Abstracts tagged "Lupus nephritis"

Abstract Number: 1826 • 2014 ACR/ARHP Annual Meeting
A Renal Activity Index May Predict Histological Activity in Lupus Nephritis in Children
Khalid Abulaban¹, Michael Bennett², Marisa Klein-Gitelman³, Stacy P. Ardoin⁴, Kelly A. Rouster-Stevens⁵, Lori B. Tucker⁶, Kasha Wiley⁷, Shannen Nelson⁸, Karen Onel⁹, Nora G. Singer¹⁰, Kathleen M. O'Neil¹¹, Elizabeth Brooks¹², B Anne Eberhard¹³, Lawrence K. Jung¹⁴, Lisa F. Imundo¹⁵, Tracey Wright¹⁶, David Witte¹⁷, Jun Ying¹⁸, Prasad Devarajan² and Hermine I. Brunner¹⁹, ¹Pediatric Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²Nephrology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ³Anne & Robert H Lurie Childrens Hospital of Chicago, Chicago, IL, ⁴Pediatric & Adult Rheumatology, Ohio State University College of Medicine, Columbus, OH, ⁵Pediatrics, Emory University School of Medicine, Atlanta, GA, ⁶Rheumatology, BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, ⁷Rheumatology, Cincinnati Children's Hospital Medical Center, c, OH, ⁸Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁹Pediatric Rheumatology, University of Chicago Hospitals, Chicago, IL, ¹⁰Medicine, Division of Rhuematology, Division of Rheumatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, ¹¹Division of Pediatric Rheumatology, Riley Hospital for Children, Indianapolis, IN, ¹²Rheumatology, Univ Hospitals of Cleveland, Cleveland, OH, ¹³Pediatrics/Rheumatology, Cohen Children's Medical Center, Lake Success, NY, ¹⁴Pediatric Rheumatology, Children's National Medical Center, Washington, DC, ¹⁵Assoociate Professor of Pediatrics in Medicine - Rheumatoology, Columbia University Medical Center, New York, NY, ¹⁶Pediatrics/Rheumatology, UT Southwestern Medical Center, Dallas, TX, ¹⁷Rheumatology, Cincinnati Children's Hospital, Cincinnati, OH, ¹⁸University of Cincinnati, Cincinnati, OH, ¹⁹Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose Lupus Nephritis (LN) occurs in up to 80% of childhood-onset Systemic Lupus Erythematosus (cSLE) and it has a worse prognosis than adults. The current…
Abstract Number: 963 • 2014 ACR/ARHP Annual Meeting
Reduction in Proteinuria and Normalization of C4 Complement Levels Predict Response to Treatment of Lupus Nephritis with Low-Dose Pulse Cyclophosphamide and Abatacept
Sarah Goglin¹, David Wofsy², Miriam G. Cisternas³ and Maria Dall'era¹, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²University of California, San Francisco, San Francisco, CA, ³MGC Data Services, Carlsbad, CA
Background/Purpose: The response to treatment of lupus nephritis is unpredictable. There is a need to identify clinical and biochemical characteristics that can predict treatment outcome…
Abstract Number: 2719 • 2013 ACR/ARHP Annual Meeting
Urinary Angiostatin As Alternative To Biopsy In lupus Nephritis Patients Among Egyptian
Shereen Algergawy¹, Osama Alshaar² and Rania Zakaria³, ¹rheumatology and rehabilitation, associate prof at benha university faculty of medicine rheumatology and rehabilitation department Egypt, cairo, Egypt, ²clinical pathology, benha university faculty of medicine, benha, Egypt, ³pathology, benha university faculty of medicine, benha, Egypt
Background/Purpose: Lupus nephritis (LN) is one of the most frequent manifestations of SLE and can be present in 60% of SLE patients. Kidney biopsy remains…
Abstract Number: 2547 • 2013 ACR/ARHP Annual Meeting
Anti-Ribosomal P Antibody Has a Protective Role In The Development Of Chronic Kidney Disease In Patients With Lupus Nephritis
Kyung-Eun Lee¹, Dong-Jin Park¹, Tae-Jong Kim², Yong-Wook Park¹ and Shin-Seok Lee², ¹Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, ²Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea
Background/Purpose: Anti-ribosomal P antibody (anti-P) in patients with systemic lupus erythematosus (SLE) is associated with neuropsychiatric manifestation. Of interest, recent studies have suggested that anti-P…
Abstract Number: 1262 • 2013 ACR/ARHP Annual Meeting
Comparison Of Remission Rates For Pediatric Membranous Plus Proliferative Lupus Nephritis Versus Isolated Proliferative Lupus Nephritis: An Analysis Of The Childhood Arthritis and Rheumatism Research Alliance Registry
Alexis Boneparth¹, Norman T. Ilowite¹ and The CARRA Registry Investigators², ¹Pediatrics, The Children's Hospital at Montefiore, Bronx, NY, ²Duke Clinical Research Institute, Durham, NC
Background/Purpose: Lupus nephritis (LN) affects many patients with pediatric systemic lupus erythematosus (pSLE) and is a significant cause of disease morbidity. Inability to achieve remission…
Abstract Number: 1263 • 2013 ACR/ARHP Annual Meeting
Childhood-Onset Systemic Lupus Erythematosus In Ontario: Long Term Outcomes In a Population-Based Cohort With Universal Health Care Coverage
Deborah M. Levy¹, Nadia Gunraj², Janet E. Pope³, J. Carter Thorne⁴, Wesley Fidler⁵, Peter B. Dent⁶, Johannes Roth⁷, Roberta A. Berard⁸, Murray Berall⁹, Astrid Guttmann¹⁰ and Earl D. Silverman¹¹, ¹Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ²Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, ³Medicine/Rheumatology, St. Joseph's Health Care, University of Western Ontario, London, ON, Canada, ⁴Southlake Regional Health Centre, Newmarket, ON, Canada, ⁵Rheumatology, St. Joseph's Hospital, Thunder Bay, ON, Canada, ⁶McMaster University, Hamilton, ON, Canada, ⁷University of Ottawa, Ottawa, ON, Canada, ⁸Children's Hospital of Western Ontario, London, ON, Canada, ⁹Nephrology, Humber River Regional Hospital, Toronto, ON, Canada, ¹⁰Pediatrics, Institute for Clinical Evaluative Sciences, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ¹¹Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Background/Purpose: Little is known about the long-term morbidity and mortality of childhood-onset SLE (cSLE) after transition to adult care; however, linking clinical data to administrative…
Abstract Number: 645 • 2013 ACR/ARHP Annual Meeting
Transcript Profiling Of Blood and Kidney Biopsies From Chinese Patients With Lupus Nephritis Reveals Concordant Activation Of Type I IFN Signaling In The Blood and Kidney, Reduced B Cell Presence In The Blood, and Increased Macrophages In The Kidney
Zheng Liu¹, Chris, A. Morehouse¹, Xinfang Huang², Philip Brohawn¹, Nan Shen², Yihong Yao¹ and Brandon W. Higgs¹, ¹Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ²Dept of Rheumatology, Shanghai Ren Ji Hospital, Shanghai, China
Background/Purpose: Up-regulated expression of type I interferon-regulated genes has consistently been observed within the peripheral blood in a large proportion of patients with active systemic…
Abstract Number: 582 • 2013 ACR/ARHP Annual Meeting
A Real-World Survey Of Clinical Practice Among Rheumatologists and Nephrologists In The United States Reveals Differences In Care Of Non-Nephritis Systemic Lupus Erythematosus and Lupus Nephritis As Compared With American College Of Rheumatology Treatment Guidelines
Neelufar Mozaffarian¹, Steve Lobosco² and Adam Roughley², ¹AbbVie, North Chicago, IL, ²Adelphi Real World Ltd., Macclesfield, United Kingdom
Background/Purpose: Current pharmacotherapy for systemic lupus erythematosus (SLE) and lupus nephritis (LN) includes combinations of nonsteroidal anti–inflammatory drugs (NSAIDs), antimalarials (AMs), glucocorticoids (GCs), and cytotoxic…
Abstract Number: 589 • 2013 ACR/ARHP Annual Meeting
A Survey Of Physician and Patient Satisfaction With Control Of Systemic Lupus Erythematosus and Lupus Nephritis
Neelufar Mozaffarian¹, Steve Lobosco² and Adam Roughley², ¹AbbVie, North Chicago, IL, ²Adelphi Real World Ltd., Macclesfield, United Kingdom
Background/Purpose: Patient satisfaction with disease control is an important component of overall health and well-being. Current treatment options for systemic lupus erythematosus (SLE) ±lupus nephritis…
Abstract Number: 594 • 2013 ACR/ARHP Annual Meeting
Renal Biopsy Findings In Lupus Patient With Insignificant Proteinuria : Relation To Disease Activity and Clinical Manifestations
Abdel Azeim M. Al-Hefny¹, Samah El-bakry², Sameh A. Mobasher³, Ola H. Nada⁴ and Nouran Abaza⁵, ¹Department of Internal Medicine and Rheumatology, Professor of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt, Cairo, Egypt, ²Department of Internal Medicine and Rheumatology, Assistant professor of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt, ³Department of Internal Medicine and Rheumatology, Lecturer of Internal Medicine and Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt, ⁴Department of Pathology, Faculty of Medicine, Ain Shams University, Lecturer of Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt, ⁵Physical medicine, Rheumatology and Rehabilitation, Lecturer of Physical medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Background/Purpose: Lupus nephritis (LN) remains one of the most serious manifestations of systemic lupus erythematosus (SLE) and is associated with significant morbidity and mortality. Early…
Abstract Number: 600 • 2013 ACR/ARHP Annual Meeting
Factors Associated With Long-Term Renal Function Deterioration In Lupus Nephritis Treated Initially With Combined Prednisolone and Mycophenolate Mofetil (MMF) Or Tacrolimus (Tac)
Chi Chiu Mok¹, Chi Hung To¹, King Yee Ying², Cheuk-Wan Yim³ and Woon Leung Ng⁴, ¹Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, ²Department of Medicine, Princess Margaret Hospital, Hong Kong, Hong Kong, ³Dept of Medicine, United Christian Hospital, Hong Kong, Hong Kong, ⁴Medicine, United Christian Hospital, Hong Kong, Hong Kong
Background/Purpose: To study the risk factors for renal function decline in patients with lupus nephritis treated initially with combined steroid and MMF or Tac.Methods: Data…
Abstract Number: 580 • 2013 ACR/ARHP Annual Meeting
Lupus Nephritis Flares Precipitated By Switching From Mycophenolate Mofetil to Azathioprine in Pre-Pregnancy Planning
Natasha Jordan and David D'Cruz, Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease that affects women of childbearing age. Lupus nephritis is a major cause of morbidity and…
Abstract Number: L18 • 2013 ACR/ARHP Annual Meeting
Long-Term Evaluation of Bone Mineral Density Change in Women Receiving Depot Leuprolide Acetate during Cyclophosphamide Therapy for Severe Lupus Nephritis
Nathan Meier¹ and Mary Anne Dooley², ¹Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Cohort studies demonstrate that 11-83% of female patients receiving cyclophosphamide (CYC) for treatment of severe manifestations of SLE develop premature ovarian failure (POF), dependent…
Abstract Number: 2249 • 2012 ACR/ARHP Annual Meeting
Comparison of Mycophenolate Mofetil and Intravenous Cyclophosphamide As Induction Therapy in Korean Patients with Lupus Nephritis
Dong-Jin Park¹, Kyung-Eun Lee¹, Tae-Jong Kim¹, Yong-Wook Park¹ and Shin-Seok Lee², ¹Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, ²Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea
Background/Purpose: Although intravenous cyclophosphamide (IVC) pulses are generally accepted as standard therapy for induction treatment of active proliferative lupus nephritis (LN), several clinical trials have…
Abstract Number: 306 • 2012 ACR/ARHP Annual Meeting
Children with Probable SLE by ACR Criteria May Need More Aggressive Lupus Treatment Early in the Disease Course
Anjali Patwardhan¹, Igor Dvorchik² and Charles H. Spencer³, ¹Pediatric Rheumatology, Nationwide Childrens Hospital, Columbus, OH, ²Biostatistics Division, Nationwide Children's Hospital,, Columbus, OH, ³Rheumatology, Nationwide Childrens Hospital, Columbus, OH
Background/Purpose: This research explores whether delay of the childhood-onset SLE (cSLE) diagnosis until 4/11 ACR criteria are met affects patient outcome negatively Methods: Institutional Review…

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