ACR Meeting Abstracts

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Abstracts tagged "macrophages"

  • Abstract Number: 0061 • ACR Convergence 2024

    Comparative Transcriptional Profiling of IPF and RA-ILD Lung Tissue Demonstrates Both Overlapping and Distinct Cell-specific Signaling Pathways

    Joshua Sciurba1, Daniel Kass1, Eleanor Valenzi2, John Sembrat2, Robert Lafyatis3 and Dana Ascherman4, 1University of Pittsburgh School of Medicine, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA, 3Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 4Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA

    Background/Purpose: Transcriptional profiling represents a powerful tool for deciphering disease-relevant pathways and deriving functional biomarkers.  Given the shared demographic, genetic, and clinico-epidemiologic features between rheumatoid…
  • Abstract Number: 0972 • ACR Convergence 2024

    Downregulated Fli1 in Scleroderma Myeloid Cells Contributes to Cardiac Fibrosis via a Galectin-3/mTOR Dependent Pathway

    Fatima El adili1, Moyo Mudhibadhi2, Giovanni ligresti3, Maria Trojanowska2 and Andreea Bujor3, 1Boston Medical Center, Boston, MA, 2Boston university medical school, Boston, MA, 3Boston University, Boston, MA

    Background/Purpose: Cardiac fibrosis is a common complication in Systemic sclerosis (SSc), but the pathogenesis is largely unknown. We have previously shown that monocytes isolated from…
  • Abstract Number: 2550 • ACR Convergence 2024

    Infiltrating and Resident Macrophages in Lupus Nephritis: Scar Associated Macrophage Phagocytic Dysfunction and Fibroblast Activation

    Chirag Raparia1, Paul Hoover2, Arnon Arazi3, Nir Hacohen4 and Anne Davidson5, 1Donald and Barbara Zucker School of Medicine At Hofstra/Northwell, Shoreham, NY, 2Brigham and Women's Hospital, SWAMPSCOTT, MA, 3Feinstein Institutes for Medical Research, Melrose, MA, 4Broad Institute of MIT and Harvard, Boston, MA, 5Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: Lupus nephritis (LN) is driven by a heterogeneous population of renal macrophages. We have previously reported that the renal macrophage subpopulations are similar in…
  • Abstract Number: 0062 • ACR Convergence 2024

    Pro-Fibrotic Effects of Malondialdehyde-Acetaldehyde-Adducted and/or Citrullinated Proteins on Macrophages and Human Lung Fibroblasts

    Lauren Klingemann1, Nozima Aripova1, Nigina Aripova2, Michael Duryee1, Carlos Hunter1, Jill Poole1, Bryant England1, Ted Mikuls1 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2WUSTL, St. Louis, MO

    Background/Purpose: Clinically evident rheumatoid arthritis-associated interstitial lung disease (RA-ILD) affects approximately 10-15% of patients with rheumatoid arthritis (RA) and accounts for the most overrepresented cause…
  • Abstract Number: 0973 • ACR Convergence 2024

    Mechano-transduction via MRTF-A Pathway Is Required for Cytokine Release by Scleroderma Macrophages

    Sandra Lopez Garces1, Guan Hui Tricia Lim2, Jorlin Liu3, Maahia Choudhary3, Juno Erin Vimalenthiran,3, Angela Tam1, David Abraham3, Christopher Denton4, Bahja Ahmed Abdi1 and Richard Stratton5, 1University College London, London, United Kingdom, 2Centre for Rheumatology and Connective Tissue Diseases, University College London Medical School, Royal Free Campus, London, United Kingdom, 3UCL, London, United Kingdom, 4University College London, Northwood, United Kingdom, 5UCL, London, England, United Kingdom

    Background/Purpose: In keeping with hallmark clinical evidence of stiffening and fibrotic thickening of the skin, we and others have previously demonstrated a role for the…
  • Abstract Number: 2593 • ACR Convergence 2024

    A Long-term Synovial Tissue 3D Model Incorporating Fibroblasts, Macrophages, Endothelial Cells, and Other Immune Cells Such as Innate Lymphoid Cells Enables Animal Model-Independent Rheumatoid Arthritis Research

    Miriam Bollmann1, Oskar Landberg2, Negar Ayoubzadeh2, Charlotte A. Jonsson2, Inger Gjertsson2 and Mattias Svensson2, 1University of Gothenburg, Göteborg, Sweden, 2University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with multiple tissues contributing to its pathology, including the synovial membrane. The RA synovial membrane…
  • Abstract Number: 0074 • ACR Convergence 2024

    Tofacitinib Therapy Ameliorates Inflammation in a Mouse Model of Psoriasis and Arthritis by Inducing Type 2 Immunity

    Maria de la Luz Garcia-Hernandez1, Javier Rangel-Moreno1, Ananta Paine2, Angel Rangel-Garcia1, Marissa Krantz3, Delaney Martino1, Marc Nuzzo1 and Christopher Ritchlin4, 1University of Rochester, Rochester, NY, 2ORNA Tx, Southborough, MA, 3University of Rochester, Rochester, NY, 4Department of Medicine, Allergy, Immunology, and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY

    Background/Purpose: Psoriatic arthritis (PsA), a chronic progressive inflammatory arthritis, affects peripheral joints and causes patient disability. PsA patients also have skin plaques initiated by activation…
  • Abstract Number: 1396 • ACR Convergence 2024

    Low CD47 Expression on B Cells, Induces High B Cell Phagocytosis by Macrophages and Is a Predictive Biomarker of Anti-rituximab Antibodies and Lower Response in Rheumatoid Arthritis

    Samuel Bitoun1, Bineta Ly2, Audrey Paoletti2, Catherine Menier Menier3, Marc Pallardy4, Bernard Maillere5 and Xavier Mariette6, and ABIRISK consortium, 1Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicetre, France, 2Rheumatology departement, Université Paris Saclay, Inserm UMR 1184,Hopital Bicêtre, APHP, FHU CARE, Le Kremlin Bicêtre, France, 31 CEA, INRAE, Département Médicaments et Technologies pour la Santé, SIMoS, Université de Paris-Saclay, Gif sur Yvette, France, 4Université Paris-Saclay, INSERM, Inflammation Microbiome Immunosurveillance, Orsay, France, 5CEA, INRAE, Département Médicaments et Technologies pour la Santé, SIMoS, Université de Paris-Saclay, Gif sur Yvette, France, 6Service de Rhumatologie, Hôpital Bicêtre, AP-HP, Le Kremlin Bicetre, France

    Background/Purpose: Rituximab (RTX) provides long lasting efficacy in the control of rheumatoid arthritis. Among factors associated with RTX failure are the occurrence of anti-drug antibodies…
  • Abstract Number: 2594 • ACR Convergence 2024

    A Novel Therapeutically Active CSF-1R Agonist Promotes Tissue Macrophages Inflammation Resolution and Induces Tissue Repair Pathways

    Saul Kivimae1, Sandip Mukherjee2, Phi Quach3, Rhoneil Pena4, Olga Zemska3, Michal Olszewski5, Jicai Huang3, Michael Labson6, Donald Walker1, Mekhala Maiti7, Chakrapani Tripathi8, Thomas Chang3, Suresh Adapala9, Damon Hamel3, Katherine Brendza3, Takahiro Miyazaki3 and Jonathan Zalevsky1, 1Nektar Therapeutics, San Francisco, CA, 2Nurix Therapeutics, San Francisco, 3Nektar Therapeutics, San Francisco, 4Sutro Biopharma, South San Francisco, 5Vaxcyte, San Francisco, 6Guardant Health, Palo Alto, 7Alumis, Inc, South San Francisco, 8Theragent Inc, Arcadia, CA, 9Inotiv, Rockville, MD

    Background/Purpose: Current standard of care chronic inflammatory disease therapies are designed to suppress inflammation and are not optimized for inflammation resolution and restoration of tissue…
  • Abstract Number: 0096 • ACR Convergence 2024

    Simultaneous Contribution of Brain-Intrinsic and Peripheral Disease Mechanisms to Neuropsychiatric Symptoms of Systemic Lupus Erythematosus (NPSLE)

    Hadijat Makinde1, Mohammad Khan1, Cecilia Stumpf2, Yidan Wang3, Tyler Therron2, Margaret Goldman2, Deborah Winter4 and Carla Cuda1, 1Northwestern University, Chicago, IL, 2Northwestern University, Chicago, 3Northwestern University, Hanover Park, IL, 4Northwestern University, Skokie, IL

    Background/Purpose: While NPSLE are among the least understood complications, increasing evidence points to microglia, a brain-resident innate immune cell population, as a driver of disease.…
  • Abstract Number: 1643 • ACR Convergence 2024

    Single Nuclei Multiome and Spatial Transcriptomic Analysis of Early, Untreated SSc Skin Identifies Signaling Interactions Between Macrophages and Fibroblasts

    Helen Jarnagin1, Dillon Popovich2, Rezvan Parvizi3, Rosemary Gedert4, Lam C. Tsoi5, Rachael Wasikowski5, Zhiyun Gong1, Madeline Morrisson6, Laurent Perreard7, Fred Kolling IV7, Dinesh Khanna4, Johann Gudjonsson4 and Michael Whitfield3, 1Dartmouth College, Lebanon, NH, 2Dartmouth College, West Lebanon, NH, 3Geisel School of Medicine at Dartmouth, Hanover, NH, 4University of Michigan, Ann Arbor, MI, 5Michigan, Dept. of Dermatology, Ann Arbor, MI, 6Geisel School of Medicine at Dartmouth College, Hanover, NH, 7Geisel School of Medicine, Dartmouth College, Lebanon

    Background/Purpose: We generated a vertically integrated dataset on treatment naïve patients with dcSSc (diffuse Systemic Sclerosis) skin that includes bulk RNA-seq, single nuclei multiome, and…
  • Abstract Number: 2645 • ACR Convergence 2024

    Human NCF1-p.R90H Variant Promotes Pulmonary Fibrosis in the Bleomycin-induced Mouse Model and Systemic Sclerosis Patients via Expansion of SPP1+Monocytes-derived Macrophages

    Xinran Yuan1, Xiaodong Qin2, Kenji Takemoto1, Jian Zhao1, Matthew Sanderson1, Xue Xu1, Kristi L Helke3, Bethany Wolf4, Joel Guthridge5, Judith A James6, Xiaodong Zhou7, Shervin Assassi8, Carol Feghali-Bostwick4, Dandan Wang9, Lingyun Sun10 and Betty P Tsao1, 1Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 2Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China (People's Republic), 3Department of Comparative Medicine, Medical University of South Carolina, Charleston, SC, 4Medical University of South Carolina, Charleston, SC, 5Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 7Division of Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 8UTHealth Houston Division of Rheumatology, Houston, TX, 9Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical Schoo, Nanjing, Jiangsu, China (People's Republic), 10Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China (People's Republic)

    Background/Purpose: We previously identified a systemic lupus erythematosus (SLE) causal risk variant, p.Arg90His (p.R90H, rs201802880) substitution encoded in neutrophil cytosolic factor 1 (NCF1), an essential component…
  • Abstract Number: 0263 • ACR Convergence 2024

    Characteristics and Coinfections of Diffuse Alveolar Hemorrhage in Rheumatic Patients

    Eduardo Briones-García1, Shaul Navarro-Lara2, Marco A Ortiz-Bustamante2, Iris Paola García Herrera3, Carla M Roman-Montes2 and Guillermo A Guaracha-Basañez4, 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Immunology and Rheumatology Department., Ciudad de México, Distrito Federal, Mexico, 2Departamento de Infectología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador-Zubirán., México city, Mexico, 3Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 4Instituto Nacional de Ciencias Medicas y Nutricion “Salvador Zubirán”, Mexico City, Distrito Federal, Mexico

    Background/Purpose: Diffuse alveolar hemorrhage (DAH) is a severe respiratory complication observed in certain rheumatic diseases, such as systemic lupus erythematosus (SLE), ANCA-associated vasculitides (AAV), and…
  • Abstract Number: 1686 • ACR Convergence 2024

    Urine Proteomics in Class II Lupus Nephritis Reveals Immune Activation and Pro-Fibrotic Signatures

    Jasmine Shwetar1, Jill Buyon2, Michelle Petri3, Kelly Ruggles4 and Andrea Fava5, 1New York School of Medicine, Ann Arbor, MI, 2NYU Grossman School of Medicine, New York, NY, 3Johns Hopkins University School of Medicine, Timonium, MD, 4NYU Grossman School of Medicine, Brooklyn, NY, 5Johns Hopkins University, Baltimore, MD

    Background/Purpose: Lupus nephritis (LN) is a pathologically diverse autoimmune disease that can lead to end-stage kidney disease and mortality. Although Class II LN is considered…
  • Abstract Number: 0279 • ACR Convergence 2024

    Macrophage Intracellular Fates of Monosodium Urate and Calcium Pyrophosphate Crystals: Phagocytosis, Exchanged/expulsion and Dissolution of Crystals

    Charles Leroy1, Nghia Pham2, François Brial3, Brenda Kischkel4, gwénaêlle Jayat5, Elena Ishow6, Christèle Combes7, Leo Joosten4, Augustin Latourte8, Pascal Richette9 and Hang-Korng Ea10, 1Inserm 1132 / Université Paris Cité, levallois-perret, France, 2INSERM 1132, BIOSCAR, Lariboisière hospital, Paris, France, 3Inserm 1132/ Université Paris Cité, Paris, France, 4Radboudumc, Nijmegen, Netherlands, 5Université Paris cité / Inserm 1132, paris, France, 6Université de Nantes / Ceisam, Nantes, France, 7INP-ENSIACET, Toulouse, France, 8AP-HP, Paris, France, 9Lariboisière Hospital, Paris, France, 10Université Paris Cité, INSERM UMR 1132 BIOSCAR, Paris, France

    Background/Purpose: Gout, due to the presence of monosodium urate crystals (MSU) and calcium pyrophosphate (CPP) crystal deposition disease are both responsible for recurrent inflammation flares.…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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