ACR Meeting Abstracts

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Abstracts tagged "macrophage activation syndrome"

  • Abstract Number: 2017 • 2013 ACR/ARHP Annual Meeting

    Hyper Ferritinemia Suggests a High Frequency Of Macrophage Activation Syndrome In a Large Adult Severe Sepsis Cohort: A Role For Anakinra?

    Bita Shakoory1, Joseph A. Carcillo2 and Steven Opal3, 1Medicine/Rheumatology, Temple University, Philadelphia, PA, 2Pediatrics, University of Pittsburg Medical Center, Pittsburgh, PA, 3Medicine, Brown University, Providence, RI

    Background/Purpose: Inreased ferritin levels are protective during infection whereas but very very high level are associated with MAS in rheumatologic disease cTo determine frequency of…
  • Abstract Number: 2018 • 2013 ACR/ARHP Annual Meeting

    Hemophagocytic Lymphohistiocytosis As a Clinical Syndrome Of Autoimmune Diseases, Haematology, Oncology and Infectious Diseases

    César Antonio Egües Dubuc, Vicente Aldasoro Cáceres, Miren Uriarte Ecenarro, Carlos Meneses Villalba, Nerea Errazquin Aguirre, Iñaki Hernando Rubio, Olga Maiz Alonso, Jorge Cancio Fanlo, Esther Uriarte Isacelaya and Joaquin Belzunegui Otano, Rheumatology, Donostia University Hospital, San Sebastián, Spain

    Background/Purpose :Hemophagocytic Lymphohistiocytosis (HLH) is a severe and acute inflammatory syndrome usually fatal without treatment. HLH includes a spectrum of diseases produced by the proliferation and activation of…
  • Abstract Number: 79 • 2013 ACR/ARHP Annual Meeting

    Synovial Activation In Experimental OA Drives Immuno suppressive Effects Of Adipose-derived Stem Cells After Local Administration and Protects Against Chondrogenesis In Ligaments

    Peter L.E.M. van Lent1, Rik Schelbergen1, Menno C. ter Huurne2, Arjen B. Blom1, Johannes Roth3, Thomas Vogl4, Christian Jorgensen5 and Wim B. van den Berg6, 1Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Immunology, Institute of Immunology University of Muenster, Muenster, Germany, 4Institute of Immunology, University of Muenster, Muenster, Germany, 5Department of therapy & Immuno-Rhumatology, Inserm U844, CHU saint-Eloi, Université Montpellier 1, CHU Lapeyronie, Montpellier, France, 6Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background/Purpose: A substantial subpopulation of patients with early osteoarthritis (OA) show a thickened synovial lining layer comprising macrophages expressing an activated phenotype (reflected by production of…
  • Abstract Number: 2525 • 2012 ACR/ARHP Annual Meeting

    Bruton’s Tyrosine Kinase Inhibition Suppresses Inflammatory Cytokine Production and Affects Gene Expression in Human Macrophages and RA Synovial Tissue Explants

    Linda M. Hartkamp1, Inge E. van Es1, Jay S. Fine2, Michael Smith2, John Woods2, Satwant Narula3, Julie DeMartino2, Paul P. Tak4 and Kris A. Reedquist1, 1Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Inflammation Discovery, Hoffmann-La Roche, Nutley, NJ, 3Inflammatory Discovery, Hoffmann-La Roche, Nutley, NJ, 4Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic and progressive autoinflammatory disorder characterized by the infiltration of inflammatory cells, including B-cells, T-cells and macrophages, in the…
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