ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Lupus nephritis"

  • Abstract Number: 012 • 2023 Pediatric Rheumatology Symposium

    Thrombotic Microangiopathic Changes in Kidney Biopsies of Childhood-Onset Systemic Lupus Erythematous Patients with and Without Severe Hematologic Disturbances

    Cathy Tsin1, Megan Troxell1, Vivek Charu1, Rufei Lu2 and Joyce Hsu3, 1Stanford University, Palo Alto, CA, 2UCSF, San Francisco, CA, 3Stanford Medicine, Children's Health, Palo Alto, CA

    Background/Purpose: Outcomes for pediatric patients with lupus nephritis (LN) remain suboptimal. LN may present with thrombotic microangiopathy (TMA) seen on kidney biopsy. Childhood-onset SLE patients…
  • Abstract Number: 005 • 2023 Pediatric Rheumatology Symposium

    Real-World Application of the Pediatric Glucocorticoid Toxicity Index in Children with Lupus Nephritis: A Feasibility and Initial Validation Study

    Emily Zhang1, Gabrielle Alonzi1, Madeline Hlobik1, Esra Meidan1, Mindy Lo1, Olha Halyabar2, Melissa Hazen1, Ezra Cohen3, Lauren Henderson1, Siobhan Case4, Margaret Chang1, Camille Frank1, Ankana Daga1, Jonathan Hausmann5, Ahmad Bakhsh1, Liyoung Kim1, Daniel Ibanez1, Holly Wobma1, Mia Chandler6, Fatma Dedeoglu1, Robert Sundel1, Peter Nigrovic1, Karen Costenbader7, Mary Beth Son1 and Joyce Chang1, 1Boston Children's Hospital, Boston, MA, 2Children's Hospital/Boston Medical Center, Boston, MA, 3Boston Medical Center, Boston, MA, 4Brigham and Women's Hospital, Boston Children's Hospital, Boston, MA, 5Boston Children's Hospital / Massachusetts General Hospital, Boston, MA, 6Boston Children's Hospital; Brigham and Women's Hospital, Boston, MA, 7Brigham and Women's Hospital/ Harvard Medical School, Boston, MA

    Background/Purpose: The morbidity of chronic glucocorticoid (GC) use is rarely captured as a standardized clinical outcome in pediatric rheumatic conditions. The newly developed pediatric glucocorticoid…
  • Abstract Number: 047 • 2023 Pediatric Rheumatology Symposium

    Clinical Characteristics and Outcomes of North American Youth with Lupus Nephritis Requiring Dialysis Treated with Cyclophosphamide

    Christine Wang1, Rebecca Sadun2, Wenru Zhou3, Kristen Miller3, Claire Palmer3, Stacy Ardoin4, Christine Bacha5, Emily Hause6, Joyce Hui-Yuen7, Nicole Ling8, Maria Pereira9, Meredith Riebschleger1, Kelly Rouster-Stevens10, Aliese Sarkissian11, Julia Shalen12, William Soulsby13, Marinka Twilt14, Eveline Wu15, Laura Lewandowski16, Scott Wenderfer17 and Jennifer Cooper18, 1University of Michigan, Ann Arbor, MI, 2Duke University, Durham, NC, 3University of Colorado, Denver, CO, 4Nationwide Children's Hospital, Columbus, OH, 5Akron Children's Hospital, Akron, OH, 6University of Minnesota, Minneapolis, MN, 7Cohen Children's Medical Center, Northwell Health, Lake Success, New York; Center for Autoimmune, Musculoskeletal, and Hematopoietic Diseases Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, 8UCSF, San Francisco, CA, 9Baylor College of Medicine, Houston, TX, 10Emory University/Children's Healthcare of Atlanta, Atlanta, GA, 11UNC- Chapel Hill, Durham, NC, 12Johns Hopkins University, Baltimore, MD, 13University of California, San Francisco, San Francisco, CA, 14Alberta Children's Hospital, Calgary, AB, Canada, 15UNC Chapel Hill, Chapel Hill, NC, 16NIAMS, NIH, Bethesda, MD, 17British Columbia Children's Hospital, Vancouver, BC, Canada, 18University of Colorado/Children's Hospital Colorado, Denver, CO

    Background/Purpose: Few studies have evaluated the clinical characteristics and outcomes of youth with lupus nephritis (LN) treated with cyclophosphamide (CYC) who initially required kidney replacement…
  • Abstract Number: 050 • 2023 Pediatric Rheumatology Symposium

    Predictive Value of the 2019 EULAR/ACR SLE Criteria’s Extra-Renal Domains to Renal Response One Year After Treatment in a Pediatric Lupus Nephritis Cohort

    Sara Patrizi1, Megha Tandel2, Derek Boothroyd2 and Joyce Hsu1, 1Stanford Medicine, Children's Health, Palo Alto, CA, 2Quantitative Sciences Unit, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA

    Background/Purpose: In 2019, new classification criteria for SLE were developed by the EULAR/ACR. Prior research in adult lupus cohorts found a positive correlation between high…
  • Abstract Number: 0323 • ACR Convergence 2022

    Identifying Distinct Phenotypes of Patients with Juvenile Systemic Lupus Erythematosus: Results from a Cluster Analysis by the Egyptian College of Rheumatology (ECR) Study Group

    Nevin Hammam1, Mohamed Bakrey Mahmoud2, Aly Bakhiet3, Rasha El Owaidy4, Hend Abdel Nabi5, Ahmed M Elsaman6, Iman Khalifa7, Abeer M NourEl-Din8, Rawhya R ElShereef9, Eman Hassan10, Faten Ismail9, Iman I El-Gazzar11, Abdelhafeez Moshrif12, Noha M Khalil13, Marwa A Amer14, Hanan M Fathy15, Nancy Abdel Salam15, Samar Tharwat16, Mervat I Abd Elazeem17, Hanan M Fathi18 and Tamer A Gheita11, 1Rheumatology Department, Faculty of Medicine, Assiut University, Assiut, Egypt, PASADENA, CA, 2Higher Institute for Computer Science and Information Systems, 6th of October City, Cairo, Egypt, 3Higher Institute for Computer Science and Information Systems, 6th of October City, Assiut, Egypt, 4Pediatric Allergy, Immunology and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt, 5Pediatrics Department, Rheumatology and Nephrology Unit, Tanta University, Gharbia, Egypt, 6Rheumatology Department, Faculty of Medicine, Sohag University, Sohag, Egypt, 7Pediatrics Department, Rheumatology and Nephrology Unit, Helwan University, Cairo, Egypt, 8Pediatrics Department, National Research Centre (NRC), Cairo, Egypt, 9Rheumatology Department, Faculty of Medicine, Minia University, Minia, Egypt, 10Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt, 11Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt, 12Rheumatology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt, 13Internal Medicine Department, Rheumatology Unit, Faculty of Medicine, Cairo University, Cairo, Egypt, 14Rheumatology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt, 15Pediatrics Department, Rheumatology and Nephrology Unit, Alexandria University, Alexandria, Egypt, 16Internal Medicine, Rheumatology Unit, Mansoura University, Dakahlia, Egypt, Dakahlia, Egypt, 17Rheumatology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt, 18Rheumatology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt

    Background/Purpose: Juvenile systemic lupus erythematosus (J-SLE) is a complex autoimmune disease characterized by a great heterogeneity in organs involvement. A better understanding of the organ…
  • Abstract Number: 0540 • ACR Convergence 2022

    Evaluation of Traditional Laboratory Markers as Predictors of Renal Flares: A Post-hoc Analysis of Four Phase III Clinical Trials of SLE

    Sandra Jägerback1, Alvaro Gomez1 and Ioannis Parodis2, 1Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 2Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: In patients with systemic lupus erythematosus (SLE), renal involvement is associated with high morbidity, and renal flare is a major contributing factor to poor…
  • Abstract Number: 0992 • ACR Convergence 2022

    Interim Results from the Phase 2 MISSION Study Evaluating Zetomipzomib (KZR-616), a First-in-Class Selective Immunoproteasome Inhibitor for the Treatment of Lupus Nephritis

    Amit Saxena1, Samir Parikh2, Richard Furie3, Richard Leff4, Steven Hua4, Li Long5 and Noreen Henig4, 1NYU School of Medicine, New York, NY, 2The Ohio State University, Columbus, OH, 3Northwell Health, Great Neck, NY, 4Kezar Life Sciences, South San Francisco, CA, 5Kezar Life Sciences, Inc., South San Francisco, CA

    Background/Purpose: Zetomipzomib is a first-in-class selective inhibitor of the immunoproteasome that is active in multiple autoimmune disease models, including murine models of SLE and LN.…
  • Abstract Number: 1478 • ACR Convergence 2022

    Urine ALCAM Is a Strong Predictor of Lupus Nephritis

    Dalena Chu1, Noa Schwartz2, Jeanette Ampudia1, Joel Guthridge3, Judith James3, Jill Buyon4, Stephen Connelly1, Maple Fung1, Cherie Ng1, AMP SLE/RA consortium5, Michelle Petri6, Chandra Mohan7 and Chaim Putterman8, 1Equillium, Inc., La Jolla, CA, 2Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY, 3Oklahoma Medical Research Foundation, Oklahoma City, OK, 4NYU Grossman School of Medicine, New York, NY, 5Accelerating Medicines Partnership, Los Angeles, CA, 6Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD, 7University of Houston, Houston, TX, 8Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: T cells play a critical role in the pathogenicity of SLE and lupus nephritis (LN). Hence, identifying T cell co-stimulatory pathways and mediators that…
  • Abstract Number: 2072 • ACR Convergence 2022

    Estimating Corticosteroid-Related Morbidity in Lupus Nephritis: The Glucocorticoid Toxicity Index

    Ilana Usiskin and Vasileios Kyttaris, Beth Israel Deaconess Medical Center, Boston, MA

    Background/Purpose: Patients with lupus nephritis (LN) are often treated with high doses of glucocorticoids and experience glucocorticoid-related toxicity. Quantifying this toxicity may be a useful…
  • Abstract Number: 0331 • ACR Convergence 2022

    Anti-dsDNA Antibodies by Multiplex Flow Immunoassay and Critihidia Luciliae Assays in NYU Lupus Registry: Discordance, Association with Nephritis, and Disease Flare Predictive Value

    Devyn Zaminski1, Amit Saxena1, Peter Izmirly2, Jill Buyon2 and H Michael Belmont1, 1NYU School of Medicine, New York, NY, 2NYU Grossman School of Medicine, New York, NY

    Background/Purpose: SLE is characterized by autoantibody production. The most common lupus-specific serology is the anti-dsDNA antibody (anti-DNA). Traditionally, anti-DNA is measured by an enzyme immunoassay…
  • Abstract Number: 0541 • ACR Convergence 2022

    Prevalence of Venous Thrombo-Embolism in Lupus Nephritis and Associated Risk Factors

    Tara Tofighi, Jiandong Su and Zahi Touma, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada

    Background/Purpose: Patients with SLE have an increased risk of developing venous thrombo-embolism (VTE) based on several cohort studies, accounting for significant morbidity and mortality. Lupus…
  • Abstract Number: 1001 • ACR Convergence 2022

    Effect of Atacicept on Renal Function in Patients with Systemic Lupus Erythematosus (SLE)

    David Isenberg1, Celia Lin2, Amy Kao3, Aida Aydemir4 and Caroline Gordon5, 1University College London, London, United Kingdom, 2Vera Therapeutics, Inc, Burlingame, CA, 3EMD Serono, Billerica, MA, 4EMD Serono Research & Development Institute, Inc, Billerica, MA, 5Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom

    Background/Purpose: Atacicept is a fusion protein that blocks B-lymphocyte stimulator and a proliferation-inducing ligand, which are increased in patients with SLE. APRIL-SLE was a double-blind,…
  • Abstract Number: 1480 • ACR Convergence 2022

    Is Lupus Podocytopathy a New Variant of Lupus Nephritis?

    Clarice P. Lin1 and Richard C. Chou2, 1University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Department of Medicine, Buffalo, NY, 2University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Division of Allergy, Immunology, & Rheumatology, Department of Medicine, Buffalo, NY

    Background/Purpose: Kidney disease is a common manifestation of systemic lupus erythematosus (SLE); when it presents as glomerulonephritis also known as lupus nephritis (LN), it predicts…
  • Abstract Number: 2077 • ACR Convergence 2022

    Does Early Complete Remission Preclude Adverse Outcomes in Lupus Nephritis?

    KONSTANTINOS TSELIOS1, Dafna Gladman2, Jiandong Su3 and Murray Urowitz4, 1McMaster University, Population Health Research Institute, Hamilton, ON, Canada, 2Toronto Western Hospital, Schroeder Arthritis Institute, Toronto, ON, Canada, 3Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 4University of Toronto, University Health Network, Schroeder Arthritis Institute, Toronto, ON, Canada

    Background/Purpose: Background: Early complete remission (within 12 months from diagnosis) is considered an important protective factor against development of advanced chronic kidney disease (CKD) in…
  • Abstract Number: 0333 • ACR Convergence 2022

    Autoantibody Trajectories Associate with Classification and Treatment Response in Lupus Nephritis

    Andrea Fava1, Carla J. Guthridge2, Joseph Kheir2, Catriona Wagner3, Michelle Petri4, Jill Buyon5, Betty Diamond6, the Accelerating Medicines Partnership (AMP) RA/SLE7, Joel Guthridge2 and Judith James2, 1Johns Hopkins University, Baltimore, MD, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Oklahoma Medical Research Foundation, Oklahoma, 4Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD, 5NYU Grossman School of Medicine, New York, NY, 6Feinstein Institutes for Medical Research, Manhasset, NY, 7Multiple Insitutions

    Background/Purpose: Autoantibodies are a hallmark of lupus nephritis (LN). While there is known heterogeneity in autoantibody expression among LN patients, the association of autoantibodies with…
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