Adrianos Nezos1, Eleni Kotsifaki1, Charalampos Skarlis2, Konstantinos Markakis1, Haralampos Moutsopoulos3, Michael Koutsilieris1, Clio Mavragani1 and Anna Psarrou1, 1National & Kapodistrian University of Athens, Athens, Greece, 2National &Kapodistrian University of Athens, Athens, Greece, 3National & Kapodistrian University of Athens/ Academy of Athens, Athens, Greece

    Background/Purpose: B-cell non-Hodgkin's lymphoma (B-NHL) is one of the major complications of primary Sjögren’s syndrome (SS). Chronic inflammation and macrophages in SS minor salivary glands…
  • Abstract Number: 996 • 2019 ACR/ARP Annual Meeting

    The Role of Flip in Differentiation and Survival of Synovial Tissue Resident Macrophages

    Qi Huang1, Renee Doyle 1, Shang-Yang Chen 2, Alexander Misharin 3, Deborah Winter 4 and Richard Pope 5, 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2Northwestern University, Chicago, 3Northwestern University Feinberg School of Medicine, chicago, 4Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, 5Northwestern University Feinberg School of Medicine, Division of Rheumatology, chicago, IL

    Background/Purpose: We previously identified that under homeostatic conditions Flip was necessary for macrophage (MΦ) survival.  The mechanisms responsible for the differentiation of monocyte-derived MΦs into…
  • Abstract Number: 1056 • 2019 ACR/ARP Annual Meeting

    Profibrotic Macrophage Activation in Systemic Sclerosis Is Dependent on the Mechanosensing MRTF-A Pathway

    Tricia Lim1, Kristina Krogmannova 1, Shiwen Xu 1, Bahja Ahmed Abdi 2, David Abraham 1, Christopher Denton 3 and Richard Stratton 1, 1University College London, London, United Kingdom, 2University College London, London, 3University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom

    Background/Purpose: An M2-like alternative activation state of macrophages has been linked to the pathogenesis of several fibrotic disorders, including systemic sclerosis (SSc). MRTF-A is an…
  • Abstract Number: 1073 • 2019 ACR/ARP Annual Meeting

    Identification of Distinct Pro-Fibrotic Monocyte and Macrophage Subsets in Systemic Sclerosis

    Angela Tam1, Lauren Reinke-Breen 2, Glenda Trujillo 2, Shiwen Xu 1, Christopher Denton 3, David Abraham 1, Gabor Jarai 2 and Voon Ong 4, 1University College London, London, United Kingdom, 2Bristol-Myers Squibb, Pennington, 3University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom, 4UCL Medical School, Royal Free Campus, London

    Background/Purpose: Chronic inflammation may modulate the balance of classical, intermediate and non-classical monocyte subsets (defined by CD14/CD16 expression)1.  Monocytes are heterogeneous and subsets can be…
  • Abstract Number: 2002 • 2019 ACR/ARP Annual Meeting

    Presence of the MerTK Receptor on Human Synovial Tissue Macrophages Lowers Inflammatory Cytokine Production and Activation of the MerTK+CD206+ Subpopulation Limits the Inflammatory Response of Synovial Fibroblasts

    Samuel Finlay1, Stefano Alivernini 2, Aziza Elmesmari 3, Barbara Tolusso 2, Luca Petricca 2, Clara Di Mario 4, Annunziata Capacci 2, Andrew Filer 5, Gianfranco Ferraccioli 2, Iain McInnes 1, Elisa Gremese 2 and Mariola Kurowska-Stolarska 1, 1Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, 2Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, 3Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, Scotland, United Kingdom, 4Institute of Rheumatology - Università Cattolica del Sacro Cuore, Rome, Italy, 5Institute of Inflammation and Ageing College of Medical and Dental Sciences University of Birmingham, Birmingham, United Kingdom

    Background/Purpose: Background: A substantial proportion of Rheumatoid Arthritis patients do not respond to treatment and only a small proportion achieve sustained disease remission. We showed…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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